CN101240331A - Skin beauty treatment health care method based on mEPHX gene polymorphism - Google Patents
Skin beauty treatment health care method based on mEPHX gene polymorphism Download PDFInfo
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- CN101240331A CN101240331A CNA200710166337XA CN200710166337A CN101240331A CN 101240331 A CN101240331 A CN 101240331A CN A200710166337X A CNA200710166337X A CN A200710166337XA CN 200710166337 A CN200710166337 A CN 200710166337A CN 101240331 A CN101240331 A CN 101240331A
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Abstract
The present invention relates to a skin beauty healthcare method based on mEPHX gene polymorphism, comprising the steps of: (1) detecting the gene locus related to skin beauty healthcare for gene polymorphism; (2) deciding the skin feather, according to the detection result; and (3) choosing a beauty healthcare scheme in accordance with the skin feather. The gene locus related to skin beauty healthcare is a -1238T-A/2557C-G/Y113H/H139R locus of the mEPHX gene, if the detection result is homozygous positive or heterozygous positive, judge the possibility and tendency of EPHX activity decrease of the skin, and predict the easy-to-show problems of pathological aging, acne and poor detoxifying function. The invention is capable of finding skin feather from gene level and finding out the interior reasons of the skin problems, so that the blindness in skin beauty healthcare is eliminated and the beauty healthcare effect is greatly improved.
Description
Technical field
The present invention relates to the method for a kind of beautifying skin and health care, its polymorphism according to the mEPHX gene (SNPs) is selected the scheme of skin care product and skin beauty health-care scheme.
Technical background
Skin beauty health-care relates to an importance of people's quality of life, has a large amount of different types of skin care product and skin beauty health-care mode to select for people on the market.Different skin care product have their own characteristics each, and function and beauty and health care mechanism have nothing in common with each other, and how selecting the skin care product of the most suitable self skin characteristic is the difficult problem that people face.People generally can only determine some simple characteristics of own skin with visual inspection at present, for example wetness degree (dryness or oiliness), black and white degree and whether macula lutea etc. is arranged, perhaps adopt instrument such as hygronom that skin is carried out simple physics test (mainly being wetness degree), carry out the selection of skin care product according to these simple understandings, therefore the skin care product of selecting often are not optimum, band bears the character of much blindness, not reaching the ideal beauty and health care thought, then need to bear the risk that test brings through repeatedly on probation for many years.The basic reason that these problems occur is only to test with naked-eye observation with to the skin surface simple physics, can only reflect the external problem that has occurred, can not disclose the inherent characteristics of skin, therefore not only can not find out the immanent cause that skin problem takes place, can only be to cure the symptoms, not the disease, more inscrutable advolution trend is carried out the preventive health care at possibility and proneness that skin goes wrong, prevents trouble before it happens.
The research of Human genome is for the growth secret that discloses human body self provides a kind of strong means.People have begun to recognize gradually the vital role of some gene in human body skin health at present.For example MnSOD expression of gene albumen is the main enzyme of skin anti-peroxidation damage, and peroxidation can produce the free radical molecule at skin, damage dna, collagen fibers of skin and protein, thereby injured skin tissue and cell, directly cause skin aging and skin chloasma, SOD then decomposes these superoxide, avoids superoxide to assemble in cell and tissue, reduces the damage of superoxide to skin; HGPX1 expression of gene albumen is the main enzyme of skin hydroperoxide decomposition, hydroperoxide are mainly from environmental pollution and meta-bolites, damage dna, collagen fibers of skin and protein, thereby injured skin tissue and cell, cause skin aging and skin chloasma, hGPX1 then hydroperoxide decomposition makes it to become innoxious substance, reduces the damage of hydroperoxide to skin; MEPHX expression of gene albumen is that skin decomposes environment and is infected with some chemical substance on the skin and the main enzyme of poisonous substance, for example can decompose carcinogenic substances polycyclic aromatic hydrocarbons (polycyclic aromatic hydrocarbons, PAHs), this material is mainly derived from automobile exhaust gas and smoking dirt; TNF-alpha expression of gene albumen is being kept aspect the skin immune function controlling extremely importantly, can make the skin immunization cell keep the ability of opposing environmental infection thing; MMP1 expression of gene albumen then can decompose the collagen protein of skin, cause skin collagen fracture and skin aging, and the UVB in the sunlight can induce skin to produce MMP1 albumen, causes skin injury.
The applicant studies show that, genotype (or the gene mononucleotide polymorphism of specific site in some gene relevant with skin, SNPs, be called for short gene pleiomorphism) can affect the activity of corresponding enzyme in the skin to a great extent, and then affect the growth and the state of health of skin, disadvantageous genotype is immanent cause or the major cause that causes skin problem, has determined possibility and proneness that skin goes wrong.Therefore people can find the immanent cause that skin goes wrong according to the gene pleiomorphism detected result, and the production and the development trend of prediction skin are selected optimum skin care product and skin beauty health-care method, carry out the beauty and health care of skin targetedly.
For example, applicant 450 people that voluntary accepting is detected carried out MnSOD gene 47C-T A16V locus gene polymorphism and skin remove active oxygen (ROS) free radical can masterpiece following simultaneous test.ROS (comprising: O
2-, H
2O
2And OH
) damage is playing an important role aspect the generation of skin problem, and SOD skin is to prevent that ROS from producing and removing the main enzyme of ROS.Paraquat is the inductor that produces ROS in the cell, and test is induced with Paraquat and produced ROS, detection of skin ROS clearance rate then in the cell.Gene pleiomorphism has 126 people (account for detect total number of persons 28%), ROS clearance rate 26.7 ± 3.6% for the male that isozygotys; Gene pleiomorphism has 234 people (account for population of samples 52%), ROS clearance rate 74.2 ± 13.8% for the heterozygosis male; And in negative all the other people of gene pleiomorphism, ROS clearance rate 90.9 ± 1.2%.Demonstrate thus MnSOD gene 47C-T the gene pleiomorphism in A16V site active relevant with skin MnSOD, this locus gene polymorphism is positive and the heterozygosis male of isozygotying, can cause the active reduction of skin MnSOD, and the positive influence degree that the MnSOD activity is reduced of isozygotying is greater than the heterozygosis positive.
228 people that the applicant detects voluntary accepting carried out hGPX1 gene 593C-T the ability of P197L locus gene polymorphism and skin hydroperoxide decomposition detect, made following simultaneous test.Hydroperoxide (OH
) damage is playing an important role aspect the generation of skin problem, and hGPX1 is skin removing OH
Main enzyme.UVA produces OH in the cell
Inductor, test induces the epiderm skin cell to produce OH with UVA
, detection of skin OH then
Clearance rate.The detection of skin hGPX1, gene pleiomorphism has 39 people (account for detect total number of persons 17%), skin OH for the male that isozygotys
Clearance rate is 53.2 ± 6.3%; Gene pleiomorphism has 109 people (account for detect total number of persons 48%), skin OH for the heterozygosis male
Clearance rate is 73.3 ± 8.9%;The gene pleiomorphism that demonstrates hGPX1 gene xxxx site thus is active relevant with skin GPX1, this locus gene polymorphism is positive and the heterozygosis male of isozygotying, can cause the active reduction of skin GPX1, and the positive influence degree that the GPX1 activity is reduced of isozygotying is greater than the heterozygosis positive.。
137 people that the applicant detects voluntary accepting have carried out the-1238T-A/2557C-G/Y113H/H139R locus gene polymorphism of mEPHX gene and the ability of skin hydroperoxide decomposition detects, and have made following simultaneous test.Skin is to pollutent, and for example PAHs mainly by the mEPHX detoxifcation, smears the residual quantity that a small amount of PAHs detects PAHs then at experimenter's skin.Gene pleiomorphism has 14 people (account for detect total number of persons 10%) for the male that isozygotys, and the residual quantity of its PAHs is 91 ± 1.1%; Gene pleiomorphism has 66 people (account for detect total number of persons 48%) for the heterozygosis male, and the residual quantity of PAHs is 49 ± 21.8%; And in all the other people of feminine gender that gene pleiomorphism is, the residual quantity of PAHs is 7.8 ± 6.4%.The gene pleiomorphism that demonstrates mEPHX gene xxxx site thus is active relevant with skin EPHX, this locus gene polymorphism is positive and the heterozygosis male of isozygotying, can cause the active reduction of skin EPHX, and the positive influence degree that the EPHX activity is reduced of isozygotying is greater than the heterozygosis positive.
137 people that the applicant detects voluntary accepting have carried out the-308G-A/-850C-T/L29S/R32W locus gene polymorphism of TNF-alpha gene and the detection of skin EPHX and the ability of adjusting JUN gene and type i collagen synthase gene and have detected, and have made following simultaneous test.TNF-alpha plays an important role aspect synthetic at skin immunization and type i collagen by regulating JUN gene/type i collagen synthase gene, and the applicant judges the activity of TNF-alpha by detecting the JUN gene activation time.Negative person under inspection's JUN gene activation time and gene pleiomorphism for the male person under inspection comparison of isozygotying (3 people are arranged, account for the detection total number of persons 2%), OR=3.0, P=0.02; With heterozygosis male person under inspection (29 people are arranged, account for detect total number of persons 21%), OR=2.1, P=0.01.The gene pleiomorphism that demonstrates TNF-alpha gene xxxx site thus is relevant with skin immunization power, this locus gene polymorphism is positive and the heterozygosis male of isozygotying, can cause the reduction of skin immunization power, and the positive influence degree that skin immunization power is reduced of isozygotying is greater than the heterozygosis positive.
The-1607G-GG locus gene polymorphism and MMP1 mRNA that 68 people that the applicant detects voluntary reception have carried out the MMP1 gene detect, and have made following simultaneous test.UVB is the inductor that produces MMP in the cell, and test is induced skin with UVB, detects MMP1 mRNA then.Gene pleiomorphism has 29 (account for population of samples 42%) for the male that isozygotys, and MMP1 mRNA expresses and is higher than negative crowd: OR=2.2, P=0.01 under the effect of B band ultraviolet in sunlight; Gene pleiomorphism has 30 people (account for population of samples 44%) for the heterozygosis male, and MMP1 mRNA expresses and is higher than negative crowd: OR=1.6, P=0.01 under the effect of B band ultraviolet in sunlight.The gene pleiomorphism that demonstrates the-1607G-GG site of MMP1 gene thus is correlated with the skin collagen degree of decomposition, this locus gene polymorphism is positive and the heterozygosis male of isozygotying, in sunlight under the effect of B band ultraviolet, can cause the rising of skin collagen degree of decomposition, and the positive influence degree that skin collagen is decomposed of isozygotying is greater than the heterozygosis positive.
Above-mentioned detection is to carry out on a large amount of gene locus analyses and screening basis, wherein gene pleiomorphism detects the sequencing technologies and the SNP quick diagnosis technology of generally acknowledging at present that adopt, detected result is divided into the positive of isozygotying, heterozygosis positive or negative according to detected sequence, for example: the-3-850C-T site of TNF-alpha gene, be the negative of C/C type, what be the C/T type is the heterozygosis positive, is the positive of isozygotying that is of T/T type.The method that detects enzymic activity adopts the ELISA method of generally acknowledging at present, and the method for detection of skin immunizing power adopts the RT-PCR method of generally acknowledging at present, and the method for detection of skin collagen protein degree of decomposition is the RT-PCR method of generally acknowledging at present.
Summary of the invention
For overcoming the blindness of skin beauty health-care under the prior art, the invention provides a kind of skin beauty health-care method based on the mEPHX gene pleiomorphism, this method can be found skin intrinsic characteristics, selects optimum skin beauty health-care scheme according to skin characteristic.
The present invention realizes that the above-mentioned purpose technical scheme is: a kind of skin beauty health-care method based on the mEPHX gene pleiomorphism comprises the following steps: that (1) carry out gene pleiomorphism to the gene locus relevant with skin beauty health-care and detect; (2) by the detected result of gene pleiomorphism, skin characteristic is judged; (3) at skin characteristic, selection meets the beauty and health care scheme of skin characteristic, the-1238T-A/2557C-G/Y113H/H139R site that the described gene locus relevant with skin beauty health-care is the mEPHX gene, when detected result is the isozygoty positive or heterozygosis when positive, judge that skin has active possibility and the proneness that reduces of EPHX, it is aging to be easy to occur pathologic, give birth to acne, the bad problem of function of detoxification, wherein detected result is the active possibility that reduces of skin EPHX when isozygotying the positive, it is that heterozygosis is when positive that proneness and reduction degree generally all can be higher than this gene pleiomorphism.
The invention has the beneficial effects as follows: by the detection of related gene polymorphism, can find the characteristics of skin from the gene level, judge possibility and proneness that immanent cause that skin problem occurs and skin go wrong effectively, carry out beautifying skin and health care targetedly, eliminate the blindness when selecting skin care product and skin beauty health-care scheme, improved the beauty and health care effect.
Embodiment
Method of the present invention mainly is made of following three steps:
(1) gene locus relevant with skin beauty health-care being carried out gene pleiomorphism detects;
(2) by the detected result of gene pleiomorphism, skin characteristic is judged;
(3), select to meet the beauty and health care scheme of skin characteristic at skin characteristic.Here, so-called beauty and health care scheme mainly is meant the selection to skin care product under normal conditions, also can comprise the use of skin care product, perhaps adopts other nursing care mode of using outside the skin care product.And use the nursing care mode of skin care product and use other nursing care mode outside the skin care product to use simultaneously, also can use separately.
At first, should choose gene and site, these genes and site should obtain certainly its dependency with skin beauty health-care through checking.The development of modern genetic science is for finding and confirming that this dependency provides the foundation.The present gene theory of generally acknowledging and applicant's available research achievements such gene and the site of alleged occurrence, its gene pleiomorphism is to skin growth and healthyly play important effect, its unfavorable morphosis the immanent cause of skin problem.Along with the development of scientific research, may find that also new gene is relevant with the beauty treatment and the health care problem of skin with the site, these discoveries all can be applied among the present invention, for enforcement of the present invention provides more broad application prospect.
When carrying out the gene pleiomorphism detection, can adopt various existing technique of gene detection, for example sequencing technologies, enzyme incision technology, chip technology SNP quick diagnosis technology, little satellite technology, real time round pcr and mass-spectrometric technique etc.Can select concrete detection method according to the characteristics of different detection techniques and user's physical condition.Along with development of science and technology, will have more and more, technique of gene detection appearance more and more easily, these technology all can be used in the present invention.
The described gene locus relevant with skin beauty health-care can be the 47C-T/A16V site of MnSOD gene, the polymorphism in this site affects the activity of skin MnSOD, when detected result is the isozygoty positive or heterozygosis when positive, active possibility and the proneness that reduces of prompting skin MnSOD.The judgement that can make is that skin has active possibility and the proneness that reduces of MnSOD thus, problem such as be easy to occur irritatedly to give birth to that acne, pathologic are aging, pigmentation macula lutea and reparative regeneration are bad.This gene pleiomorphism be when isozygotying the positive active possibility, proneness and the reduction degree that reduces of skin MnSOD generally all can be higher than this gene pleiomorphism be that heterozygosis is when positive.
The described gene locus relevant with skin beauty health-care can be the 593C-T/P197L site of hGPX1 gene, the polymorphism in this site affects the activity of skin GPX1, when detected result is the isozygoty positive or heterozygosis when positive, active possibility and the proneness that reduces of prompting skin GPX1.The judgement that can make is that skin has active possibility and the proneness that reduces of GPX1 thus, be easy to occur irritated, give birth to acne, problem such as pathologic is aging, immunologic function is bad and reparative regeneration is bad.This gene pleiomorphism be when isozygotying the positive active possibility, proneness and the reduction degree that reduces of skin GPX1 generally all can be higher than this gene pleiomorphism be that heterozygosis is when positive.
The described gene locus relevant with skin beauty health-care can be the-1238T-A/2557C-G/Y113H/H139R site of mEPHX gene, the polymorphism in this site affects the activity of skin EPHX, when detected result is the isozygoty positive or heterozygosis when positive, active possibility and the proneness that reduces of prompting skin EPHX.The judgement that can make is that skin has active possibility and the proneness that reduces of EPHX thus, be easy to occur pathologic aging, give birth to problems such as acne, function of detoxification be bad.This gene pleiomorphism be when isozygotying the positive active possibility, proneness and the reduction degree that reduces of skin EPHX generally all can be higher than this gene pleiomorphism be that heterozygosis is when positive.
The described gene locus relevant with skin beauty health-care can be the-308G-A/-850C-T/L29S/R32W site of TNF-alpha gene, the polymorphism in this site affects the immunizing power of skin, when detected result is the isozygoty positive or heterozygosis when positive, possibility and proneness that prompting skin immunization power reduces.The judgement that can make is that skin has possibility and the proneness that immunizing power reduces thus, problem such as be easy to occur that pathologic is aging, poor circulation and reparative regeneration are bad.This gene pleiomorphism is that generally all can be higher than this gene pleiomorphism be that heterozygosis is when positive for skin immunization power reduces when isozygotying the positive possibility, proneness and reduction degree.
The described related locus that influences the gene of skin growth and health can be the-1607G-GG site of MMP1 gene, the polymorphism in this site affects the degree of decomposition of skin collagen, when detected result is the isozygoty positive or heterozygosis when positive, prompting is easy under the activation of the B band ultraviolet in daylight, up to synthetic MMP1, matter between the degraded skin cells.Thus the judgement that can make be skin have B band ultraviolet in daylight activate under up to possibility and the proneness of synthetic MMP1, problem such as be easy to occur physiological ageing, pathologic is aging and day photosensitiveness is aging.This gene pleiomorphism be when isozygotying the positive degree of decomposition of skin collagen to be higher than this gene pleiomorphism be the degree of decomposition of heterozygosis when positive.
Possibility and proneness that result who detects according to gene pleiomorphism and the skin that reflects thereof go wrong can be carried out the nursing of beauty and health care aspect targetedly to skin.Detected result is divided negative, heterozygosis is positive and positive three kinds the situation of isozygotying under, corresponding skin care also can be divided into three ranks: general duty nursing, intensive nursing care and special intensive nursing care.
So-called general duty nursing is corresponding to there not being gene pleiomorphism to cause possibility and proneness that skin goes wrong.In this case, the skin care product that can select general function for use according to the external physical feature (wetness degree, black and white degree etc.) and the environmental aspect of skin, nursing such as moistening, preserve moisture and/or brighten.These skin care product can directly be bought in market, need not special additive or special nursing prescription.For the polymorphism of 5 kinds of above-mentioned gene locuss, this nursing can be suitable for the negative people of detected result, also be suitable for detected result and be isozygotying positive and heterozygosis male people's general duty nursing.
So-called intensive nursing care and special intensive nursing care are to detect the targeted nursing of carrying out when demonstration exists bad possibility of skin and proneness at gene pleiomorphism, mainly be to apply special nursing composition (can be described as and strengthen composition), in order to offset the detrimentally affect that the specific gene type brings.For example in above-mentioned 5 kinds of gene pleiomorphisms detected, detected result was reduction or other the corresponding problem that the heterozygosis positive and the male genotype of isozygotying all can cause corresponding enzymic activity, causes certain bad possibility and proneness.Therefore, offset the detrimentally affect that these specific gene types bring, just should replenish corresponding enzyme, perhaps apply other beneficiating ingredients that can play with this kind of enzyme same function, perhaps apply other beneficiating ingredients that can improve the skin respective conditions, perhaps implement other effective skin beauty health-care methods.
Apply and strengthen dose of components and should decide according to particular case such as character, bad possibility and tendentious power, the use-pattern of strengthening composition itself.Stronger for bad possibility and proneness, apply strengthen dose of components just should be greatly, Here it is so-called special intensive nursing care; More weak for bad possibility and proneness, replenish strengthening dose of components just should be smaller, Here it is so-called intensive nursing care.Because in above-mentioned 5 kinds of detections, the positive bad possibility that causes of isozygotying is relative with proneness higher, should carry out corresponding special intensive nursing care, positive bad possibility and the proneness that causes of heterozygosis is relatively low, should carry out corresponding intensive nursing care.
The using method of reinforcement composition and formulation etc. should be decided according to the characteristics of the facility on using and this composition itself.Can be added in the common skin care product strengthening composition, form corresponding reinforcing formulation or special reinforcing formulation, so that when using skin care product, obtain corresponding intensive nursing care or special intensive nursing care; Also can use separately strengthening composition, the paste (comprising the various formulations that can be coated in skin surface) that for example will contain this reinforcement composition is coated in skin surface or the oral medicine that contains corresponding reinforcement composition, or contains injection of corresponding reinforcement composition medicine etc.
Can strengthen composition according to prior art or other various possible choices of technology.Along with development of science and technology, alternative reinforcement composition will get more and more.For example, be the isozygoty positive or heterozygosis when positive in the 47C-T/A16V site of MnSOD gene detected result, to be that skin MnSOD is active reduce for the bad possibility of skin and proneness, and the reinforcement composition of use can be active SOD; Be the isozygoty positive or heterozygosis when positive in the 593C-T/P197L site of hGPX1 gene detected result, the bad possibility of skin and proneness are the active reductions of skin GPX1, eliminate the active adverse consequences that reduces of skin GPX1, can use VC as strengthening composition; Be the isozygoty positive or heterozygosis when positive in the-1238T-A/2557C-G/Y113H/H139R site of mEPHX gene detected result, the bad possibility of skin and proneness are the active reductions of skin EPHX, and the reinforcement composition of use can be to be used to prevent the rational aged Seaweed Extract of tetter under the prior art; Be the isozygoty positive or heterozygosis when positive in the-308G-A/-850C-T/L29S/R32W site of TNF-alpha gene detected result, the immunizing power that the bad possibility of skin and proneness are skin reduces, and the reinforcement composition of use can be to be used to prevent the rational aged Seaweed Extract of tetter under the prior art equally; Be the isozygoty positive or heterozygosis when positive in the-1607G-GG site of MMP1 gene detected result, the bad possibility of skin and proneness are to be easy under the activation of the B band ultraviolet in daylight up to synthetic MMP1, the reinforcement composition that uses can be a hyaluronic acid, perhaps adopts other to prevent ultraviolet measure.
Described gene pleiomorphism detects and generally can not carry out when skin problem occurring, so that prevent trouble before it happens, at carrying out beauty and health care under the bad possibility of skin and the tendency.Described gene pleiomorphism detects and also can carry out after skin problem occurring, so that find out the true cause that skin problem occurs, suit the medicine to the illness " medicine " down.For example for the skin aging problem, may be that day photosensitiveness is aging, it also may be the chemical toxicant damage, when the-1607G-GG of MMP1 gene locus gene polymorphism detected result is the isozygoty positive or heterozygosis when positive, prompting day photosensitiveness aged possibility, when the-1238T-A/2557C-G/Y113H/H139R of mEPHX gene locus gene polymorphism detected result is the isozygoty positive or heterozygosis when positive, the prompting chemical pollutant causes the aged possibility, after determining senile cause, may adopt corresponding intensive nursing care or special intensive nursing care, and can take other to prevent measure (for example avoid sun exposure or away from chemical pollutant).
The applicant adopts the mode of above-mentioned introduction, and 39 people that voluntary accepting is tested have carried out skin beauty health-care nursing test.According to experimenter person investigation, by time length 6-12 month in skin fine and smooth degree of lubrication, pale degree, the aspect sensations such as (going wrinkle) that prevents to wear out obviously improve account for 69%; Accounted for 51% by time length 12-24 month what sensation aspect the elimination chloasma was obviously improved; 85% people thinks that the effect of this beauty and health care is better than the beauty and health care effect that they adopted in the past and compares, and the people of residue 15% thinks and the no significant difference of beauty and health care effect in the past.
Claims (5)
1. skin beauty health-care method based on the mEPHX gene pleiomorphism comprises the following steps: that (1) carry out gene pleiomorphism to the gene locus relevant with skin beauty health-care and detect; (2) by the detected result of gene pleiomorphism, skin characteristic is judged; (3) at skin characteristic, selection meets the beauty and health care scheme of skin characteristic, the-1238T-A/2557C-G/Y113H/H139R site that the described gene locus relevant with skin beauty health-care is the mEPHX gene, when detected result is the isozygoty positive or heterozygosis when positive, judge that skin has active possibility and the proneness that reduces of EPHX, it is aging to be easy to occur pathologic, give birth to acne, the bad problem of function of detoxification, wherein detected result is the active possibility that reduces of skin EPHX when isozygotying the positive, it is that heterozygosis is when positive that proneness and reduction degree generally all can be higher than this gene pleiomorphism.
2. the skin beauty health-care method based on the mEPHX gene pleiomorphism as claimed in claim 1 is characterized in that the technique of gene detection that adopts is one or more in the following method: sequencing technologies, enzyme incision technology, chip technology, SNP quick diagnosis technology, little satellite technology, real time round pcr and mass-spectrometric technique etc.
3. the skin beauty health-care method based on the mEPHX gene pleiomorphism as claimed in claim 1 or 2, it is characterized in that positive and positive three kinds of situations of isozygotying of feminine gender, heterozygosis according to the gene test result, the nursing of described skin beauty health-care aspect correspondingly is divided into rank: general duty nursing, intensive nursing care and special intensive nursing care, wherein general duty nursing is corresponding to not causing possibility and the proneness that skin goes wrong because of gene pleiomorphism, according to the skin care product that the external physical feature and the environmental aspect of skin are selected general function for use, moisten, preserve moisture and/or brighten nursing; So-called intensive nursing care and special intensive nursing care are to detect the targeted nursing of carrying out when demonstration exists bad possibility of skin and proneness at gene pleiomorphism, mainly be to apply special reinforcement composition, in order to offset the detrimentally affect that the specific gene type brings, described reinforcement composition is corresponding enzyme, or the beneficiating ingredient of same function is arranged with this kind of enzyme, or can improve the beneficiating ingredient of skin respective conditions, wherein strengthen composition in special intensive nursing care dosage greater than the dosage in intensive nursing care.
4. the skin beauty health-care method based on the mEPHX gene pleiomorphism as claimed in claim 3, it is characterized in that being the isozygoty positive or heterozygosis when positive in mEPHX gene the-1238T-A/2557C-G/Y113H/H139R site detected result, the reinforcement composition of use is to be used to prevent the rational aged Seaweed Extract of tetter.
5. the skin beauty health-care method based on the mEPHX gene pleiomorphism as claimed in claim 3, it is characterized in that described gene pleiomorphism detects does not carry out when skin problem occurring, perhaps after skin problem occurring, carry out, the described mode that applies the reinforcement composition is that the reinforcement composition is added in the common skin care product, form corresponding reinforcing formulation or special reinforcing formulation, or the paste application that will contain this reinforcement composition is at skin surface, or the oral medicine that contains corresponding reinforcement composition, or contain the injection of corresponding reinforcement composition medicine.
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| CN105803106A (en) * | 2016-05-27 | 2016-07-27 | 福建爱我健康生物科技有限公司 | Primer, probe and kit for evaluating skin moisturizing conditions |
| CN105950738A (en) * | 2016-05-27 | 2016-09-21 | 福建爱我健康生物科技有限公司 | Primer, probe and kit for evaluating skin anti-allergy condition |
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| CN105950738A (en) * | 2016-05-27 | 2016-09-21 | 福建爱我健康生物科技有限公司 | Primer, probe and kit for evaluating skin anti-allergy condition |
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