CN101249098A - Polygonatum polysaccharide effervescence tablet - Google Patents
Polygonatum polysaccharide effervescence tablet Download PDFInfo
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- CN101249098A CN101249098A CNA2008100914233A CN200810091423A CN101249098A CN 101249098 A CN101249098 A CN 101249098A CN A2008100914233 A CNA2008100914233 A CN A2008100914233A CN 200810091423 A CN200810091423 A CN 200810091423A CN 101249098 A CN101249098 A CN 101249098A
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- polygonatum
- polygonatum polysaccharide
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- grain
- health food
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Abstract
The invention discloses health food with antifatigue, memory improving and anti-aging effects, specifically a formulation and a preparation method of Polygonatum polysaccharide effervescent tablets. The effervescent tablet contains, as major active components, polysaccharides extracted from a plant of the genus Lilium belonging to the Liliaceae family, such as Polygonatum sibiricum, Polygonatum kingianum or Polygonatum cyrtonema; and pharmaceutically-acceptable disintegrating agent, diluting agent, flavoring agent and lubricating agent. The components are in appropriate proportion and processed properly. The health food has the advantages of definite components, remarkable effect, convenience for carrying and administration, and good taste and appearance. The health food is taken orally directly or taken as a beverage after water infusion, which is superior to other similar products. The health food is particularly suitable for brain workers.
Description
Technical field
The invention belongs to the functional health-care food field, relate to a kind of with prescription and the preparation of the polygonatum polysaccharide that extracts as the functional effervescent tablet of primary raw material.
Background technology
Rhizoma Polygonati, Liliaceae as a kind of herbaceos perennial Rhizoma Polygonati, Yunnan Rhizoma Polygonati or Polygonatum cyrtonema Hua (2005 editions officinal three sources) rhizome of integration of edible and medicinal herbs, has the effect that lung moistening YIN nourishing, invigorating the spleen and replenishing QI, kidney tonifying are filled out marrow.Head sees Lei Gong's Treatise on Preparation and Broiling of Materia Medica, and " not Lu " be classified it as top grade, says its " clothes make light of one's life by commiting suicide prolong life not hungry " for a long time, and Compendium of Material Medica thinks that it is to take a tonic or nourishing food to build up one's health product on Middle Palace, has the effect of life lengthening.
Polygonatum polysaccharide is one of effective site of Rhizoma Polygonati; have obvious anti-fatigue, memory reinforcing effect; can regulate simultaneously function of immune system with enhancing body; the significantly increase of the intravital free radical of elimination machine; strengthen intravital protection factor (SOD); number of ways comes antagonism to cause the damage of aging factor to body, delays the aging of body, and this is confirmed by multinomial modern study.
Though people are more and more higher to the expectation demand of quality of life, but allegro life and huge operating pressure go to make quite a few people especially mental worker's health be in the subhealth state level, the aging that the hypoimmunity and the improper natural law occur (comprises fatigue, hypomnesis, symptoms such as insomnia, baldness, constipation).In view of the unique effects of Rhizoma Polygonati and the safety of integration of edible and medicinal herbs, the prescription of a series of slow down aging such as Rhizoma Polygonati cake, Rhizoma Polygonati cream, Rhizoma Polygonati ball just there are ancient times.The modern functional food about Rhizoma Polygonati or polygonatum polysaccharide of having developed listing or report has King solomonseal rhizome tea, wine, medicated porridge, buccal tablet, electuary, oral liquid etc., but does not see the report that polygonatum polysaccharide effervescence tablet is arranged.
The object of the present invention is to provide a kind of can resisting fatigue, improve memory, anti-aging health food---polygonatum polysaccharide effervescence tablet, mainly be applicable to the brain worker, comprise office's white collar and student, this product is clear and definite than other product compositions, effect is remarkable, carry, taking convenience, characteristics such as mouthfeel, outward appearance are good, and can be directly oral, also can wash by water and cook beverage and drink, these characteristics are that other product forms can not be substituted.
Summary of the invention
1. main active of the present invention is: polygonatum polysaccharide---derive from Rhizoma Polygonati, Yunnan Rhizoma Polygonati or Polygonatum cyrtonema Hua (three sources of 2005 editions pharmacopeia one one " the Rhizoma Polygonati ") rhizome of Liliaceae lilium.
2. the extraction of polygonatum polysaccharide
Get the Rhizoma Polygonati medical material, pulverize, get powder and added distilled water, in 60 ℃ of supersound extraction 30min, 3000rmin by 1: 20
-1Centrifugal 15min, residue was by 1: 10 adding distil water supersound extraction, and is centrifugal, merges supernatant concentration to 1/4 to 1/5 of original volume.
Concentrated solution adds activated carbon decolorizing 2 times, and sucking filtration keeps filtrate.
Filtrate adds 95% ethanol of 5 times of volumes, and alcohol is analysed 24h, 3000rmin in 4 ℃ of refrigerators
-1Centrifugal 10min removes supernatant.
Precipitate is respectively washed 3 times with dehydrated alcohol, ether successively, 3000rmin
-1Centrifugal 5min removes supernatant.
60 ℃ of freeze-day with constant temperature of precipitate promptly get polygonatum polysaccharide to constant weight.
3. the preparation of tablet
Polygonatum polysaccharide (crossing 400 orders) is mixed with sour disintegrating agent mutually, evenly moistening with ethanol, cross 16-22 mesh sieve and dry, after sieve, granulate gets sour grain.Alkali phase disintegrating agent, diluent is evenly moistening with ethanol, cross 16-22 mesh sieve and dry, after sieve, granulate gets the alkali grain.Mixed acid grain and alkali grain add lubricant, correctives, mixing, tabletting.Every heavy 1～3g.
The specific embodiment
Further specify preparation method in conjunction with concrete embodiment:
Embodiment 1: in weight portion, unit is a kilogram, takes by weighing respectively: 300 parts of polygonatum polysaccharides, 200 parts of citric acids, 100 parts of sodium bicarbonate, 120 parts of xylitol, 200 parts of pregelatinized Starch, 30 parts of PEG4000,40 parts of sorbitol, 10 parts in essence sodium.
Polygonatum polysaccharide (requiring fineness to reach 400 orders) is mixed with citric acid, evenly moistening with ethanol, cross 16-22 mesh sieve and dry, after sieve, granulate gets sour grain.Xylitol sodium bicarbonate, pregelatinized Starch is evenly moistening with ethanol, cross 16-22 mesh sieve and dry, after sieve, granulate gets the alkali grain.Mixed acid grain and alkali grain add PEG4000, sorbitol, essence sodium, then with this mixture tabletting, and every heavy 2g.
Embodiment 2: in weight portion, unit is a kilogram, takes by weighing respectively: 300 parts of polygonatum polysaccharides, 200 parts of citric acids, 100 parts of sodium bicarbonate, 20 parts of xylitol, 300 parts of pregelatinized Starch,, 30 parts of PEG4000,40 parts of sorbitol, 10 parts in essence sodium.
With spray drying after the dissolving of polygonatum polysaccharide adding distil water.Polygonatum polysaccharide, citric acid, xylitol, sodium bicarbonate, pregelatinized Starch are mixed, add magnesium stearate, sorbitol, essence sodium, then with this mixture tabletting, every heavy 2g.Active component polygonatum polysaccharide 0.6g.
Embodiment 3: in weight portion, unit is a kilogram, takes by weighing respectively: 200 parts of polygonatum polysaccharides, 100 parts of astragalus polysaccharidess, 200 parts of citric acids, 100 parts of sodium bicarbonate, 120 parts of xylitol, 200 parts of pregelatinized Starch, 30 parts of PEG4000,40 parts of sorbitol, 10 parts in essence sodium.
Polygonatum polysaccharide, astragalus polysaccharides (requiring fineness to reach 400 orders) are mixed with citric acid, evenly moistening with ethanol, cross 16-22 mesh sieve and dry, after sieve, granulate gets sour grain.Xylitol sodium bicarbonate, pregelatinized Starch is evenly moistening with ethanol, cross 16-22 mesh sieve and dry, after sieve, granulate gets the alkali grain.Mixed acid grain and alkali grain add PEG4000, sorbitol, essence sodium, then with this mixture tabletting, and every heavy 2g.Active component polygonatum polysaccharide 0.4g, astragalus polysaccharides 0.2g.
Claims (5)
1. one kind is the effervescent tablet of main active with the polygonatum polysaccharide, and directly oral or soaked drinking has resisting fatigue, improves health cares such as memory and slow down aging.
2. as the effervescent tablet of right 1 requirement, it is characterized in that forming by the supplementary material of following percentage by weight:
Polygonatum polysaccharide 5%-25%;
Disintegrating agent 15%-45%;
Correctives 0.1-2%;
Diluent 0%-40%;
Lubricant 0.5%-3%.
3. its main effective ingredient of polygonatum polysaccharide effervescence tablet that requires as right 2 is: polygonatum polysaccharide derives from Rhizoma Polygonati, Yunnan Rhizoma Polygonati or Polygonatum cyrtonema Hua rhizome.
Its disintegrating agent is: acid source is one or more in citric acid, tartaric acid, L MALIC ACID, the citric acid, and alkali source is a kind of in sodium bicarbonate, potassium bicarbonate, the sodium carbonate or two kinds.
Its correctives is: can be arbitrarily edible or medicinal aromatic and sweeting agent such as apple essence, acesulfame potassium, sorbitol, essence sodium in one or more.
Its diluent is: one or more in pregelatinized Starch, xylitol, lactose, the mannitol can not add yet.
Its lubricant is: be soluble oils such as PEG4000, PEG6000.
4. its preparation of polygonatum polysaccharide effervescence tablet that requires as right 2 is characterised in that:
The extraction of polygonatum polysaccharide:
Get the Rhizoma Polygonati decoction pieces, pulverize, get powder and added distilled water, in 60 ℃ of supersound extraction 30min, 3000rmin by 1: 20
-1Centrifugal 15min, residue was by 1: 10 adding distil water supersound extraction, and is centrifugal, merges supernatant concentration to 1/4 to 1/5 of original volume.Concentrated solution adds activated carbon decolorizing 2 times, and sucking filtration keeps filtrate.Filtrate adds 95% ethanol of 5 times of volumes, and alcohol is analysed 24h, 3000rmin in 4 ℃ of refrigerators
-1Centrifugal 10min removes supernatant.Precipitate is respectively washed 3 times with dehydrated alcohol, ether successively, 3000rmin
-1Centrifugal 5min removes supernatant.60 ℃ of freeze-day with constant temperature of precipitate promptly get polygonatum polysaccharide to constant weight.
The preparation of tablet:
Polygonatum polysaccharide (crossing 400 orders) is mixed with sour disintegrating agent mutually, evenly moistening with ethanol, cross 16-22 mesh sieve and dry, after sieve, granulate gets sour grain.Alkali phase disintegrating agent, diluent is evenly moistening with ethanol, cross 16-22 mesh sieve and dry, after sieve, granulate gets the alkali grain.Mixed acid grain and alkali grain add lubricant, correctives, mixing, tabletting.Every heavy 1～3g.
5. the effervescent tablet that requires as right 1 wherein can add the active component that other have health-care effect, as: astragalus polysaccharides, Vc etc.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100914233A CN101249098A (en) | 2008-04-11 | 2008-04-11 | Polygonatum polysaccharide effervescence tablet |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100914233A CN101249098A (en) | 2008-04-11 | 2008-04-11 | Polygonatum polysaccharide effervescence tablet |
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| CN101249098A true CN101249098A (en) | 2008-08-27 |
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| CNA2008100914233A Pending CN101249098A (en) | 2008-04-11 | 2008-04-11 | Polygonatum polysaccharide effervescence tablet |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210453A (en) * | 2011-04-26 | 2011-10-12 | 珠海经济特区尔康药业有限公司 | Effervescent chewing gum and preparation method thereof |
| CN102318869A (en) * | 2011-08-30 | 2012-01-18 | 异优坊（上海）生物科技有限公司 | American ginseng healthcare beverage and preparation method thereof |
| CN104000272A (en) * | 2014-05-15 | 2014-08-27 | 山东省林业科学研究院 | Fig effervescent tablet and preparation method thereof |
| CN104055187A (en) * | 2014-05-15 | 2014-09-24 | 山东省林业科学研究院 | Mulberry effervescent tablet and preparation method thereof |
| CN104479035A (en) * | 2014-11-24 | 2015-04-01 | 云南中医学院 | Polygonatum kingianum polysaccharide extract with sugar and lipid metabolism regulating activity and preparation method thereof |
| CN105982835A (en) * | 2016-03-24 | 2016-10-05 | 成都悟道科技有限公司 | Compound solid mouth wash effervescent tablet and preparation method thereof |
| KR101779536B1 (en) | 2017-05-11 | 2017-09-18 | 주식회사농심 | Composition for treating sleep disorder and enhacning sleeping time containing polygonatum extract |
| CN107897620A (en) * | 2017-12-20 | 2018-04-13 | 安徽省旌德博仕达农业科技有限公司 | A kind of sealwort effervescence tablet beverage and preparation method thereof |
| CN107996937A (en) * | 2017-12-12 | 2018-05-08 | 苏州卫生职业技术学院 | Compound health-care effervescent tablet and its preparation process containing plant polyose |
| CN109673908A (en) * | 2018-12-03 | 2019-04-26 | 西南大学 | A kind of rhizoma polygonati instant solid beverage and preparation method thereof |
-
2008
- 2008-04-11 CN CNA2008100914233A patent/CN101249098A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210453A (en) * | 2011-04-26 | 2011-10-12 | 珠海经济特区尔康药业有限公司 | Effervescent chewing gum and preparation method thereof |
| CN102318869A (en) * | 2011-08-30 | 2012-01-18 | 异优坊（上海）生物科技有限公司 | American ginseng healthcare beverage and preparation method thereof |
| CN104055187B (en) * | 2014-05-15 | 2016-03-23 | 山东省林业科学研究院 | Mulberries effervescent tablet and preparation method thereof |
| CN104055187A (en) * | 2014-05-15 | 2014-09-24 | 山东省林业科学研究院 | Mulberry effervescent tablet and preparation method thereof |
| CN104000272B (en) * | 2014-05-15 | 2015-07-08 | 山东省林业科学研究院 | Fig effervescent tablet and preparation method thereof |
| CN104000272A (en) * | 2014-05-15 | 2014-08-27 | 山东省林业科学研究院 | Fig effervescent tablet and preparation method thereof |
| CN104479035A (en) * | 2014-11-24 | 2015-04-01 | 云南中医学院 | Polygonatum kingianum polysaccharide extract with sugar and lipid metabolism regulating activity and preparation method thereof |
| CN104479035B (en) * | 2014-11-24 | 2019-04-05 | 云南中医学院 | There is one kind glucose-lipid metabolism to adjust active polygonatum kingianurn polyoses extract and preparation method thereof |
| CN105982835A (en) * | 2016-03-24 | 2016-10-05 | 成都悟道科技有限公司 | Compound solid mouth wash effervescent tablet and preparation method thereof |
| KR101779536B1 (en) | 2017-05-11 | 2017-09-18 | 주식회사농심 | Composition for treating sleep disorder and enhacning sleeping time containing polygonatum extract |
| CN107996937A (en) * | 2017-12-12 | 2018-05-08 | 苏州卫生职业技术学院 | Compound health-care effervescent tablet and its preparation process containing plant polyose |
| CN107897620A (en) * | 2017-12-20 | 2018-04-13 | 安徽省旌德博仕达农业科技有限公司 | A kind of sealwort effervescence tablet beverage and preparation method thereof |
| CN109673908A (en) * | 2018-12-03 | 2019-04-26 | 西南大学 | A kind of rhizoma polygonati instant solid beverage and preparation method thereof |
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| C06 | Publication | ||
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| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080827 |