CN101268971A

CN101268971A - Internally bare bracket of vascellum

Info

Publication number: CN101268971A
Application number: CNA2008101061401A
Authority: CN
Inventors: 乔爱科; 顾兆勇; 贯建春; 孟宪龙; 张宏斌
Original assignee: Beijing University of Technology
Current assignee: Beijing University of Technology
Priority date: 2008-05-09
Filing date: 2008-05-09
Publication date: 2008-09-24
Anticipated expiration: 2028-05-09
Also published as: CN101268971B

Abstract

An endovascular bare stent belongs to the technical field of biomedical engineering. The stent is a tubelike mesh-screen stent 1 which is arranged in the blood vessels along the vessel wall. The invention is characterized in that the cross-section of the mesh-screen of the mesh stent 1 takes the shape of a trapezium. The long edge of the trapezium is the outer side 3 of the mesh-screen stent. The short edge of the trapezium is the inner side 2 of the mesh-screen stent. The ratio of short side of the trapezium to long side of the trapezium is less than 50 percent. The penetrating ratio of the mesh-screen of the mesh-screen stent 1 is 40 percent to 80 percent. After the stent covers the aneurysm, the resistance of the blood flowing into the tumor cavity is large, and the resistance of the blood flowing out of the tumor cavity is small; therefore, the blood flowing in the tumor cavity is inhibited so as to reach the purpose of treatment. The stent has little effect on perforating branches vessel, can easily be sent to tortuous intracranial artery, thereby causing the nerves involved in the treatment of cerebral aneurysms more extensive, saving more patients, and being good Gospel for doctors and patients.

Description

A kind of internally bare bracket of vascellum

Technical field

The invention belongs to the biomedical engineering technology field, relate to a kind of endovascular stent that is used for interventional therapy.

Background technology

In the medical science, aneurysmal Therapeutic Method is except that surgical clips is closed, and what often adopt is interventional therapy method.The endovascular stent Therapeutic Method has very remarkable advantages with respect to traditional operative treatment, and promptly wound is slight, mortality rate is low, average of operation periods is short, cost is low etc., so more and more receive clinical medical attention.First support is used for clinical aneurysm treatment also only has year surplus in the of ten apart from the present time from Parodi in 1991.This technology still is at an early stage of development at present, also exists many problems to remain to be furtherd investigate in the treatment, particularly must consider a series of complicated factors when the treatment intracranial aneurysm.

Overlay film frame is suitable for aneurysmal embolotherapy most.Use when overlay film frame is treated aneurysm in the blood vessel, the blood flow of tumor mouth is stoped by one deck physical barriers, can be when keeping parent artery unobstructed, isolate pathological changes rapidly, end the blood flow in it, can reduce aneurysmal hemodynamics damage, promote the formation of tumor intracavity thrombosis, reach therapeutic purposes.But the topmost defective of overlay film frame is the little blood vessel of wanting in inaccessible its institute's coverage of branch, and seals these peripheral vessels branches and perforating branches may cause serious consequence.Adopt the selectivity overlay film frame in the sealing aneurysm neck, can avoid the shutoff perforating branch, but the location of operation difficulty is big.Because the cerebral arteries many places are in the tip position, tiny and tortuous blood vessel is had relatively high expectations to vertical motility of the importing of support and compliance, operation, cause the interior overlay film frame of blood vessel also to be subjected to certain restriction, be difficult for sending to the extremely tortuous year tumor position of little blood vessel in the application of intracranial; In addition, overlay film frame also is not suitable for treating the aneurysm that is positioned at furcation or the opening aneurysm near aortic bifurcation in the blood vessel.Therefore, the application of overlay film frame at present only limits to the outer blood vessel of cranium, internal carotid artery near-end and vertebra basilar artery, uses less in entocranial artery.

The appearance of intracranial special stand Neuroform and can shirk turn (Guglielmidetechable coil in conjunction with electrolysis, GDC), GDC, all kinds of liquid embolizing agent and the different materials after the modification is in clinical integrated application, to the treatment refractory aneurysms particularly the wide carotid aneurysm of intracranial play a role, make aneurysmal endovascular treatment indication more extensive.Yet the same existence of Neuroform support may cause near the perforating branches blood vessel pressurized aneurysm or obturation, putting in place and discharge problems such as still there being certain difficulty for tortuous entocranial arteries such as anterior cerebral arterys.

Summary of the invention

The purpose of this invention is to provide and a kind ofly make the easy inflow of blood but be not easy effusive internally bare bracket of vascellum, the drawback of having avoided existing support above-mentioned to exist.

Solution of the present invention is: a kind of internally bare bracket of vascellum is provided, this support is for being positioned over endovascular tubulose mesh wire stents 1 along blood vessel wall, it is characterized in that: the cross section of the twine of described mesh wire stents 1 is trapezoidal, trapezoid long limit is the mesh wire stents outside 3, trapezoid minor face is mesh wire stents inboard 2, and the ratio on trapezoid minor face and long limit is less than 50%.The penetrating rate of the silk screen of described mesh wire stents 1 is 40% to 80%.Because trapezoid long limit is the mesh wire stents outside 3, trapezoid minor face is mesh wire stents inboard 2, and the ratio on trapezoid minor face and long limit is less than 50%, and the penetrating rate of silk screen of mesh wire stents 1 less than 80%, guaranteed that the easy inflow of blood but is not easy to flow out mesh wire stents 1.The cross section of twine also can be triangle, and leg-of-mutton base is the mesh wire stents outside 3, and leg-of-mutton drift angle is mesh wire stents inboard 2, and the penetrating rate of the silk screen of this mesh wire stents is 40% to 80%.The cross section of twine also can be for long limit and minor face trapezoidal with radian all, the convex surface of radian is all towards the support outside, and trapezoid long limit is the mesh wire stents outside 3, trapezoid minor face is mesh wire stents inboard 2, and the ratio on trapezoid minor face and long limit is less than 50%, and the penetrating rate of the silk screen of this mesh wire stents 1 is 40% to 80%.The cross section of twine can also be semicircle, and semicircular diameter limit is the mesh wire stents outside 3, and semicircular circular arc limit is mesh wire stents inboard 2, and the penetrating rate of the silk screen of this mesh wire stents 1 is 40% to 80%.More than design has all reached the purpose that blood easy inflow but is not easy to flow out mesh wire stents 1.

The invention has the beneficial effects as follows: after adopting such scheme, the easy inflow of the blood in the blood vessel at placing rack place but is not easy to flow out blood vessel, makes the pathological tissues at this place can not get competent blood supply, can suppress its development; Because support is not that overlay film is totally enclosed, thereby can not influence near the blood supply of branch vessel fully.

Description of drawings

Fig. 1 is the population structure sketch map of silk screen bare bracket in the blood vessel;

Fig. 2 is the cross sectional representation 1 of the twine of mesh wire stents;

Fig. 3 is the cross sectional representation 2 of the twine of mesh wire stents;

Fig. 4 is the cross sectional representation 3 of the twine of mesh wire stents;

Fig. 5 is the cross sectional representation 4 of the twine of mesh wire stents;

Among the figure, 1 mesh wire stents, 2, the support inboard, 3, the support outside.

The specific embodiment

Twine in the blood vessel that the present invention introduces in the mesh wire stents 1 is different with the twine in traditional mesh wire stents, the cross section of traditional twine is square or circular, and the cross section of the twine of this paper introduction is trapezoidal (as Fig. 2), and trapezoid long limit is in the support outside 3, and trapezoid minor face is in support inboard 2.Like this, the penetrating rate of blood vessel inside and outside of cavity does not wait, and the penetrating rate in the lumen of vessels is little, and the penetrating rate outside the lumen of vessels is big.It is easy to make blood flow go into blood vessel like this, flows out the blood vessel difficulty.Obvious in order to guarantee the inside and outside penetrating rate variance of lumen of vessels, trapezoid minor face is less than 50% with the ratio on long limit; Also have, mesh wire stents 1 inside and outside total average penetrating rate can not be excessive, do not suppress the effect that blood flow goes out blood vessel otherwise have, but can not be too small, otherwise can influence the blood supply of branch vessel, so the inside and outside total average penetrating rate of support should be 40% to 80%.In addition, the cross section of twine also can be triangle (as Fig. 3), and leg-of-mutton base is the mesh wire stents outside 3, and leg-of-mutton drift angle is mesh wire stents inboard 2, and the penetrating rate of the silk screen of this mesh wire stents 1 is 40% to 80%.The cross section of twine also can for long limit and minor face all with trapezoidal (as Fig. 4) of radian, the convex surface of radian is all towards the support outside, and trapezoid long limit is the mesh wire stents outside 3, trapezoid minor face is mesh wire stents inboard 2, and the ratio on trapezoid minor face and long limit is less than 40%, and the penetrating rate of the silk screen of this mesh wire stents 1 is 40% to 80%.The cross section of twine can also be semicircle (as Fig. 5), and semicircular diameter limit is the mesh wire stents outside 3, and semicircular circular arc limit is mesh wire stents inboard 2, and the penetrating rate of the silk screen of this mesh wire stents is 40% to 80%.More than design has all reached the purpose that blood easy inflow but is not easy to flow out mesh wire stents 1.

The network structure of the mesh wire stents 1 of introduction of the present invention can adopt at present the version at any one blood vessel network of usefulness, runs through dowel, non-homogeneous amplitude waveform configuration and other any structures (as Fig. 1) that are suitable for support is put into blood vessel such as circle or rhombus as peak before and after sinusoidal wave form annular support body+V-arrangement connector structure, U-loop shape supporter+U type structure, the U type annular support body.

The making of the mesh wire stents 1 of introduction of the present invention can be adopted at present the making material in any one blood vessel mesh wire stents of usefulness, as Nickel-titanium alloy for medical purpose, medical stainless steel etc.

When the support of introduction of the present invention covers such as aneurysm cavity, correspondingly to flow into the resistance in tumor chamber big and to flow out the resistance in tumor chamber little for blood, thereby the tumor intracavity blood is flowed to be suppressed, promote tumor intracavity formation blood clot or thrombosis so that the aneurysm atrophy, reduce the tumor cavity pressure, reduce aneurysm and increase and disruptive potential danger, reach the purpose of treatment.

The support that the present invention introduces is very little to the influence of perforating branches blood vessel, and there are not the constraint of overlay film, submissive row to increase to make it to send to tortuous entocranial artery easilier, so the operation cost will reduce greatly, make that neural interventional therapy cerebral aneurysm indication is more extensive, can save more patients' life, this all is good Gospel undoubtedly concerning doctor and patient.

Claims

1. internally bare bracket of vascellum, this support is for being positioned over endovascular tubulose mesh wire stents (1) along blood vessel wall, it is characterized in that: the cross section of the twine of described mesh wire stents (1) is trapezoidal, trapezoid long limit is the mesh wire stents outside (3), trapezoid minor face is mesh wire stents inboard (2), and the ratio on trapezoid minor face and long limit is less than 40%; The penetrating rate of the silk screen of described mesh wire stents (1) is 40% to 80%.

2. internally bare bracket of vascellum according to claim 1 is characterized in that: the twine cross section of described mesh wire stents (1) is a triangle, and leg-of-mutton base is the mesh wire stents outside (3), and leg-of-mutton drift angle is mesh wire stents inboard (2); The penetrating rate of the silk screen of described mesh wire stents 1 is 40% to 80%.

3. internally bare bracket of vascellum according to claim 1, it is characterized in that: the cross section of the twine of described mesh wire stents (1) is trapezoidal with radian all for long limit and minor face, the convex surface of radian is all towards the support the inside, and trapezoid long limit is the mesh wire stents outside (3), trapezoid minor face is mesh wire stents inboard (2), and the ratio on trapezoid minor face and long limit is less than 40%; The penetrating rate of the silk screen of described mesh wire stents (1) is 40% to 80%.

4. internally bare bracket of vascellum according to claim 1 is characterized in that: the cross section of the twine of described mesh wire stents (1) is for semicircle, and semicircular diameter limit is the mesh wire stents outside (3), and semicircular circular arc limit is mesh wire stents inboard (2); The penetrating rate of the silk screen of described mesh wire stents (1) is 40% to 80%.