CN101199555A - Lactobacillus drug film - Google Patents
Lactobacillus drug film Download PDFInfo
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- CN101199555A CN101199555A CNA200610130288XA CN200610130288A CN101199555A CN 101199555 A CN101199555 A CN 101199555A CN A200610130288X A CNA200610130288X A CN A200610130288XA CN 200610130288 A CN200610130288 A CN 200610130288A CN 101199555 A CN101199555 A CN 101199555A
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- lactobacillus
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- vagina
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Abstract
The invention discloses a lactobacillus drug membrane, belonging to drugs for treating vaginal diseases or medical allocation product containing bacteria. The invention is prepared according to the following weight percentage of the raw materials : chitosan, sucrose fatty acid ester and glycerol, etc. are added into pva solution with polymerization degree of 1500; and then lactobacillus is added into the pva solution ; all the raw materials are well mixed with the pva solution to be reserved; the mixed solution is coated on polyester film of the substrate by the coating machine, and is dried to be made into monolayer drug membrane; and the drug membrane is sheared to have certain area. The lactobacillus drug membrane is applicable to trichomonas vaginitis, mycotic vaginitis, chronic cervicitis and the disease of lactobacillus reduction in the vagina caused by washing the vagina excessively on women.
Description
Technical field
The present invention relates to be used for the treatment of the medicine of vagina, or be the medicine configuration product of feature with the lamellar base material, or the medicine that contains antibacterial disposing product, specifically is a kind of lactobacillus drug film.
Background technology
Normal vagina is not to be aseptic, in the liquid that vagina is arranged, contains a large amount of microorganisms, and facultative lactobacillus accounts for about 80-90%.Lactobacillus is called as vagina " healthy bodyguard ", and has constituted normal vaginal microbial flora with other various bacteria, keeps the normal environment of vagina.Lactobacillus can utilize glucose as substrate, produces lactic acid by it self metabolism, suppresses the excessive multiplication of pathogenic bacterium by the effect of complexity, thereby becomes the natural cover for defense of resisting various malignant bacterias invasions together.Therefore, for the women, over-drastic vagina lavation frequently uses disinfectant such as external washout with traditional Chinese herbs agent, potassium permanganate solution to come washing vagina and pudendum, to a certain extent, is worthless.In the viable count that the healthy women vagina is discharged, the quantity of lactobacillus can reach 8,000 ten thousand/milliliter.So medically often determine the cleannes of vagina and the quality of judgement vagina self-cleaning function with the quantity of lactobacillus in the vaginal secretions.According to investigations, the Urban Women edeitis rose in recent years year by year, and particularly trichomonal vaginitis, colpitis mycotica and chronic cervicitis sickness rate are high in the young women, and one of reason that causes these three kinds of diseases is exactly incorrect cleaning pudendum.
Chinese patent 1097126 discloses " a kind of medical active lactobacillus capsule " a kind of medical active lactobacillus capsule, the main powder-type capsule of forming by active lactobacillus and excipient, it is characterized in that: active lactobacillus mainly is active streptococcus faecalis, lactobacillus acidophilus, its content is greater than 5,000 ten thousand/every gram, and excipient mainly is made up of 1: 1 medical starch and Paris white.Active bacterium of the present invention mainly is to add agar as culture medium isolated spawn culture propagation and getting from lactasinum with the filtrate of boiling bean dregs.The present invention can change " physiology " state of vagina subenvironment by the direct administration of vagina, and vaginitis, cervical erosion etc. is had curative effect preferably.
Chinese patent 1718196 discloses " a kind of pharmaceutical composition, preparation method and application in medical science that contains lactobacillus ", it contains the identification code for the treatment of effective dose is 44346222 lactobacillus, it is 3.75-5.3 that an amount of acid, alkali and pharmacological-acceptable carrier, described an amount of acid, alkali make its mixed pharmaceutical composition pH value.The invention still further relates to this preparation of drug combination method and the application in medical science, particularly the purposes in the medicines such as preparation treatment bacterial vaginitis, colpitis mycotica, gonococcal vaginitis.Confirm by pharmacodynamics test, when the concentration of lactobacillus reaches certain value (1 * 10
7CFU/ gram) after, the suppression ratio of pathogenic bacterium has been reached near 100%.By interior therapeutic bacterial vaginitis experiment confirm, lactobacillus has the sure curative effect of treatment bacterial vaginitis.Confirm by interior therapeutic colpitis mycotica and gonococcal vaginitis experimentation, lactobacillus is on the basis that produces effective therapeutical effect, tool is significantly rebuild the intravaginal microecological environment, replenish normal flora and correct the outstanding advantage of dysbacteriosis, to prophylactic recurrence or infect again and can produce positive effect.
Summary of the invention
The present invention reduces problem in order to solve the vagina lactobacillus that the over-drastic vagina lavation of women, medication cause, and a kind of lactobacillus drug film of directly inserting vagina is provided.
The present invention realizes by following technical scheme.
A kind of lactobacillus drug film, this medicine film prepares by following raw materials by weight percent:
The polyvinyl alcohol of the degree of polymerization 1500 (PVA) 1000g, add cold water 5000ml, be heated to 75-85 ℃, be incubated 72 hours, make aqueous solution, chitosan 75-85g, the sucrose fatty acid ester 90-110g, the glycerol 130-160g that add add the lactobacillus 1.5-3g of hundred million/mg of 0.5-1 then, and mix homogeneously is standby;
With film applicator with above-mentioned mixed bacteria liquid coated on the substrate polyester thin film, 35-40 ℃ of drying made monolayer medicine film, is cut into certain area;
Described lactobacillus drug film, it prepares by following raw materials by weight percent: the polyvinyl alcohol of the degree of polymerization 1500 (PVA) 1000g, add cold water 5000ml, be heated to 80 ℃, be incubated 72 hours, add chitosan 80g, sucrose fatty acid ester 100g, glycerol 150g in the aqueous solution of making, add lactobacillus 3g then, mix homogeneously;
Described lactobacillus drug film, its medicine film contains hundred million/5 * 5cm of lactobacillus 0.5-1.
Make monolayer medicine film with film applicator, be cut into 3000 of the pasters that every 5 * 5cm contains hundred million of lactobacillus 0.5-1.
Its good effect of Zhi Bei the present invention is like this: after the use, make the interior lactobacillus quantity of vaginal secretion surpass 8,000 ten thousand, reach normal level, cough the infection that prevents that vaginal dysbacteriosis from causing.
Using method: get 1 of medicine film 5 * 5cm of the present invention, throw off basement membrane, lactobacillus drug film is inserted vagina get final product.
Store: low temperature, lucifuge, 6 months effect duration.
Indication: women trichomonal vaginitis, colpitis mycotica, chronic cervicitis, and the vagina lactobacillus that the excessive lavation of vagina causes reduces disease.
The specific embodiment
The present invention will be described in detail below in conjunction with embodiment.
Implement sharp 1:
A kind of lactobacillus drug film, this medicine film prepares by following raw materials by weight percent:
Take by weighing polyvinyl alcohol (PVA) 1000g of the degree of polymerization 1500, add cold water 5000ml, be heated to 80 ℃, be incubated 72 hours, add chitosan 80g, sucrose fatty acid ester 100g, glycerol 150g in the aqueous solution of making, add lactobacillus 3g then, mix homogeneously is standby;
The 100000000/mg of market milk acidfast bacilli that the present invention adopts.
With film applicator with above-mentioned mixed bacteria liquid coated on the substrate polyester thin film, make hundred million/5 * 5cm of lactobacillus 0.5-1, through 35-40 ℃ of drying, make monolayer medicine film; Be cut into the area of regulation.
Embodiment 2:
A kind of lactobacillus drug film, this medicine film prepares by following raw materials by weight percent:
Take by weighing polyvinyl alcohol (PVA) 1000g of the degree of polymerization 1500, add cold water 5000ml, be heated to 80 ℃, be incubated 72 hours, add chitosan 85g, sucrose fatty acid ester 110g, glycerol 160g in the aqueous solution of making, add lactobacillus 3g then, mix homogeneously is standby;
With film applicator with above-mentioned mixed bacteria liquid coated on the substrate polyester thin film, make hundred million/5 * 5cm of lactobacillus 0.5-1, through 35-40 ℃ of drying, make monolayer medicine film; Be cut into the area of regulation.
The present invention all has the effect that controls inflammation in various degree to 20-50 year volunteer's 300 clinical practices among the crowd, use a week after, produce effects 153 examples account for 51%, effective 94 examples account for 31%; Total effective rate reaches more than 80%.
Claims (3)
1. lactobacillus drug film is characterized in that this medicine film paster prepares by following raw materials by weight percent:
The polyvinyl alcohol 1000g of the degree of polymerization 1500, add cold water 5000ml, be heated to 75-85 ℃, be incubated 72 hours, make aqueous solution, chitosan 75-85g, the sucrose fatty acid ester 90-110g, the glycerol 130-160g that add add the lactobacillus 1.5-3g of hundred million/mg of 0.5-1 then, and mix homogeneously is standby;
With film applicator with above-mentioned mixed bacteria liquid coated on the substrate polyester thin film, 35-40 ℃ of drying made monolayer medicine film; Be cut into the area of regulation.
2. lactobacillus drug film according to claim 1, it is characterized in that polyvinyl alcohol 1000g by the degree of polymerization 1500, add cold water 5000ml, be heated to 80 ℃, be incubated 72 hours, add chitosan 80g, sucrose fatty acid ester 100g, glycerol 150g in the aqueous solution of making, add lactobacillus 3g then, mix homogeneously.
3. lactobacillus drug film according to claim 1 and 2 is characterized in that this medicine film contains hundred million/5 * 5cm of lactobacillus 0.5-1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200610130288XA CN101199555A (en) | 2006-12-15 | 2006-12-15 | Lactobacillus drug film |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200610130288XA CN101199555A (en) | 2006-12-15 | 2006-12-15 | Lactobacillus drug film |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101199555A true CN101199555A (en) | 2008-06-18 |
Family
ID=39515035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200610130288XA Pending CN101199555A (en) | 2006-12-15 | 2006-12-15 | Lactobacillus drug film |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101199555A (en) |
-
2006
- 2006-12-15 CN CNA200610130288XA patent/CN101199555A/en active Pending
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080618 |