CN101222948A - Spray device for dispensing a cooling fluid - Google Patents
Spray device for dispensing a cooling fluid Download PDFInfo
- Publication number
- CN101222948A CN101222948A CNA2006800262489A CN200680026248A CN101222948A CN 101222948 A CN101222948 A CN 101222948A CN A2006800262489 A CNA2006800262489 A CN A2006800262489A CN 200680026248 A CN200680026248 A CN 200680026248A CN 101222948 A CN101222948 A CN 101222948A
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- China
- Prior art keywords
- cooling fluid
- injection apparatus
- skin defect
- applicator
- shower nozzle
- Prior art date
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- 239000012809 cooling fluid Substances 0.000 title claims abstract description 95
- 239000007921 spray Substances 0.000 title abstract description 5
- 239000012530 fluid Substances 0.000 claims abstract description 38
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 230000007547 defect Effects 0.000 claims description 67
- 238000002347 injection Methods 0.000 claims description 60
- 239000007924 injection Substances 0.000 claims description 60
- 230000001681 protective effect Effects 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 21
- 239000006260 foam Substances 0.000 claims description 17
- 238000001816 cooling Methods 0.000 claims description 11
- 239000010409 thin film Substances 0.000 claims description 11
- 230000000994 depressogenic effect Effects 0.000 claims description 5
- 230000009028 cell transition Effects 0.000 claims description 3
- 238000000151 deposition Methods 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 208000000260 Warts Diseases 0.000 description 21
- 201000010153 skin papilloma Diseases 0.000 description 21
- 238000001704 evaporation Methods 0.000 description 12
- 239000010408 film Substances 0.000 description 12
- 230000008020 evaporation Effects 0.000 description 10
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- 230000003902 lesion Effects 0.000 description 8
- 208000028990 Skin injury Diseases 0.000 description 7
- 239000007789 gas Substances 0.000 description 6
- -1 polypropylene Polymers 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000003380 propellant Substances 0.000 description 6
- 229920000742 Cotton Polymers 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 5
- 239000004743 Polypropylene Substances 0.000 description 5
- 238000009835 boiling Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 229920001155 polypropylene Polymers 0.000 description 5
- 238000007789 sealing Methods 0.000 description 3
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
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- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229950000845 politef Drugs 0.000 description 2
- 229920006324 polyoxymethylene Polymers 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 1
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- SYRIRLOOSKFSFC-UHFFFAOYSA-N butane Chemical compound CCCC.CCCC SYRIRLOOSKFSFC-UHFFFAOYSA-N 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
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- 230000007613 environmental effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- 235000013847 iso-butane Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
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- 229920001778 nylon Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
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- IJDNQMDRQITEOD-UHFFFAOYSA-N sec-butylidene Natural products CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
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- Thermotherapy And Cooling Therapy Devices (AREA)
- Nozzles (AREA)
Abstract
A spray device for dispensing a cooling fluid comprises a reservoir in which the cooling fluid is stored in liquid form at an overpressure, a fluid outlet valve, and a spray head which has a capillary tube. The capillary tube is arranged in a valve tappet in such a way that the inlet end of the capillary tube is connected to the fluid outlet valve of the reservoir and causes the cooling fluid to pass into the capillary tube when the fluid outlet valve is actuated. In the reservoir, there is a further capillary tube whose inlet end extends into the cooling fluid stored in the reservoir, and whose outlet end is connected to the fluid outlet valve.
Description
Technical field
The present invention relates to a kind of injection apparatus that is used for the dispensing cooling fluid, and relate to a kind of method for the treatment of skin defect.
Background technology
This class injection apparatus has been common and has been used in various fields.For example, be used to remove skin defect, as wart, such as patent documentation EP-A-O 281212 or EP-A-O 608954 description.In these documents, the start liquid outlet valve makes in the container cooling fluid of storing with liquid form at first be delivered to valve chamber by pipeline from container, and from valve chamber by another line transportation to cotton swab that is installed in pipe outlet or open celled foam plug.The fluidic boiling point of liquid cooled is lower than 0 ℃, usually between-50 ℃ to 0 ℃, soaks into cotton swab or by evaporating after the open-celled foams, as a result cotton swab or open-celled foams sub-cooled.This cotton swab or open-celled foams contact with wart to be treated subsequently, and this program can accurately be finished according to the geometry characteristic of cotton swab or open-celled foams.Yet the shortcoming of these devices is that the amount of the cooling fluid that single therapy is required is relatively large.
WO-A-03/051522 has proposed a kind of injection apparatus, treats that wherein distributing fluid is stored in the container with liquid state, under the help of propellant, uses with the form of aerosol subsequently.Yet propellant causes environmental problem usually.In order when keeping the identical amount for the treatment of distributing fluid, to reduce the amount of required propellant,, WO-A-03/051522 discloses and has had shower nozzle capillaceous, treats that wherein distributing fluid and propellant introduce together or separately.In capillary tube, fluid and propellant form aerosol, and this aerosol is made up of fine droplets, and can be subsequently by dispensing.EP-A-I 516829 discloses suitable relatively shower nozzle.
Summary of the invention
The object of the present invention is to provide a kind of injection apparatus of cooling fluid, with respect to prior art, this injection apparatus dispensing few cooling fluid of trying one's best guarantees the cooling of very effective target, described target such as skin defect (as wart).
According to the present invention, this purpose is achieved through the following technical solutions: a kind of injection apparatus of dispensing cooling fluid, feature are the features of independent claims.The favourable improvement of this injection apparatus has formed dependent claims.
For this purpose, be provided with capillary tube at shower nozzle incessantly, other capillary tube (as standpipe) equally also is set in bin.The entrance point capillaceous that is arranged in the bin stretches in the interior liquid cooled fluid of bin.Therefore, when valve is activated, produce aerosol in the capillary tube, this aerosol further evaporates, and (have very little valve chamber, this valve chamber volume is less than 50mm by the fluid issuing valve subsequently
3) enter the capillary tube in the shower nozzle.
At the port of export capillaceous of shower nozzle, cooling fluid is a gaseous state, and comes out from the capillary tube of shower nozzle.In the expansion that takes place subsequently, cooling fluid cools off rapidly, thereby produces effectively cooling, and producing simultaneously that this effectively cools off only need relatively very a spot of cooling fluid.
Though internal diameter capillaceous is 2mm in theory to the maximum, maximum is 1.2mm only in the practice, especially is between the 0.35mm to 1mm.Thereby guaranteed effective cooling, consumed cooling fluid seldom simultaneously.
Preferably, shower nozzle is provided with the reception opening, and to hold applicator, applicator guides to intended target with fluid.For example, in the treatment of skin defect (for example wart), need as far as possible accurately to guide cooling fluid, to prevent to involve healthy tissue to intended target.
This applicator can have tubular portion, and tubular portion is connected shower nozzle securely, for example can be connected to shower nozzle by buckle.This connection is reliably, and if suitably, can remove connection once more.Described tubular portion itself is designed to special mode, maybe can be provided with other devices, make cooling fluid accurately dispensing to intended target.
Therefore, in the embodiment of injection apparatus of the present invention, the free end of tubular portion has bell-shaped end area, and the internal diameter of this bell-shaped end area is greater than the internal diameter of all the other tubular portions.The capillary tube of shower nozzle leads by tubular portion, and its port of export is arranged on the bell-shaped end area of tubular portion.The bell-shaped end area of tubular portion is placed on the target, and this zone is isolated from the outside.Cooling fluid guides by capillary tube, enters the bell-shaped end area of tubular portion, is gaseous state at this regional cooling fluid, and from outlet ejection capillaceous.As the expansible result of the cooling fluid in the bell-shaped area, cooling fluid cools off rapidly, thereby parameter according to used fluid and external condition and bell-shaped end area, the fluid of capillary tube ejection can keep gaseous state, become liquid state even solid-state or gluey, and can hit the mark (as wart), evaporation subsequently.In this process, pressure can spill from the opening of the wall of bell-shaped end area.
In another embodiment according to injection apparatus of the present invention, applicator has porous or open-porous body, and this porous or open-porous body are arranged on outside the shower nozzle, above the tubular portion.Be arranged on zone on the tubular portion in porous or open-porous body, described tubular portion is provided with through hole, and cooling fluid enters porous or open-celled foams by through hole.As expansible result, the gaseous state cooling fluid cools off rapidly, and the temperature of cooling fluid can be brought down below boiling point, and therefore, cooling fluid becomes liquid state, perhaps depends on used cooling fluid, cooling fluid even can be rendered as solid-state or the gel state of aggregation.Under the situation of liquid aggregate state, cooling fluid " soaks into " porous or open-porous body, subsequently evaporation.In this process, described porous or open-porous body are cooled rapidly, and accurately contact with target (for example wart) subsequently.
Injection apparatus can be provided with protective cap, and this protective cap can rotate between open position and make position, and can fix (locking) at open position.
Especially; in above-mentioned embodiment according to injection apparatus of the present invention; be provided with porous or open-porous body; rotating protective cap can be designed as the fluid issuing valve only could be started under the protective cap closure state; at this moment, cooling fluid can enter at ordinary times in the porous or open-porous body that the protection owing to protective cap is difficult to enter.This is to touch porous or open-porous body in order to prevent the child from starting the fluid issuing valve because of carelessness.Children will be accomplished these, and in fact they must unclamp and rotate described lockable protective cap.The fluid issuing valve cannot be opened when therefore, injection apparatus was set to protective cap and opens.
In another embodiment according to injection apparatus of the present invention, injection apparatus comprises the adapter that is arranged on the port of export capillaceous, and this adapter is applicable to and connects the applicator of guiding cooling fluid to intended target.Particularly, adapter can have tubular shape, and is adapted at being moved on the capillary tube.Equally, adapter can be connected to finger key, and valve tappet is fixed to described finger key, wherein is provided with capillary tube.More specifically, adapter can be connected to finger key by buckle.This makes applicator be mounted to opening capillaceous reliably, and if desired, applicator can be removed.
Equally, in the embodiment of above-mentioned injection apparatus, shower nozzle can comprise the shell with elastic safety element, and this elastic safety element prevents that finger key is activated.Shower nozzle can also comprise slide block, and this slide block is set to be moved and makes described safety element distortion, thereby allows to start described finger key.This embodiment is to child's safety, and anti-locking apparatus is started because of carelessness.
More specifically, in this embodiment of injection apparatus, applicator can be set to and can press towards slide block, makes slide block movement and makes elastic safety element strain, thereby allow finger key to start.The embodiment that this of injection apparatus is practical is easy to operation for the adult, and can involuntarily not started by the child.
In yet another embodiment of the present invention, applicator can comprise the slotted column part of tool, and wherein applicator also comprises the ring protection portion around exit opening, influenced by cooling fluid to prevent the zone around the target.What this embodiment made cooling fluid accurately is applied to cutaneous lesion to be treated.Injection apparatus can be provided with various applicators with exit opening of different-diameter, thereby the user can select the applicator of the most suitable skin injury to be treated.Ring protection portion has guaranteed the be not cooled fluid influence of the zone of cutaneous lesion.The groove of column part evaporates the cooling fluid film of cutaneous lesion rapidly, thereby cooling cell effectively improves the therapeutic efficiency of skin injury.
The invention still further relates to a kind of method for the treatment of skin defect, wherein cooling fluid is painted on one section time enough of skin defect to be treated, and the cell of skin defect is gone to pot.In the method, use device is injected in cooling fluid on the skin defect, and this device is a gaseous state at the cooling fluid of the port of export capillaceous.Cooling fluid is directly injected on the skin defect from outlet capillaceous, to form thin film on skin defect.This thin film evaporates subsequently, thus the cell of sub-cooled skin defect.
After being ejected the port of export capillaceous, gasiform cooling fluid expands and goes up formation thin film (as liquid) at skin defect to be treated (as wart).Film on the skin defect (as wart) is a thin film, and this point is very important, because in the evaporation process, thin film is gone up evaporation on the surface (that is the surface that does not contact with wart) away from wart.On the other hand, in order to destroy the cell of skin defect effectively, must make the cell of skin defect be in low temperature.Film is thick more, and is high more away from the temperature difference between the film of skin defect surface and the film surface that contacts with skin defect.Therefore, the thickness of preferred film is at 0.05mm to 0.5mm.This can realize by the cooling fluid that is coated with scheduled volume, for example 25 μ l to 250 μ l.This can pass through the unlatching of the finger key of control injection apparatus, or metering valve is realized.Thereby, the temperature on skin defect surface is reached-50 ℃ or lower.
In a preferred variant of this method, adopt device with applicator, be provided with the capillary outlet end in the applicator.Applicator prevents on skin, and surrounds and the sealing skin defect, then from the port of export capillaceous to skin defect direct injection cooling fluid.This is the efficient variant of treatment skin defect, because by suitably selecting the internal diameter of applicator, treatment only influences the cell of skin defect, and does not influence the defective around the defective.In addition, utilized cooling fluid efficiently.
In a variant of this method, the applicator of the device that is adopted has ring protection portion, thereby prevents that skin defect to be treated zone on every side from being sprayed the cooling fluid of skin defect and influencing.
The invention still further relates to the method for another kind of treatment skin defect, wherein cooling fluid is coated in one section time enough of skin defect to be treated equally, and the cell of skin defect is gone to pot.In the method, adopt device that cooling fluid is injected on the skin defect, wherein install at the port of export capillaceous gasiform cooling fluid is provided, and cooling fluid is spurted into porous or open-celled foams from the port of export capillaceous.Subsequently, cooling fluid can be from porous or open celled foam evacuator body, thereby makes porous or open-celled foams sub-cooled.This supercooled porous or open-celled foams are pressed towards skin defect subsequently, thereby make the cell transition cooling of skin defect.
The advantage of this method is, makes amount that porous or open-celled foams reach the required cooling fluid of low temperature very seldom, by supercooled porous or open-celled foams are pressed to skin defect, can accurately treat skin defect.
Description of drawings
Below in conjunction with the drawings and specific embodiments the present invention is further described, wherein:
Fig. 1 is the sketch map according to the container that has fluid issuing valve and shower nozzle of the injection apparatus of the embodiment of the invention;
Fig. 2 is the cross section cross-sectional schematic of tubular portion that is used to connect shower nozzle according to the embodiment of the invention;
Fig. 3 is the amplification cross section view of tubular portion among Fig. 2;
Fig. 4 is the shower nozzle that is connected with tubular portion, and porous or open-porous body are fixed on (protective cap is opened) on the tubular portion;
Fig. 5 has showed the shower nozzle among Fig. 4, and its protective cap is in the close position;
Fig. 6 has showed the protective cap that is shown in an open position, and is shown in an open position the rotatable and lockable characteristic of the protective cap of (rotating 180 °) with explanation;
Fig. 7 has showed the protective cap that is in the close position after the startup;
Fig. 8 has showed among another embodiment according to injection apparatus of the present invention, is connected to the bell-shaped end of the tubular portion of shower nozzle;
Fig. 9 has showed the optional embodiment of the valve tappet of convex outlet valve;
Figure 10 has showed bell-shaped end shown in Figure 8 embodiment around skin defect to be treated;
Figure 11 has showed another embodiment according to the shower nozzle of injection apparatus of the present invention, and wherein applicator is installed on the shower nozzle;
Figure 12 is a rearview embodiment illustrated in fig. 11;
Figure 13 is along the profile of XIII-XIII among Figure 12;
Figure 14 and Figure 15 are the perspective view of finger key of the shower nozzle embodiment of Figure 13;
Figure 16 has showed the vertical section by Figure 14 and finger key shown in Figure 15;
Figure 17 is the bottom view of Figure 14 and finger key shown in Figure 15;
Figure 18 is along the profile of XIII-XIII line among Figure 17;
Figure 19 is along the profile of XIX-XIX line among Figure 17;
Figure 20 is along the profile of XX-XX line among Figure 17;
Figure 21 is the perspective view of valve tappet of the embodiment of shower nozzle shown in Figure 13;
Figure 22 has showed the vertical section of valve tappet shown in Figure 21;
Figure 23 is the slide block perspective view of shower nozzle shown in Figure 13;
Figure 24 is the bottom view of slide block shown in Figure 23;
Figure 25 is the perspective view of the adapter of shower nozzle shown in Figure 13;
Figure 26 has showed the vertical section of adapter shown in Figure 25;
Figure 27 and Figure 28 are the perspective view that is connected to the applicator of shower nozzle shown in Figure 13;
Figure 29 is the top view of Figure 17 and applicator shown in Figure 28;
Figure 30 has showed the vertical section of Figure 27 and applicator shown in Figure 28;
Figure 31 and Figure 32 are the shell perspective view of shower nozzle embodiment shown in Figure 13;
Figure 33 is the front view of Figure 31 and shell shown in Figure 32;
Figure 34 has showed among Figure 33 the vertical section along the XXXIV-XXXIV line.
The specific embodiment
Fig. 1 has showed the sketch map of conventional vessel 1, and it has comprised according to some strength members of injection apparatus of the present invention.Capillary tube 10 (standpipe) stretches into the inside of container 1, and its entrance point stretches in the cooling fluid (not shown), and cooling fluid is stored in the container 1 with liquid state.The port of export 11 of capillary tube 10 is connected to fluid issuing valve 2, and end capillaceous is housed inside in the fluid issuing valve 2.Fluid issuing valve 2 comprises valve chamber 20, and this valve chamber volume is very little, at least less than 50mm
3Be provided with valve body 21 in the valve chamber 20, spring 22 displacements relatively of this valve body 21.Sealing ring 23 seal valve chambers 20, and internal tank is isolated from the outside.Another sealing ring 12 is arranged between the wall 13 and lid 14 of container 1.
As mentioned above, tubular portion can insert the opening 33 of shower nozzle 3.The design of this tubular portion 5 as shown in Figures 2 and 3.The locking protuberance 50 of tubular portion 5 can be by opening 33 guiding of shower nozzle 3, and locking protuberance 50 cooperates with the buckle form, and is connected (seeing Fig. 4 and Fig. 5) with shower nozzle 3.Equally as seen, tubular portion 5 is provided with through hole 52 in zone, Qi Bi upper edge 51.
Fig. 4 has showed shower nozzle 5 and applicator, and this applicator comprises tubular portion 5 and porous on the tubular portion 5 or the open-porous body 6 (shown in dotted line) that is attached thereto.This porous or open-porous body 6 can be made by open celled foam polyurethane (PU), polypropylene (PP) or polyethylene (PE) or cellulose (cellulose) or gauze.Among Fig. 4, protective cap 4 is shown in an open position, and (as locking) can be fixed at this guarded by location medicated cap.Among Fig. 4, shower nozzle 3 is provided with safety collar 34.The effect of safety collar 34 is that when protective cap 4 was shown in an open position, finger key 32 can not be operated, so fluid openings valve 2 can not be activated (to the feature of children's safety).Make corresponding mechanism that protective cap 4 pivots to Fig. 5 make position shown in the dotted line of Fig. 4 and Fig. 5, but Fig. 6 and Fig. 7 are more detailed.
Fig. 6 is the sketch map of protective cap 4 and safety collar 34, and wherein protective cap 4 is shown in an open position, and can see tubular portion 5 (on it not fixedly porous or open-porous body).Fig. 6 is along longitudinal axis Rotate 180 °, so tubular portion 5 points to a left side rather than right.Protective cap 4 has " active region " 40, and this active region has certain flexibility, and also is provided with this active region (invisible among Fig. 6) in an opposite side.In active region 40, be provided with slit-shaped passage 400, localized locking member 35 stretches in this passage 400.Need not other ancillary methods, locking member has just prevented that protective cap 4 from swaying from open position, and protective cap 4 is locked in open position, because locking member 35 is maintained in the passage 400.
For protective cap 4 is pivoted, the user presses the active region 40 of both sides (front and back of Fig. 6) simultaneously, thereby locking member 35 passes through slit passage 400 fully, thereby protective cap 4 can sway.The user rotates protective cap, until protective cap arrival make position as shown in Figure 7.In rotation process, locking member 35 slides in corresponding slotted recess (not being passage), sees Fig. 4 and Fig. 5, until arriving make position.Equally, another slit-shaped passage can be set, make protective cap 4 can be locked in make position shown in Figure 7.
In order to treat skin defect (for example wart), the user at first moves to make position with protective cap 4 from open position,, that is to say in conjunction with the description that Fig. 6 and Fig. 7 did as above, moves to the position of Fig. 5 from the position of Fig. 4.In the make position of Fig. 5, the user presses finger key 32, and fluid openings valve 2 (Fig. 1) is opened, and cooling fluid is through capillary tube 10 (standpipe), wherein produces the aerosol step evaporation of going forward side by side, and enters capillary tube 30 subsequently.Subsequently, the gaseous state cooling fluid is by tubular portion 5, and specifically, the through hole 52 and the port of export by tubular portion enter porous or open-porous body 6.Along with expansible generation, cooling fluid is cooled to and is lower than its boiling point, and can become liquid (or, depend on employed cooling fluid and other conditioned disjunction parameters, even solid-state or gluey), and soaks into porous or open-porous body 6.In the cooling fluid evaporation process of porous that the quilt subsequently soaks into or open-porous body 6, porous or open-porous body 6 are cooled off (for example being lower than-50 ℃) rapidly, in order to treat, this porous or open-porous body 6 can directly contact with the target area of skin defect to be treated (as wart) subsequently.
Fig. 8 has showed the port of export of another embodiment of tubular portion 5 a.At this, applicator includes only tubular portion 5a, and its free end has bell-shaped end area 51a.This moment, the capillary tube 30a (not having in the cross section to show) of strength was longer than the embodiment that has porous or open-porous body the preceding; The port of export 301a of capillary tube 30a puts in bell-shaped end area 51a.The wall of bell-shaped end area 51a is provided with through hole 52a (for example four, each is around 90 ° of circumferential backlash, wherein two as shown in Figure 8), and pressure releases by this through hole.
Tubular portion 5a can be by polypropylene, polyethylene, metal, PON, politef (Teflon), glass or pottery or any other stable plastics.
Its work process is as follows: the Starting mode of injection apparatus is the same with the foregoing description, and protective cap 4 can be designed as removable fully (for example shown in Figure 1), and if suitably, other features to children's safety can be set.Bell-shaped end area 51a is placed on the skin, and around and seal skin defect to be treated (as wart).When handling finger key 32, cooling fluid is transported to the port of export 301a of capillary tube 30a with gaseous form.Expand in bell-shaped area 51a, cooling fluid cools off rapidly as a result, for example be cooled to be lower than its boiling point, thereby cooling fluid impacts skin defect with gaseous state, becomes liquid form (or depending on used cooling fluid and other conditioned disjunction parameters), evaporation subsequently.Skin defect (for example wart) is by sub-cooled, thereby goes to pot.
For example, during from the port of export 301a of capillary tube 30a ejection, cooling fluid can form aerosol at the gaseous state cooling fluid, and goes up at as shown in figure 10 skin defect W (as wart) and to form fluid film LF.The thickness of the fluid film on the skin defect is preferably 0.05mm to 0.5mm, to obtain high efficient cooling effect.This is in the surface evaporation (that is, on the surface that does not contact with skin defect W) away from skin defect W because of fluid film LF.Therefore, fluid film LF is thick more, the evaporating surface of fluid film LF and and skin defect W contact surface between temperature difference big more.Thickness is in above-mentioned scope and can obtains by the cooling fluid that sprays 25 μ l to 250 μ l.This can realize (because the flow of capillary tube 30a is little, so this can realize) by the action of finger key 32 of control injection apparatus, perhaps realizes by the metering valve of the each cooling fluid that sprays of setting measurement.Can buy this metering valve on the market.Therefore, by a small amount of cooling also, the lip-deep temperature of skin defect W can reach-50 ℃ or lower.
Above-mentioned injection apparatus embodiment is the treatment field that is used for skin defect.The common internal diameter of capillary tube is 2mm to the maximum, preferably is 1.2mm to the maximum, and when for example being used for wart, internal diameter is between 0.35mm to 1mm.Be used for further reducing the other internal diameter that dwindles the mouth of pipe of the required cool stream scale of construction even less than 0.2mm.Cooling fluid can adopt dimethyl ether, propane, iso-butane, normal butane (n-butane), propelling gas (propellant gases) 134A, 157 or 227, or CO
2The pressure of container can be, 12 crust 50 ℃ time for example.The temperature that is reached during treatment in some cases, is lower than conventional temperature between-25 ℃ to-55 ℃, be lower than boiling point-25 ℃.
However, injection apparatus of the present invention is not limited to be used for the treatment field of wart or skin defect, on the contrary, can be used for accurately determining target and the very important situation of efficient cooling.
Shown in Figure 11-34, shower nozzle and part thereof are in confined state (Figure 11 to 13) and decomposing state among the figure, only show single part in the decomposing state according to another embodiment of the shower nozzle of injection apparatus of the present invention.
Figure 11 is the confined state side view of shower nozzle 3b, and wherein applicator 6b is arranged on the shower nozzle 3b, and its set-up mode is as hereinafter describing in detail.Figure 12 is the rearview of the shower nozzle 3b of assembling, and wherein as seen finger key 32b more detailed.Figure 13 is the vertical section (along the line XIII-XIII of Figure 12) of the shower nozzle 3b of confined state.
As shown in figure 13, the valve tappet 31b of support capillary tube 30b is fixed to shower nozzle 3b.Valve tappet 31b is connected to finger key 32b, and this describes in detail hereinafter.Be provided with slide block 35b, this slide block 35b can move axially (in Figure 13 for to the right), thereby acts on the elastic safety element 34b (locking spring) on the shell 36b.Therefore, this has guaranteed that finger key 32b can not be depressed because of carelessness before elastic safety element (locking spring) distortion.Like this, just can press finger key 32b, so shower nozzle can prevent that the child is not intended to operation.Port of export opening 33b is provided with tubulose adapter 5b, and applicator 6b is installed on the adapter 5b.As shown in figure 13, the shower nozzle after the assembling can be fixed on by the rib 360b of projection on the cooling fluid container, and rib 360b is arranged on the inwall of shell 36b of shower nozzle 3b, and its form as shown in Figure 1.
Figure 14 and Figure 15 are the perspective view of finger key 32b, and Figure 16 is the longitudinal section by finger key 32b, and Figure 17 is the bottom view of finger key 32b, and Figure 18-20 is respectively along the cutaway view of the homologous lines of Figure 17.The global shape of finger key 32b can be referring to the finger key perspective view of Figure 14 and Figure 15.Finger key 32b comprises bigger operating space 320b, can start injection apparatus by depressing operating space 320b.As shown in figure 14, a plurality of latches and director element are arranged under the finger key 32b, and it is outstanding to face down under the finger key 32b.The effect of these latches and director element is more detailed description hereinafter.
The first couple of latch 321b is arranged on the center near finger key 32b, as shown in figure 16.Each latch 321b is provided with inside outstanding rib 322b (seeing Figure 18), makes the clamping of the valve tappet 31b that supports capillary tube 30b.For the suitable guiding of clamping front and back valve tappet 31b is provided, pair of guide elements 323a and 324b are set respectively.
Figure 21 is the perspective view of the valve tappet 31b of support capillary tube 30b, and Figure 22 is the profilograph by valve tappet 31b and capillary tube 30b.
For valve tappet 31b and finger key 32b are installed, at first guide capillary tube 30b to pass opening 33b, then with valve tappet 31b from following clamping, thereby valve tappet 31 is fixed reliably by latch 321b and is not dropped, and prevent axial displacement by abutment surface 310b, wherein abutment surface 310b is in abutting connection with the corresponding proximal surface of finger key 32, as shown in figure 17.
In case the valve tappet 31b that supports capillary tube 30b is by clamping, next step is that slide block 35b is mounted to above-mentioned preassembled finger key/valve tappet assembly.
Figure 23 is the perspective view of slide block 35b, and Figure 24 is the amplification bottom view of slide block 35b.Slide block 35b is a tablet spare, and this tablet spare comprises the opening 350b of relatively large longitudinal extension.The rear end of slide block 35b has outstanding fin 351b downwards, and this fin 351b will can be depressed finger key 32b towards elastic safety element 34b (locking spring) effect.The front end of slide block 35b has outstanding adjacency section 352b downwards, and applicator 6b acts on this adjacency section 352b, and slide block 35 is moved axially backward, make elastic safety element 34b distortion then, thereby finger key 32b can be depressed.
For slide block 35b being installed in preassembled finger key/valve tappet assembly, slide block 35b is from following clamping.The opening 350b of slide block 35 is around valve tappet 31b.For the clamping of slide block 35b, finger key 32 comprises two couples of latch 325b and 326b, can be referring to Figure 17 to Figure 20.Latch 325b and 326b are respectively arranged with inwardly outstanding rib 327b or 328b, make the slide block 35b can clamping.At this moment, assembling in advance comprises valve tappet 31b and the slide block 35b of finger key 32b, support capillary tube 30b.
This comprises finger key 32b, the valve tappet 31b that supports capillary tube 30b and the assembly in advance of slide block 35b, is inserted into shell 36b from below, makes the flexible opening portion of capillary tube 30b install (seeing Figure 34) by the opening 361b of shell 36b.
Next step is that tubulose adapter shown in Figure 25 is installed.Figure 26 is the profilograph of adapter 5b.For installation adapter 5b, it is moved axially to shell 36b and finger key 32b, cross from the port of export of the outstanding capillary tube 30b of the opening 361b of shell 36b.Adapter 5b has groove 50b and tapering part 51b.Finger key 32b has inwardly outstanding flange 330b (seeing Figure 16).Along with adapter 5b moves towards shell 36b or finger key 32b on the port of export of capillary tube 30b vertically, tapering part 51b is through flange 330b, this flange 330b buckles into the groove 50b of adapter 5b, thereby by the buckle connection adapter 5b is assembled to finger key 32b.
Figure 31 and Figure 32 are the perspective view of shell 36b, and Figure 33 is the front view of shell 36b, and Figure 34 is along the cutaway view of XXXIV-XXXIV line among Figure 33.Among Figure 34, can clearly see elastic safety element (locking spring) 34b and rib 361b, rib 361b is used for shell (perhaps shower nozzle) is installed in the container of cooling fluid.
When above-mentioned assembling in advance has been installed on the shell 36b, shower nozzle 3b installation.Be used for skin for cooling fluid, at present embodiment, applicator 6b will be installed on the shower nozzle 3b.
Figure 27 and Figure 28 are the perspective view of applicator 6b, and Figure 29 is the top view of applicator 6b, and Figure 30 is the cutaway view of applicator 6b.The end of applicator 6b has extension 60b, and the other end is provided with the 61b of ring protection portion, and the 61b of this ring protection portion is around opening 62, and cooling fluid impacts skin injury to be treated by opening 62b, to form fluid film in cutaneous lesion.In addition, applicator 6b has cylindrical part 63b, and this cylindrical part 63b is provided with the slit 630b for the liquid evaporation of cutaneous lesion.
In case applicator 6b has been installed in adapter 5b by above mode, injection apparatus has been ready to use (seeing Figure 13).The assembly of supposing Figure 13 is installed in container in the mode of similar Fig. 1.For the treatment of skin injury (for example wart), the opening 62b of applicator 6b is placed on the wart, and ring protection portion is around around the wart, to prevent the healthy skin fluid impact that is cooled.Certainly, many applicator 6b that similarly have different size opening 62b can be set, thereby can treat the skin injury of different size, and only contact with cutaneous lesion.As shown in figure 13, place applicator 6b when, its opening 62b (Figure 30) is positioned at around the skin injury, and injection apparatus is along being depressed gently towards the skin injury direction.As a result, extension 60b (Figure 30) depresses towards the adjacency section 352 of slide block 35b, thereby slide block 35b is moved towards elastic safety element 34b (locking spring).After making elastic safety element 34b (locking spring) be deformed into to a certain degree, can depress finger key 32b, thereby start valve, make cooling fluid directly also accurately be ejected into cutaneous lesion.After finishing course of injection, the user no longer depresses finger key 32, and finger key 32 moves up, and pin finger key 32b once more until elastic safety element 34b (locking spring), thereby injection apparatus can not started because of carelessness by the child.
Among Fig. 1, only shown valve 2 with closed valve body 21, so under the situation of the injection apparatus that adopts reversed position, mass flow (percentage ratio of contained drop in the cooling fluid) adopts stand up position less than device, because in the reversed position, the cooling fluid that has only the gas phase in the container 1, the capillary tube 10 of flowing through, this is because the entrance point of capillary tube 10 (standpipe) only stretches in the gas phase.In order to overcome the dispensing of container 1 pure gas phase cooling fluid outward in this case, valve body 21 can be provided with small through hole, and this small through hole connects valve chamber 20 and container 1 inside.Therefore, no matter injection apparatus adopts stand up position or reversed position, the liquid and gas mixture of cooling fluid can be discharged from container 1.This has caused the thin film on the skin defect to be treated thinner a little, and however, thin thin film can further improve the efficient of therapeutic process, because have only the thin layer that directly contacts with skin defect can destroy cell.Therefore, the thick more therapeutical effect (effect of cooling procedure depends on the gross thickness of described thin film) that must not improve of the thin film of cooling fluid on the cutaneous lesion to skin defect.
Claims (19)
1. injection apparatus that is used for the dispensing cooling fluid is characterized in that: comprise the fluidic bin of the liquid cooled of depositing over pressure (1), fluid issuing valve (2) and shower nozzle (3,3b), this shower nozzle (3; 3b) be installed on the described bin (1), and this shower nozzle has the valve tappet of being arranged on (31,31b) Nei capillary tube (30,30b), when fluid issuing valve (2) when being activated, this entrance point capillaceous (300) is connected to the fluid issuing valve (2) of described bin (1), and make cooling fluid through capillary tube, wherein, described bin (1) also contains another capillary tube (10), the entrance point of this capillary tube (10) stretches in the interior liquid cooled fluid of described bin (1), and the port of export of this capillary tube (10) is connected with fluid issuing valve (2).
2. injection apparatus according to claim 1 is characterized in that: described internal diameter capillaceous is 2mm to the maximum, preferably is 1.2mm to the maximum, more preferably at 0.35mm to 1mm.
3. injection apparatus according to claim 1 and 2 is characterized in that: described shower nozzle (3,3b) be provided with hold applicator (5,6,5a, (33,361b), this applicator is guided cooling fluid into intended target to opening 6b).
4. injection apparatus according to claim 3 is characterized in that: described applicator has tubular portion, and (5,5a), this tubular portion firmly is connected with described shower nozzle (3).
5. injection apparatus according to claim 4 is characterized in that: and described tubular portion (5,5a) be connected to described shower nozzle (3) by buckle.
6. according to claim 4 or 5 described injection apparatus, it is characterized in that: the free end of described tubular portion has bell-shaped end area (51a), the internal diameter of this bell-shaped end area (51a) is greater than the internal diameter of all the other tubular portions, the capillary tube (30a) of described shower nozzle (3) is by described tubular portion guiding, and the described port of export capillaceous (301a) is arranged in the bell-shaped end area (51a) of described tubular portion.
7. according to claim 4 or 5 described injection apparatus, it is characterized in that: described applicator has and is arranged on the described tubular portion and the porous or the open-porous body (6) of described shower nozzle outside, be arranged on the zone (51) of described tubular portion in this porous or open-porous body (6), described tubular portion is provided with through hole (52), and cooling fluid flows into described porous or open-porous body (6) by this through hole (52).
8. according to any described injection apparatus of claim 1 to 6; it is characterized in that: described injection apparatus is provided with the protective cap (4) that can rotate around the axis; this protective cap (4) can sway between open position and make position, and can be locked at open position.
9. according to claim 7 or 8 described injection apparatus; it is characterized in that: described protective cap (4) is when being in closure state; fluid issuing valve (2) can be activated, and makes cooling fluid enter at ordinary times described porous or open-porous body (6) that the protection owing to protective cap (4) is difficult to enter.
10. injection apparatus according to claim 3 is characterized in that: described injection apparatus comprises the adapter (5b) that is arranged on the capillary outlet end, and this adapter can connect the lead described applicator (6b) of intended target of cooling fluid.
11. injection apparatus according to claim 10, it is characterized in that: described adapter (5b) has tubular shape, this adapter can move on described capillary tube and be connected with finger key (32b), described valve tappet is installed in this finger key (32b), and described capillary tube is arranged in the described valve tappet.
12. injection apparatus according to claim 11 is characterized in that: (50b, 330b) mode is connected with described finger key (32b) described adapter (5b) by the buckle connection.
13. according to claim 11 or 12 described injection apparatus, it is characterized in that: described shower nozzle (3b) comprises shell (36b), this shell has elastic safety element (34b), this elastic safety element prevents that usually described finger key (32b) is activated, wherein, described shower nozzle (3b) also comprises slide block (35b), and the setting of this slide block makes it to move and makes the elastic safety deformed element, thereby can start described finger key (32b).
14. injection apparatus according to claim 13 is characterized in that: described applicator (6b) can be depressed towards slide block (35b), makes this slide block movement and makes elastic safety element (34b) distortion and allow described finger key (32b) to start.
15. according to any described injection apparatus of claim 10 to 14; it is characterized in that: described applicator (6b) comprises the have slit cylindrical part (63b) of (630b); also comprise ring protection portion (61b); this ring protection portion is around its outlet (62b), to prevent the target peripheral region fluid impact that is cooled.
16. method for the treatment of skin defect, it is characterized in that: cooling fluid is painted on skin defect the preceding paragraph to be treated and enough makes the destroyed time of this skin defect cell, wherein, by injection apparatus cooling fluid is ejected on the skin defect, the capillary outlet end of this injection apparatus provides the gaseous state cooling fluid, this cooling fluid is directly injected on the skin defect from the port of export capillaceous, make and form thin film on the skin defect, this thin film evaporates subsequently, makes the cell transition cooling of skin defect.
17. method according to claim 16, it is characterized in that: described injection apparatus has applicator, be provided with the described port of export capillaceous in this applicator, wherein said applicator is placed on the skin and surrounds skin defect, and cooling fluid is directly injected on the skin defect from the port of export capillaceous subsequently.
18. method according to claim 17 is characterized in that: described injection apparatus has applicator, and this applicator has ring protection portion, is injected into the cooling fluid impact of skin defect on every side to prevent skin defect to be treated.
19. method for the treatment of skin defect, it is characterized in that: cooling fluid is painted on skin defect the preceding paragraph to be treated and enough makes the destroyed time of this skin defect cell, wherein, by injection apparatus cooling fluid is ejected on the skin defect, the capillary outlet end of this injection apparatus provides the gaseous state cooling fluid, wherein cooling fluid is directly injected to porous or open-celled foams from the port of export capillaceous, cooling fluid is from this porous or open celled foam evacuator body subsequently, make this porous or open-celled foams sub-cooled, supercooled porous or open-celled foams are pressed on the skin defect, make the cell transition cooling of skin defect.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1194/05 | 2005-07-18 | ||
| CH11942005 | 2005-07-18 | ||
| US11/210,339 | 2005-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101222948A true CN101222948A (en) | 2008-07-16 |
Family
ID=39632349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800262489A Pending CN101222948A (en) | 2005-07-18 | 2006-07-17 | Spray device for dispensing a cooling fluid |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN101222948A (en) |
| UA (1) | UA90328C2 (en) |
| ZA (1) | ZA200800513B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106726102A (en) * | 2017-01-13 | 2017-05-31 | 镇江市宜尔医疗器械有限公司 | One kind injection cold therapy device |
| CN107809978A (en) * | 2015-05-04 | 2018-03-16 | 牡蛎壳公司 | For treating dermopathic pen and its application method |
-
2006
- 2006-07-17 UA UAA200802006A patent/UA90328C2/en unknown
- 2006-07-17 CN CNA2006800262489A patent/CN101222948A/en active Pending
-
2008
- 2008-01-17 ZA ZA200800513A patent/ZA200800513B/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107809978A (en) * | 2015-05-04 | 2018-03-16 | 牡蛎壳公司 | For treating dermopathic pen and its application method |
| US11376056B2 (en) | 2015-05-04 | 2022-07-05 | Oystershell Nv | Pen for the treatment of dermatological disorders and method for use thereof |
| CN106726102A (en) * | 2017-01-13 | 2017-05-31 | 镇江市宜尔医疗器械有限公司 | One kind injection cold therapy device |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200800513B (en) | 2009-01-28 |
| UA90328C2 (en) | 2010-04-26 |
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