CN101204559A - Medicaments composite for coronary heart disease, angina and epigastralgia and preparation method thereof - Google Patents
Medicaments composite for coronary heart disease, angina and epigastralgia and preparation method thereof Download PDFInfo
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- CN101204559A CN101204559A CNA2007101783422A CN200710178342A CN101204559A CN 101204559 A CN101204559 A CN 101204559A CN A2007101783422 A CNA2007101783422 A CN A2007101783422A CN 200710178342 A CN200710178342 A CN 200710178342A CN 101204559 A CN101204559 A CN 101204559A
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Abstract
The invention discloses a medicine combination used for treating coronary heart disease angina and epigastric pain and a preparation method thereof; the medicine combination is mainly made from snakegourd fruit, salvia, bulbus allii macrostemi, pinellia ternata, rhizoma corydalis, tangerine peel, citrus aurantium, cassia twig, villous amomum fruit and sandalwood. The medicine combination of the invention has the function of activating Yang and eliminating phlegm, and promoting blood circulation and relieving congestion and is mainly indicated for chest distress of phlegm obstruction and blood stasis, angina pectoris and stomachache; the medicine combination can also be used for treating chronic gastritis, gastroduodenal ulcer, stomach neurosis, chronic hepatitis, and chronic pancreatitis. The medicine combination of the invention is characterized by simple prescription, convenient production, convenient administration for patients and remarkable curative effects, thus presenting a wide application value.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof, belong to the technical field of pharmaceuticals of the activate yang eliminating phlegm and the relieving accumulation of pathogens of invigorating blood circulation.Cure mainly expectorant and stop up the thoracic obstruction, angina pectoris and the gastric abscess etc. of blood stasis, card is seen fullness in the chest pain, chest pain radiating to the back, localized pain, the cough with asthma of panting, is losed heart and can not put down for sleeping in, white and greasy fur or ecchymosis be arranged and deep and stringy pulse or stringy and tense pulse etc., also can be used for treating diseases such as chronic gastritis, gastroduodenal ulcer, stomach neurosis, chronic hepatitis and chronic pancreatitis.
Background technology
Angina pectoris and gastric abscess are a kind of frequently-occurring diseases, and the patient is in the majority with the old people, serious harm humans health, and its sickness rate presents ascendant trend year by year in recent years.The traditional Chinese medical science thinks that the pathogenesis of angina pectoris and gastric abscess mostly is imbalance of YIN and YANG, and the contrary painstaking effort that disorderly cause of mechanism of qi are retarded by silt, blockage of the cardiac vessels, and expectorant is stopped up blood stasis, therefore treating the thoracic obstruction should defer to the pain relieving of traditional Chinese medical science blood circulation and channel invigorating, be aided with the method that invigorates vital energy and reinforce the heart, the activate yang eliminating phlegm and the relieving accumulation of pathogens of invigorating blood circulation are to reach therapeutic effect.
Present doctor trained in Western medicine is used for the treatment for the treatment of coronary heart disease and angina pectoris such as persantin and pentaerythritol tetranitrate sheet etc. mainly are the outbreaks of alleviating through the row symptom, and can not reach the purpose of effecting a permanent cure, and toxic side effect; Chinese medicine is in the advantage that oneself is then arranged aspect the treatment angina pectoris, all has certain curative effect such as Radix Salviae Miltiorrhizae Tabellae, Radix Salviae Miltiorrhizae drop pill, DIAOXINXUE KANG, TONGXINLUO JIAONANG etc. in the market, curative effect is low, onset is slow but also exist, need the problem of drug combination, certain side effect is also arranged simultaneously, therefore need exploitation good effect, the low Chinese patent medicine of side effect.
The purpose of this invention is to provide a kind of Chinese medicine preparation that expectorant is stopped up the diseases such as the thoracic obstruction, angina pectoris and gastric abscess of blood stasis for the treatment of, also can be used for treating diseases such as chronic gastritis, gastroduodenal ulcer, stomach neurosis, chronic hepatitis and chronic pancreatitis.Through clinical treatment observation, find that this pharmaceutical composition is for angina pectoris and gastric abscess, diseases such as chronic gastritis, gastroduodenal ulcer, stomach neurosis, chronic hepatitis and chronic pancreatitis have splendid therapeutic effect, alleviate the symptom of various discomforts, do not found untoward reaction simultaneously.
Summary of the invention
The object of the present invention is to provide a kind of evident in efficacy, taking convenience, side effect little, the treatment expectorant that can be fit to take is for a long time stopped up the Chinese medicinal capsule of the thoracic obstruction, angina pectoris and the gastric abscess of blood stasis.
The present invention also provides the preparation method of this Chinese medicinal capsule.
Pharmaceutical composition of the present invention can be used for treating expectorant, and to stop up the thoracic obstruction, angina pectoris and the gastric abscess of blood stasis greasy or ecchymosis and deep and stringy pulse or stringy and tense pulse etc. are arranged, and also can be used for treating diseases such as chronic gastritis, gastroduodenal ulcer, stomach neurosis, chronic hepatitis and chronic pancreatitis.
Pharmaceutical composition of the present invention is prepared from by the following weight parts proportion raw material:
10～200 parts in real 100～1000 parts of Chinese juniper beach wormwood, 100～800 parts of Radix Salviae Miltiorrhizaes, 100～700 parts of Bulbus Allii Macrostemonis, 100～700 parts of the Rhizoma Pinelliaes, 50～500 parts of Rhizoma Corydalis, 50～500 parts of Pericarpium Citri Reticulataes, 50～500 parts of Fructus Aurantii Immaturuss, 10～300 parts of Ramulus Cinnamomi, 10～200 parts of Fructus Amomis and Lignum Santali Albi.
Pharmaceutical composition of the present invention is prepared from by following preferred weight part proportion raw material:
20～100 parts in real 300～700 parts of Chinese juniper beach wormwood, 200～600 parts of Radix Salviae Miltiorrhizaes, 200～500 parts of Bulbus Allii Macrostemonis, 200～500 parts of the Rhizoma Pinelliaes, 100～300 parts of Rhizoma Corydalis, 100～300 parts of Pericarpium Citri Reticulataes, 100～300 parts of Fructus Aurantii Immaturuss, 50～200 parts of Ramulus Cinnamomi, 20～100 parts of Fructus Amomis and Lignum Santali Albi.
Pharmaceutical composition of the present invention is prepared from by following optimum weight part proportion raw material:
50 parts in real 500 parts of Chinese juniper beach wormwood, 400 parts of Radix Salviae Miltiorrhizaes, 300 parts of Bulbus Allii Macrostemonis, 300 parts of the Rhizoma Pinelliaes, 200 parts of Rhizoma Corydalis, 200 parts of Pericarpium Citri Reticulataes, 200 parts of Fructus Aurantii Immaturuss, 100 parts of Ramulus Cinnamomi, 50 parts of Fructus Amomis and Lignum Santali Albi.
Chinese medicinal capsule of the present invention can be prepared from by following method:
1, Chinese juniper beach wormwood reality, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis and the Rhizoma Pinelliae powder with described weight portion is broken into coarser powder, and 80% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1;
2, Rhizoma Corydalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus and the Ramulus Cinnamomi with described weight portion is ground into coarser powder, with 75% alcohol heating reflux twice, and each each 2 hours, filter, be condensed into extractum 2;
3, the Lignum Santali Albi of described weight portion and Fructus Amomi are worn into fine powder with a small amount of Chinese liquor dissolving in back, merge with extractum 1 and extractum 2, spray drying behind the mixing incapsulates and gets final product.
Prescription of the present invention is made up of ten flavor Chinese medicines such as Chinese juniper beach wormwood reality, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis, the Rhizoma Pinelliae, Rhizoma Corydalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus, Ramulus Cinnamomi, Fructus Amomi and Lignum Santali Albi.Modern pharmacological research shows: real and Radix Salviae Miltiorrhizae is a monarch drug with the Chinese juniper beach wormwood in the side, and the Chinese juniper beach wormwood is real can removing heat-phlegm, the promoting the circulation of QI the chest stuffiness relieving, and the eliminating stagnation eliminating carbuncle is used for the thoracic obstruction, and blocked-up chests etc. can be controlled the turbid numbness of wind-phlegm with Bulbus Allii Macrostemonis and Rhizoma Pinelliae compatibility and hinder, activating YANG and eliminating stagnation, breast reduces phlegm out; Radix Salviae Miltiorrhizae can promoting blood flow to regulate menstruation, and removing heat from blood eliminating carbuncle, the trusted subordinate Teng Tong that is used for blood stasis be with lumps in the chest and abdomen, can control trusted subordinate due to the blood stasis stagnation of QI, gastralgia with Fructus Amomi and Lignum Santali Albi compatibility; With Bulbus Allii Macrostemonis, the Rhizoma Pinelliae, Rhizoma Corydalis, Pericarpium Citri Reticulatae and Fructus Aurantii Immaturus is ministerial drug, Bulbus Allii Macrostemonis energy activating YANG and eliminating stagnation, and the circulation of qi promoting intestinal stasis relieving is good at the logical yang-energy in the heart of a surname, and warnming and eliminating YIN-cold expectorant is turbid to stagnate, and dredges mechanism of qi in the heart, has the merit of circulation of qi promoting the chest stuffiness relieving, is used for thoracic obstruction card; Rhizoma Pinelliae energy drying dampness to eliminate phlegm, dissolving lump and resolving mass is used for the thoracic obstruction, blocked-up chest and epigastric oppression etc.; Rhizoma Corydalis energy blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain are used for all pains of the blood stasis stagnation of QI; Pericarpium Citri Reticulatae energy regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm is used for the phlegm dampness obstruction pattern card, and the chest and diaphragm that can control impairment of dispersing and descending function of the lung is full vexed; The capable expectorant of Fructus Aurantii Immaturus energy dispelling the stagnated QI, dissolving lump and resolving mass can be controlled the turbid retardance of expectorant, feeling of oppression and fullness in the chest and epigastrium, the stagnation of phlegm thoracic obstruction etc. with the Ramulus Cinnamomi compatibility; With Ramulus Cinnamomi, Fructus Amomi and Lignum Santali Albi is adjuvant drug, Ramulus Cinnamomi energy warming the meridian and promoting blood circulation, activating YANG and prormoting functioning of QI; Fructus Amomi can removing dampness whet the appetite the circulation of qi promoting warming middle-JIAO; During Lignum Santali Albi can be regulated the flow of vital energy and be transferred, dispersing cold for relieving pain; With Chinese liquor is messenger drug, and up liter looses, and strengthens the effect that the Bulbus Allii Macrostemonis circulation of qi promoting activates yang.All medicine compatibilities, the effect of playing the activate yang eliminating phlegm and the relieving accumulation of pathogens of invigorating blood circulation altogether.
Pharmaceutical composition of the present invention shows through clinical experiment, we's taking convenience, side effect is little, can be fit to take for a long time, patient's taking convenience, splendid therapeutical effect is arranged, alleviated the symptom of various discomforts, can be used for treating the thoracic obstruction that expectorant is stopped up blood stasis, angina pectoris and gastric abscess etc., card is seen the fullness in the chest pain, chest pain radiating to the back, localized pain, the cough with asthma of panting, losing heart, it is for sleeping in to put down, white and greasy fur or ecchymosis is arranged and deep and stringy pulse or stringy and tense pulse etc. also can be used for treating chronic gastritis, gastroduodenal ulcer, stomach neurosis, disease such as chronic hepatitis and chronic pancreatitis.
Through clinical experiment, this Chinese medicinal capsule carries out observation of curative effect to 223 routine angina pectoris cases, finds that total effective rate reaches 94.17%, and cure rate reaches 80.72%, therefore is with a wide range of applications.
The specific embodiment
Embodiment 1
Chinese juniper beach wormwood real 100g, Radix Salviae Miltiorrhizae 100g, Bulbus Allii Macrostemonis 100g, Rhizoma Pinelliae 100g, Rhizoma Corydalis 100g, Pericarpium Citri Reticulatae 100g, Fructus Aurantii Immaturus 100g, Ramulus Cinnamomi 100g, Fructus Amomi 50g and Lignum Santali Albi 50g.Chinese juniper beach wormwood reality, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis and the Rhizoma Pinelliae powder of described weight portion are broken into coarser powder, and 80% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1; Rhizoma Corydalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus and the Ramulus Cinnamomi of described weight portion are ground into coarser powder, with 75% alcohol heating reflux twice, each each 2 hours, filter, be condensed into extractum 2; The Lignum Santali Albi of described weight portion and Fructus Amomi are worn into behind the fine powder with a small amount of Chinese liquor dissolving, merged with extractum 1 and extractum 2, spray drying behind the mixing divides the capsule of packing into to get final product.Every capsules contains 0.5g.Instructions of taking: every day 3 times, each 5.
Embodiment 2
Chinese juniper beach wormwood real 300g, Radix Salviae Miltiorrhizae 300g, Bulbus Allii Macrostemonis 250g, Rhizoma Pinelliae 250g, Rhizoma Corydalis 200g, Pericarpium Citri Reticulatae 200g, Fructus Aurantii Immaturus 100g, Ramulus Cinnamomi 50g, Fructus Amomi 50g and Lignum Santali Albi 50g.Chinese juniper beach wormwood reality, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis and the Rhizoma Pinelliae powder of described weight portion are broken into coarser powder, and 80% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1; Rhizoma Corydalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus and the Ramulus Cinnamomi of described weight portion are ground into coarser powder, with 75% alcohol heating reflux twice, each each 2 hours, filter, be condensed into extractum 2; The Lignum Santali Albi of described weight portion and Fructus Amomi are worn into behind the fine powder with a small amount of Chinese liquor dissolving, merged with extractum 1 and extractum 2, spray drying behind the mixing divides the capsule of packing into to get final product.Every capsules contains 0.5g.Instructions of taking: every day 3 times, each 5.
Embodiment 3
Chinese juniper beach wormwood real 500g, Radix Salviae Miltiorrhizae 400g, Bulbus Allii Macrostemonis 300g, Rhizoma Pinelliae 300g, Rhizoma Corydalis 200g, Pericarpium Citri Reticulatae 200g, Fructus Aurantii Immaturus 200g, Ramulus Cinnamomi 100g, Fructus Amomi 50g and Lignum Santali Albi 50g.Chinese juniper beach wormwood reality, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis and the Rhizoma Pinelliae powder of described weight portion are broken into coarser powder, and 80% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1; Rhizoma Corydalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus and the Ramulus Cinnamomi of described weight portion are ground into coarser powder, with 75% alcohol heating reflux twice, each each 2 hours, filter, be condensed into extractum 2; The Lignum Santali Albi of described weight portion and Fructus Amomi are worn into behind the fine powder with a small amount of Chinese liquor dissolving, merged with extractum 1 and extractum 2, spray drying behind the mixing divides the capsule of packing into to get final product.Every capsules contains 0.5g.Instructions of taking: every day 3 times, each 5.
Claims (4)
1. pharmaceutical composition for the treatment of angina pectoris and gastric abscess is characterized in that the medicine material that raw material contains following weight portion proportioning forms: 10～200 parts in real 100～1000 parts of Fructrs Trichosanthis, 100～800 parts of Radix Salviae Miltiorrhizaes, 100～700 parts of Bulbus Allii Macrostemonis, 100～700 parts of the Rhizoma Pinelliaes, 50～500 parts of Rhizoma Corydalis, 50～500 parts of Pericarpium Citri Reticulataes, 50～500 parts of Fructus Aurantii Immaturuss, 10～300 parts of Ramulus Cinnamomi, 10～200 parts of Fructus Amomis and Lignum Santali Albi.
2. require described pharmaceutical composition according to right 1, it is characterized in that the medicine material that raw material contains following weight portion proportioning forms: 20～100 parts in real 300～700 parts of Chinese juniper beach wormwood, 200～600 parts of Radix Salviae Miltiorrhizaes, 200～500 parts of Bulbus Allii Macrostemonis, 200～500 parts of the Rhizoma Pinelliaes, 100～300 parts of Rhizoma Corydalis, 100～300 parts of Pericarpium Citri Reticulataes, 100～300 parts of Fructus Aurantii Immaturuss, 50～200 parts of Ramulus Cinnamomi, 20～100 parts of Fructus Amomis and Lignum Santali Albi.
3. require the pharmaceutical composition of described treatment angina pectoris and gastric abscess according to right 1,2, it is characterized in that the optimised quantity of each raw material is: 50 parts in real 500 parts of Chinese juniper beach wormwood, 400 parts of Radix Salviae Miltiorrhizaes, 300 parts of Bulbus Allii Macrostemonis, 300 parts of the Rhizoma Pinelliaes, 200 parts of Rhizoma Corydalis, 200 parts of Pericarpium Citri Reticulataes, 200 parts of Fructus Aurantii Immaturuss, 100 parts of Ramulus Cinnamomi, 50 parts of Fructus Amomis and Lignum Santali Albi.
4. require described medicine according to right 3, Chinese juniper beach wormwood reality, Radix Salviae Miltiorrhizae, Bulbus Allii Macrostemonis and the Rhizoma Pinelliae powder of described weight portion is broken into coarser powder, 80% alcohol dipping percolation after 48 hours leaves standstill after-filtration, gets supernatant concentration and becomes extractum 1; Rhizoma Corydalis, Pericarpium Citri Reticulatae, Fructus Aurantii Immaturus and the Ramulus Cinnamomi of described weight portion are ground into coarser powder, with 75% alcohol heating reflux twice, each each 2 hours, filter, be condensed into extractum 2; The Lignum Santali Albi of described weight portion and Fructus Amomi are worn into behind the fine powder with a small amount of Chinese liquor dissolving, merged with extractum 1 and extractum 2, spray drying behind the mixing divides the capsule of packing into to get final product.Every capsules 0.5g.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101783422A CN101204559A (en) | 2007-11-29 | 2007-11-29 | Medicaments composite for coronary heart disease, angina and epigastralgia and preparation method thereof |
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| CNA2007101783422A CN101204559A (en) | 2007-11-29 | 2007-11-29 | Medicaments composite for coronary heart disease, angina and epigastralgia and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600420A (en) * | 2012-04-01 | 2012-07-25 | 李承平 | Medicine composition for blood stasis and qi stagnation |
| CN102652822A (en) * | 2012-05-04 | 2012-09-05 | 袁加海 | Traditional Chinese medicine oral liquid used for curing coronary heart disease |
| CN103463394A (en) * | 2013-09-17 | 2013-12-25 | 张春元 | Traditional Chinese medicine composition for treating coronary heart disease angina |
| CN104667174A (en) * | 2015-02-03 | 2015-06-03 | 辽宁中医药大学 | Liquid capsule for treating coronary heart disease with yang deficiency and blood stasis and preparation method of liquid capsule |
| CN105169179A (en) * | 2015-09-18 | 2015-12-23 | 马鞍山德宏堂生物科技有限公司 | Traditional Chinese medicine composition for treating epigastric pain |
| CN105435196A (en) * | 2016-01-02 | 2016-03-30 | 宋士兰 | Externally-applied traditional Chinese medicine ointment for treating qi stagnation and blood stasis coronary angina pectoris with chronic gastritis and preparation method thereof |
| CN111870645A (en) * | 2020-07-09 | 2020-11-03 | 何庆勇 | Composition for treating coronary heart disease, traditional Chinese medicine composition and application thereof |
-
2007
- 2007-11-29 CN CNA2007101783422A patent/CN101204559A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102600420A (en) * | 2012-04-01 | 2012-07-25 | 李承平 | Medicine composition for blood stasis and qi stagnation |
| CN102652822A (en) * | 2012-05-04 | 2012-09-05 | 袁加海 | Traditional Chinese medicine oral liquid used for curing coronary heart disease |
| CN103463394A (en) * | 2013-09-17 | 2013-12-25 | 张春元 | Traditional Chinese medicine composition for treating coronary heart disease angina |
| CN103463394B (en) * | 2013-09-17 | 2015-05-20 | 张春元 | Traditional Chinese medicine composition for treating coronary heart disease angina |
| CN104667174A (en) * | 2015-02-03 | 2015-06-03 | 辽宁中医药大学 | Liquid capsule for treating coronary heart disease with yang deficiency and blood stasis and preparation method of liquid capsule |
| CN104667174B (en) * | 2015-02-03 | 2018-02-06 | 辽宁中医药大学 | A kind of iquid capsule for treating coronary heart disease syndrome of yang deficiency and blood stasis and preparation method thereof |
| CN105169179A (en) * | 2015-09-18 | 2015-12-23 | 马鞍山德宏堂生物科技有限公司 | Traditional Chinese medicine composition for treating epigastric pain |
| CN105435196A (en) * | 2016-01-02 | 2016-03-30 | 宋士兰 | Externally-applied traditional Chinese medicine ointment for treating qi stagnation and blood stasis coronary angina pectoris with chronic gastritis and preparation method thereof |
| CN111870645A (en) * | 2020-07-09 | 2020-11-03 | 何庆勇 | Composition for treating coronary heart disease, traditional Chinese medicine composition and application thereof |
| CN111870645B (en) * | 2020-07-09 | 2022-04-29 | 何庆勇 | Composition for treating coronary heart disease, traditional Chinese medicine composition and application thereof |
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Open date: 20080625 |