CN101239118A - Composition comprising panax ginseng and paulliniacupana extracts - Google Patents

Composition comprising panax ginseng and paulliniacupana extracts Download PDF

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Publication number
CN101239118A
CN101239118A CNA2008100741696A CN200810074169A CN101239118A CN 101239118 A CN101239118 A CN 101239118A CN A2008100741696 A CNA2008100741696 A CN A2008100741696A CN 200810074169 A CN200810074169 A CN 200810074169A CN 101239118 A CN101239118 A CN 101239118A
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vitamin
plant
extract
dietary supplements
amazon
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瓦尔特·贾尼塞洛
法比奥·索尔达蒂
艾伯托·维格纳特利
马库斯·彼得斯
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Boehringer Ingelheim International GmbH
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/60—Edible seaweed
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The present invention provides a method of improving human cognitive skill by took a composite, the composite includes (1) plant ginseng extract of collaboratively effective quantity; (2) plant Amazon Chinese Soapberry Fruit extract of collaboratively effective quantity.

Description

The compositions that contains Radix Ginseng and Amazon fragrant Fructus Sapindi Mukouossi extract
The application is a Chinese patent application (denomination of invention: the compositions that contains Radix Ginseng and Amazon fragrant Fructus Sapindi Mukouossi extract; The applying date: on JIUYUE 26th, 2003; Application number: dividing an application 03823190.5).
Background of invention
1. technical field
The present invention relates to a kind ofly by taking compositions to improve the method for people's cognitive skill, said composition comprises:
(1) the plant Radix Ginseng of effective dose (Panax ginseng) extract; With
(2) the plant paullinia sorbilis Martius of effective dose (Paullinia cupana) extract.
2. background technology
Radix Ginseng (Panax ginseng C.A.Meyer) root contains some triterpene glycosides that are called ginsenoside's (or panaxcoside), thinks that it helps to improve the adaptability and the physical behavior of Radix Ginseng extract performance.It is used to treat anemia, diabetes, insomnia, neurasthenia, gastritis, abnormal blood pressure, dyspepsia, supertension and fatigue.
French patent application RF2 712 191 is claimed and openly have compositions to the anti-fatigue active that is easy to lose weight, and said composition contains the extract of Radix Ginseng and the extract of Guarana (Guarana) seed.
French patent application FR2 710 267 discloses a kind of Orally administered composition that is used for the treatment of impotence, and said composition is by bird rope deoxycholic acid, Radix Ginseng extract, Brazilian heavy curtain heavy curtain wood (Muira puama) extract, Yohimbine (gohimbine) hydrochlorate, Guarana extract, Semen Strychni (Nux vomiea) extract, damiana (Pamiana) extract, nicotiamide, nicotinic acid, tocopherol acetas, the two ammonia hydramine (clenbuterol Hydzochloride) of hydrochloric acid and excipient.
First purpose of the present invention is to provide a kind of improve memorizing rate and memory method for quality normal, health objects, prevents the method that man memory speed goes down along with the reduction of cognitive function and suppresses cognitive tired method.
Another purpose of the present invention is to provide a kind of and contains the method that the medicinal herbs component preparation improves the method for memorizing rate and prevents to reduce memorizing rate by taking, and its herbal treatment and/or dietary supplements are to make according to the controllable method of the medicinal herbs therapeutic quality of preserving composition.
A further object of the invention is to provide a kind of to be improved the method for memorizing rate and prevents the method that memorizing rate goes down, and this method comprises the medicinal herbs composition, and makes side effect minimum or do not have, and is safe for internal consumption therefore.
The general introduction of invention
Be unexpectedly, found that people's cognitive skill can improve by taking a kind of compositions, said composition contains
(1) plant man's conopsea extraction of effective dose; With
(2) the plant Amazon fragrant Fructus Sapindi Mukouossi extract of effective dose.
To be a kind of compositions on the other hand be used for improving the medicine aspect the cognitive skill or the purposes of dietary supplements in manufacturing in the present invention, and said composition contains
(1) plant man's conopsea extraction of effective dose; With
(2) the plant Amazon fragrant Fructus Sapindi Mukouossi extract of effective dose.
In addition, the present invention relates to a kind of pharmaceutical composition or dietary supplements, mainly comprise
(1) plant man's conopsea extraction of effective dose;
(2) the plant Amazon fragrant Fructus Sapindi Mukouossi extract of effective dose;
(3) one or more vitamin;
(4) one or more mineral and/or trace element; With
(5) Ren Xuan carrier and/or auxiliary agent.
In addition, the present invention relates to a kind of dietary supplements, comprise vitamin, mineral, trace element and with the caffeine of Guarana form of extract.
Detailed description of the invention
A kind of preparation is prepared or made jointly to two kinds of compositions (1) and (2) randomly with composition (3), (4) and (5).For example preparation comprises the extract of dry ginseng's root or other plant component, and is optional with its efflorescence, and the paullinia sorbilis Martius seed extract of doing, and perhaps other plant component is chosen wantonly it is ground.Preparation can be with the powder in tablet, coated tablet, chewable tablet, powder, the capsule, soft shell capsule, syrup, solution or suspension, for example water base, ethanol based or the known suitable mode of its mixture, dragee, gel, injection or other those of skill in the art.Oral administered dosage form preferably.
Be used for term " people " or " people of its needs " or " patient " of context, relate to the healthy woman or the man that will improve cognitive skill.Usually these people be the mean age be 42.5 years old between 18-80 year, the adult or the aging people in preferred 20-65 year.
The term " effective dose " that is used for the present invention means when take in single dosage form together composition (1) and (2) and optional (3) and (4), is enough to improve the amount of cognitive skill.In general, the combination of composition (1) and (2) can show synergistic, this means that influence to cognitive skill is higher than single component (1) and (2) and/or single component (1), (2), (3) and (4) desired pure additive effect.
Term " plant " should be understood to plant itself and the plant part that comprises active component.For example above-mentioned leaf, stem, seed, fruit or root.Preferably plant or plant ingredient are carried out drying.Optional is, they are cut into slices, and grinds or efflorescence.
Term " extract " is meant with suitable solvent such as water, ethanol, butanols, acetone, its mixture, ether, oil or extracts the plant or the plant ingredient of other any suitable solvent extraction of understanding thoroughly in the plant technology.These extracts can use if can accept then on the pharmacology, perhaps the solvent of the solution that produced is removed, and residue can use like this, perhaps further handle the back and use, for example again dissolving back or resuspending in the suitable solvent of pharmacology.
Term " main active " and main active substances mean all active component of major decision pharmacological action.Preparation preferably contains and determines pharmacological action 75% at least, is more preferably all the components of 90% relevant plant.
Term " raising of cognitive skill " refers to the improvement to all situations, wherein the people is considered to obtain the intelligence behavior, comprises quality, accuracy and speed, learning capacity, short-term and secular memory, attention, the agility of memory and because of the reduction of caused fatigue of high work load and/or the intelligence behavior necessity that meets the demands.
Term " pharmaceutical composition " refers to such compositions, and said composition is suitable for prescription and OTC medicine, and can obtain from doctor, chemicals shop or medicine shop.
Term " dietary supplements " refers to such compositions, and it replenishes regular dietary intake with other nutrient, improving the quality of living, and can write out a prescription and not only in pharmacy, also can freely buy from food supply retail shop or supermarket.
Preferred end user's conopsea extraction, it contains and other material ginsenoside and polysaccharide material together, preferably contain 3% at least, 3.5-5.0% more preferably, the ginsenoside of 3.6-4.4% particularly is best with normal man's conopsea extraction of trade name G115 , and it can be with commercially available product from Pharmaton S.A., CH-6934Bioggio, Switzerland buys.
Usually the Guarana extract is prepared by the paullinia sorbilis Martius seed.This kind of plant belongs to Sapindaceae, a kind of xyloid liana of cultivating in central Amazon district.The most important composition of paullinia sorbilis Martius is caffeine, tannin and saponin and polysaccharide, disaccharide, fat and resin.
Seed will carefully carry out drying and grind to form small pieces, the especially 0.5-1.5mm of preferred 0.1-5.0mm.For reaching predetermined content of caffeine, extraction is in the temperature that improves, and preferred temperature is carried out with ethanol water in 60-80 ℃ of scope, and the time was at least 6 hours to 10 hours.Method for optimizing is the complete percolation that uses ethanol water in the presence of the weak base having.Preferred vaporising under vacuum ethanol, and under vacuum the half-dried residue of dry extraction.The dry extract of gained preferably grinds and sieves.
The preferred dry extract that uses content of caffeine up to 12% paullinia sorbilis Martius.
In a preferred embodiment of the invention, the weight ratio of Radix Ginseng extract and Guarana extract is 1: 10-10: 1, preferred 1: 5-2: 1, particularly 1: 3-1: 1, and best is about 1: 1.9.
Preferably, the present invention relates to a kind of method, wherein said compositions also comprises
(3) one or more vitamin; With
(4) one or more mineral and/or trace element.
Particularly
Wherein said one or more vitamin (3) are selected from provitamin A, vitamin B 1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D3, d, 1-alpha-tocopherol acetate (vitamin E), folic acid, biotin (biotin) and vitamin PP; And/or
Wherein said one or more mineral and/or trace element (4) are selected from copper, calcium, ferrum, zinc, selenium, phosphorus and magnesium.
Preferably, pharmaceutical composition of the present invention or dietary supplements mainly comprise
(1) 20-100mg plant man conopsea extraction;
(2) 50-100mg plant Amazon fragrant Fructus Sapindi Mukouossi extract;
(3) 0.001-120mg one or more, preferred two kinds to 12 kinds, 5 kinds of-11 kinds of vitamin particularly;
(4) 0.01-400mg one or more, preferred two kinds-10 kinds, especially 4 kinds of-7 kinds of mineral and/or trace element; With
(5) Ren Xuan carrier and/or auxiliary agent.
Best pharmaceutical composition or dietary supplements mainly comprise
Normal man's conopsea extraction G115 of 30-50mg, particularly about 40mg
60-90mg's, particularly about 75mg contains the Amazon fragrant Fructus Sapindi Mukouossi extract that is up to 12% weight caffeine
The provitamin A of 1000-1200IU, particularly about 1100IU (vitamin A activity)
1.0-2.0mg, the vitamin B1 of about 1.4mg particularly
1.0-2.0mg, the vitamin B2 of about 1.6mg particularly
1.0-3.0mg, the vitamin B6 of about 2.0mg particularly
0.5-2.0 μ g, the vitamin B12 of particularly about 1.0 μ g
The vitamin C of 10-100mg, particularly about 60mg
The vitamin D3 of 50-300IU, particularly about 160IU
The d of 10-20mg, particularly about 15mg, 1-alpha-tocopherol acetate (dimension .E)
100-300 μ g, the folic acid of particularly about 200 μ g
100-200 μ g, the biotin of particularly about 150 μ g
The vitamin PP of 10-30mg, particularly about 18mg
0.1-1.0mg, the copper of about 0.5mg particularly
0-150mg, particularly 0 or the calcium of about 120mg
The ferrum of 1-10mg, particularly about 5mg
The zinc of 1-10mg, particularly about 5mg
0-150mg, particularly 0 or the phosphorus of about 90mg
10-150 μ g, the selenium of particularly about 30 μ g
The magnesium of 5-100mg, particularly 10-70mg
And optional carrier and/or auxiliary agent.
Preferably be configured in pharmaceutical composition or dietary supplements in soft shell capsule or the tablet.
Contain the compositions of the pre-selected amount of the present invention of Radix Ginseng extract (1), Guarana extract (2), vitamin (multiple) (3) and mineral (4), preferred package is in the soft gelatin that contains cattle, pig, vegetable and Succinylated gelatin shell.Optional is that soft gelatin shell is transparent basically, so that improve capsular aesthetic feeling quality.Common soft gelatin shell comprises following main component and optional ingredients.
Gelatin is the main component of the soft gelatin shell of the present invention.The gelatin raw material that is used to make soft capsule obtains the skin of described collagen-based materials such as animal, white conjunctive tissue or bone by the partial hydrolysis collagen-based materials.Gelatin materials can be divided into A type gelatin and Type B gelatin, and A type gelatin is obtained by acid-processing Corii Sus domestica, and it has the isoelectric point, IP between pH 7 and pH 9; And the Type B gelatin is obtained by alkali-processing bone and animal (cattle) skin, and it has the isoelectric point, IP between pH 4.7 and pH 5.2.The mixture of A type gelatin and Type B gelatin can be used for obtaining to have the necessary viscosity of capsule of manufacturing and albefaction (bloom) strength characteristics.The gelatin that is fit to the capsule manufacturing can be by Sigma ChemicalCompany, St.Louis, and Mo buys.For the general remark of gelatin and gelatin-based capsules, can be referring to the Pharmaceutical Sciences of Remingtons, the 16th edition, Mack publishing company, Easton, Pa. (1980), the 1245th page and 1576-1582 page or leaf; With people such as Borkan, the U.S patent 4935243 that announce June 19 nineteen ninety; These two parts of documents are introduced as a reference in full.
The capsular soft gelatin shell of the present invention when beginning to prepare, comprises the gelatin of about 20%-about 60%, the gelatin of preferably about 25%-about 50%, and best is the gelatin of about 40%-about 50%.Gelatin can be A type and Type B, or it has the mixture of the about 60-of albefaction value (bloom numbers) about 300.
Plasticizer is another composition of the soft gelatin shell of the present invention.In order to produce soft gelatin shell, can mix one or more plasticizers.So the soft gelatin that obtains has as the necessary flexible nature of capsule.The useful plasticizer of the present invention comprises glycerol, anhydro sorbitol, sorbitol or similar low-molecular-weight polyhydric alcohol and composition thereof.
Shell of the present invention when beginning to prepare, generally contains the plasticizer of the 10%-that has an appointment about 35%, the preferred plasticizer of about 10%-25%, and best is the plasticizer of about 10%-about 20%.Being used for preferred plasticizer of the present invention is glycerol.
Soft gelatin shell of the present invention can also comprise water.Although in theory without limits, but think that water helps soft gelatin shell to dissolve rapidly or break when contacting with the gastro-intestinal Fluid that run in the human body.
Shell of the present invention when beginning to prepare, generally comprises the water of about 15%-about 50%, is more preferably the water of about 25%-about 40%, and best is the water of about 30%-about 40%.
Can mix the composition that other optional member in the soft gelatin shell comprises the coloring agent, flavoring agent, antiseptic, antioxidant, essence and other the aesthetic happiness that contain coloured coating.
Compositions of the present invention can be encapsulated in can be basically to be suitable in the reasonable time any traditional soft gelatin shell that contains compositions at interval, prepare soft gelatin shell of the present invention can by in conjunction with gelatin, water, plasticizer and the optional ingredients of appropriate amount in suitable containers, and shake and stir, be heated to about 65 ℃ simultaneously, up to obtaining uniform solution.This soft gelatin shell preparation is used to adopt the compositions that the standard packaging method encapsulates scheduled volume, monomeric to produce, the Perle of sealing.Gelatine capsule is made predetermined shape and size, so that easy-to-swallow.Perle size of the present invention is fit to easy-to-swallow, and typically contains the active compound of the about 2000mg of 100mg-that has an appointment.Perle and method for packing are described in people such as P.K.Wilkinson, " Softgels:ManufacturingConsiderations ", Drugs and Pharmaceutical Sciences, 41 (Specialized DrugDelivery Systems) P.Tyle, editor. (Marcel Dekker, Inc., New York, 1990) pp.409-449; People such as F.S.Horn, " Capsules, Soft ", Encyclopedia ofPharmaceuticalTechnology, volume .2, J.Swarbrick and J.C.Boylan compile (Marcel Dekker, Inc., NewYork, 1990) pp.269-284; People such as M.S.Patel, " Advances in Softgel FormulationTechnology ", Manufacturing Chemist, vol.60, no.7, pp26-28 (July 1989); People such as M.S.Patel, " Softgel Technology ", Manufacturing Chemist, vol.60, no.8, pp47-49 (August 1989); R.F.Jimerson, " Softgel (Soft Gelatin Capsule) Update ", Drug Development and Industrial Pharmacy (Interphex ' 86 Conference), volume .12, no.8﹠amp; 9, pp1133-1144 (1986); And W.R.Ebert, " Soft Elastic Gelatin Capsules:AUnique Dosage Form ", Pharmaceutical Technology, volume .1, no.5, PP44-50 (1977); These documents are incorporated herein by reference in full.Resulting Perle is soluble in water and gastrointestinal fluid.When swallowable capsule, gelatin shell is dissolved rapidly in gastrointestinal tract or is broken, and thus active constituents of medicine is introduced physiological system from liquid core.
Tablet of the present invention generally contains employed at least a medicine or the acceptable excipient of diet in the solid dosage forms formula technique usually.
The appropriate excipients that can mix comprises lubricant, for example magnesium stearate and stearic acid; Disintegrating agent, for example cellulose derivative; Starch; Binding agent, modified starch for example, polyvinylpyrrolidone and cellulose derivative; Glidants, for example silica sol; Compression aid, for example cellulose derivative; And antiseptic, suspending agent, wetting agent, flavoring agent, bulking agent (bulking agent), binding agent, coloring agent, be fit to the sweeting agent of its form.
Suitable is that when compositions existed with tablet, said composition can further comprise film coating, for example HYDROXY PROPYL METHYLCELLULOSE (HPMC).Suitable film coating is the clear films coating, although opaque film coating also can use, for example, is obtained when using the film coating material that cooperates opacifier or pigment such as titanium dioxide, color lake or dyestuff.Advantageously, it is minimum that the coating that has now found that opaque film coating is reduced to the decolouring of tablet, when the decolouring phenomenon can occur in long term store.Decolouring also can be advanced the tablet core and avoided by means of mixing coloring agent.Suitable tablet also can film coating, for example, and on demand from the purpose of aesthetics and/or help to swallow.
The mixed with excipients of extract elder generation and label is suppressed on suitable tablet machine again.
Therefore, depend on the shape and size of used perforating tool for producing suitable resistance to fracture and having the necessary compression stress of tablet of necessary disintegration time.Preferred compression stress is the 2-20kN scope.The compression stress height can cause active substance (1)-(4) of tablet to postpone to discharge.But unsettled tablet on the low compression stress manufacturing machine.Label can have different patterns; Preferred styles is biplanar or convexo-convex and avette or oval-shaped.
Coating solution can mix in water with coloured material and plasticizer by film former and prepare.Use suitable coating tray, the solution that applies thin film is coated on the label.
Preferred tablet has oval shape, is beneficial to swallow.Under the coated tablet situation of the extract (1) that contains the 115mg combination and (2), oval tablet is about 10-20mm, wide about 5-10mm.
In another preferred embodiment of the present invention, compositions contains vitamin, mineral, trace element and with the caffeine of Guarana form of extract.Caffeine in the Guarana extract can recover human body and neurobehavioral.This is than gentle from the caffeine of coffee or tea acquisition usually.
Preferably, dietary supplements of the present invention is to comprise day necessary dosage of various active component of absorption in a packing, especially the caffeine of 0.05-1.00 gram.
Be more preferably, dietary supplements of the present invention contains following 5 kinds of compositions at least:
Calcium phosphate, sodium lauryl sulphate, calcium hydrogen phosphate, magnesium oxide, potassium chloride, vitamin C, polyvinylpyrrolidone, nicotiamide, ferrous fumarate (II), vitamin E, zinc oxide, manganese sulfate, calcium pantothenate, stearic acid (stearinic acid), magnesium stearate, silicon dioxide, copper sulfate, vitamin B6, vitamin B2, lactose, vitamin B1, beta-carotene (carotine), vitamin A, chromium, sodium, folic acid, biotin, potassium iodide, sodium selenate, vitamin K1, vitamin D3, vitamin B12, vitamin B3 and vitamin B5; And/or
At least a following ingredients:
Micro-algae (microalgae), Radix Ginseng, Ginkgo (ginkgo), Fructus Anisi Stellati (anise), Cynara scolymus L (Cyhara cardunculus.) (artichoke), valeriana (valerian), Eucalyptus (eucalyptus), Fructus Foeniculi (fennel), bot hip, hops (hops), St. John's plant (Saint-John ' s-wort), Chamomile, cava cava, Bulbus Allii, Passiflora (passionflower), Mentha arvensis L. syn.M.haplocalyxBrig, Tai Jiagen (taiga root), Fructus Crataegi, Rhizoma Zingiberis Recens, Herba Medicaginis (alfalfa), Radix Aneurolepidii, Asimina (pawpaw), silicon dioxide, Lac regis apis, Gentiana lutea, yeast, Artemisia absinihium L (wormwood) or these plants are with combing, grind, efflorescence, pressurization, fermentation and/or the converted products that extracts with and seed, leaf or stem.
By adding the extract of one or more medicinal herbs,, can realize additive effect as Semen Ginkgo or Radix Ginseng.For example, the adding of micro-algae can provide the supplementing iodine amount for health.The adding of Semen Ginkgo can improve neurobehavioral and improve the toleration of tense situation.
In order to allow to take medicine when really needing, preparation comprises 2-6 sheet or capsular product, collects in the packing of the 7 * 12cm that is made by synthetic material.By this manner of packing, make vitamin coffee because of and the compositions of mineral can be easy in handbag, carry.
In order to determine the cooperative effect of medicine of the present invention and/or dietary supplements, use the computerization version of the SerialSevens test of improvement.Original Serial Sevens test (M.Hayman, Arch.Neurol.Psychiatry 17:125-130 (1947)) occurs with many kinds of forms, comprise a part [L.A.Taylor et.al., J.Behav.Med.11:279-291 (1985)] as Mini-Mental State Examination.In the new computer version of research now, for the participant provides a numerical value, instruct them to reduce to 7 one by one by this numerical value, their three figure places are replied in the numerical value dish of input keyboard.
Give and placebo for first group participant, take the compositions that contains Radix Ginseng extract (1) and vitamin for second group, take the compositions that contains Guarana extract (3) and vitamin for the 3rd group, and the 4th group is taken the compositions that contains Radix Ginseng and two kinds of extracts of Guarana (1) and (2) and vitamin.
Duration of trial is 2 minutes.A kind of stereotyped command screen report participant uses return key to calculate as far as possible fast and exactly by given numerical value and returns 7 to import each response value.Also can give an oral account the instruction participant, if they are wrong, they should deduct from new error number.Beginning numeral between the 800-900 is any generation, and only appears on the screen up to first and reply generation, and Shu Ru each numeral is represented with asterisk after this.Work is to keep the score with the sum of deduction.But the also misregistration numeral of replying.Under the situation of mistake, if they are correct for new numeral, replying as far as possible with on the occasion of score subsequently then.
Test is expression clearly, and compositions of the present invention has improved correct deduction number and reduced the error that is caused by the participant.
In addition, the effect of the present composition is tested in following research:
(A) in order to contrast quality of life (QoL) parameter of accepting in the present composition object, according to Drugs Exptl Clin Res 1996; 22 (6): the described method of 323-329 is carried out test double blinding, placebo control, randomized, parallel group.
Viewed increase in accepting the group of the present composition significantly is better than being seen conventional multivitamin group from statistics.The negative effect of compositions all is minimum in two groups.Can be observed body weight and diastolic blood pressure in the group with conventional multivitamin preparation for treating significant increase is all arranged, but do not have in the group with the invention combination treatment, the present composition is than only much effective aspect improvement stands quality of life in the colony of highly physical and neural activity pressure with conventional multivitamin preparation.
(B), check the influence of dietary supplements to quality of life (QoL) associated health in the non--clinical colony of 313 health adults.This research is according to people such as Ussher, Brit J HealthPsychol 5, and the paper that 173-187 (2000) is announced carries out.
Compositions of the present invention shows that the aspect of improving to muscle power strain, behavior strain, cognitive strain and whole strain is more remarkable.
(C) according to Current Theapeutic Research 1994; 55 (1): illustrated method among the 32-42, other two-blind contrast is carried out in the influence of quality of life of the compositions of the necessary material that comprises standardization Radix Ginseng G115  and placebo.
It is fully that the present composition and placebo improve the person under inspection, but sees that from baseline improvement is more obvious during accepting the group of the present composition.According to Visual Analogue Scales score, the object of accepting the present composition total points, agility, relax and appetite aspect more significant improvement is arranged.
In order to improve cognitive skill, the day clothes dosage of capsule or tablet should be equivalent to the 50-200mg of combined extracts (1) and (2), preferred 70-160mg, particularly 90-130mg.The extract total amount of every day can be divided in 1-3 capsule or tablet, preferably takes a kind of single dosage form.Daily dose should once be taken, preferably in the morning.
After taking the present composition, can find the successful first raising of cognitive skill immediately.Yet,, can expect the improvement unforgettable, that continue of people in addition of cognitive skill in 6 weeks of using continuously.Optimizing effect when life-time service can keep or strengthen.
Program as the embodiment that is used to prepare the present composition will describe in detail hereinafter.Embodiment only follows and does not limit theme of the present invention as detailed explanation, and the extract of medicinal herbs also can add wherein in addition.
Embodiment 1
Make the method for Guarana extract formulation
Herbal medicinal product, the Guarana extract of standard (coding PC102) prepares by following method:
1. source plant: paullinia sorbilis Martius H.B.et Kunth
2. the part of Shi Yonging: dried seed
3. extraction solvent: ethanol (95-96%v/v): deionized water (50: 50) (v/v)
4. the ratio of medicinal herbs and standardized extract: limit 3-7: 1
5. the composition of medicinal herbs preparation: 80-90% natural extract
20-10% maltodextrin MD01
6. standard-run quantity scale: 360kg
Production stage:
1. with exsiccant paullinia sorbilis Martius H.B.et Kunth coarse pulverization on grinder (10mm), obtain the fragment of about 0.5-1.5mm size.The Guarana seed of pulverizing is transferred in the percolation filter, and the ethanol extraction with 50% alkalizes with sodium carbonate.Under identical condition, repeat extraction step, to exhaust medical herbs.Usually need 5 extractions, each continues 3 hours at every turn.When the dry residue of last percolate＜0.5%, think that diafiltration finishes.
2. make the percolate of acquisition be lower than 50 ℃ temperature and concentrate in the vacuum lower part.
3. add hydrochloric acid and reach 5.5-6.5 up to pH value.
4. under 2-5 ℃, left standstill 8 hours centrifugal mixture.
5. in vacuum, be lower than under 50 ℃ of temperature, enriched mixture is till the soft extract that obtains about 70% dry residue.
6. make soft extract being lower than under 70 ℃ the temperature, in vacuum, carry out drying.
7. measure the total alkaloid content of the dry extract after grinding and add maltodextrin MD01, to obtain needed titer.
8. product grinds with centrifugal mill, mixes and sieves.
Embodiment 2
Soft capsule
Preparation contains the Perle of following active ingredients:
The active component formula ratio
Medical herbs Radix Ginseng standard extract 40mg
Amazon fragrant Fructus Sapindi Mukouossi extract PC102 75mg
Provitamin vitamin A 1110IU (dimension A activity)
Vitamin B1 1.4mg
Vitamin B2 1.6mg
Vitamin B6 2.0mg
Vitamin B12 1.0 μ g
Vitamin C 60mg
Vitamin D3 160IU
D, 1-alpha-tocopherol acetate (dimension E) 14.9mg
Folic acid 200 μ g
Biotin 150 μ g
Vitamin PP 18mg
Mineral and trace copper 0.5mg
Ferrum 5mg
Zinc 5mg
Selenium 30 μ g
Magnesium 10mg
Each composition mixing and encapsulation are advanced gelatin, water and plasticizer to form Perle.
Embodiment 3
Tablet
The active component formula ratio
Medicinal herbs Radix Ginseng standardized extract 40mg
Paullinia sorbilis Martius extracts PC102 75mg
Provitamin vitamin A 1110IU (dimension A activity)
Vitamin B1 1.4mg
Vitamin B2 1.6mg
Vitamin B6 2.0mg
Vitamin B12 1.0 μ g
Vitamin C 60mg
Vitamin D3 160IU
D, 1-alpha-tocopherol acetate (dimension E) 14.9mg
Folic acid 200 μ g
Biotin 150 μ g
Vitamin PP 18mg
Mineral and trace copper 0.5mg
Calcium 120mg
Ferrum 5mg
Zinc 5mg
Phosphorus 93mg
Selenium 30 μ g
Magnesium 62.5mg
Each composition and excipient are mixed together and suppress in flakes.
Embodiment 4
Active component formula ratio [%]
Medicinal herbs Radix Ginseng standardized extract 15
Amazon fragrant Fructus Sapindi Mukouossi extract PC102 35
Micro-algae 15
Vitamin, mineral and trace element 35
Embodiment 5
Active component formula ratio [%]
Medicinal herbs Amazon fragrant Fructus Sapindi Mukouossi extract PC102 55
Micro-algae 15
Vitamin, mineral and trace element 30

Claims (16)

1. one kind is improved the method for people's cognitive skill by taking compositions, and said composition contains
(1) plant man's conopsea extraction of cooperative effective quantity; With
(2) the plant Amazon fragrant Fructus Sapindi Mukouossi extract of cooperative effective quantity.
2. by the described method of claim 1, wherein said compositions further contains
(3) one or more vitamin; With
(4) one or more mineral and/or trace element.
3. by claim 1 or 2 described methods, wherein said plant man's conopsea extraction contains at least 3% ginsenoside.
4. by each described method in the aforementioned claim, wherein the plant Amazon fragrant Fructus Sapindi Mukouossi extract contains the caffeine up to 12%.
5. by each described method in the aforementioned claim, wherein one or more vitamin (3) are selected from provitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B 12, vitamin C, vitamin D3, d, 1-alpha-tocopherol acetate, folic acid, biotin and vitamin PP.
6. by each described method in the aforementioned claim, wherein said one or more mineral and/or trace element (4) are selected from copper, calcium, ferrum, zinc, selenium, phosphorus and magnesium.
7. the purposes of compositions, it is suitable for making improves building up one's health by taking tonic or dietary supplements of cognitive skill, and said composition contains
(1) plant man's conopsea extraction of cooperative effective quantity; With
(2) cooperative effective quantity plant Amazon fragrant Fructus Sapindi Mukouossi extract.
8. pharmaceutical composition or dietary supplements mainly contain
(1) plant man's conopsea extraction of cooperative effective quantity;
(2) the plant Amazon fragrant Fructus Sapindi Mukouossi extract of cooperative effective quantity;
(3) one or more vitamin;
(4) one or more mineral and/or trace element; With
(5) Ren Xuan carrier and/or auxiliary agent.
9. by described pharmaceutical composition of claim 8 or dietary supplements, mainly contain
(1) plant man's conopsea extraction of 20-60mg;
(2) the plant Amazon fragrant Fructus Sapindi Mukouossi extract of 50-100mg;
(3) one or more vitamin of 0.001-120mg;
(4) one or more mineral of 0.01-400mg and/or trace element; With
(5) Ren Xuan carrier and/or auxiliary agent.
10. by described pharmaceutical composition of claim 8 or dietary supplements, mainly contain
The standardization Radix Ginseng extract of 30-50mg
The Amazon fragrant Fructus Sapindi Mukouossi extract of 60-90mg
The provitamin A of 1000-1200IU
1.0-2.0mg vitamin B1
1.0-2.0mg vitamin B2
1.0-3.0mg vitamin B6
1.0-2.0 the vitamin B12 of μ g
The vitamin C of 10-100mg
The vitamin D3 of 50-300IU
The d of 10-20mg, 1-alpha-tocopherol acetate (dimension .E)
The folic acid of 100-300 μ g
The biotin of 100-200 μ g
The vitamin PP of 10-30mg
0.1-1.0mg copper
The calcium of 0-150mg
The ferrum of 1-10mg
The zinc of 1-10mg
The phosphorus of 0-150mg
The selenium of 50-150 μ g
The magnesium of 5-100mg
And optional carrier and/or auxiliary agent.
11. a dietary supplements contains following compositions:
A) vitamin
B) mineral and optional trace element
C) caffeine that obtains by Guarana.
12. by the described dietary supplements of claim 11, it comprises day required dosage of absorption in a packing.
13., contain the caffeine of 0.05-1.00 gram by claim 11 or 12 described dietary supplements.
14. each the described dietary supplements by among the claim 11-13 contains at least 5 kinds of following ingredients:
Calcium phosphate, sodium lauryl sulphate, calcium hydrogen phosphate, magnesium oxide, potassium chloride, vitamin C, polyvinylpyrrolidone, nicotiamide, ferrous fumarate (II), vitamin E, zinc oxide, manganese sulfate, calcium pantothenate, stearic acid, magnesium stearate, silicon dioxide, copper sulfate, vitamin B6, vitamin B2, lactose, vitamin B 1, beta-carotene, vitamin A, chromium, sodium, folic acid, biotin, potassium iodide, sodium selenate, vitamin K1, vitamin D3, vitamin B12, vitamin B3 and vitamin B5.
15., contain at least a following ingredients by each described dietary supplements among the claim 11-14:
The converted products of combing, fragmentation, efflorescence, compacting, fermentation and/or the extraction of micro-algae, Radix Ginseng, Ginkgo, Fructus Anisi Stellati, Cynara scolymus L (Cyhara cardunculus.), valeriana, Eucalyptus, Fructus Foeniculi, bot hip, hops, St. John's plant, Chamomile, cava cava, Bulbus Allii, Passiflora, Mentha arvensis L. syn.M.haplocalyxBrig, Tai Jiagen, Fructus Crataegi, Rhizoma Zingiberis Recens, Herba Medicaginis, Radix Aneurolepidii, Asimina, silicon dioxide, Lac regis apis, Gentiana lutea, yeast, Artemisia absinihium L or described plant and seed, leaf or stem.
16. by each described pharmaceutical composition or dietary supplements among the claim 8-15, it is to be mixed with soft shell capsule or tablet form.
CNA2008100741696A 2002-09-28 2003-09-26 Composition comprising panax ginseng and paulliniacupana extracts Pending CN101239118A (en)

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DE20215011U DE20215011U1 (en) 2002-09-28 2002-09-28 Dietary supplement or energy mix tablets or capsules contain vitamin and mineral combinations together with caffeine derived from guarana
EP03005568.5 2003-03-12

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102397183A (en) * 2011-08-24 2012-04-04 珲春华瑞参业生物工程有限公司 Ginseng and soapberry fermentation extract and its application in cosmetics

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102397183A (en) * 2011-08-24 2012-04-04 珲春华瑞参业生物工程有限公司 Ginseng and soapberry fermentation extract and its application in cosmetics
CN102397183B (en) * 2011-08-24 2013-04-17 珲春华瑞参业生物工程有限公司 Ginseng and soapberry fermentation extract and its application in cosmetics

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