CN101224168B - Blood plasma bag air-cleaning device - Google Patents
Blood plasma bag air-cleaning device Download PDFInfo
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- CN101224168B CN101224168B CN2007101686776A CN200710168677A CN101224168B CN 101224168 B CN101224168 B CN 101224168B CN 2007101686776 A CN2007101686776 A CN 2007101686776A CN 200710168677 A CN200710168677 A CN 200710168677A CN 101224168 B CN101224168 B CN 101224168B
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Abstract
A plasma bag air removal device pertains to screw rod transmission extrusion devices; the invention overcomes the shortcomings caused by adopting the existing manual control to remove the air, thereby rapidly and efficiently removing the air mixed in the plasma bag. A machine base which is arranged at one end of a supporting framework of the invention is fixedly provided with a silicone pad, a guide rod penetrates the supporting framework, the guide rod is fixedly connected with an extrusion board and a moving board, the moving board is connected with a trapezoidal screw rod by a screw nut of the screw rod, the trapezoidal screw rod is connected with a stepping motor by an elastic coupling and a reducer sequentially, the interior of the silicon pad is sealed with an elastic steel plate, the elastic steel plate is fixed on the machine base and shows a simple supported beam structure; the central position of the elastic steel plate is fixedly provided with a luminous diode, a photosensitive resistance is arranged on the machine base which is corresponding to the position of the luminous diode; the resistance change signal of the photosensitive resistance is converted to the voltage analog signal to be sent to a single chip microcomputer by an amplification circuit and an A/D conversion circuit. The invention can simplify the realization mode of the control, improve working efficiency, save labor costs and allow the whole air extrusion process to be more reliable.
Description
Technical field
The invention belongs to the pressurizing unit of screw mandrel transmission, particularly in the blood constituent separation process to plasma bags in the device removed automatically of air.
Background technology
The medical science blood transfusion is moved towards the component blood transfusion epoch gradually from transfusion of whole blood.Blood constituent comprises blood plasma, erythrocyte, platelet etc., and blood separator separates blood constituent, and component blood is transferred in the different blood bags, in different environment, preserves, and when patient needs certain component blood, can take at any time easily.
Blood plasma is separated from whole blood; Transfer in the plasma bags, the blood separation transfer process inevitably has the doping of air, after separating plasma is accomplished; Remove air in the plasma bags; Be placed on plasma bags and carry out the quick-freezing processing under-40 ℃ of temperature, be placed on then in-20 ℃ of environment and preserve, processing can make blood plasma preserve about 1 year like this.Generally speaking, it is fuller that the blood plasma in the blood bag is all adorned, if earlier with the air purge in the bag but directly carry out freezing processing; Because blood plasma solidifies; Volume increases, and makes that the expansible space of blood plasma is smaller owing to there is air to mix, and the blood bag is burst easily.And if earlier the air purge in the bag is carried out again freezingly, the expansion space of blood plasma just increases to some extent, the blood bag can not burst so easily yet.Also verified this phenomenon through experiment.So, remove air earlier and can make the more blood plasma of blood bag splendid attire not bursting under the identical prerequisite of blood bag.And because the doping of air makes blood plasma apt to deteriorate, the pot-life descends.
Mainly be to utilize hand operated control method to remove air in the plasma bags at present, make complex operation like this, working strength of workers is very big, and can have bigger personal error.
Summary of the invention
The present invention provides a kind of blood plasma bag air-cleaning device, overcomes existing employing and manually controls the removing shortcoming that air brought, and removes miscellaneous air in the plasma bags with quickness and high efficiency ground.
A kind of blood plasma bag air-cleaning device of the present invention; The support of support frame one end is the silica gel backing plate fixedly, and guide rod passes support frame, and the guide rod end is fixedly connected with stripper plate; The guide rod middle part is fixedly connected with moving plate; Moving plate connects trapezoidal screw through fixed feed screw nut on it, and trapezoidal screw connects motor through yielding coupling, decelerator successively, it is characterized in that:
Spring steel plate of encapsulation in the said silica gel backing plate, spring steel plate central authorities are unsettled, and two ends are fixed on the support through supporting screw, are simple beam structure; The spring steel plate middle position is fixed with light emitting diode, is fixed with photoconductive resistance with the light emitting diode correspondence position on the support;
Said photoconductive resistance change in resistance signal is converted into voltage analog signal and passes to single-chip microcomputer through amplifying circuit and A/D change-over circuit.
Described a kind of blood plasma bag air-cleaning device is characterized in that: through the current constant of said light emitting diode; Said photoconductive resistance is connected with fixed resistance, and the fixed resistance terminal voltage is passed to single-chip microcomputer as the output signal through amplifying circuit and A/D change-over circuit.
The present invention utilizes compressional movement to realize the air purge action, utilizes photoelectric sensor-single-chip microcomputer-host computer to realize extruding control automatically.Plasma bags hangs on the peg, and is placed between stripper plate and the silica gel backing plate, and motor drives trapezoidal screw and rotates, and trapezoidal screw upper screw rod nut is realized compressional movement together with the stripper plate move left and right.Pressure that is squeezed of encapsulation can produce the spring steel plate of elasticity of flexure deformation in the silica gel backing plate, and spring steel plate is fixed on the support outer wall through the screw at two ends, and spring steel plate central authorities are unsettled, are simple beam structure.Post a light emitting diode that passes to constant current at the spring steel plate middle position, a photoconductive resistance is posted in support outer wall and light emitting diode corresponding position.During extruding blood bag; Because the effect of extruding force makes spring steel plate produce flexural deformation; The distance of light emitting diode and photoconductive resistance changes; The continuous variation of this distance makes the light intensity that photoconductive resistance receives take place to change continuously, and light intensity changes and then causes photoconductive resistance resistance rate to change continuously, and change in resistance is converted into voltage analog signal again and is converted into digital signal through amplifying circuit and A/D change-over circuit and passes to single-chip microcomputer.When blood plasma in the blood bag is depressed into heat seal head place, mean the air purge completion, single-chip microcomputer order motor stops operating, and extruding stops.Can obtain when blood plasma in the blood bag is extruded into heat seal head place through experiment, the numerical value of digital variable signal, the numerical value that this sign extruding finishes is called threshold value.How much relevant threshold value is with the interior blood plasma of blood bag.In application, before the extruding air, host computer will take by weighing blood plasma weight earlier, obtains the threshold value under this weight through interpolation arithmetic, then threshold value is passed to the single-chip microcomputer of control air extruding.Carry out in the process in extruding so, when digital signal arrived this threshold value, single-chip microcomputer order motor stopped operating, and extruding stops.
It is simple that the present invention controls implementation; Only utilized the photoelectric characteristic of photoconductive resistance to detect the squeezed state variation, and adopted single-chip microcomputer to realize simple action control, increased work efficiency; The labor savings cost, and make that whole air extrusion process is more reliable.
Description of drawings
Fig. 1 is a structural representation of the present invention;
Fig. 2 is the local enlarged diagram of Fig. 1;
Fig. 3 is that squeeze pressure makes steel plate produce the flexural deformation sketch map;
Fig. 4 is the circuit theory diagrams that the photoconductive resistance change in resistance changes change in voltage into;
Fig. 5 (a) is the sketch map when blood plasma exceeds bag mouth and is h during the blood plasma extruding in the plasma bags, and a blood plasma volume is V1 in the bag;
Fig. 5 (b) is the sketch map when blood plasma exceeds bag mouth and is h during the blood plasma extruding in the plasma bags, and a blood plasma volume is V2 in the bag, and V2＞V1;
Fig. 6 is that blood plasma volume and threshold value concern sketch map under the blood bag condition of the same type.
Labelling among the figure: stripper plate 1, guide rod 2, support 3 supports transverse slat 4, trapezoidal screw 5; Yielding coupling 6, decelerator 7, motor 8 supports riser 9, and the feed screw nut 10; Moving plate 11, peg 12, silica gel backing plate 13, light emitting diode 14; Photoconductive resistance 15, spring steel plate 16, supporting screw 17, fixed resistance 18.
The specific embodiment
Device of the present invention and realization principle are:
As shown in Figure 1; Support 3, support transverse slat 4 and support riser 9 constitute support frames, and the support 3 of support frame one end is silica gel backing plate 13 fixedly, and guide rod 2 passes support frame; Guide rod 2 ends are fixedly connected with stripper plate 1; The guide rod middle part is fixedly connected with moving plate 11, and moving plate 11 connects trapezoidal screw 5 through fixed feed screw nut 10 on it, and trapezoidal screw 5 connects motor 8 through yielding coupling 6, decelerator 7 successively; Peg 12 is fixed on the support 3.
During work, plasma bags hangs on the peg 12, and is placed between stripper plate 1 and the silica gel backing plate 13.Stripper plate 1 adopt have elasticity, special material polycarbonate fiber that mechanical performance is good, and the material of silica gel backing plate 13 is a silica gel, silica gel is high resilience also, and higher mechanical strength is stablized, had to chemical property.The realization of extruding action has mainly utilized feed screw nut's 10 structures, and feed screw nut 10 is fixedly mounted on the moving plate 11, and moving plate 11 is fixedly connected with guide rod 2.Trapezoidal screw 5 rotates, and feed screw nut 10 drives stripper plate 1 through moving plate 11 and guide rod 2 and realizes move left and right.Adopt motor 8 as drive motors, accurately locate to realize simple open loop control and stripper plate.The axis of the axle of motor 8, decelerator 7 and trapezoidal screw 5 all on same straight line, can reduce driving error so as far as possible.
As shown in Figure 2, the present invention has used a light emitting diode 14 and a photoconductive resistance 15.Under the effect of light, the resistivity of photoconductive resistance can change along with the variation of spatial light intensity continuously.Utilize this characteristic of photoconductive resistance to monitor extrusion process.Photoconductive resistance 15 is equivalent to optical receiver, is attached on the outer wall of support 3, and light emitting diode 14 then is equivalent to optical receiver, and it keeps luminous state always, and passes through constant current.Diode is attached on the spring steel plate 16, and is corresponding with the photoconductive resistance position.The two ends of spring steel plate 16 are fixed on the support through two supporting screws 17, are simple beam structure.Steel plate is encapsulated in the silica gel backing plate 13 together with light emitting diode.In the extrusion process; Because the effect of extruding force; Spring steel plate 16 occurs bending and deformation, and light emitting diode 14 changes with the distance of photoconductive resistance 15, and the light intensity that the continuous variation of this distance makes photoconductive resistance receive takes place to change continuously; The light intensity variation then causes photoconductive resistance resistance rate to change continuously, and photoconductive resistance change in resistance signal is converted into voltage analog signal and passes to single-chip microcomputer through amplifying circuit and A/D change-over circuit.
Carrying out along with extrusion process; Air in the plasma bags is extruded gradually; The pressure of blood plasma increases gradually in the bag; The blood bag is just big more to the squeeze pressure that silica gel backing plate 13 produces, and then makes that the bending deformation quantity of spring steel plate 16 is also increasing, and the distance between light emitting diode 14 and the photoconductive resistance 15 is more and more littler.As shown in Figure 3, during original state, spring steel plate 16 does not have flexural deformation, and the distance between light emitting diode 14 and the photoconductive resistance 15 is X0, and along with the carrying out of extruding, the distance between light emitting diode and the photoconductive resistance diminishes, and is X, X＜X0.
Squeeze pressure is discussed below and apart from the relation between the variable X, spring steel plate can be regarded the fixed simply supported beam in two ends as, is received distributed force F effect perpendicular to the beam axis direction.Under the effect of F, spring steel plate produces elastic bending deflection, is amount of deflection perpendicular to the displacement of the lines of axis direction.The size of amount of deflection and distributed force F, active position and spring steel plate self relating to parameters.Be located under the effect of F power, the amount of deflection of light emitting diode position spring steel plate is v, X=X0-v so.F is big more, and amount of deflection v is also big more certainly, and X is just more little so, so can obtain:
X=f
1(F), f
1(F) be monotonic decreasing function.(1)
As shown in Figure 4, light emitting diode 14 keeps luminance always, and is constant through its electric current, and promptly the light intensity that produces in the space of light emitting diode does not change in time and changes.And far away more apart from light emitting diode, spatial light intensity more a little less than, and spatial light intensity is only relevant with distance parameter.Along with diminishing gradually of the distance X between light emitting diode and the photoconductive resistance 15, the light intensity that photoconductive resistance 15 receives is grow gradually just, and the light intensity that receives changes only relevant with X.Can know that by the photoconductive resistance photoelectric characteristic light intensity is forced to such an extent that photoconductive resistance resistance rate is more little more; And the photoconductive resistance resistance is more little, and the electric current that then passes through is big more, and fixed resistance 18 terminal voltages with this photoconductive resistance polyphone are just big more so, and with the terminal voltage of fixed resistance 18 as the output signal.The fixed resistance terminal voltage signal is passed to single-chip microcomputer through amplifying circuit and A/D change-over circuit.What single-chip microcomputer obtained is digital variable signal, and it is the digitized result of voltage analog signal, and the value of establishing this digital variable signal is Y, learns that through above analysis Y is only relevant with X.And X is more little, and the fixed resistance terminal voltage is big more, and Y is also just big more.Obtain:
Y=f
2(X), f
2(X) be monotonic decreasing function.(2)
Stripper plate extruding blood bag, the air in the blood bag is extruded gradually, and the blood bag is crushed, thereby makes that the pressure of blood plasma increases gradually in the blood bag.The blood bag is pressed on the silica gel backing plate 13, and silica gel backing plate 13 and spring steel plate are produced squeeze pressure.The contact area S of the pressure P of liquid and plasma bags and silica gel backing plate 13 is relevant in squeeze pressure F and the plasma bags.And:
F＝P×S (3)
Can draw by above-mentioned (1), (2), (3) formula:
Y＝f
2(X)＝f
2(f
1(F))＝f
2(f
1(P×S)) (4)
Obtain by (4) formula:
(P * S), f (F) is monotonically increasing function (5) to Y=f (F)=f
Different blood donor's blood plasma density difference are little, in the error allowed band, can think equal.Blood plasma in plasma bags pushes and surpasses bag mouth, and the interior blood plasma volume of bag shown in Fig. 5 (a) is that the interior blood plasma volume of bag shown in V1, Fig. 5 (b) is V2, and V2＞V1; It is h that fluid column exceeds the bag mouth height.The distribution of the interior liquid pressure of bag this moment is only relevant with liquid-column height h.
Need carry out heat seal to the sebific duct of plasma bags after air purge finishes, not have residual air in the blood bag when guaranteeing the heat seal sebific duct, blood plasma must push and exceed bag mouth in the bag, arrives heat seal head place.The sign that i.e. extruding finishes is exactly that plasma flow goes out bag mouth, arrives heat seal head place.If to exceed the bag mouth height be h=H to liquid when air extrusion was accomplished.When blood plasma in the blood bag is depressed into heat seal head place, mean the air purge completion, single-chip microcomputer order motor stops operating, and extruding stops.The value of digital signal was called threshold value when the sign air extrusion was accomplished.
If when h=H, obtain Y=Y
tY so
tIt is exactly the threshold value that the sign extruding finishes.In extrusion process, host computer is used Y through the digital value of the control motor stall that blood plasma weight is set
fY=Y is promptly worked as in expression
fThe time motor stall.Y under the ideal situation
fShould be provided with and Y
fEquate that blood plasma liquid is extruded into heat seal head place in the time of could guaranteeing the motor stall.
As long as blood plasma extruding exceeds bag mouth, how much blood plasma is what it doesn't matter in the pressure distributions in the plasma bags and the bag, the blood bag that varies in weight for blood plasma, as long as to exceed the bag mouth height identical when blood plasma, when being H, the pressure distributions in the plasma bags is identical.
Promptly when h=H, no matter how much blood plasma has in the blood bag, pressure distributions P is identical in the blood bag.But the amount of blood plasma is different in the blood bag, and the blood bag is different with the contact area S of silica gel backing plate 13, shown in Fig. 5 (a), Fig. 5 (b).
When h=H, obtain so by (5) formula:
Y
t=f ' (S), f ' is monotonic increase (6) (S)
Can find out that from Fig. 5 (a), Fig. 5 (b) with a kind of blood bag, when h equated, blood plasma was many more in the blood bag, the contact area of blood bag and stripper plate is more little, can know Y by (6) formula
tMore little.Also learn through experiment, for a kind of blood bag and h=H the time, the many more Y of amount of blood plasma in the blood bag
tMore little.
Fig. 6 be through experiment obtain under blood bag type the same terms, blood plasma weight and threshold value concern sketch map.Can learn that on scheming along with increasing of plasma volume, the digital threshold that the sign extruding finishes descends, but suppression ratio is milder, and when the blood plasma in the blood bag was many, threshold value remained unchanged basically.
Remove before the air; To weigh to plasma bags, obtain the weight of bag interior blood plasma, and pass to host computer to weight data; Host computer utilizes that blood plasma weight and threshold value graph of a relation obtain the threshold value under this weight through processing operations such as interpolation among Fig. 6; Weigh and accomplish the back host computer and send the threshold value under this weight to single-chip microcomputer, order single-chip microcomputer to begin to push air, Single-chip Controlling air extrusion process.
Claims (2)
1. a blood plasma bag air-cleaning device comprises host computer and single-chip microcomputer, and the support of support frame one end is the silica gel backing plate fixedly; Guide rod passes support frame; The guide rod end is fixedly connected with stripper plate, and the guide rod middle part is fixedly connected with moving plate, and moving plate connects trapezoidal screw through fixed feed screw nut on it; Trapezoidal screw connects motor through yielding coupling, decelerator successively, it is characterized in that:
Spring steel plate of encapsulation in the said silica gel backing plate, spring steel plate central authorities are unsettled, and two ends are fixed on the support through supporting screw, are simple beam structure; The spring steel plate middle position is fixed with light emitting diode, is fixed with photoconductive resistance with the light emitting diode correspondence position on the support;
Obtain under blood bag type the same terms blood plasma weight and threshold value graph of a relation through experiment; Before the extruding air, host computer takes by weighing blood plasma weight earlier, through blood plasma weight and threshold value graph of a relation interpolation arithmetic are obtained the threshold value under this weight, then this threshold value is passed to the single-chip microcomputer of control air extruding;
Carry out in the process in extruding, light intensity changes and to cause photoconductive resistance resistance rate to change continuously, and said photoconductive resistance change in resistance signal is converted into voltage analog signal and is converted into digital signal through amplifying circuit and A/D change-over circuit and passes to single-chip microcomputer; When digital signal arrived this threshold value, single-chip microcomputer order motor stopped operating, and extruding stops.
2. a kind of blood plasma bag air-cleaning device as claimed in claim 1 is characterized in that: through the current constant of said light emitting diode; Said photoconductive resistance is connected with fixed resistance, and the fixed resistance terminal voltage is passed to single-chip microcomputer as the output signal through amplifying circuit and A/D change-over circuit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101686776A CN101224168B (en) | 2007-12-07 | 2007-12-07 | Blood plasma bag air-cleaning device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101686776A CN101224168B (en) | 2007-12-07 | 2007-12-07 | Blood plasma bag air-cleaning device |
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| Publication Number | Publication Date |
|---|---|
| CN101224168A CN101224168A (en) | 2008-07-23 |
| CN101224168B true CN101224168B (en) | 2012-01-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007101686776A Expired - Fee Related CN101224168B (en) | 2007-12-07 | 2007-12-07 | Blood plasma bag air-cleaning device |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105662355A (en) * | 2016-04-25 | 2016-06-15 | 陈丽 | Wireless sensing detection device |
| CN105920689B (en) * | 2016-06-24 | 2018-02-02 | 深圳市爱康生物科技有限公司 | A kind of extruding of full-automatic blood component separator and weighing device |
| CN114191631B (en) * | 2021-11-19 | 2023-09-08 | 佛山沃塘医疗科技有限公司 | Blood separation method |
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| CN101224168A (en) | 2008-07-23 |
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