CN101182380A - Method for synthesizing anti-phase sephadex gel - Google Patents
Method for synthesizing anti-phase sephadex gel Download PDFInfo
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- CN101182380A CN101182380A CNA2006101073984A CN200610107398A CN101182380A CN 101182380 A CN101182380 A CN 101182380A CN A2006101073984 A CNA2006101073984 A CN A2006101073984A CN 200610107398 A CN200610107398 A CN 200610107398A CN 101182380 A CN101182380 A CN 101182380A
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- polyvinyl acetate
- dextran
- epoxy chloropropane
- distilled water
- dissolved
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Abstract
The invention provides a synthesis method of phase-inversion cross-linking polydextran gel. Polydextran and sodium hydroxide are dissolved in distilled water to prepare polydextran lye; an appropriate amount of polyvinyl acetate is weighed and dissolved in epichlorohydrin under the stirring condition to prepare polyvinyl acetate epichlorohydrin solution; under the stirring condition, the polydextran lye is poured into the polyvinyl acetate epichlorohydrin solution for the cross-linking reaction; after being washed in order, the reaction products are dried to prepare the products.
Description
Affiliated technical field:
The present invention relates to a kind of synthetic method of gel, especially a kind of synthetic method of anti-phase sephadex gel.
Background technology:
At present, numerous contrivers in practice, have developed the synthetic method of multiple gel through unremitting effort for many years.By retrieval: China application (patent) number: 01126015.7, the applying date: 2001.08.24
Open (bulletin) number: CN1401423 open (bulletin) day: 2003.03.12
Application (patent) number: 01134029.0 applying date: 2001.10.06
Open (bulletin) number: CN410474 open (bulletin) day: 2003.04.16
Summary of the invention:
The present invention takes by weighing dextran 100g earlier, sodium hydroxide 10g is dissolved in the distilled water of 75ml and is configured to dextran alkali lye, take by weighing polyvinyl acetate 25-60g, under agitation condition, be dissolved in the epoxy chloropropane of 500-900ml, being configured to polyvinyl acetate epoxy chloropropane solution, is under the condition of 500rpm stirring speed, dextran alkali lye is poured into carried out crosslinking reaction in the polyvinyl acetate epoxy chloropropane solution, temperature is 50 ℃, reacts 5 hours.Reaction product is successively with 3 times of amounts ethanol and distilled water washs 3 times, again through 50 ℃ of hyperthermia dryings 2 hours, get final product product.
Technical scheme:
Technical scheme of the present invention is: one. raw material: dextran (molecular weight 40,000) 100g (benchmark), epoxy chloropropane 500-900ml, polyvinyl acetate (molecular weight 3-5 ten thousand) 25-60g, sodium hydroxide 10g, distilled water 75ml.Two. synthesis technique: take by weighing dextran 100g, sodium hydroxide 10g is dissolved in the distilled water of 75ml and is configured to dextran alkali lye, take by weighing polyvinyl acetate 25-60g, being dissolved under agitation condition in the epoxy chloropropane of 500-900ml, being configured to polyvinyl acetate epoxy chloropropane solution, is under the condition of 500rpm stirring speed, dextran alkali lye is poured in polyvinyl acetate and the epoxy chloropropane solution, carry out crosslinking reaction, temperature is 50 ℃, reacts 5 hours.Reaction product is successively with 3 times of amounts ethanol and distilled water washs 3 times, again through 50 ℃ of oven dry 2 hours, get final product product.
Beneficial effect:
The present invention relates to a kind of synthetic method of anti-phase sephadex gel.Have the raw material cheapness, adjustable extent is wide, is polymerization reaction medium with the distilled water of cheapness, the advantage that product cost is low.
Embodiment one:
Raw material: dextran (molecular weight 40,000) 100g (benchmark), epoxy chloropropane 500-900ml, polyvinyl acetate (molecular weight 3-5 ten thousand) 25-60g, sodium hydroxide 10g, distilled water 75ml.Two. synthesis technique: take by weighing dextran 100g, sodium hydroxide 10g is dissolved in the distilled water of 75ml and is configured to dextran alkali lye, take by weighing polyvinyl acetate 25-60g, being dissolved under agitation condition in the epoxy chloropropane of 500-900ml, being configured to polyvinyl acetate epoxy chloropropane solution, is under the condition of 500rpm stirring speed, dextran alkali lye is poured in polyvinyl acetate and the epoxy chloropropane solution, carry out crosslinking reaction, temperature is 50 ℃, reacts 5 hours.Reaction product is successively with 3 times of amounts ethanol and distilled water washs 3 times, again through 50 ℃ of oven dry 2 hours, get final product product.
Embodiment:
One. raw material: dextran (molecular weight 40,000) 100g (benchmark), epoxy chloropropane 500-900ml, polyvinyl acetate (molecular weight 3-5 ten thousand) 25-60g, sodium hydroxide 10g, distilled water 75ml.Two. synthesis technique: take by weighing dextran 100g, sodium hydroxide 10g is dissolved in the distilled water of 75ml and is configured to dextran alkali lye, take by weighing polyvinyl acetate 25-60g, being dissolved under agitation condition in the epoxy chloropropane of 500-900ml, being configured to polyvinyl acetate epoxy chloropropane solution, is under the condition of 500rpm stirring speed, dextran alkali lye is poured in polyvinyl acetate and the epoxy chloropropane solution, carry out crosslinking reaction, temperature is 50 ℃, reacts 5 hours.Reaction product is successively with 3 times of amounts ethanol and distilled water washs 3 times, again through 50 ℃ of oven dry 2 hours, get final product product.
Claims (3)
1. the synthetic method of an anti-phase sephadex gel is characterized in that: one. raw material: the every 100g of dextran is the molecular weight 40,000 of benchmark, molecular weight 3-5 ten thousand, sodium hydroxide 10g, the distilled water 75ml among epoxy chloropropane 500-900ml, the every 25-60g of polyvinyl acetate; Two. synthesis technique: take by weighing dextran 100g, sodium hydroxide 10g is dissolved in the distilled water of 75ml and is configured to dextran alkali lye, take by weighing polyvinyl acetate 25-60g, being dissolved under agitation condition in the epoxy chloropropane of 500-900ml, being configured to polyvinyl acetate epoxy chloropropane solution, is under the condition of 500rpm stirring speed, dextran alkali lye is poured in polyvinyl acetate and the epoxy chloropropane solution, carry out crosslinking reaction, temperature is 50 ℃, reacts 5 hours; Reaction product is successively with 3 times of amounts ethanol and distilled water washs 3 times, again through 50 ℃ of oven dry 2 hours, get final product product.
2. according to the synthetic method of a kind of anti-phase sephadex gel described in the claim 1, it is characterized in that: the every 100g of dextran is the molecular weight 40,000 of benchmark, molecular weight 3-5 ten thousand, sodium hydroxide 10g, the distilled water 75ml among epoxy chloropropane 500-900ml, the every 25-60g of polyvinyl acetate;
3. according to the synthetic method of a kind of anti-phase sephadex gel described in the claim 1, it is characterized in that: take by weighing dextran 100g, sodium hydroxide 10g is dissolved in the distilled water of 75ml and is configured to dextran alkali lye, take by weighing polyvinyl acetate 25-60g, under agitation condition, be dissolved in the epoxy chloropropane of 500-900ml, be configured to polyvinyl acetate epoxy chloropropane solution, stirring speed is under the condition of 500rpm, dextran alkali lye is poured in polyvinyl acetate and the epoxy chloropropane solution, carry out crosslinking reaction, temperature is 50 ℃, reacts 5 hours; Reaction product is successively with 3 times of amounts ethanol and distilled water washs 3 times, again through 50 ℃ of oven dry 2 hours, get final product product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101073984A CN101182380A (en) | 2006-11-13 | 2006-11-13 | Method for synthesizing anti-phase sephadex gel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101073984A CN101182380A (en) | 2006-11-13 | 2006-11-13 | Method for synthesizing anti-phase sephadex gel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101182380A true CN101182380A (en) | 2008-05-21 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006101073984A Pending CN101182380A (en) | 2006-11-13 | 2006-11-13 | Method for synthesizing anti-phase sephadex gel |
Country Status (1)
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| CN (1) | CN101182380A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990440A (en) * | 2014-05-13 | 2014-08-20 | 武汉汇研生物科技有限公司 | Preparation method for glucan bioseparation and purification medium |
| CN107096509A (en) * | 2017-04-13 | 2017-08-29 | 艾美科健（中国）生物医药有限公司 | The sephadex and preparation method of a kind of succinic acid of amido containing α function base |
| CN108721206A (en) * | 2017-04-14 | 2018-11-02 | 常州药物研究所有限公司 | Treat the composition and preparation method thereof of ureteral vesicoureteral reflux, stress incontinence and incontinence of faces |
-
2006
- 2006-11-13 CN CNA2006101073984A patent/CN101182380A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103990440A (en) * | 2014-05-13 | 2014-08-20 | 武汉汇研生物科技有限公司 | Preparation method for glucan bioseparation and purification medium |
| CN107096509A (en) * | 2017-04-13 | 2017-08-29 | 艾美科健（中国）生物医药有限公司 | The sephadex and preparation method of a kind of succinic acid of amido containing α function base |
| CN108721206A (en) * | 2017-04-14 | 2018-11-02 | 常州药物研究所有限公司 | Treat the composition and preparation method thereof of ureteral vesicoureteral reflux, stress incontinence and incontinence of faces |
| CN108721206B (en) * | 2017-04-14 | 2021-11-09 | 常州药物研究所有限公司 | Composition for treating vesicoureteral reflux, stress urinary incontinence and fecal incontinence and preparation method thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Open date: 20080521 |