CN101214255A - Syringopicroside dropping pills and preparation technique thereof - Google Patents
Syringopicroside dropping pills and preparation technique thereof Download PDFInfo
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- CN101214255A CN101214255A CNA2008100638483A CN200810063848A CN101214255A CN 101214255 A CN101214255 A CN 101214255A CN A2008100638483 A CNA2008100638483 A CN A2008100638483A CN 200810063848 A CN200810063848 A CN 200810063848A CN 101214255 A CN101214255 A CN 101214255A
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- syringopicroside
- coating
- drop pill
- preparation
- pharmaceutical preparation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The present invention relates to a syringopicroside preparation and a preparation technology thereof. The preparation contains the materials with the following weight portions: 1 percent to 50 percent of and 99 percent of syringopicroside to 50 percent of the auxiliary material. The prepared preparation has high biological utilization degree, stable quality and good curative effect. The drug has the bacteriostasis effect with wide spectrum and has good curative effect towards upper respiratory tract infection, enteritis, bacillary dysentery, acute and chronic bronchitis, acute gastroenteritis, mastitis and hepatitis. The present invention has simple and stable preparation technology and is fit for the industrialization production.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof.Be particularly syringopicroside dropping pill formulation of syringopicroside monomer formulation specifically.Said preparation is that material medicine adds suitable adjuvant and makes through certain preparation technology by the syringopicroside monomer.
Background technology
At present, Folium Caryophylli is the dried leaves of oleaceae plant Syringa oblata Lindl., Korea Flos Caryophylli or foreign Flos Caryophylli, obtains effective site through extracting refining, and its antibacterial action is obvious, and the antibacterials of 24 Pseudomonas is all had stronger inhibition ability.Be used for intestinal infection diseases such as enteritis, bacillary dysentery clinically and receive effect preferably.Though it is clinical with the Folium Caryophylli to be that the preparation of raw material has been applied to, its dose is big, color is dark, impurity is many, finished product stability is poor, is difficult to enter the international market.The present invention's employing isolated monomer one syringopicroside from Folium Caryophylli is used as medicine, overcome above-mentioned shortcoming, better stability of preparation, of light color, impurity is few, pharmacological action is clear and definite, it can be developed to the various preparations that are applicable to clinical use, be to further developing that Flos Caryophylli is studied, lay the first stone for it enters the international market.
Summary of the invention
The object of the present invention is to provide a kind of syringopicroside drop pill and preparation technology thereof.In order to achieve the above object, the technical solution used in the present invention is: it contains:
The syringopicroside of 1-50% weight portion
The adjuvant of 99-50% weight portion.
Described pharmaceutical preparation is any in drop pill, pellet, capsule, pill, the granule.
It contains
Medicine: syringopicroside
Adjuvant:
(1) substrate: Polyethylene Glycol PEG, sodium stearate, glycerin gelatine etc.;
(2) condensing agent is: liquid paraffin, vegetable oil, methyl-silicone oil;
(3) coating solution: acrylic acid resin II number, acrylic acid resin III number, alcoholic solution, tween 80,
Diethyl phthalate, Oleum Ricini, Pulvis Talci.
Get substrate 30-50g, after being heated to whole fusions in the water-bath, add syringopicroside powder 5-50g, be transferred in the reservoir rapidly after stirring, airtight and the insulation at 60-80 ℃, drip system from top to bottom with drop pill machine constant speed, with the drop pill drop that forms to the greatest extent and remove condensing agent, pour in the dish that is lined with absorbent paper, after to be dried, the ball core that conforms to quality requirements was placed in the coating pan preheating 5-10 minute, and coating pan pressure is controlled at 0.4Mpa, regulates coating pan rotating speed 40-70rpm, coating solution flow velocity 10-30ml/min, use gun spraying in the ball wicking surface that rotates the coating solution for preparing, make even coating, with 40-50 ℃ of hot air drying, spray coating liquid is in the ball core repeatedly, till meeting the requirements of coating weightening finish 2-6%, behind the coating, coated granule was put into the drying baker inner drying 24 hours, the solvent evaporates of soaking in making promptly gets coated drop pill.
Advantage of the present invention is:
The inventor has carried out number of research projects to Flos Caryophylli, and physicochemical property, pharmacology, drug effect, pharmacokinetics, preparation process, the quality standard of medicine of the present invention carried out systematic research.The clinical experiment result show medicine of the present invention be the curative effect height, rapid-action, side effect is little, stay-in-grade preparation.For treating the ideal medicament of various inflammation.
The specific embodiment
Below embodiments of the invention are described in further detail.
Embodiment 1,
Get substrate Macrogol 4000 (PEG-4000) 42g, after being heated to whole fusions in the water-bath, add syringopicroside powder 5g, be transferred to rapidly after stirring in the reservoir, airtight and the insulation at 72 ℃, condensing agent is a methyl-silicone oil, the condensing agent temperature is 14 ℃, drip system from top to bottom with drop pill machine constant speed, with the drop pill drop that forms to the greatest extent and go out condensing agent, pour in the dish that is lined with absorbent paper, after to be dried, the ball core that conforms to quality requirements was placed in the coating pan preheating 10 minutes.Coating pan pressure is controlled at 0.4Mpa, regulates coating pan rotating speed 55rpm, coating solution flow velocity 20ml/min.Will be by acrylic acid resin II number, acrylic acid resin III number, the coating solution of alcoholic solution, tween 80, diethyl phthalate, Oleum Ricini, Pulvis Talci preparation uses gun spraying in the ball wicking surface that rotates, make even coating, with 40-50 ℃ of hot air drying, spray coating liquid is in the ball core, till meeting the requirements of coating weightening finish 4% repeatedly.Behind the coating, coated granule was put into the drying baker inner drying 24 hours, the solvent evaporates of soaking in making promptly gets coated drop pill 1000 balls.
Embodiment 2,
Get substrate polyethylene glycol 6000 (PEG-6000) 42g, after being heated to whole fusions in the water-bath, add syringopicroside powder 20g, be transferred to rapidly after stirring in the reservoir, airtight and the insulation at 72 ℃, condensing agent is a methyl-silicone oil, the condensing agent temperature is 14 ℃, drip system from top to bottom with drop pill machine constant speed, with the drop pill drop that forms to the greatest extent and go out condensing agent, pour in the dish that is lined with absorbent paper, after to be dried, the ball core that conforms to quality requirements was placed in the coating pan preheating 10 minutes.Coating pan pressure is controlled at 0.4Mpa, regulates coating pan rotating speed 55rpm, coating solution flow velocity 20ml/min.Will be by acrylic acid resin II number, acrylic acid resin III number, the coating solution of alcoholic solution, tween 80, diethyl phthalate, Oleum Ricini, Pulvis Talci preparation uses gun spraying in the ball wicking surface that rotates, make even coating, with 40-50 ℃ of hot air drying, spray coating liquid is in the ball core, till meeting the requirements of coating weightening finish 4% repeatedly.Behind the coating, coated granule was put into the drying baker inner drying 24 hours, the solvent evaporates of soaking in making promptly gets coated drop pill 1000 balls.
Embodiment 3,
Get substrate Macrogol 4000 (PEG-6000) 50g, after being heated to whole fusions in the water-bath, add syringopicroside powder 30g, be transferred to rapidly after stirring in the reservoir, airtight and the insulation at 72 ℃, condensing agent is a methyl-silicone oil, the condensing agent temperature is 14 ℃, drip system from top to bottom with drop pill machine constant speed, with the drop pill drop that forms to the greatest extent and go out condensing agent, pour in the dish that is lined with absorbent paper, after to be dried, the ball core that conforms to quality requirements was placed in the coating pan preheating 10 minutes.Coating pan pressure is controlled at 0.4Mpa, regulates coating pan rotating speed 55rpm, coating solution flow velocity 20ml/min.Will be by acrylic acid resin II number, acrylic acid resin III number, the coating solution of alcoholic solution, tween 80, diethyl phthalate, Oleum Ricini, Pulvis Talci preparation uses gun spraying in the ball wicking surface that rotates, make even coating, with 40-50 ℃ of hot air drying, spray coating liquid is in the ball core, till meeting the requirements of coating weightening finish 4% repeatedly.Behind the coating, coated granule was put into the drying baker inner drying 24 hours, the solvent evaporates of soaking in making promptly gets coated drop pill 1000 balls.
Claims (4)
1. syringopicroside pharmaceutical preparation, it is characterized in that: it contains:
The syringopicroside of 1-50% weight portion
The adjuvant of 99-50% weight portion.
2. syringopicroside pharmaceutical preparation according to claim 1, it is characterized in that: it contains medicine: syringopicroside
Adjuvant:
(1) substrate: Polyethylene Glycol PEG, sodium stearate, glycerin gelatine etc.;
(2) condensing agent is: liquid paraffin, vegetable oil, methyl-silicone oil;
(3) coating solution: acrylic acid resin II number, acrylic acid resin III number, alcoholic solution, tween 80, diethyl phthalate, Oleum Ricini, Pulvis Talci.
3. the preparation technology of syringopicroside drop pill according to claim 1 and 2 is:
Get substrate 30-50g, after being heated to whole fusions in the water-bath, add syringopicroside powder 5-50g, be transferred in the reservoir rapidly after stirring, airtight and the insulation at 60-80 ℃, drip system from top to bottom with drop pill machine constant speed, condensing agent is use up and removed to the drop pill drop that forms, pour in the dish that is lined with absorbent paper, after to be dried, the ball core that conforms to quality requirements was placed in the coating pan preheating 5-10 minute, and coating pan pressure is controlled at 0.4Mpa, regulates coating pan rotating speed 40-70rpm, coating solution flow velocity 10-30ml/min, use gun spraying in the ball wicking surface that rotates the coating solution for preparing, make even coating, with 40-50 ℃ of hot air drying, spray coating liquid is in the ball core repeatedly, till meeting the requirements of coating weightening finish 2-6%, behind the coating, coated granule was put into the drying baker inner drying 24 hours, the solvent evaporates of soaking in making promptly gets coated drop pill.
4. syringopicroside pharmaceutical preparation according to claim 1 is characterized in that: described pharmaceutical preparation is any in drop pill, pellet, capsule, pill, the granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100638483A CN101214255A (en) | 2008-01-14 | 2008-01-14 | Syringopicroside dropping pills and preparation technique thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100638483A CN101214255A (en) | 2008-01-14 | 2008-01-14 | Syringopicroside dropping pills and preparation technique thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101214255A true CN101214255A (en) | 2008-07-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100638483A Pending CN101214255A (en) | 2008-01-14 | 2008-01-14 | Syringopicroside dropping pills and preparation technique thereof |
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| CN (1) | CN101214255A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102106816A (en) * | 2010-12-16 | 2011-06-29 | 天津迈迪瑞康生物医药科技有限公司 | Resveratrol nanometer preparation and preparation method thereof |
| CN102475711A (en) * | 2010-11-30 | 2012-05-30 | 李永吉 | New application of syringopicroside in pharmacy |
-
2008
- 2008-01-14 CN CNA2008100638483A patent/CN101214255A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475711A (en) * | 2010-11-30 | 2012-05-30 | 李永吉 | New application of syringopicroside in pharmacy |
| CN102475711B (en) * | 2010-11-30 | 2013-11-13 | 李永吉 | Novel application of syringopicroside in preparation of medicines |
| CN102106816A (en) * | 2010-12-16 | 2011-06-29 | 天津迈迪瑞康生物医药科技有限公司 | Resveratrol nanometer preparation and preparation method thereof |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080709 |