CN101198373A - DC tissue treatment - Google Patents

DC tissue treatment Download PDF

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Publication number
CN101198373A
CN101198373A CNA2006800212297A CN200680021229A CN101198373A CN 101198373 A CN101198373 A CN 101198373A CN A2006800212297 A CNA2006800212297 A CN A2006800212297A CN 200680021229 A CN200680021229 A CN 200680021229A CN 101198373 A CN101198373 A CN 101198373A
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electrode
liner
reactant
tissue
treatment
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Chinese (zh)
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Y·罗森贝格
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ECPoint Medical Inc
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ECPoint Medical Inc
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Abstract

Disclosed are a method and a device useful for performing cosmetic or medical procedures of an in vivo portion of tissue. The method includes contacting an in vivo portion of tissue with a portion of a pad, substantially saturating the pad with a reactant, contacting the pad with a first electrode so that the first electrode is proximate to the portion of the pad proximate to the in vivo portion of tissue. The method further includes contacting the pad with a second electrode so as to provide an electrical path between the first electrode and the second electrode through the reactant, passing a DC voltage through a circuit including the first electrode, the reactant and the second electrode, thereby forming at least one of: an electrolytic effect, and an electrolytic product of the reactant, proximate to the first electrode.

Description

DC tissue treatment
Technical field
The present invention relates to by applying the apparatus and method that higher unidirectional current is used for tissue treatment.
Background technology
Well-known electric current can be used for beauty treatment and medical treatment: continuous or pulse low-voltage DC (unidirectional current) is used for the electrodeposition substance of electrolytic therapy and/or tissue, and alternating current (alternating current) is used for incised tissue.
The electropolishing treatment of tissue comprises (also having other) utilization following mode and definition here:
1. electrophoresis: under the electromotive force effect that puts on the particle electrodes in contact, particle is by liquid or colloid motion.
2. ionotherapy: on intact skin, import ionised species (for example active pharmaceutical ingredient) by applying unidirectional current.
3. electric osmose: under effect of electric field, liquid flows out or sees through biomembrane, and wherein, not charged solute causes that along electric osmose gradient moves.
4. electrolysis drying: utilize electric current to make the electrolysis desiccant enter tissue and from the tissue remove moisture content.
5. coron: produces the motion of particle or liquid owing to electromotive force is different or by the motion generation potential difference of particle or liquid.
6. electricity depilation: utilize electric current to remove hair.
7. electric current is treated tinea unguium: the fungal infection that utilizes electric current treatment fingernail.
Electropolishing treatment is limited to the use low-voltage DC, because HVDC electrical interference N﹠M activity can cause pain and tissue injury.
Yet low-voltage DC is that a kind of effectiveness insufficiently carried out the mode of electrolysis to tissue, often causes the therapeutant deposition deficiency in the tissue.In addition, in order to obtain enough electrodeposition substances, low-voltage DC is treated for a long time, and this may be difficult to stand to accepting treatment person, causes the utilization rate of medical facilities low simultaneously.
Even use low-voltage DC to carry out that electropolishing treatment neither be safe from danger fully.For example, because near the low-voltage DC electrophoresis that carelessness is discharged heart may cause potential fatal ventricular fibrillation.In addition, because electronics can not move in water, the reaction at tissue-electrode interface place often causes the material generation oxidation-reduction reaction that contacts with electrode, often causes tissue injury.
Although there is the low and such shortcoming of treatment time length of efficient, beauty therapeutic also is to use the unidirectional current electropolishing treatment, for example:
Hyperhidrosis
Hyperhidrosis (perspire is too much) mainly occurs in various body surfaces, comprises palm, axillary fossa, sole, face and trunk surface.The usual method for the treatment of light to moderate hyperhidrosis is to use 25% aluminum chloride several times weekly.The hyperhidrosis iontophoresis of failing to respond to any medical treatment in the part commonly used is treated.
Electropolishing treatment uses the device of 15-18mA low-voltage DC is provided, thereby causes the iontophoresis of the solution that generally includes aluminum chloride.Treat several times weekly, continue 20-30 minute at every turn.Remission and patient's satisfaction have sizable difference: many patients think that this therapy takes time very much, efficient low and/or cost high.
There are two kinds of sweat glands, eccrine sweat gland and secreting from sweat gland.The eccrine sweat gland opening is subjected to the control of sympathetic nerve choline at skin, and thermal stimulus and psychology stimulation are all responded.Secrete from sweat gland relevantly with the mammalian sex abnormal smells from the patient, bigger than eccrine sweat gland, opening is discharged adrenergic sympathetic fiber and is arranged at hair follicle.Eccrine sweat gland reacts the different electrical components generations of iontophoresis with secreting from sweat gland probably.With iontophoresis unit more efficiently, not only can make treatment quicker, and use double-current can produce better effect: first electric current is used to secrete from sweat gland, and second electric current is used for eccrine sweat gland.
May using of electropolishing treatment
Except being used for the iontophoresis of hyperhidrosis, much can have benefited from the effectively beauty curing of the dc electrolysis device of effect in addition.
The electricity depilation
With reference to Fig. 1, hair 204 grows from hair follicle 208, because hair follicle 208 is the incomplete as yet cornified zones of hair shaft, so hair follicle 208 absorption electrolysates are very fast.
The life cycle of hair follicle 208 is divided into 3 stages: trophophase, catagen and resting stage.The trophophase stage is the period of active growth.Catagen indicates the decline of hair follicle 208, and the resting stage stage is withholding period.On people's scalp, the trophophase stage continues about 3-4.The catagen stage continues about 2-3, and the resting stage stage continues about 3 months.
Tinea unguium
Tinea unguium is to cause fingernail or toenail thickening, variable color, deformity and/or rimose infection.Deformity mainly is aesthetic problem at first, if but not treat, fingernail will thickening, causes compressing, inflammation and pain in the shoes of sealing.
For diabetics, tinea unguium is general and dangerous; Nearest studies show that what tinea unguium was arranged in the diabetics does not infect the amputation rate height of tinea unguium than those.
Tinea unguium is difficult to treatment because nail growth slowly and also the blood supply that obtains seldom.The tinea unguium pathogen generally includes fungus and/or yeast; Fungal pathogens comprises trichophyton and alpha fungus; The blastomycosis substance comprises white candida mycoderma and Candida parapsilosis.
The every day treatment that partial antifungal therapy need continue 6 months to 1 year can make just that fingernail is got well, clean, thin outward appearance.In addition, exist higher mortality and the treatment after relapse rate.
Accurately directionally separating deposition tinea unguium healing potion at the deep layer endocellular electricity makes the minimizing of treatment number of times possibly and makes the relapse rate step-down.
The photochemistry seborrheic keratosis
The photochemistry seborrheic keratosis is the piece that scale or sclerderm are arranged that appears at the skin surface area that is exposed under the sunlight, for example appears at face, ear, the baldness crown, neck, the back of the hand and forearm and lip.
The photochemistry seborrheic keratosis may be the first step that develops into skin carcinoma.According to estimates, nearly 10% damage (redder, more fragile) than other parts, next step will develop into squamous cell cancer.
The very serious photochemical cheilitis of keratinization disease that appears on the lip may develop into squamous cell cancer.General 1/5th the cancer that is caused by cheilitis shifts.Bigger problem is that the keratinization cancer is not only limited to squamous cell cancer, and may develop into more pernicious metastasis melanin tumor.
For fear of potential bigger diffusion with to the extensive treatment of the malignant tumor that causes subsequently, it is necessary treating.The Therapeutic Method of present photochemical cutin disease comprises curettage, eliminates art, freezing chemical stripping and partial smearing emulsifiable paste, for example comprises the emulsifiable paste of 5-fluorouracil (5-FU).Originally every type treatment all has success in various degree, but some months all had higher recurrent rate after several years.
The root that the treatment of photochemistry seborrheic keratosis must reach in the skin basement membrane is just effective.A kind of after about why photochemical seborrheic keratosis is eliminated again the theory of recurrence be to cause the skin scar for fear and do not carry out above-mentioned treatment in enough depths.A kind of within the basement membrane or under the electrolysis system of deposition of medicament probably can successfully treat the photochemistry seborrheic keratosis, and can not recur, do not have the damage of part excision or cutting yet.
Inoperable tumor
The example that is difficult to the tumor by surgical resection is the cancerization liver tumor.The leukaemia relevant with hepatocarcinoma can not select excision hepatocarcinoma, because in the process of operation, can be diffused in all organs by blood flow and lymphatic vessel easily.
Two types hepatocarcinoma is arranged, hepatocarcinoma and cancer of biliary duct.Hepatocarcinoma is the cancer of hepatocyte (main functional hepatocyte).Hepatocarcinoma is main hepatocarcinoma.Hepatocarcinoma normally is grown in the spheroma in the liver, and invasion and attack are around its normal structure.People with hepatitis virus B infection history has the danger of suffering from hepatocarcinoma.
Cancer of biliary duct is a cholangiocellular carcinoma.Cancer of biliary duct betides bile duct, normally owing to Liver fluke (parasite of a kind of Clonorchis of being called) infection causes.Cancerous cell is difficult to find with X ray along bile duct slabbing or wire growth.
Many hepatocarcinoma cases are come from other organ metastasis.Because it has very high blood fluidity and many biological functions is arranged, so liver is the place of modal viral metastasis cancer cell growth.The tumor regular meeting that results from colon, pancreas, stomach, lung or breast at first is diffused into liver.
The treatment of hepatocarcinoma changes according to the size of tumor.Diameter is eliminated with the ethanol or the acetic acid that are expelled in the tumor usually less than 5 centimetres tumor.
For greater than 5 centimetres tumor, the first-selected therapy of hepatocarcinoma typically uses the chemotherapy that cell toxicant toxin active pharmaceutical ingredient (API) destroys cancerous cell.In tachometer journey each time, API often directly enters Hepatic artery by intravenous injection in large quantities.Usually continue several days a course of treatment, next is the convalescent period of recovering from side effect.The course of treatment, number of times depended on that to the reaction of API how hepatocarcinoma type and it.
Chemotherapeutic API often is gathered in the tissue beyond the liver of quick growth, causes side effects, comprise to the resistance that infects descend, feel sick, aphtha and alopecia.
The normal associating with chemotherapy of X-ray therapy uses or is used for infringement more than 5 centimetres, and its use X ray or other high-energy ray kill cancer cell also makes the tumor atrophy.X-ray therapy regular meeting increases chemotherapeutic side effect.
The electrolysis system of deposition of cells toxic substance in hepatic tissue has the great potential for the treatment of hepatocarcinoma, has improved survival rate and has reduced side effect.
The alternative method of dc electrolysis
Consider that the dc electrolysis treatment of tissue is dangerous and efficient is low, often will use the device of alternating current (alternating current) to be used for electropolishing treatment.Yet, because low frequency ac follows pain and causes muscle and nerve injury, so can only use high-frequency alternating current.
The safe high-frequency alternating current frequency that medical treatment is used has been defined as per second 10,000 or more a plurality of cycle, can not cause muscle contraction like this and can not exert an influence to nerve.Consider that low frequency ac can cause damage, administrative organization is limited in armarium the high frequency more than the 10MHz usually.
High-frequency alternating current can not be used for electrophoretic procedures, because alternating current constantly changes polarity in oscillatory process, causes cell membrane to hinder electrophoresis motion.Therefore, this shortcoming of high-frequency alternating current is limited to its application the tissue treatment that needs higher temperature.For example, alternating current is used for heat production, with resection organization, burn hemorrhage blood vessel and/or destroy excess tissue (comprising the electricity depilation).
The U.S. Patent application U.S.2001023330 that announces discloses a kind of transdermal alternating current Iontophoretic device that the pulse ac electricity of frequency below 100Hz is provided.Yet in order to reduce tissue injury, each pulse duration is less than 2 milliseconds, and is so just similar with the low-voltage DC treatment, reduced deposition and increased treatment time.
United States Patent (USP) 6,553,253 disclose utilize with the AC rectification frequency be lower than 1 megahertz unidirectional current and with electric power delivering therapeutic material.Because this low frequency has the danger that causes ventricular fibrillation, so need the operation of specialty.
The PCT patent application WO2003/103522 that announces discloses and has utilized syringe as first electrode and in conjunction with second remote electrode (similar with the single electrode Electrosurgical system) material to be expelled in the tissue, and electropolishing treatment is provided.
Following article is fully incorporated in this as a reference for the invention provides background technology:
Rosemberg，Y.and?Korenstein，R.″Incorporation?of?macromoleculesinto?cells?and?vesicles?by?low?electric?fields：induction?of?endocytotic-likeprocess″in?Bioelchem.Biophys.Res.Comm.1997，42，275-281.
Antov Y，Barbul?A，Mantsur?H，and?Korenstein?R.″Electroendocytosis：exposure?of?cells?to?pulsed?low?electric?fieldsenhances?adsorption?and?uptake?of?macromolecules″in?BiophysicalJournal?2005，88(3)，2206-2223.
Entin?I，Plotnikov?A，Korenstein?R，Keisari?Y.″Tumor?growthretardation，cure，and?induction?of?antitumor?immunity?in?B16melanoma-bearing?mice?by?low?electric?field-enhanced?chemotherapy″inClinical?Cancer?Research?2003，9(8)，3190-3197.
Nordenstrom BE. " Electrochemical treatment of cancer:Variableresponse to anodic and cathodic fields " American Journal of ClinicalOncology.1989 Dec; 12 (6): 530-6; And the Chinese patent 1042838 of United States Patent (USP) 4,289,135,4,572,214 and 4,974,595 and Nordenstrom etc., or the like.
For the patent that the invention provides background technology comprises:
Utilize electromagnetic energy to destroy the 6th, 063, No. 076 United States Patent (USP) " Method andsystem for removal of hair " of hair sheath;
Utilize 4th, 155, No. 363 United States Patent (USP)s " Electronically controlled apparatus for electrolytic depilation " of rest periods for the electric current of 1-3 second;
Utilize 5th, 443, No. 441 United States Patent (USP)s " Apparatus and method for transdermal delivery of cosmeticcompositions " of about 0.1mA to the interior electric current of about 10mA scope;
Apply the 6th, 039, No. 746 patents " Patch electrolysis system and method for removing hair from skin " of Faradaic current by the sheet that invests skin surface;
Rely on the sedimentary European patent EP 0824003 of iontophoresis " Hair removal device and method " of thioglycolate salt depilatory;
Utilize electromagnetic energy to destroy the open WO2001/87171 " Method andSystem for Removal of Hair with a Conductive Layer " of PCT of hair sheath;
By removing hair and handling the European patent EP 0783347 " Method of Hair Removal " that the hair follicle that exposes suppresses hair regeneration;
Although effectively and fast organize electropolishing treatment that very big demand is arranged and have many good qualities, also do not have to provide to overcome the above-mentioned insufficient device of organizing electropolishing treatment.
Summary of the invention
Embodiments of the invention utilize high electric current to carry out the method and apparatus of effectively and fast organizing electropolishing treatment and not having the problems referred to above by providing, and have successfully overcome of the prior art to the small part defective.
The electropolishing treatment device and the Therapeutic Method of tissue are provided according to an aspect of the present invention; Wherein said device comprises: contain the electrolysis conversion equipment (ECD) of reactant, the described reactant of at least a portion is eletrolyzable.ECD also comprises the liner that immerses reactant substantially, and described liner has the liner lower surface, have the electric insulation layer of the last insulating surface that contact with the liner lower surface substantially and pass through first opening of insulating barrier.In addition, ECD comprises two terminals, described two terminals comprise be used to connect dc source and first and second terminals, at least two electrodes are contact pad designed substantially and have to each other at interval, make first electrode contact that connects first end substantially near the liner of first opening, second electrode contact that connects second end is substantially away from the first opening liner.
In a representational embodiment, described device also comprises the dc source that is connected with described two-terminal, and making the electrode of winning is anode.Alternatively, dc source is connected with described terminal, and making the electrode of winning is negative electrode.
In the representational embodiment of another kind, the liner that is right after opening is flexible, and liner contains the material that is selected from by spinning in the group that cloth, non-woven fabrics, fabric, fiber, sponge material, rubber, cotton material, woollen, polyester and polyamide form.
Alternatively, first opening has and is selected from following shape in the heart: square, oval, annular, circular, rectangle, crooked shape, triangle, circle section or arc.
In the representational embodiment of another kind, at least a portion of reactant is a solution, and reactant contains one of API and salt.Alternatively, reactant selectively contains at least a material that is selected from following group: the API of antimitotic agent, optical active matter, enzyme, atomic particle radioactive substance, immunizing antigen labelling, the API of cell receptor labelling and the API of genetic marker.In the representational embodiment of another kind, described reactant contains at least a material that is selected from the group of being made up of desiccant, depilatory, antifungal and catalyst.
In some representational embodiments, the electrolysate of reactant contains at least a material that is selected from following group: at least a material of the group that the API of the API of antimitotic agent, optical active matter, enzyme, atomic particle radioactive substance, immunizing antigen labelling, the API of cell receptor labelling and genetic marker forms.Perhaps, the electrolysate of described reactant contains at least a material that is selected from the group of being made up of desiccant, depilatory, antifungal and catalyst.In some embodiments, the described reactant of at least a portion is subjected to following at least a on influence: electrophoresis, iontophoresis, electric osmose and coron.
In a kind of representational embodiment, comprise material to the material of small part first electric insulation layer: flexible, pliable and tough, plastic and rigidity with following characteristic.Alternatively, to small part first electric insulation layer not porous pass through gas.
In the representational embodiment of another kind, contain material to the material of small part first electric insulation layer: lining paper tinsel, film, thin slice, thin film, non-woven fabrics and/or spin cloth with following group.Alternatively, first insulant can be selected from the group of being made up of paper, polyester, polyethylene, polypropylene and silicones.The thickness of other first insulating barrier is less than about 5 μ m.Under the another kind of situation, the thickness of first insulating barrier is less than about 100 μ m; In another embodiment, the thickness of first insulating barrier is greater than about 5 μ m.In another embodiment, the thickness of first insulating barrier is greater than about 100 μ m.
Described insulant can cut.
In another representational embodiment, first insulating barrier comprises the lower surface that contacts with first basic unit substantially, and described first basic unit has substantially and aligned first opening of described insulating barrier first opening.
Selectively, the thickness of first basic unit is less than about 15 μ m.Under the another kind of situation, the thickness of first basic unit is less than about 100 μ m; In another embodiment, the thickness of first basic unit is not more than about 15 μ m.Under the another kind of situation, the thickness of first basic unit is not more than about 100 μ m.
In a representational embodiment, first basic unit is selected from the group of being made up of aluminum, rustless steel, noble metal and plastics to small part.
In some representative embodiments, comprise second electric insulation layer, wherein, at least two electrodes and liner are contained between first electric insulation layer and second electric insulation layer.
Alternatively, second electric insulation layer and first electric insulation layer link together substantially, thereby have held liner and at least two electrodes substantially jointly.
In some embodiments, second basic unit has covered second insulating barrier substantially.In addition, be selected from the group of forming by aluminum, rustless steel, noble metal and plastics to small part second basic unit.Alternatively, second basic unit and first basic unit link together substantially, thereby have electrically sealed substantially to small part first and second insulating barriers.
In a representational embodiment, described device also contains the dc source that is connected with described terminal; Dc source provides the voltage at least about 1 volt.Under the another kind of situation, dc source provides the voltage at least about 2 volts; Even at least about 4 volts; Perhaps even at least about 6 volts.
In another embodiment, dc source provides and is not more than about 40 volts voltage; Perhaps dc source provides and is not more than about 60 volts voltage.Alternatively, dc source provides and is not more than about 80 volts voltage; Perhaps dc source provides and is not more than about 100 volts voltage.
In other other representative embodiments, dc source is used to provide the electric current at least about 0.1mA; Perhaps dc source is used to provide the electric current at least about 2mA.Under the another kind of situation, dc source is used to provide the electric current at least about 3mA; Perhaps dc source is used to provide the electric current at least about 4mA.Also have, dc source is used to provide the electric current that is not more than about 100mA; Perhaps dc source is used to provide the electric current that is not more than about 250mA; Also have in other embodiments, dc source is used to provide the electric current that is not more than about 500mA; Perhaps dc source is used to provide the electric current that is not more than about 1000mA.
In a kind of representational embodiment, dc source is used to provide successive electric current.Under the another kind of situation, dc source is used to provide pulse current, and described electric current has at least about 1 * 10 -5The pulse width of second.In other embodiments, described electric current has at least about 3 * 10 -9The pulse width of second.Also have in other embodiments, described electric current has and is not more than about 0.1 second pulse width.Also have in other embodiments, described electric current has and is not more than about 0.01 second pulse width.In other embodiments, described electric current has and is not more than about 1 * 10 -sThe pulse width of second.Also have, in other embodiments, described electric current has and is not more than about 3 * 10 -9The pulse width of second.
In some representational embodiments, the described stepped construction that goes up insulating barrier, liner and a flat of following insulating barrier formation.The stepped construction of described flat is flexible substantially.
In other representative embodiments, first insulating barrier comprises at least two walls that become the angle, defines an internal volume chamber between two walls, and wherein first electrode, second electrode and liner are contained in the described volume.Selectively, described at least two become the wall at angle to form a needle like configuration substantially.Selectively, syringe needle columnar structure is used for piercing tissue.Also have, selectively, described device is substantially in the implantable.
In some embodiments, the tissue in the implantable substantially group of forming by soft tissue, skeleton, cartilage and fluid of described device.
In other representative embodiments, provide described unidirectional current to the one at least in galvanic transducer and the battery by alternating current.
Alternatively, described dc source is used to provide the voltage at least about 1 volt.Under the another kind of situation, described dc source is used to provide the voltage at least about 2 volts; Perhaps, described dc source is used to provide and is not more than about 100 volts voltage.Also have in other the embodiment, described dc source is used to provide and is not more than about 1000 volts voltage.
Also have, in some embodiments, dc source is used to provide continuous current.
In a kind of representational embodiment, the agitator that is connected with the unidirectional current that is provided is provided described device, and described agitator produces at least about 1 * 10 -5The pulse width of second.In other embodiments, described electric current has at least about 3 * 10 -9The pulse width of second.Also have in other embodiments, described electric current has and is not more than about 0.1 second pulse width.
Also have in other embodiments, described electric current has and is not more than about 0.01 second pulse width.In other embodiments, described electric current has and is not more than about 1 * 10 -5The pulse width of second.Also have, in other embodiments, described electric current has and is not more than about 3 * 10 -9The pulse width of second.
In some representational embodiments, described device comprises that at least one is suitable for receiving and amplifying the signal amplifier of at least one unipolar pulse.In addition, described at least one signal amplifier is suitable for providing first polarity to first end, and provides second polarity to second end.
Alternatively, at least one signal amplifier comprises in resistance, electric capacity and the transistor at least a.
In some embodiments, dc source is used to provide the electric current at least about 0.1mA; Perhaps dc source is used to provide the electric current at least about 2mA.Under the another kind of situation, dc source is used to provide the electric current at least about 3mA; Perhaps dc source is used to provide the electric current at least about 4mA.
In some embodiments, dc source is used to provide the electric current that is not more than about 100mA; Perhaps dc source is used to provide the electric current that is not more than about 250mA; Perhaps, dc source is used to provide the electric current that is not more than about 500mA; Perhaps dc source is used to provide the electric current that is not more than about 1000mA.
In some representative embodiments, at least a portion first basic unit conducts electricity.Also have, in other embodiments, described device comprises the lateral electrode that the current-carrying part with first basic unit electrically contacts.Alternatively, lateral electrode is used to produce AC field.In some embodiments, described lateral electrode comprises at least one changer.
In other representative embodiments, described device comprises at least four electrodes, comprises contact pad designed third electrode and the 4th electrode, makes third electrode pass through described reactant and is electrically connected with the 4th electrode.
Alternatively, described device also comprises at least two openings, first opening and second opening, and wherein second opening closes on third electrode.
A kind of method of the interior part of body of treated tissue is provided according to an aspect of the present invention.Described method comprises that the part with in-vivo tissue contacts with the part of liner, allows reactant immerse described liner substantially.Described method also comprises: contact described liner with first electrode, make the part of electrode near close tissue regions in the liner of winning; Contact described liner with second electrode, so that between first electrode and second electrode, provide an electric pathway by described reactant.Described method also comprises: by comprising the circuit transmission unidirectional current of first electrode, reactant and second electrode, thereby at least a effect of the electrolysate of effect of producing electrolysis and reactant occurs near first electrode.
In some representative embodiments, second electrode and tissue regions electricity are isolated so that prevent that substantially electric current from passing through tissue.
In some representational embodiments, described electricity isolation is included between described liner and the in-vivo tissue part near second electrode and puts into an electrical insulator.
In some representational embodiments, the voltage of the electric current that passes through is at least about 1 volt.Under the another kind of situation, the voltage of the electric current that passes through is at least about 2 volts; Even at least about 4 volts; Perhaps even at least about 6 volts.
In other embodiment, provide the voltage that is not more than about 40 volts transmission current; The voltage that is not more than about 60 volts transmission current perhaps is provided.The voltage that is not more than about 80 volts transmission current selectively is provided; Perhaps dc source provides and is not more than about 100 volts voltage.
In other representative embodiments, dc source is used to provide the electric current at least about 0.1mA; Perhaps dc source is used to provide the electric current at least about 2mA.Under the another kind of situation, dc source is used to provide the electric current at least about 3mA; Perhaps dc source is used to provide the electric current at least about 4mA.Also have, dc source is used to provide the electric current that is not more than about 100mA; Perhaps dc source is used to provide the electric current that is not more than about 250mA; Also have in other embodiments, dc source is used to provide the electric current that is not more than about 500mA; Perhaps dc source is used to provide the electric current that is not more than about 1000mA.
In some embodiments, comprise dc source, described dc source is used to provide successive electric current.
In other embodiments, dc source is used to provide pulse current, and described electric current has at least about 1 * 10 -5The pulse width of second.In other embodiments, described electric current has at least about 3 * 10 -9The pulse width of second.Also have in other embodiments, described electric current has and is not more than about 0.1 second pulse width.Also have in other embodiments, described electric current has and is not more than about 0.01 second pulse width.In other embodiments, described electric current has and is not more than about 1 * 10 -5The pulse width of second.Also have, in other embodiments, described electric current has and is not more than about 3 * 10 -9The pulse width of second.
Alternatively, when the transmission unidirectional current, electrolysate is moved and is forming chemical electrical gradient near first electrode of placing along tissue surface, and forms first distance in the surface underneath infiltration of described tissue.
In a representative embodiments, electrolysate increases in time in described subsurface displacement.
In a representative embodiments, realize that the device of described method comprises first opening with transversal zone, along with the increase of migration thing, described product is forming a transversal zone below described surface that the transversal zone of first opening links to each other.
In some representative embodiments, described reactant contains API.Alternatively, described API is selected from the API that the forms group by antifungal, anticarcinogen, depilatory, treatment pre-cancer and hyperhidrosis treatment API, in some embodiments, antifungal API is selected from the group of being made up of miconazole, clotrimazole, econazole, first ketoconazole, ciclopirox olamine, naftifine and terbinafine.
In other embodiments, anticancer API is selected from least a in following group: antimitotic agent, optical active matter, atomic particle radioactive substance, the API immunizing antigen labelling or hereditary change.
In alternate embodiment, depilation API is selected from following group: ornithine mercaptoacetate depilatory and the reactant that produces hydroxidion.
Alternatively, the anti-API of cancer in earlier stage is selected from the group that Jie Sina solution (Jessners solution), trichloroacetic acid, bleomycin (bleomycin), hydroxyurea or fluorouracil (5-FU) are formed.
Also have in some embodiments, described reactant comprises and is selected from following group reactant: the hyperhidrosis therapeutant that comprises aluminum chloride API.In other embodiments, cancer is carried out electropolishing treatment with anticancer API.
In some embodiments, described tissue contains too much hair, and described reactant contains at least a depilation API.
Alternatively, described tissue contains a fungus first folds in a garment, and described product comprises at least one antifungal API.Another kind of situation, described tissue comprise at least one middle cancerous cell, and described reactant comprises at least a anticancer API.
In some other embodiment, described tissue contains at least a hyperhidrosis sweat gland, and described reactant comprises at least a hyperhidrosis therapeutant.
In some optional embodiments, described tissue contains at least one and shows the cornified cell of photochemistry, and described reactant comprises at least a precancerous therapeutant.
Also have in some embodiments, described method comprises alternating voltage is applied to described tissue, thereby strengthened electrolysis.
In other embodiments, described method comprises the lateral electrode that a described tissue of contact is provided, and applies alternating current to described lateral electrode, thereby increases the speed that described product moves.
Also have in other embodiments, described method also comprises with third electrode and contacts described liner with the 4th electrode, an insulating barrier is placed between described tissue and the described liner near described third electrode, at least the transmission of the unidirectional current of 1mA is by described third and fourth electrode, and first electrolysate moves near in the tissue surface of described the 4th electrode.
Alternatively, described first and third electrode have first polarity, the described second and the 4th electrode has opposite polarity.
In some embodiments, comprised second electrolysate, wherein first reactant acts on first polarity, and second reactant acts on opposite polarity.
According to an aspect of the present invention, a kind of beauty method is provided, utilize electropolishing treatment to improve the skin area that lacks aesthetic feeling, described method comprises: the skin area that lacks aesthetic feeling with the liner contact, contact described liner with first electrode with second electrode, an insulating barrier is put between described skin and described second electrode, between first and second electrodes, transmitted unidirectional current, thereby beautify described skin area at least about 1mA.
In some embodiments, skin is at least a in hirsutism skin, tinea skin, hyperhidrosis skin and the photochemistry keratinization skin.
Alternatively, described method also comprises the lateral electrode that the described skin of contact is provided, and applies alternating current to described lateral electrode.
Also have in the representative embodiments, described method also comprises with third and fourth electrode and contacts described skin, and the transmission unidirectional current is by third and fourth electrode, improved the speed of beautifying described skin and beautified at least a in the area of described skin.
Therefore, by being provided for implementing to organize the apparatus and method safely and effectively of electropolishing treatment, embodiments of the present invention have successfully overcome at least some defectives of present known devices; Described device comprises that the control unidirectional current sends structure by the electrolysis of tissue, and this will make an explanation below.
If there is not specified otherwise, the same meaning of all technology used here and the those of ordinary skill common sense in scientific terminology and described field.Although can be used in operation of the present invention or the test with method and material similar or that be equal to described herein, only describe some suitable method and materials below.If contradictory, description that should the edition with parallel text patent comprises explanation.In addition, described material, method and embodiment just are used for explaining rather than in order to limit.
Description of drawings
Here for example unidirectional current tissue treatment of the present invention is described by the reference accompanying drawing.Concrete now with reference to detailed accompanying drawing, be stressed that, shown details only is used for for example and preferred implementation of the present invention is described explanatoryly, and is to think the content of the most useful and easy to understand principle of the present invention and concept nature aspect in order to provide.In view of this consideration, except for the necessary content of the understanding of ultimate principle of the present invention, CONSTRUCTED SPECIFICATION of the present invention is not shown in more detail, makes the those skilled in the art can understand the some forms of the present invention of how specifically implementing in conjunction with the description of these accompanying drawings.
Fig. 1 is the sketch map according to the electrolysis conversion equipment (ECD) with two electrodes of the embodiment of the invention;
Fig. 2 is the sketch map in conjunction with the electrolytic circuit of the ECD of Fig. 1 according to the embodiment of the invention;
Fig. 3 is the block chart according to the device of the circuit of the embodiment of the invention and Fig. 2;
Fig. 4 is the ECD sketch map with three electrodes according to the embodiment of the invention;
Fig. 5 is the electrolytic circuit sketch map in conjunction with the ECD of Fig. 4 according to the embodiment of the invention;
Fig. 6 is the ECD sketch map with four electrodes according to the embodiment of the invention;
Fig. 7 is the electrolytic circuit sketch map in conjunction with the ECD of Fig. 6 according to the embodiment of the invention;
Fig. 8 is the sketch map according to the implantable ECD of the embodiment of the invention;
Fig. 9 is the test set sketch map in conjunction with the ECD of Fig. 1 according to the embodiment of the invention.
The specific embodiment
Loosely say, the present invention relates to utilize to continue or the pulse direct current electric current is improved looks to tissue and/or medical treatment.Can understand principle and operation better with reference to accompanying drawing and corresponding description according to DC tissue treatment of the present invention system.
Before in detail explaining at least one embodiment of the present invention, should be appreciated that application of the present invention is not limited to the configured and disposed details of the assembly that the following description and drawings address/illustrate.The present invention can otherwise realize or operate or finish with several different methods.In addition, should be appreciated that wording used herein and term are for illustration purpose, should not be considered as limited tailor-made usefulness.
Can understand principle of the present invention, purposes and embodiment well with reference to appended explanation, diagram and embodiment, by conscientiously studying appended explanation, diagram and embodiment carefully, the those skilled in the art can realize teaching of the present invention under the situation of not paying creative work or not experimentizing.In the accompanying drawing, same reference number refers to same parts.
Usually, term of using here and laboratory operation program used in the present invention comprise the technology in biology, engineering, material science, medical science and the physics field.These technology all have comprehensive elaboration in the literature.
If there is not additional description, all technology used herein all have identical implication with scientific terminology, can both be understood by the general technical staff of the technical field of the invention.In addition, description, material, method and embodiment are illustrative, are not to limit.Method and material similar to the description here or that be equal to can be used in enforcement of the present invention or the test.
Here employed " comprising " is construed as the described feature of appointment, numerical value, step or parts with speech such as " containing " or similar wording, adds one or more extra features, numerical value, step, parts or its combination but do not get rid of.These speech contained " by ... form " and speech such as " in fact by ... compositions ".
Here the phrase of using " in fact by ... form " or similar wording represent to have described feature, numerical value, step or element; add one or more extra features, numerical value, step, parts or its combination but do not get rid of, be combined under the situation of the basic feature that do not change parts required for protection, device or method in fact and novelty but be only applicable to extra feature, numerical value, step, element or its.
" method " speech is meant mode, means, technology and the program that is used to finish particular task, comprises but is not limited to mode, means, technology and program that the those skilled in the art knows or is easy to the mode, means, technology and the program that develop out from mode, means, technology and the program of knowing.Carry out method of the present invention comprise manually, automatically or both carry out or finish selected task or step in combination.
Teaching of the present invention has been considered at least three kinds of embodiments of system's structure:
Comprise the unitary systems 200 of two electrode ECD (Fig. 2);
Comprise the unitary systems 300 of three electrode ECD (Fig. 5);
Comprise the unitary systems 400 of four electrode ECD (Fig. 7).
For make describe cheer and bright, after system 200 introduced all-sidely, illustrative system 300 and 400 structures that exist and/or the difference on the program again.Here reference system 200 described used any structures, reactant, circuit product or current type, magnitude of voltage, current value and/or pulse width can be applied to system 300 and 400.
The device of two electrodes
With reference to Fig. 1, electrolysis conversion equipment (ECD) described here is meant to have at least one negative electrode 110 (being (+) utmost point 110 among the figure) and at least one anode 130 (being (-) utmost point 130 among the figure) that applies pulse or continuous direct current to it.
2-ECD 143 comprises (+) electrode 110, should electrically contact with (-) electrode 130 by the pad 146 of knitting that is full of reactant 145 by (+) electrode; Reactant 145 generally includes the electrolyte that contains salt and/or API.
Apply unidirectional current to electrode 110 and 130, form ion 184 along pad 146 like this, and the top insulator has prevented that unidirectional current from acting on other object, for example, operator's hands.
In an example embodiment, (compliant) of pad 146 flexibilities of close opening 164.In addition, pad 146 can comprise or can be in fact be made up of in the material of number of different types one or more, and described material comprises and spins cloth, non-woven fabrics, fabric, fiber, sponge material, rubber, cotton material, woollen, polyester fiber and polyamide.
In example embodiment, basic unit 148 comprises one deck layer material, and this material for example can not capillary electrolysis thing 144 interior liquid state and the gaseous reactants that form.Basic unit 148 for example comprises aluminum, rustless steel, noble metal or plastics; Noble metal refers to be selected from the metal of stainless, non-stainless steel metal (titanium, platinum, gold and Nitinol) here.
The common thickness of basic unit 148 is greater than about 15 μ m and less than about 100 μ m.Perhaps, the thickness of basic unit 148 is greater than about 10 μ m and less than about 15 μ m; Described thickness is decided according to the position and the type of electric current, voltage and tissue 188.
Basic unit 148 usually by the insulating barrier 174 that comprises lining paper tinsel, the scraps of paper, thin film, thin slice, film, non-woven fabrics and/or spin cloth with knit pad 146 and insulate mutually.Under the another kind of situation, insulating barrier 174 contains aluminum, rustless steel, noble metal and plastics.
Under the another kind of situation, insulating barrier 174 contains the material of impermeable gas, for example paper, polyester, polyethylene, polypropylene and silicones.In another kind of example embodiment, the material of that net 174 contains is impermeable (for example producing with reactant 144) gas.
The thickness of net 174 is usually greater than about 1 μ m and less than about 15 μ m.Under the another kind of situation, the thickness of insulating barrier 174 is greater than about 5 μ m and less than about 100 μ m; In another embodiment, the thickness of insulating barrier 174 is greater than 100 μ m.
Under the another kind of situation, the thickness of insulating barrier 174 is not more than about 10 μ m or is not more than about 15 μ m; Described different-thickness is decided according to the position of electric current, voltage and tissue 188.
The thin layer that basic unit 148 and insulating barrier 174 combine guarantees that the ion 184 at opening 164 places and reactant 144 can easily enter tissue 188.Window 164 can comprise a variety of shapes, for example square, oval, annular, circular, rectangle, crooked shape, triangle, circle section or arc; For example, the shape that depends on tissue 188 zones of generation treatment.In an example embodiment, in order to treat the tinea unguium fingernail, opening 164 can comprise an arch that covers the fingernail radian.
Alternatively, the operator can be cut into specific shape with opening 164.In an example embodiment, the operator cuts thin basic unit 148 and thin dielectric layer 146 to modify the shape of opening 164.
As seeing some basic unit 148 of the both sides of opening 164 and insulating barrier 146 among Fig. 1.In another kind of example embodiment, opening 164 extends to the direction of hair 204, and opening 164 is open fully in the side near hair 204 like this.In this embodiment, liner 146 even can highlight by border 141 towards hair 204.This embodiment can optionally be used for sensitive organization 188, and wherein curer can be restrained oneself flexible liner 164, but can not adapt to harder basic unit 148 and laying 146.
In a representative embodiments, comprise the textile material of comparison flexibility, the amorphous materials or the porous or more inflexible material of comparison flexibility to the small part liner.
Before using 2-ECD 143, liquid 155 is applied to the surface of tissue 188, with help organizing 188 with the contacting of the ion 184 at opening 164 places.Basic unit 148 covers (+) utmost point 110 and insulating barrier 174, has stoped (+) electric current to enter in the tissue 188 basically.Therefore the electrical connection of (+) utmost point 110 and (-) utmost point 130 is limited to liner 148 basically.
By stoping the inflow of electric current basically, 2-ECD 143 is safe, the dangerous heart accident that can not be correlated with.Electrode 110 and electrode 130 directly contact tissue 188 these structures also avoided above-mentioned any to organizing 188 polarization infringement.
Though owing to electrode 110 and 130 not contact tissue relative safety is provided, 2-ECD 143 has also increased other makes the comfortable feature of patient.For example in many treatments, move to 300mA at 10mA, avoided the heat of reactant 145 and/or product 144 by making 2-ECD 143.
High electric current, the electric current that for example is higher than 1000mA may be given birth to heat and induce reaction thing 145 and/or product 144 are heated, and cause the patient uncomfortable and/or organize 188 impaired.
When electric current passed through blow-out patch 146 between electrode 110 and 130, along with the electrolysis of reactant 145, product 144 moved in the tissue 188 fast.
Electric field in the liner 146 impels ion 184 to diffuse through liner 146 and gather opening 164 along direction 121.The concentration of opening 164 place's ions 184 constantly raises, and forms organizing 188 electrochemical gradients that absorption affinity arranged along direction 123.
Electrolysate 144 and the material serial movement of following enter tissue 188, make the ion at opening 164 places supply with constantly minimizing.Yet ion 184 is constantly produced by reactant 145 electrolysis between (+) utmost point 110 and (-) utmost point 130, makes the ion 184 that produces move on to opening 164.
Electrochemical gradient and suitable reactant 145 make ion 184 move through tissue 188, increased simultaneously electroactive, the described electroactive at least a above-mentioned activity that comprises: ionotherapy, electric osmose, electrolysis drying, coron, electricity depilation and electric current treatment tinea unguium.
For example, when the fingernail of treatment fungal infection, reactant 145 contains Desenex's agent usually, for example miconazole, clotrimazole, econazole, first ketoconazole, ciclopirox olamine, naftifine and terbinafine.
When the treatment cancer, reactant 145 contains at least a anticarcinogen, for example antimitotic agent, optical active matter, atomic particle radioactive substance, the API immunizing antigen labelling or hereditary change.
When handling hair 204 (for example on the person of hirsutism), reactant 145 contains at least a local depilatory, for example ornithine mercaptoacetate depilatory.In addition or as selecting, the reactant 145 that generates hydroxidion will as described belowly be used for generation (OH-) ion.
When treating photochemical seborrheic keratosis, reactant 145 contains at least a part and prevents precancerous medicament, for example Jie Sina solution, trichloroacetic acid, bleomycin (bleomycin), hydroxyurea or fluorouracil (5-FU).
In addition, during the treatment hyperhidrosis, reactant 145 contains a kind of sweat gland desiccant alternatively, for example contains the medicament of aluminum chloride.
In a kind of representational embodiment, cell reaction thing 145 comprises the electropolishing treatment agent, API for example, and API moves through liner 146 and tissue 188 by causing electric action between atom, forms product 144 in tissue 188.
In some embodiments, when for example treating the holostrome skin ulcer, healing potion 145 is included in and forms in the tissue 188 and dry 188 the electrolysis desiccant of organizing.
In addition or as a kind of selection, for example for infective holostrome skin ulcer, reactant 145 comprises the solution of the complex that contains electrolyzer and independent no electric charge healing potion.
In some representational embodiments, healing potion 145 enters in the tissue 188 by liner 146 by the electric osmose gradient that electrolytic ion 184 forms.
In some representational embodiments, reactant 145 forms product 144, for example has the product with reactant 145 essentially identical chemical formulas and/or composition.In other embodiments, product 144 has chemical formula and/or the composition different with reactant 145; This species diversity for example is owing to the interaction with tissue 188 forms.
Use some medicament, product 144 accumulates in the gap of tissue 188; It promptly is a kind of iuntercellular product 144.In other embodiments, product 144 accumulates in the cell of tissue 188, promptly is product 144 in a kind of cell.
As seeing among Fig. 9, the assay device that the inventor makes up comprises a kind of mylar 910, and the major part of this mylar primary stricture window 164 makes electrolysate 144 move in the paper tape 920 simultaneously.
Formula 930 has been summarized the typical consequence that produces: the time, (t) was long more, and the infiltration capacity (p) that product enters paper 920 is just big more.Suppose that paper 920 is roughly corresponding to tissue 188 (Fig. 1).Under this hypothesis, penetrate in the tissue 188 like the application class of ECD-2143 with causing product 144 greater amounts.
Although do not know the basis of the degree of depth and time relation, suppose the surface of electrolysate 144 initial deposition at paper 920 (corresponding to tissue 188).When electrolysate 144 was gathered in the top layer, electric cushioning effect was played on the top layer basically, thereby product 144 obtains having than the conductive passage of high electrochemical in second deep layer.Thereby, suppose that the degree of depth of reactant 144 increases continuously in time.
As opening less on the cross section 164, less here opening 164 has increased the speed that diffuses in the tissue 188.In addition, less opening 164 has been concentrated the deposition of product 144.
For example, when opening 164 hour, reactant 144 forms and extends to the interior narrower cylinder of tissue 188.Make between the size of opening 164, the concentration degree of product and the deposition velocity and can design different ECD-2 Unit 143, specific application is respectively arranged.
For example, in the treatment of (described below) hyperhidrosis, it is too much that the opening 164 of expansion helps treating fast large-area perspire; In (described below) tinea unguium treatment, when infector was positioned at immediate first folds in a garment, the opening 164 of special shape helped product 144 is focused in the long and narrow array.
In some embodiments, extra housing 141 (for example containing metal) is used to gain in strength and/or the further electric 2-ECD 143 of isolation, for example allows to imbed in the tissue, for example in electricity depilation and deep layer oncotherapy.
Embeddable ECD
In a representational embodiment, as shown in Figure 8,2-ECD 800 comprises a successive contact basic unit 148, can embed in the tissue 188 like this.Alternatively, ECD-2 800 tapers or aciculiform termination 820, described termination helps passing, thrusts and/or places in the tissue 188.
For 2-ECD 800 is put into body, for example put into internal organs (for example liver), use peritoneoscope usually with Min. wound; 2-ECD 800 and laparoscopically unite to use obtained treatment and rehabilitation fast, and stayed minimum postoperative scar.
In a representational embodiment, the reactant 144 that is used for the treatment of hepatocarcinoma contains the anticancer agent of immunizing antigen labelling.2-ECD 800 makes the product 145 efficient dispensers of labelling the product of labelling a large amount of and concentrated apace in tumor tissues, and does not diffuse in the whole tissue 188; Reduced side effect owing to anticancer API not really concentrates and/or the general diffusion causes.
Another kind of situation, 2-ECD 800 can implant soft tissue, skeleton, cartilage and mobile place (for example bladder).Alternatively, aluminum, rustless steel, noble metal or plastics are contained at least a portion second basic unit 148.
The integration performance of 2-ECD 800 is very important when implanting especially for a long time in certain embodiments; Basic unit 148, insulating barrier 174, liner 146 and upper insulation layer 128 all are smooth thin slices.Alternatively, described constructed by lamellae is flexible basically.
For example, when carrying out cartilage ion electropolishing treatment, the flexibility that is implanted to the 2-ECD 800 in the joint (for example knee) is very important.Because knee will move, 2-ECD 800 needs flexible with the damage of control to articular surface.When being applied to the tissue 188 (for example knee joint) of skeleton projection, also need flexibility.
System 200
As mentioned above, in system 200 as shown in Figure 2, except receiving continuous unidirectional current, 2-ECD 143 also can the received pulse unidirectional current.In representational embodiment, system 200 comprises the power supply 102 with ground plane 106.
Power supply 102 contains alternating current is converted to galvanic transducer, its provide at least about 1 volt, at least about 2 volts, at least about 4 volts or at least about 6 volts voltage.Under the another kind of situation, power supply 102 provides and is not more than 40 volts, be not more than 60 volts, be not more than 80 volts or be not more than 100 volts voltage.Under the another kind of situation, power supply 102 comprises one or more unidirectional current batteries.
Agitator 250 receives electric energy that power supplys 102 supply with and and then provides the signal of telecommunication 104 that comprises one pole (+) pulse to signal amplifier 150.
Pulse current for example have at least about 0.1 second, at least about 0.01 second, at least about 1 * 10 -5Second or at least about 3 * 10 -9The pulse width of second.
Under the another kind of situation, pulse current for example has and is not more than about 0.1 second, is not more than about 0.01 second, is not more than about 1 * 10 -5Second or be not more than about 3 * 10 -9The pulse width of second.
After receiving pulse current from agitator 250, signal amplifier 150 is amplified to electric current at least about 0.1mA, at least about 2mA, at least about 3mA or at least about 4mA.
Under the another kind of situation, signal amplifier 150 for example is amplified to electric current and is not more than 100mA, is not more than 250mA, is not more than 500mA or is not more than 1000mA.
Signal amplifier 150 generally includes: resistance 182, electric capacity 184 and transistor 152; Transistor 152 is connected with the resistance 160 with ground plane 162.
Electrode 110 is connected with 131 with line end 111 respectively usually with 130, with from power supply 102 received currents.Electrode 110 and 130 provides higher unipolar pulse electric current usually, at 0 volt to change between just (+) 3 volts.Selectively, power supply 102 from least about 1 volt, at least about 2 volts, at least about 4 volts, at least about 6 volts or at least about 40 volts of fluctuations.In addition, power supply 102 upwards fluctuates to and is not more than 40 volts, is not more than 60 volts, is not more than 80 volts or be not more than 100 volts.
The variation of voltage is subjected to the influence of tissue 188 (Fig. 1) type of the potential ionic nature of reactant 145 (Fig. 1), the length of penetration that needs and/or treatment usually.
In one embodiment, agitator 250 is suitable for producing and comprises 1 * 10 -2Second is to 1 * 10 -5Second and/or 1 * 10 -5Second is to 3 * 10 -9The pulse width of second.
In some embodiments, the unipolar pulse that agitator 250 forms in 100kHz and the 300MHz frequency range, this frequency range:
Even if a) under high voltage, also do not excite nerve and muscle;
B) help a large amount of depositions of electrolysate 144, preferably do not cause pain or tissue injury.
In addition, change the power frequency of agitator 250 generations alternatively to promote that product 144 accumulates in the tissue 188 with certain depth and/or structure.
In a representational embodiment, use the frequency of 10MHz to carry out surface texture treatment, for example hyperhidrosis and hair removal; 1MHz is used for stepping on degree of depth treatment, for example photochemistry seborrheic keratosis; 300kHz is used for deep structure, for example the utricule of inflammation; Back a kind of depth therapy is often owing to Sheng Re follows convection current.
Signal generates
Fig. 3 is the sketch map of system 100, wherein, comprises that the power supply 102 of alternating current/unidirectional current transducer is supplied with 0 to 12 volt unidirectional current to signal generator 250.Signal generator 250 be created on 0 and (+) 3-12 volt between the high frequency one pole signal of telecommunication of fluctuation.Voltage obtains amplifying in signal amplifier 252, electric current is elevated to 50-300mA, and is sent to electrode 110 and 130.
Three electrode assemblies
With reference to Fig. 4,3-ECD 140 comprises all elements of 2-ECD 143, increased a lateral electrode 120 that is connected to the positive direct-current electricity by electric capacity 156 in addition, therefore promoted surperficial alternating current lateral electrode 120 to produce alternating current, improve the dynamic movement of product 144 like this, thereby helped the deposition of product 144.
In a representative embodiments, strengthened the deposition of product 144 from the alternating current of lateral electrode 120, mainly be retained on the surface of tissue 188 simultaneously.Based on this reason, the alternating current that can infer from lateral electrode 120 works, and not to organizing the chemical electrical gradient in 188 or the deposition of electrolysate 144 to have a negative impact.
System 300
With reference to Fig. 5, system 300 uses the identical circuit with 2-ECD 143 (Fig. 2) in fact, has only increased the lateral electrode 120 that is connected to (+) electric current by electric capacity 156.
The effective influence that flows to the electric current of lateral electrode 120 is to have produced to strengthen the slight surperficial alternating current that tissue absorbs.System 300 can be used for the API transmission via skin, increases API permeability and treatment speed.
Four electrode assemblies
With reference to Fig. 6,4-ECD 195 comprises two groups of (+) electrodes and (-) electrode:
First (+) electrode 130 and second (-) electrode 110 are first group;
The 3rd (+) electrode 120 and the 4th (-) electrode 190 are second group.
In some representational embodiments:
(+) electrode 130 places the top of opening 165, forms the electrolysate 147 that comes (+) ion 185 and autoreaction thing 149;
The 3rd (+) electrode 120 places the top of opening 164, forms (-) ion 184 and from the electrolysate 145 of reactant 145.
Said structure is for being useful when two kinds of products 144 and 147 of opposite polarity are used for same treatment for example.
Another kind of situation, when treatment need have same polar two kinds of products 144 and 147, but these two kinds of products need be in tissue 188 in conjunction with the time, (-) electrode 110 and 190 places the top of opening 165 and 164 respectively.
In another embodiment, liner 170 and 180 (Fig. 7) has identical polarity, but the electromotive force of liner 170 is different with the electromotive force of liner 180.In a representational embodiment, the 3rd reactant 175 is used for this embodiment, and wherein reactant 175 contains the catalyst that is useful on activation product 144 and 147.
Alternatively, catalyst 175 also has the electrokinetics performance, for example imports tissue 188 by injection.As mentioned above, the galvanic electricity material is made a response to electric potential difference.
In a representational embodiment, product 144 and 147 is deposited on two separate areas, for example diffusion towards each other.Simultaneously, electrokinetics catalyst product 179 is deposited on the 3rd zone, for example between product 144 and 147, makes all these three kinds of products 175,144 and 147 combine, and catalyst is a product 179 with product 144 and 147 catalysis.
Realizing that the mode that above-mentioned three kinds of products move is useful, is useful during for example for the treatment brain injury, and catalysate can not pass through blood brain barrier (BBB) in this case.Can pass through forerunner's reactant of BBB by introducing, and, in cerebral tissue, react, and the required reactant 145 that contains required medicine is provided the local accessible zone (for example brain stem) that 2-ECD 400 is applied to brain.
System 400
With reference to Fig. 7, system 400 is the schematic descriptions to the circuit that comprises 4-ECD 195.Similar with aforementioned system, the electrode 110 and 130 of path 150 on device feature 180 provides electric pulse.The electrode 120 and 190 of alternate path 151 on device feature 170 provides electric pulse.
In addition, the 3rd path 153 is independent mutually to guarantee electric current, pulse width and voltage between parts 180 and 170, makes parts 180 and 170 independently operate.In addition, path 153 causes pulse alternately, therefore when on 180 current impulse being arranged, does not just have pulse on 170, and vice versa.
Biological applications
Before describing other biological application of the present invention in detail, should be appreciated that the details that this application is not limited to following description or exemplifies by embodiment.The present invention can otherwise realize or operate or finish with several different methods.That is to say, should be appreciated that wording used herein and term are for illustrative purposes, and should not be considered as limited tailor-made usefulness.
By analyzing the following examples, other purpose of the present invention, advantage and new feature will be conspicuous for the those skilled in the art, the unqualified effect of described embodiment.In addition, above described and claim each different embodiment required for protection and each side of the present invention can both find experiment support in the following embodiments.
Many biological applications except providing are here be provided in the present invention, for many other application of the present invention and/or modify should be for known to the people who is familiar with this area.
The electricity depilation
With reference to figure 1, as previously mentioned, hair 204 grows from hair follicle 208, and therefore incomplete as yet keratinization absorbs electrolysate rapidly.
Reactant 184 for example comprises salt NaCl or KCl.(OH-) ion from reactant 144 is formed at electrode (-) 130 places, and (H+) produces at electrode (+) 110 places.In a kind of representational embodiment, (OH-) ion that hair follicle 208 absorbs from the reactant 144 of liquid state, thus make hair follicle 208 poison.
Because hair follicle 208 is very little, so only need a spot of (OH-) ion from reactant 144.As long as electrochemical reaction takes place, just can keep high pH gradient.Response speed for example can slow down by add buffer in reactant 184.
In another embodiment, stretch out a syringe needle from electrode (-) 130, described electrode (-) have with Fig. 8 in 2-ECD 800 similar structures, under reactant 184 vehicular situations, described syringe needle is placed near hair follicle 208 relatively and the ion concentration in the hair follicle 208 is changed.
Representative getting in the electrolysis embodiment, termination 820 is sharp keen, so that enter tissue, opening 164 is provided with or is arranged in most advanced and sophisticated 180 li near most advanced and sophisticated 820.Alternatively, liner 146 contains generation OH -And H 2Reactant 145.
Hair follicle 208 is because OH -And poison is at trophophase and resting stage, rather than at catagen.As if yet the hair follicle 208 of catagen can be by providing suitable non-OH -Electrolysate 144 and poisoning; Above-mentioned 2-ECD 800 can provide two kinds of products 144.Therefore, use 2-ECD800 or other embodiment, the treatment of the three phases that hair follicle 208 can be grown focuses in the single therapy.
Tinea unguium
Using system 200 (Fig. 1), tinea unguium treatment behind the fingernail folds in a garment can be used suitable local response thing, described reactant comprises standard Desenex, for example: amorolfine (amorolfine), ciclopirox olamine (ciclopirox olamine), pyrithione sodium (sodiumpyrithione), bifonazole/urea (bifonazole/urea), propyleneglycoles-urea-lactic acid (propylene glycol-urea-lactic acid), imidazoles or allylamine.In order to help being suitable for the good gathering and the deep layer deposition of first folds in a garment, except the opening 164 of above-mentioned molding, basic unit 148 is mutually compound with the bending of fingernail layer to guarantee with the material that insulating barrier 174 also contains bending and/or flexibility.
Though above-mentioned treatment is not also implemented, 2-ECD 143 can help product 145 and be deposited on effectively in the cell, therefore treatment can be defined as weekly, until the infection of having removed fingernail.
Hyperhidrosis
In order to treat main hyperhidrosis, system 400 (Fig. 7) is used for the treatment of multiple types of organization alternatively.
Though the most effective combination the unknown of electric current, voltage and/or pulse width at present, but system 400 provides the selection of two kinds of different electric currents and/or cell reaction thing 145, first kind of electric current and/or cell reaction thing are applicable to the treatment eccrine sweat gland, and second kind of electric current and/or cell reaction thing are applicable to that treatment secretes from sweat gland; Therefore, except the outstanding speed of 4-ECD 195, also improved effectiveness widely.
In addition, the 3-ECD 140 with alternating current lateral electrode 120 also can act on polytype tissue 188.
The surface tumours treatment
Use 3-ECD 140, surface tumours (for example original place phosphor shaped epithelial cell cancer) may respond to the dry treatment of electrolysis that use is similar to the single electrode technology of aforementioned therapies hyperhidrosis.
Expectation can develop in the protection period of this patent and many relevant transfer systems, and " alternating current tissue treatment " speech is intended to comprise in advance all this new techniques.
Here used " pact " be meant ± 10%.
Should be appreciated that for cheer and bright feature descriptions more of the present invention are in the content of different embodiments, these features also can be incorporated in the independent embodiment.On the contrary, for simplicity of exposition, many feature descriptions of the present invention are in the content of a single embodiment, and the sub-combinations thereof of any appropriate also can be separated or carry out to these features.

Claims (24)

1. be used to provide the device of electrolysis tissue treatment, described device comprises:
I) reactant, to the described reactant of small part can electrolysis;
Ii) immerse the liner of described reactant substantially, described liner has the liner lower surface;
Iii) first electric insulation layer, described first electric insulation layer have the last insulating surface that contacts substantially with described liner lower surface and first opening by described insulating barrier;
Iv) two terminals comprise the first terminal and second terminal that are used to be connected to dc source;
V) at least two electrodes, described at least two electrodes contact substantially with described liner and described two electrode each interval one segment distances at least, first electrode of the described the first terminal of connection contacts the described liner of substantially close described first opening like this, and connects the described liner of second electrode contact cardinal principle of described second terminal away from described first opening.
2. device according to claim 1, wherein the liner near described first opening is flexible.
3. device according to claim 1, wherein said reactant contains i) active pharmaceutical ingredient and ii) at least a in the salt.
4. device according to claim 1, wherein said first insulating barrier comprises the lower surface that contacts substantially with first basic unit, described first basic unit has and aligned substantially first opening of described insulating barrier first opening.
5. device according to claim 4 also comprises second electric insulation layer, and wherein, described at least two electrodes and described liner are contained between described first electric insulation layer and described second electric insulation layer.
6. device according to claim 5, wherein said second electric insulation layer and described first electric insulation layer link together substantially, thereby hold described liner and described at least two electrodes substantially jointly.
7. device according to claim 6 comprises second basic unit that covers described second insulating barrier substantially.
8. device according to claim 7, wherein, described second basic unit and described first basic unit link together substantially, thereby have electrically sealed at least a portion of described first and second insulating barriers substantially.
9. device according to claim 8, wherein, the described stepped construction that goes up insulating barrier, described liner and the described formation of insulating barrier down flat.
10. device according to claim 9, wherein, the stepped construction of described flat is flexible substantially.
11. device according to claim 8, wherein, described first insulating barrier comprises at least two walls that become the angle, defines an inner volume between the wall at described at least two one-tenth angles, and wherein said first electrode, described second electrode and described liner are contained in the described cavity volume.
12. device according to claim 11, wherein, described at least two become the wall at angle to form an acicular texture substantially.
13. device according to claim 12, wherein, described acicular texture is used for piercing tissue.
14. device according to claim 1, wherein said device can implant substantially.
15. device according to claim 4, at least a portion of wherein said first basic unit is conducted electricity.
16. device according to claim 15 also comprises the lateral electrode that the described current-carrying part with described first basic unit electrically contacts.
17. device according to claim 16 comprises the alternating current power supply that is connected with described first lateral electrode, therefore described lateral electrode produces AC field.
18. a method for the treatment of the in-vivo tissue part, described method comprises:
I) the in-vivo tissue part is contacted with the part of liner;
Ii) immerse described liner substantially with reactant;
Iii) contact described liner, make described first electrode near close described in-vivo tissue described part partly in the described liner with first electrode;
Iv) contact described liner, thereby between described first electrode and described second electrode, provide an electric pathway by described reactant with second electrode;
V) by comprising the circuit transmission unidirectional current of described first electrode, described reactant and described second electrode,
Thereby form near described first electrode electrolysis and described reactant electrolysate one of at least.
19. method according to claim 18, wherein, described second electrode and described in-vivo tissue part electricity are isolated, to prevent that substantially electric current is by described in-vivo tissue part.
20. method according to claim 19, wherein, described electricity isolation is included between described liner and the described in-vivo tissue part near described second electrode and puts into electrical insulator.
21. method according to claim 18 wherein, is transmitted during the described unidirectional current described electrolysate:
Be moved and form chemical electrical gradient near described first electrode along the surface of described in-vivo tissue part; And
Surface underneath in described in-vivo tissue part penetrates first distance.
22. method according to claim 18 comprises alternating voltage is applied to described in-vivo tissue part, thereby strengthens described electrolysis.
23. method according to claim 22 also comprises:
I) provide the described in-vivo tissue of contact lateral electrode partly;
Ii) apply alternating current to described lateral electrode,
Thereby strengthen described electrolysis by the rate travel that increases described product.
24. a method of utilizing electropolishing treatment to beautify the skin area that lacks aesthetic feeling, described method comprises:
I) contact the skin region that lacks aesthetic feeling with liner;
Ii) contact described liner with second electrode with first electrode;
Iii) insulating barrier is placed between described skin and described second electrode; And
Iv) between described first and second electrodes, transmit unidirectional current, thereby beautify described skin area at least about 1mA.
CNA2006800212297A 2005-04-22 2006-04-20 DC tissue treatment Pending CN101198373A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67378105P 2005-04-22 2005-04-22
US60/673,781 2005-04-22
US60/763,379 2006-01-31

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CN101198373A true CN101198373A (en) 2008-06-11

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Application Number Title Priority Date Filing Date
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Country Link
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103537004A (en) * 2013-09-18 2014-01-29 生物医学投资集团（香港）有限公司 Instrument for treating skin acne and skin ageing
CN107847269A (en) * 2015-05-19 2018-03-27 康培士有限公司 It is exclusively used in the portable equipment of lighting striking and electrodesiccation
WO2021223684A1 (en) * 2020-05-02 2021-11-11 电冷科学有限公司 Device for avoiding tissue damage near active non-ablative electrode

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103537004A (en) * 2013-09-18 2014-01-29 生物医学投资集团（香港）有限公司 Instrument for treating skin acne and skin ageing
CN107847269A (en) * 2015-05-19 2018-03-27 康培士有限公司 It is exclusively used in the portable equipment of lighting striking and electrodesiccation
WO2021223684A1 (en) * 2020-05-02 2021-11-11 电冷科学有限公司 Device for avoiding tissue damage near active non-ablative electrode

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