CN101248064A - Nitrocatechol derivatives as COMT inhibitors - Google Patents

Nitrocatechol derivatives as COMT inhibitors Download PDF

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Publication number
CN101248064A
CN101248064A CNA2006800266140A CN200680026614A CN101248064A CN 101248064 A CN101248064 A CN 101248064A CN A2006800266140 A CNA2006800266140 A CN A2006800266140A CN 200680026614 A CN200680026614 A CN 200680026614A CN 101248064 A CN101248064 A CN 101248064A
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CN
China
Prior art keywords
oxadiazole
nitrophenyl
oxygen
compound
dihydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CNA2006800266140A
Other languages
Chinese (zh)
Other versions
CN101248064B (en
Inventor
D·A·利尔蒙斯
L·E·基什
P·N·莱亚尔·帕尔马
H·多斯·桑托斯·费雷拉
P·M·V·阿劳若·苏亚雷斯·达·西尔瓦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bial Portela and Cia SA
Original Assignee
Portela & Ca S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB0515327.5 priority Critical
Priority to GB0515327A priority patent/GB0515327D0/en
Priority to EP06008203 priority
Priority to EP06008203.9 priority
Priority to EP06011073 priority
Priority to EP06011073.1 priority
Application filed by Portela & Ca S A filed Critical Portela & Ca S A
Priority to PCT/PT2006/000020 priority patent/WO2007013830A1/en
Priority claimed from CN201210142381.8A external-priority patent/CN102816157B/en
Publication of CN101248064A publication Critical patent/CN101248064A/en
Application granted granted Critical
Publication of CN101248064B publication Critical patent/CN101248064B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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