CN101262817B - 用于成像的多次造影剂注射 - Google Patents

用于成像的多次造影剂注射 Download PDF

Info

Publication number
CN101262817B
CN101262817B CN2006800335475A CN200680033547A CN101262817B CN 101262817 B CN101262817 B CN 101262817B CN 2006800335475 A CN2006800335475 A CN 2006800335475A CN 200680033547 A CN200680033547 A CN 200680033547A CN 101262817 B CN101262817 B CN 101262817B
Authority
CN
China
Prior art keywords
contrast agent
testing fixture
agent application
contrast
fixture according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800335475A
Other languages
English (en)
Chinese (zh)
Other versions
CN101262817A (zh
Inventor
H·达恩克
T·舍夫特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics NV filed Critical Koninklijke Philips Electronics NV
Publication of CN101262817A publication Critical patent/CN101262817A/zh
Application granted granted Critical
Publication of CN101262817B publication Critical patent/CN101262817B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48—Diagnostic techniques
    • A61B6/481—Diagnostic techniques involving the use of contrast agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/563—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution of moving material, e.g. flow contrast angiography
    • G01R33/56366—Perfusion imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/50—NMR imaging systems based on the determination of relaxation times, e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Signal Processing (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Optics & Photonics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2006800335475A 2005-09-13 2006-09-07 用于成像的多次造影剂注射 Expired - Fee Related CN101262817B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05108409 2005-09-13
EP05108409.3 2005-09-13
PCT/IB2006/053143 WO2007031910A2 (en) 2005-09-13 2006-09-07 Multiple contrast agent injection for imaging

Publications (2)

Publication Number Publication Date
CN101262817A CN101262817A (zh) 2008-09-10
CN101262817B true CN101262817B (zh) 2011-09-07

Family

ID=37865329

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800335475A Expired - Fee Related CN101262817B (zh) 2005-09-13 2006-09-07 用于成像的多次造影剂注射

Country Status (5)

Country Link
US (2) US8175678B2 (https=)
EP (1) EP1926425B1 (https=)
JP (1) JP6059414B2 (https=)
CN (1) CN101262817B (https=)
WO (1) WO2007031910A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5416970B2 (ja) 2005-09-02 2014-02-12 ビセン メディカル， インコーポレイテッド ニコチン酸及びピコリン酸誘導近赤外線蛍光団
US8175678B2 (en) 2005-09-13 2012-05-08 Koninklijke Philips Electronics N.V. Multiple contrast agent injection for imaging
JP2011509790A (ja) * 2008-01-23 2011-03-31 ミカラキス アヴェルキオウ 超音波造影剤を用いる呼吸同期治療評価
WO2009097277A1 (en) * 2008-02-01 2009-08-06 Trustees Of Boston University Cationic contrast agents and methods of use thereof
JP5307453B2 (ja) * 2008-05-29 2013-10-02 株式会社日立メディコ 超音波診断装置
JP5360466B2 (ja) * 2008-07-11 2013-12-04 国立大学法人福井大学 Ｐｅｔ薬剤送出装置およびその作動方法
US10032268B2 (en) 2012-08-06 2018-07-24 Koninklijke Philips N.V. Dynamic contrast-enhanced imaging based permeability metric
DE102015222853A1 (de) * 2015-11-19 2017-05-24 Siemens Healthcare Gmbh Verfahren zum automatischen Ermitteln eines Kontrastmittel-Injektionsprotokolls
US11353533B2 (en) 2016-02-24 2022-06-07 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
EP3382414B1 (de) * 2017-03-28 2024-09-18 Siemens Healthineers AG Verfahren zur durchführung einer angiographischen messung und erstellung einer angiographie
CN111458321B (zh) * 2020-05-22 2021-11-23 南京诺源医疗器械有限公司 一种基于病变部位荧光反馈的诊断系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA852979B (en) * 1984-04-27 1985-11-27 Vestar Research Inc Contrast agents for nmr imaging
US5164297A (en) 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
US5304931A (en) * 1991-08-09 1994-04-19 Flamig Duane P Magnetic resonance imaging techniques
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
JPH10511701A (ja) * 1995-10-19 1998-11-10 ブラッコ インターナショナル ベスローテン フエンノートシャップ 生体組織のｎｍｒイメージングにおける標的コントラスト剤としての磁気標識化学誘引剤
US6009342A (en) * 1997-02-28 1999-12-28 The Regents Of The University Of California Imaging method for the grading of tumors
EP1118009A1 (en) 1998-09-28 2001-07-25 Nycomed Imaging As Method of magnetic resonance imaging
GB9821038D0 (en) * 1998-09-28 1998-11-18 Nycomed Imaging As Method
JP2002539880A (ja) * 1999-03-26 2002-11-26 エスターガード，レイフ 断層撮影データを使用して血液動態指数を決定する方法
US6355225B1 (en) 1999-10-05 2002-03-12 Wm. Marsh Rice University Tda Research, Inc. Fullerene contrast agent for magnetic resonance imaging and spectroscopy
GB0007873D0 (en) 2000-03-31 2000-05-17 Nycomed Imaging As Method
US6807441B2 (en) * 2000-05-19 2004-10-19 The Mcw Research Foundation Inc. Evaluation of tumor angiogenesis using magnetic resonance imaging
GB0117187D0 (en) * 2001-07-13 2001-09-05 Isis Innovations Ltd Magnetic resonance imaging
US20040073117A1 (en) * 2002-02-14 2004-04-15 Schwarz Karl Q. Method and system for delivering contrast agent
AU2003247379A1 (en) * 2002-05-17 2003-12-02 Case Western Reserve University Systems and methods for assessing blood flow in a target tissue
JP4013128B2 (ja) * 2002-09-12 2007-11-28 株式会社日立メディコ 血流動態解析装置、方法、及び画像診断装置
CA2519376A1 (en) * 2003-03-18 2004-09-30 Dyerx Medical Inc. Methods and devices for retrieval of a medical agent from a physiological efferent fluid collection site
US7649981B2 (en) * 2003-10-15 2010-01-19 Varian Medical Systems, Inc. Multi-energy x-ray source
JP4446049B2 (ja) * 2003-11-06 2010-04-07 株式会社三重ティーエルオー 心筋血流の定量化装置
US7567832B2 (en) * 2004-08-13 2009-07-28 The Mcw Research Foundation MRI method for measuring tumor hemodynamic parameters in the presence of contrast agent extravasation
JP4192136B2 (ja) 2004-09-30 2008-12-03 株式会社小松製作所 画像表示システムおよび画像表示プログラム
DK2990073T3 (en) * 2004-11-24 2018-08-13 Bayer Healthcare Llc DEVICES AND SYSTEMS FOR DELIVERING FLUIDS
US20080305049A1 (en) * 2005-01-31 2008-12-11 Hadassa Degani Mri Contrast Agents for Diagnosis and Prognosis of Tumors
US8175678B2 (en) 2005-09-13 2012-05-08 Koninklijke Philips Electronics N.V. Multiple contrast agent injection for imaging
CN101277648B (zh) * 2005-10-05 2010-12-15 皇家飞利浦电子股份有限公司 用于在血管造影中预测增强的方法和设备

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Paul S. Tofts等.Quantitative Analysis of Dynamic Gd-DTPA EnhancementinBreast Tumors Using a Permeability Model.MAGNETIC RESONANCE IN MEDICINE33 4.1995,33(4),564-568.
Paul S. Tofts等.Quantitative Analysis of Dynamic Gd-DTPA EnhancementinBreast Tumors Using a Permeability Model.MAGNETIC RESONANCE IN MEDICINE33 4.1995,33(4),564-568. *

Also Published As

Publication number Publication date
JP6059414B2 (ja) 2017-01-11
WO2007031910A2 (en) 2007-03-22
EP1926425B1 (en) 2015-08-19
EP1926425A2 (en) 2008-06-04
US10154797B2 (en) 2018-12-18
JP2009507545A (ja) 2009-02-26
WO2007031910A3 (en) 2007-10-18
US20120253179A1 (en) 2012-10-04
US8175678B2 (en) 2012-05-08
US20090130023A1 (en) 2009-05-21
CN101262817A (zh) 2008-09-10

Similar Documents

Publication Publication Date Title
US10154797B2 (en) Multiple contrast agent injection for imaging
Kim Variability in quantitative DCE-MRI: sources and solutions
US6408201B1 (en) Method and apparatus for efficient stenosis identification in peripheral arterial vasculature using MR imaging
Yasui et al. Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice
US7904135B2 (en) Magnetic resonance spatial risk map for tissue outcome prediction
US9943246B2 (en) System and method for assessing susceptibility of tissue using magnetic resonance imaging
US20100261993A1 (en) Stem and method for acquiring mri data from bone and soft tissues
US9220473B2 (en) Method for calculating a value of an absorption parameter in positron emission tomography
US20160058304A1 (en) System and method for vessel architectural imaging
US20040039277A1 (en) Magnetic resonance imaging system
JP5820549B2 (ja) 灌流イメージング
Lyng et al. Measurement of perfusion rate in human melanoma xenografts by contrast‐enhanced magnetic resonance imaging
McDouall et al. Deuterium nuclear magnetic resonance imaging of tracer distribution in D2O clearance measurements of tumor blood flow in mice
Subashi et al. An analysis of the uncertainty and bias in DCE‐MRI measurements using the spoiled gradient‐recalled echo pulse sequence
JP2009507545A5 (https=)
Cutillo et al. Determination of lung water content and distribution by nuclear magnetic resonance imaging
Krishnamurthi et al. Functional imaging in small animals using X-ray computed tomography-study of physiologic measurement reproducibility
CN106659420A (zh) 磁共振成像装置
Kavaluus et al. Retrospective four‐dimensional magnetic resonance imaging of liver: Method development
US20080272779A1 (en) Determination of Distribution Information of a Contrast Agent by Mr Molecular Imaging
US10083505B2 (en) Magnetic resonance apparatus and method for quantifying an organ function
CN101166992B (zh) 确定mr分子成像的弛豫率变化
Crawley et al. Cardiac Perfusion MRI
Le Ster et al. Radiofrequency heating measurement in vivo using MR thermometry and field monitoring: methodological considerations
Delphin MRI Signals Simulation for Validation of a New Microvascular Characterization

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110907

Termination date: 20200907