CN101214058B - Composite vitamin and mineral substance composition - Google Patents
Composite vitamin and mineral substance composition Download PDFInfo
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- CN101214058B CN101214058B CN2008100557096A CN200810055709A CN101214058B CN 101214058 B CN101214058 B CN 101214058B CN 2008100557096 A CN2008100557096 A CN 2008100557096A CN 200810055709 A CN200810055709 A CN 200810055709A CN 101214058 B CN101214058 B CN 101214058B
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Abstract
The invention provides a composite of vitamin compound and mineral substance, which consists of the active components with the following weight portions: 0.7 to 0.9 portion of vitamin A, 1 to 3 portions of vitamin B1, 1 to 3 portions of vitamin B2, 3 to 5 portions of vitamin B6, 0.004 to 0.006 portion of vitamin B12, 50 to 150 portions of vitamin C, 0.003 to 0.008 portion of vitamin D3, 10 to 30 portions of vitamin E, 1 to 5 portions of pantothenic acid, 0.3 to 0.5 portion of pteroylglutamic acid, 15 to 20 portions of nicotinic amide, 0.015 to 0.05 portion of selenium, 5 to 15 portions of zinc and 50 to 800 portions of calcium. The composite of the vitamin compound and the mineral substance of the invention is mainly applied in the supplementary of dietary vitamin and mineral substance for flying personnel, so that not only satisfying the nutrition demands of the flying personnel, but also having certain effects of enhancing the abilities of antioxidation and anti-radiation and improving the dark adaptation function of the flying personnel.
Description
Technical field
The present invention relates to a kind of suitable aircrew's B B-complex and mineral composition, belong to field of health care food.
Background technology
Flight is the nervous and complicated special work of being finished under the comprehensive stress factor influences such as climatic environment of hypoxemia, low pressure, noise, vibration, acceleration, ionising radiation and constantly variation by the aircrew.The aircrew is in special aviation operating environment, be subjected to the comprehensive function of multiple environmental factor, body is in the height stress situation of physiology and psychology, Nutrition and Metabolism differs from general crowd, the often general crowd of vitamin and mineral requirement be high, the metabolism needs that vitamin and the mineral matter by the meals absorption often is difficult for satisfying the aircrew.
The diet nutritional investigation that the aircrew is carried out shows, aircrew's part vitamin and mineral matter intake deficiency, and blood parameters also notification portion vitamin, content of mineral substances is lower than normally.Nutrition survey in 1996 shows, aircrew's diet nutrient vitamin A, Cobastab
1, Cobastab
2, intake deficiency such as calcium, significantly be lower than China's diet nutrient recommended intake; Cobastab in 4 hours saturated urine
1, Cobastab
2Experimenter's ratio not enough with ascorbic discharge rate or that lack is higher, the prompting Cobastab
1, Cobastab
2With the hypovitaminosis C ubiquity.In the nutrition surveys in 2006, not only the VAD rate do not improve, the trend of rising is arranged on the contrary, 63.9% experimenter's serum vitamin A is on the low side, wherein seriously reduction person accounts for 27.7%; Cobastab
2Lack the most serious, only 25.4% experimenter load urine in Cobastab
2Discharge rate in normal range (NR); Cobastab
1Account for 27.7% and 9.9% with the vitamin C deficiency; 66.7% experimenter's serum calcium is lower than normally; 30% experimenter's serum zinc is lower than normally; 65.0% experimenter's serum selenium is lower than normally.As seen, aircrew's vitamin and mineral matter nutritional situation allow of no optimist.And on the other hand, aircrew's serum cholesterol content of 23.5% is higher than normal value, and 47.1% triglycerides exceeds standard.In recent years, hypertension, overweight and fat illness rate raise in older aircrew to some extent, and the dyslipidemia incidence obviously increases.Hypertension, high fat of blood become aircrew's common disease and high morbidity.
This shows that aeronautical environment and flight operation have proposed corresponding specific (special) requirements to aircrew's nutrition.But the vitamin and minerals replenishers on the market mainly are the dietary supplements at the general population, and the kind of vitamin, mineral matter and quantity mainly lay particular emphasis on replenishes common, the not enough nutrient of general crowd, and it is edible all to be not suitable for the aircrew.Disclose a kind of compound vitamin composition and preparation thereof such as patent documentation CN1650994A, it is vitamin A (wherein 25% is beta carotene) 5000 IU by weight, Cobastab
13mg, Cobastab
23.4mg, Cobastab
63mg, Cobastab
129 μ g, vitamin C 90mg, vitamin D 400IU, vitamin E 30 IU, niacinamide 20mg, folic acid 400 μ g, iron 27mg, zinc 15mg, calcium 40mg, pantothenic acid 10mg, selenium 10 μ g and American ginseng extract 10mg～900mg forms.This Cernevit-12 iron content is higher, unairworthiness personnel's nutritional supplementation, and therefore, commercially available vitamin and minerals replenishers can't satisfy aircrew's demand.
Summary of the invention
The purpose of this invention is to provide a kind of B B-complex and mineral composition, to replenish aircrew's meals vitamin and mineral matter.
In order to realize the object of the invention, a kind of B B-complex of the present invention and mineral composition, main component comprises 11 kinds of vitamins and 3 kinds of mineral matters, it comprises the active component of following weight portion:
0.7～0.9 part of vitamin A, Cobastab
11～3 part, Cobastab
21～3 part, Cobastab
63～5 parts, Cobastab
120.004～0.006 part, 50～150 parts of vitamin Cs, vitamin D
30.003～0.008 part, 10～30 parts of vitamin Es, 1～5 part in pantothenic acid, 0.3～0.5 part in folic acid, 15～20 parts of niacinamide, 0.015～0.05 part on selenium, 5～15 parts on zinc, 50～800 parts of calcium.
Preferably: 0.7～0.8 part of vitamin A, Cobastab
11.5～2.5 parts, Cobastab
22～2.5 parts, Cobastab
64～5 parts, Cobastab
120.005～0.006 part, 80～150 parts of vitamin Cs, vitamin D
30.003～0.006 part, 20～30 parts of vitamin Es, 1～3 part in pantothenic acid, 0.3～0.4 part in folic acid, 16～20 parts of niacinamide, 0.02～0.04 part on selenium, 8～12 parts on zinc, 80～300 parts of calcium.
Wherein, composition of the present invention can mix by containing each active component raw material, and described Se content can be with adding selenium yeast control, the zinc composition can add zinc salt, calcium component can add calcium salt, and vitamin A can add vitamin(e) A acetate powder, Cobastab
1Can add thiamine hydrochloride, vitamin E can add Vitwas E, and pantothenic acid can add calcium pantothenate.
Of the present invention part is weight portion, is unit of weights such as this area microgram commonly used, milligram, gram, two, kilogram, ton.
The preparation method of B B-complex of the present invention and mineral composition can adopt this area conventional method to add pharmaceutic adjuvant, as starch, microcrystalline cellulose, dextrin, talcum powder, polyethylene glycol, titanium dioxide, Ac-Di-Sol, superfine silica gel powder, stearic acid, dolomol, coloured organic dyestuff etc., through premix, preparation of granules, always mix, processes such as compressing tablet, film coating make different preparations, such as tablet or capsule etc.
A B B-complex of the present invention and mineral composition suggestion day clothes effective dose is 1000mg (with the adult artificial example of 70kg).
The aircrew is owing to watch instrument board and night flight flight for a long time attentively, and than normal person's height, aircrew's nutrition survey shows that the VAD situation is comparatively serious to the requirement of vitamin A, if but a large amount of the absorption has tangible toxicity to the aircrew again.Thus, the researcher is controlled at vitamin A in the zone of reasonableness.
Cobastab
1Playing important effect aspect the human body energy metabolism, studies show that the aircrew is to Cobastab
1Requirement increase than the normal person.
Cobastab
2But catalysis is oxidation-reduction reaction widely, promotes human body energy to generate, and also can participate in the anti-oxidative defense system in the body, suppresses the body lipid peroxidation, and aircrew's Cobastab
2Lack comparatively serious.
Cobastab
6Can take and contain Cobastab by reducing the danger that hyperhomocysteinemiainjury reduces atherosclerotic and coronary heart disease
6Cernevit-12 also can stablize vestibular function to a certain extent, the generation of prevention vestibular organ bad reaction reduces spatial disorientation generation probability, thereby ensures flight safety.Also help the adjusting of blood lipid in flying personnel simultaneously.Therefore, the present invention is controlled at higher range with the content of vitamin B6.
Vitamin C has significant redox characteristic, and the co-factor or the auxilliary substrate that can be used as enzyme participate in multiple important biosynthetic process, and the oxidative stress of alleviating the aircrew is had the important physical effect.
Vitamin D
3Basic function be to keep the inside and outside calcium concentration of cell, regulate alcium and phosphor metabolization, all be essential to the function of calcification, nerve conduction, contraction of muscle and all cells of normal bone.
Vitamin E is the powerful antioxidant in the body, still comparatively comprehensive immunologic function promoter.Fat content is higher in aircrew's meals, on average account for more than 35% of heat energy quantity delivered, wherein be mainly polyunsaturated fatty acid, and polyunsaturated fatty acid in vivo the oxidation reaction in the metabolism need consume vitamin E, so it is taken in when increasing, the supply of vitamin E also should increase thereupon.The aircrew is subjected to aeronautical environment influences such as noise, vibration, high-altitude low pressure, anoxic, is subjected to the radiation effects of cosmic radiation and instrument and equipment simultaneously, and vitamin E can improve the stress ability of body, alleviates the damage that oxidative stress causes.Therefore, the present invention also controls the addition of vitamin E emphatically.
Folic acid is a kind of important B family vitamin, and is closely related with the many important biochemical processes of body, directly influences the synthetic of nucleic acid, and pair cell division, propagation and tissue growth have important role.Folic acid can reduce hyperhomocysteinemiainjury, thereby reduces the independent hazard factor of atherosclerotic and coronary heart disease, and sufficient folic acid is taken in has certain effect to the prevention cardiovascular disease.
Mineral matter zinc is improving the physical stress ability and is protecting visual aspects all to play an important role, and zinc also can act synergistically with vitamin A, improves body dark adaptation ability.
Selenium can directly be removed free radical and can suppress the generation of lipid free radical, and itself and vitamin E also have synergy, can effectively realize the anti-oxidant efficient of body, thereby improves resisting stress capability and increase resistance against diseases.Selenium can improve body's immunological function, to pre-anti-cancer, radiation injury, body reparation with delay senility health-care effect is preferably all arranged.The aircrew is subjected to the radiation effects of instrument and equipments such as cosmic radiation and instrument board, and Selenium Supplement can help the aircrew to improve stress ability and alleviate radiation injury.Therefore, personnel of the present invention have carried out choose reasonable through experimental study to the selenium amount ranges.
Calcium participates in bone formation, the conductive process of nerve impulse and keeping of nerve excitability.Nerve cell comprises the optic nerve calcium deficiency, occurs visual fatigue and dispersion attention easily.And aircrew's nutrition condition investigation is shown that aircrew's calcium level is generally on the low side.In addition, have multinomial report to show, replenishing the calcium to make blood pressure reduce.Therefore, the present invention has added an amount of calcium.
The present invention does not add the iron in the mineral matter, because excessive absorption iron can cause the damage and the fibrillatable of tissue inflammation, many organs, iron still is the catalyst of radical reaction, can cause the cross-linking reaction of peroxidation or cell membrane lipid and cell internalizing compound, causes cell senescence or death.Studies show that iron is excessive all closely related with multiple diseases such as liver diseases, cardiovascular disease, tumour, injury of kidney, hypertension.According to aircrew's physical feature, in B B-complex of the present invention and mineral composition, do not add mineral matter iron.
Therefore, the present invention and has re-added, strengthened vitamin and the mineral matter that has anti-oxidant, radioresistance, improves effects such as dark adaptation function on the basis that guarantees the sufficient replenishing vitamins of aircrew.B B-complex of the present invention and mineral composition can effectively satisfy the demand of aircrew's diet nutrient, and chronic diseases such as the existing high fat of blood of aircrew are had certain prevention effect.
Suitable aircrew's of the present invention multivitamin and mineral complex are based on aviatorial nutrition's metabolic characteristic, with reference to aircrew's dietary survey and nutrition condition investigation result, are the composite nutrient replenishers of aircrew's tailor-make.Be mainly used in replenishing of aircrew's meals vitamin and mineral matter.The present invention not only can satisfy the demand of aviatorial nutrition's element, and the aircrew is anti-oxidant to strengthening, capability of resistance to radiation and improve dark adaptation function etc. and have certain effect.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
The raw material of present embodiment Cerovite and each active component such as following table:
| The nutrient title | Raw materials used | The raw material consumption | Active component content |
| Vitamin A | Vitamin(e) A acetate powder 500000IU/g | ?5.3mg | ?800μgRE |
| Cobastab 1 | Thiamine hydrochloride | ?3.2mg | ?2.5mg |
| Cobastab 2 | Cobastab 2 | ?2.5mg | ?2.5mg |
| Cobastab 6 | Cobastab 6 | ?6.1mg | ?5mg |
| Cobastab 12 | Cobastab 12(1 ‰ content) | ?6mg | ?6μg |
| Vitamin C | Vitamin C (90%) | ?166.6mg | ?150mg |
| Vitamin D 3 | Vitamin D 3Powder 100000IU/g | ?1.2mg | ?3μg |
| Vitamin E | Vitwas E 50% | ?43.9mg | ?20mg |
| Pantothenic acid | Calcium pantothenate | ?5.2mg | ?4mg |
| Folic acid | Folic acid | ?0.3mg | ?300μg |
| Niacinamide | Niacinamide | ?20mg | ?20mg |
| Selenium | Selenium yeast (2000mg/kg) | ?19.5mg | ?39μg |
| Zinc | Zinc oxide | ?14.9mg | ?12mg |
| Calcium | Calcium carbonate | ?500mg | ?200mg |
" μ gRE " means various micrograms with the equivalent physiological activator of vitamin A (retinol).
Per 100 parts of B B-complexes of the present invention and mineral composition add 13.0 parts starch, 5.0 parts dolomol, 8.0 parts superfine silica gel powder, through premix, preparation of granules, sieve, always mix, compressing tablet, dressing make tablet.
Embodiment 2
Each active component such as the following table of present embodiment B B-complex and mineral matter capsule:
| The nutrient title | Raw materials used | Active component content |
| Vitamin A | Vitamin(e) A acetate powder 500000IU/g | 750μgRE |
| Cobastab 1 | Thiamine hydrochloride | 1.5mg |
| Cobastab 2 | Cobastab 2 | 1.5mg |
| Cobastab 6 | Cobastab 6 | 4mg |
| Cobastab 12 | Cobastab 12(1 ‰ content) | 5.5μg |
| Vitamin C | Vitamin C (90%) | 110mg |
| Vitamin D 3 | Vitamin D 3Powder 100000IU/g | 5μg |
| Vitamin E | Vitwas E 50% | 25.5mg |
| Pantothenic acid | Calcium pantothenate | 2mg |
| Folic acid | Folic acid | 350μg |
| Niacinamide | Niacinamide | 15.5mg |
| Selenium | Selenium yeast (2000mg/kg) | 22μg |
| Zinc | Zinc oxide | 10mg |
| Calcium | Calcium carbonate | 600mg |
Per 100 parts of B B-complexes of the present invention and mineral composition add 10 parts dextrin, 15 parts talcum powder, through behind the mixing, cross 100 mesh sieves, and be encapsulated, gets composition capsule.
Embodiment 3
Preparation process is with embodiment 1, and different is each active component such as the following table of present embodiment Cerovite:
| The nutrient title | Raw materials used | Active component content |
| Vitamin A | Vitamin(e) A acetate powder 500000IU/g | 850μgRE |
| Cobastab 1 | Thiamine hydrochloride | 2.2mg |
| Cobastab 2 | Cobastab 2 | 2.2mg |
| Cobastab 6 | Cobastab 6 | 3.3mg |
| Cobastab 12 | Cobastab 12(1 ‰ content) | 4.5μg |
| Vitamin C | Vitamin C (90%) | 80mg |
| Vitamin D 3 | Vitamin D 3Powder 100000IU/g | 7μg |
| Vitamin E | Vitwas E 50% | 15mg |
| Pantothenic acid | Calcium pantothenate | 3.5mg |
| Folic acid | Folic acid | 450μg |
| Niacinamide | Niacinamide | 17mg |
| Selenium | Selenium yeast (2000mg/kg) | 43μg |
| Zinc | Zinc oxide | 6mg |
| Calcium | Calcium carbonate | 350mg |
Embodiment 4
Preparation process is with embodiment 1, and different is each component such as the following table of present embodiment Cerovite:
| The nutrient title | Raw materials used | Active component content |
| Vitamin A | Vitamin(e) A acetate powder 500000IU/g | 700μgRE |
| Cobastab 1 | Thiamine hydrochloride | 1mg |
| Cobastab 2 | Cobastab 2 | 2mg |
| Cobastab 6 | Cobastab 6 | 3mg |
| Cobastab 12 | Cobastab 12(1 ‰ content) | 4μg |
| Vitamin C | Vitamin C (90%) | 50mg |
| Vitamin D 3 | Vitamin D 3Powder 100000IU/g | 6μg |
| Vitamin E | Vitwas E 50% | 10mg |
| Pantothenic acid | Calcium pantothenate | 3mg |
| Folic acid | Folic acid | 400μg |
| Niacinamide | Niacinamide | 15mg |
| Selenium | Selenium yeast (2000mg/kg) | 20μg |
| Zinc | Zinc oxide | 5mg |
| Calcium | Calcium carbonate | 80mg |
Embodiment 5
Preparation process is with embodiment 1, and different is each component such as the following table of present embodiment Cerovite:
| The nutrient title | Raw materials used | Active component content |
| Vitamin A | Vitamin(e) A acetate powder 500000IU/g | 900μgRE |
| Cobastab 1 | Thiamine hydrochloride | 3mg |
| Cobastab 2 | Cobastab 2 | 1mg |
| Cobastab 6 | Cobastab 6 | 3.5mg |
| Cobastab 12 | Cobastab 12(1 ‰ content) | 5μg |
| Vitamin C | Vitamin C (90%) | 120mg |
| Vitamin D 3 | Vitamin D 3Powder 100000IU/g | 8μg |
| Vitamin E | Vitwas E 50% | 30mg |
| Pantothenic acid | Calcium pantothenate | 1mg |
| Folic acid | Folic acid | 500μg |
| Niacinamide | Niacinamide | 16mg |
| Selenium | Selenium yeast (2000mg/kg) | 15μg |
| Zinc | Zinc oxide | 15mg |
| Calcium | Calcium carbonate | 800mg |
Experimental example 1
The purpose of this experimental example is to study B B-complex of the present invention and mineral composition for the human trial that improves the dark adaptation function.
Use the B B-complex of the present invention and the mineral composition tablet of preparation among the embodiment 1, the effect of improving of aircrew's dark adaptation function is tested.Research object is 30 of aircrews under operate as normal, the living condition, and important organ illness such as the heart, liver, kidney are not found in health check-up, and the eyes UCVA is all more than 1.0,29.2 ± 5.8 years old mean age.Test group personnel add B B-complex and the mineral composition tablet of a slice (effective dose is 1000mg) according to preparation among the embodiment 1 every day, and control group does not add, and test group and control group personnel all have dinner together.In 4 weeks of administration, detect aircrews' the quick dark adaptation time and calculate changing value in preceding, 2 weeks of taking medicine of taking medicine, 4 weeks of taking medicine respectively.
The quick dark adaptation capacity variation of table 1 aircrew value
| Group | n | 2 all changing values (s) | 4 all changing values (s) |
| The test group control group | 15 15 | 53.4±31.2 ** 12.6±6.6 | 57.6±27.6 ** 19.8±13.8 |
*Compare p＜0.01 with control group
Therefore, 2 quick dark adaptation abilities all and 4 weeks shortened 53.4 ± 31.2s and 57.6 ± 27.6s respectively after experimental group aircrew took in B B-complex of the present invention and mineral composition, changing value is significantly higher than control group (p＜0.01), illustrates that B B-complex of the present invention and mineral composition can effectively improve aircrew's dark adaptation function.
Experimental example 2
The purpose of this experimental example is to be to study the zoopery for radiation-resisting functional of B B-complex of the present invention and mineral composition.
Use the B B-complex of the present invention and the mineral composition of preparation among the embodiment 2, radiation-resisting functional is tested.Research object is 45 of Male Kunming strain mice, body weight 20 ± 6g.Be divided into normal control group, radiation control group and experimental group at random, 15 every group.Adaptability was raised after 3 days, and the normal control group is normally raised, and experimental group gives 96mgkg
-1The present composition is irritated stomach, and the radiation control group gives consubstantiality ponding and irritates stomach.After 30 days, give 7.0Gy to radiation control group and experimental group
137The disposable irradiation of Cs gamma-rays whole body, close rate is 1Gy/min.Continue behind the irradiation to raise 30 days, observe survival condition.
Table 2 mouse mean survival time and 30 days survival rates
*Compare p＜0.01 with the radiation control group
Result of study shows, takes the mouse of B B-complex of the present invention and mineral composition,
137Behind the Cs radiation gamma, on average survive fate and survival rate are significantly higher than the radiation control group, and survival rate is up to 53.3%.Point out B B-complex of the present invention and mineral composition antiradiation effect remarkable.
Experimental example 3
The purpose of this experimental example is to be to study the zoopery for anti-oxidation function of B B-complex of the present invention and mineral composition.
Use the B B-complex of the present invention and the mineral composition of preparation among the embodiment 3, the anti-oxidation function of the present composition is tested.Research object is 45 of Male Kunming strain mice, body weight 20 ± 6g.Be divided into normal control group, experiment contrast group and experimental group at random, 15 every group.Adaptability was raised after 3 days, and the normal control group is normally raised, and experimental group gives 96mgkg every day
-1The present composition is irritated stomach, and the experiment contrast group gives consubstantiality ponding and irritates stomach.After 30 days, give 7.0Gy to experiment contrast group and experimental group
137The disposable irradiation of Cs gamma-rays whole body, close rate is 1Gy/min.Shine after 3 days, put to death animal, get mouse liver and detect MDA, GSH activity.
Table 3 mouse liver MDA and GSH activity
| Group | n | MDA(mmol·mg -1) | GSH(mg·g -1) |
| Experimental group experiment contrast group | 15 15 | 17.30±4.62 ** 27.02±5.24 | 400.03±40.63 ** 238.11±34.33 |
| The normal control group | 15 | 11.82±1.62 ** | 465.09±49.10 ** |
Compare with the experiment contrast group,
*P＜0.01
By experimental result as can be seen, experimental group MDA significantly is lower than experiment contrast group (p＜0.01), GSH is significantly higher than experiment contrast group (p＜0.01), prompting body oxygen radical generates and reduces, and oxidation resistance strengthens, and shows that B B-complex of the present invention and mineral composition have antioxidant effect preferably.
Though above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (3)
1. B B-complex and mineral composition is characterized in that wherein the composition of active component is counted with weight portion:
0.7～0.9 part of vitamin A, Cobastab
11～3 part, Cobastab
21～3 part, Cobastab
63～5 parts, Cobastab
120.004～0.006 part, 50～150 parts of vitamin Cs, vitamin D
30.003～0.008 part, 10～30 parts of vitamin Es, 1～5 part in pantothenic acid, 0.3～0.5 part in folic acid, 15～20 parts of niacinamide, 0.015～0.05 part on selenium, 5～15 parts on zinc, 50～800 parts of calcium.
2. B B-complex according to claim 1 and mineral composition is characterized in that, wherein the composition of active component is counted with weight portion: 0.7～0.8 part of vitamin A, Cobastab
11.5～2.5 parts, Cobastab
22～2.5 parts, Cobastab
64～5 parts, Cobastab
120.005～0.006 part, 80～150 parts of vitamin Cs, vitamin D
30.003～0.006 part, 20～30 parts of vitamin Es, 1～3 part in pantothenic acid, 0.3～0.4 part in folic acid, 16～20 parts of niacinamide, 0.02～0.04 part on selenium, 8～12 parts on zinc, 80～300 parts of calcium.
3. B B-complex according to claim 1 and 2 and mineral composition, it is tablet or the capsule made from pharmaceutic adjuvant.
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| CN103284164A (en) * | 2013-06-08 | 2013-09-11 | 哈尔滨珍宝制药有限公司 | Composition comprising a plurality of vitamins and mineral substances |
| CN106376917A (en) * | 2015-07-28 | 2017-02-08 | 庞艳军 | Health food or drink formula for regulating emotions from multiple aspects |
| CN106473149A (en) * | 2015-08-25 | 2017-03-08 | 广州硕维食品技术有限公司 | A kind of Multi-vitamin and multi-mineral compositionss |
| CN105962326A (en) * | 2016-03-16 | 2016-09-28 | 安徽珠峰生物科技有限公司 | A multi-vitamin calcium iron zinc selenium tablet |
| CN107927795A (en) * | 2017-12-18 | 2018-04-20 | 北京康比特体育科技股份有限公司 | Suitable for the multivitamin mineral matter sublingual lozenge of sport people |
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