CN101254214A - Chinese medicine catablasm base material - Google Patents
Chinese medicine catablasm base material Download PDFInfo
- Publication number
- CN101254214A CN101254214A CNA2007100204174A CN200710020417A CN101254214A CN 101254214 A CN101254214 A CN 101254214A CN A2007100204174 A CNA2007100204174 A CN A2007100204174A CN 200710020417 A CN200710020417 A CN 200710020417A CN 101254214 A CN101254214 A CN 101254214A
- Authority
- CN
- China
- Prior art keywords
- parts
- matrix
- good
- chinese medicinal
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a matrix material for Chinese medicinal plaster, particularly to a Chinese medicinal cataplasma matrix containing Chinese medicinal extracts. The matrix comprises (by weight parts) gelatin 0.8-3, sodium carboxymethyl cellulose 4-21, polyvinylpyrrolidone 0.5-3, gum arabic 2-10, Indian gum 2-10, triethanolamine 1-6, magnesium hydroxide 0.2-2, sodium polyacrylate 2-10, carbomer 2-4, glycerol 30-50, polyvinyl alcohol 5-16, agar 0.2-2, gum tragacanth 0.5-3, colloidal silicon dioxide 2-10, sodium hydroxide 1-3, and water 20-80. The inventive matrix has the advantages of good transdermal effect, good air permeability, good affinity with various drugs, safe and environmental-friendly preparation process, no skin irritation, no anaphylaxis, comfortable application, good reusability, stable matrix properties, and no reaction with principal drug.
Description
Technical field
The present invention relates to a kind of host material of Chinese medicine plaster, specifically is a kind of Chinese medicine patcher substrate that adds Chinese medical concrete.
Background technology
Traditional Chinese medicine plaster is adhesively fixed by patch in use and fixes on the human body skin, and it exists many defectives: can form the solid state of glue after 1, pasting on skin, tear disadvantages such as fine hair, pain, local redness, pruritus, pimple in the time of can bringing avulsion; 2, be subjected to the restriction of patch fiber ductility, when plaster is affixed on joint part, can produce senses of discomfort such as tearing involves; 3, the permeability of medicine is bad, affects the treatment; 4, macromole, plaster that water content is low easily produce anaphylaxis in use, influence its dependability.
Summary of the invention
It is strong that technical problem to be solved by this invention provides a kind of transdermal effect, good permeability, good with the affinity of various medicines, good with the affinity of skin, manufacturing process safety, environmental protection, non-stimulated to skin, anaphylaxis is little, paste with comfortable, can take off subsides repeatedly, and the stable Chinese medicine patcher substrate of medium property.
Chinese medicine patcher substrate of the present invention, the weight proportion of its composition and each composition is: 20~80 parts in 0.8~3 part in gelatin, 4~21 parts of sodium carboxymethyl cellulose, 0.5~3 part of polyvinylpyrrolidone, 2~10 parts of arabic gums, 2~10 parts of gum ghatti, 1~6 part of triethanolamine, 0.2~1.5 part in magnesium hydroxide, 2~10 parts of sodium polyacrylate, 2~4 parts of carbomers, 30~50 parts of glycerol, 5~16 parts of polyvinyl alcohol, 0.2~2 part of agar, 0.5~3 part of tragacanth, 2~10 parts of micropowder silica gels, 1~3 part of sodium hydroxide and water.
The present invention is made up of the material of water soluble polymer frame structure, is used for the external plaster agent of percutaneous dosing approach, compares with traditional plaster to have the following advantages:
(1) high-comfort---because moistening, adhesion can be adjusted the position by local at any time microcosmic after sticking, and the use that can not influence adhesion strength and paste once more.Can on skin, not form the solid state of glue, pull disadvantages such as fine hair, pain, part redness, pruritus, pimple when not having avulsion naturally.And the main cause that the traditional just plaster of the latter is hung back the patient.
(2) high ductibility---because the non-woven fabrics that uses of dosage form is the good kind of any direction extensibility, when sticking on the big positions such as joint of mobility, mastic can stretch with the stretching, extension of joint, skin fully.Uncomfortable sensation such as removed that the tearing of forcing at joint part involves.
(3) high osmosis---this dosage form can guarantee contained drug at short notice rapid osmotic enter human body skin, and arrive local organization rapidly.What deserves to be mentioned is and since mastic in content of dispersion few, stick the back in local arthral fluid detected drug level much larger than blood Chinese medicine concentration.Illustrate that medicine is not after dependence is absorbed into blood, arrives performance drug effect in the articular cavity again; But passive epidermis, subcutaneous tissue and the articular cavity of penetrating into.
(4) high reliability---this dosage form seldom causes uncomfortable reactions such as allergy.Because ingredient is single, molecular weight is little, and compares reliability than macromole, plaster that water content is low and significantly improves.Clinical use PMS follow up survey for many years shows that reactions such as the allergy of this product only are 2.3%.
The specific embodiment
The Chinese medicine patcher base of the embodiment of the invention is made by following material composition: gelatin 0.08g, sodium carboxymethyl cellulose 0.5g, polyvinylpyrrolidone 0.3g, arabic gum 0.8g, gum ghatti 0.4g, triethanolamine 0.1g, magnesium hydroxide 0.1g, water 8ml, sodium polyacrylate 0.25g, carbomer 0.2g, glycerol 5ml, polyvinyl alcohol 1.3g, agar 0.09g, tragacanth 0.3g, micropowder silica gel 0.2g, sodium hydroxide 0.25g.
Its manufacturing process may further comprise the steps:
1, preparation solution I.The gelatin of above-mentioned consumption fully is dissolved in 60 ℃ of water, sodium carboxymethyl cellulose, polyvinylpyrrolidone, arabic gum, gum ghatti, triethanolamine, magnesium hydroxide with above-mentioned consumption adds in the gelatin solution respectively again, add water and fully dissolve, leave standstill and promptly get solution I.
2, preparation solution II.Sodium polyacrylate, carbomer, polyvinyl alcohol, agar, tragacanth, micropowder silica gel, sodium hydroxide are scattered in the glycerol, and stirring promptly gets solution II.
3, mixed solution I and solution II, and stir, catablasm base material of the present invention promptly got.
Claims (1)
1. Chinese medicine patcher substrate, it is characterized in that: the weight proportion of its composition and each composition is, 20~80 parts in 0.8~3 part in gelatin, 4~21 parts of sodium carboxymethyl cellulose, 0.5~3 part of polyvinylpyrrolidone, 2~10 parts of arabic gums, 2~10 parts of gum ghatti, 1~6 part of triethanolamine, 0.2~1.5 part in magnesium hydroxide, 2~10 parts of sodium polyacrylate, 2~4 parts of carbomers, 30~50 parts of glycerol, 5~16 parts of polyvinyl alcohol, 0.2~2 part of agar, 0.5~3 part of tragacanth, 2~10 parts of micropowder silica gels, 1~3 part of sodium hydroxide and water.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007100204174A CN101254214B (en) | 2007-02-26 | 2007-02-26 | Chinese medicine catablasm base material |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007100204174A CN101254214B (en) | 2007-02-26 | 2007-02-26 | Chinese medicine catablasm base material |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101254214A true CN101254214A (en) | 2008-09-03 |
CN101254214B CN101254214B (en) | 2010-10-06 |
Family
ID=39889537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007100204174A Expired - Fee Related CN101254214B (en) | 2007-02-26 | 2007-02-26 | Chinese medicine catablasm base material |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101254214B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101947322A (en) * | 2010-09-03 | 2011-01-19 | 南方医科大学 | Gel patch matrix and preparation method and application thereof |
CN104224979A (en) * | 2014-07-23 | 2014-12-24 | 江苏七〇七天然制药有限公司 | Traditional Chinese medicine cataplasm for treating emphysema by plastering on acupoints and preparation method thereof |
CN113440590A (en) * | 2021-07-30 | 2021-09-28 | 无锡市锡山区中医医院 | Toad stamen ointment |
CN113713113A (en) * | 2021-09-28 | 2021-11-30 | 四川大学 | Composition for treating oral mucosa diseases and preparation method thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1215831C (en) * | 2003-10-08 | 2005-08-24 | 西安千禾药业有限责任公司 | Chinese medicine cataplasm matrix and preparing technique thereof |
CN1215880C (en) * | 2003-10-21 | 2005-08-24 | 沈阳东陵药业股份有限公司 | Water-soluble matrix for external transdermal paster and preparing method thereof |
-
2007
- 2007-02-26 CN CN2007100204174A patent/CN101254214B/en not_active Expired - Fee Related
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101947322A (en) * | 2010-09-03 | 2011-01-19 | 南方医科大学 | Gel patch matrix and preparation method and application thereof |
CN101947322B (en) * | 2010-09-03 | 2012-07-04 | 南方医科大学 | Gel patch matrix and preparation method and application thereof |
CN104224979A (en) * | 2014-07-23 | 2014-12-24 | 江苏七〇七天然制药有限公司 | Traditional Chinese medicine cataplasm for treating emphysema by plastering on acupoints and preparation method thereof |
CN104224979B (en) * | 2014-07-23 | 2018-01-16 | 江苏七O七天然制药有限公司 | Chinese medicine patcher of acupoint application treatment pulmonary emphysema and preparation method thereof |
CN113440590A (en) * | 2021-07-30 | 2021-09-28 | 无锡市锡山区中医医院 | Toad stamen ointment |
CN113440590B (en) * | 2021-07-30 | 2022-07-12 | 无锡市锡山区中医医院 | External toad stamen ointment for treating cancer pain |
CN113713113A (en) * | 2021-09-28 | 2021-11-30 | 四川大学 | Composition for treating oral mucosa diseases and preparation method thereof |
CN113713113B (en) * | 2021-09-28 | 2023-09-19 | 四川护家卫士生物医药科技有限公司 | Composition for treating oral mucosa diseases and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
CN101254214B (en) | 2010-10-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2018347514B2 (en) | Methods and compositions for topical delivery | |
Nagai | Adhesive topical drug delivery system | |
Patil et al. | A review on topical gels as drug delivery system | |
US5731303A (en) | Transdermal and trans-membrane delivery compositions | |
US3891757A (en) | Anaesthetic topical and percutaneous administration with selected promoters | |
JP2671248B2 (en) | Method for enhancing the penetration of medicinal or cosmetic ingredients | |
DE60018797T2 (en) | HYDROXIDE RELEASING COMPOUNDS TO IMPROVE SKIN PERMEABILITY | |
AU770516B2 (en) | Polyoxyalkylene copolymers containing pourable liquid vehicles | |
DE69524614T2 (en) | MEDICINAL COMPONENTS, INCLUDING AN N-SUBSTITUTED O-TOLUIDE INDEXIVATIVE AND TRANSDERMALLY ABSORBABLE PREPARATION | |
EP3442488A1 (en) | Compositions for topical application of compounds | |
Lin et al. | Salicylic acid revisited. | |
WO2006038315A1 (en) | Preparation for percutaneous/permucosal absorption | |
Mehta | Topical and transdermal drug delivery: what a pharmacist needs to know | |
CN101254214B (en) | Chinese medicine catablasm base material | |
US3968245A (en) | Sympathomimetic topical and percutaneous administration with halogenated promoters | |
CN106821963A (en) | A kind of method of utilization cellulose base temperature and the load of pH sensitive hydrogels and slow releasing pharmaceutical | |
CN107029343B (en) | A kind of portable cutaneous penetration patch instrument and preparation method thereof | |
US3787571A (en) | Trichloroethanol and trifluoroethanol topical and percutaneous steroid adsorption promoters | |
AU637860B2 (en) | Penetration enhancement with multi-component system of n-aliphatic pyrrolidones with lower alcohols | |
CN101254215A (en) | Preparing method of Chinese medicine catablasm base material | |
WO2024035832A1 (en) | Topical product hands-free applicator drug delivery system and methods of making and using the same | |
CN100482210C (en) | External applied Chinese medicinal paste for treating arthralgia | |
US4476115A (en) | Analgesic composition and method of treating subdermal pain | |
Sonkar et al. | A review on transdermal patches as a novel drug delivery system | |
KR100192149B1 (en) | Transdermal administration preparation of a 9-aminocyclopenta (b) quinoline |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101006 Termination date: 20160226 |