CN101181412A - Chinese medicine prescription orally taken for curing leukocytopenia - Google Patents
Chinese medicine prescription orally taken for curing leukocytopenia Download PDFInfo
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Abstract
The invention discloses a Chinese traditional medicine formula which is taken orally and used for curing hypoleukocytosis, pertaining to the field of Chinese traditional medicine. The Chinese traditional medicine formula which is taken orally and used for curing the hypoleukocytosis is characterized in that raw materials for making the effective components follow the following weights: 15 grams of angelica, 15 grams of hemlock parsley, 15 grams of radix codonopsitis, 30 grams of spatholobus stem, 20 grams of red paeonia, 15 grams of epimedium, 20 grams of fructus psoraleae, 15 grams of milk veteh, 10 grams of root of rehmannia, 10 grams of dried orange peel and 15 grams of glossy privet fruit. The invention is decocted with water and is taken with one potion a day. Two weeks form a period of treatment. Through clinic experiment, the medicine of the invention gets marked effect in the curing process of the hypoleukocytosis.
Description
Technical field
The present invention relates to a kind of Chinese medicinal formulae of orally taken for curing leukocytopenia, belong to the field of Chinese medicines.
Background technology
Normal person's peripheral blood leucocyte sum is generally 5.0～10.0 * 109/ liter (L), then is called leukopenia if continue to be lower than 4.0 * 109/L.The leukocyte dyspoiesis comprises that the propagation by stem cell lowers or aregeneratory; Leukocyte destroys too much, destroys too much owing to infection, immunology factor make leukocyte, makes leukopenia in the peripheral blood; Granulocyte distributes unusual, owing to a variety of causes makes leukocytosis in the marginal pool, and leukopenia in the circulatory pool, but also form leukopenia.
Leukopenia patient's subjective symptoms is few, and is often with tired, dizzy for the most common, also have loss of appetite in addition, the extremity epidemic disease is soft, insomnia and dreamful sleep, low grade fever, fear of cold, waist epidemic disease, have palpitation and wait disease, often ignored by doctor and patient, examine and be other diseases, must check total white blood cells this moment repeatedly, as continue to be lower than at 4.0 * 109/ o'clock, diagnosable is leukopenia.
Chinese medicine is the traditional medicine of China, and through modern pharmacological research, Chinese medicine just has dual regulation in treatment aspect the hematopathy, not only can improve the immunity of body, stimulates the bone marrow hematogenesis function, and induced apoptosis in leukemia cell lines optionally.Some Chinese medicine can also be induced unusual clone, makes it transfer normal cell to, impels cell differentiation, maturation.
Summary of the invention
The present invention utilizes the strong point of Chinese medicine, and development is except a kind of Chinese medicinal formulae of orally taken for curing leukocytopenia, and it can overcome the deficiency of Chinese and western medicine in the leukopenia therapeutic process, and it is obvious to be used for the treatment of the leukopenia effect.
The present invention is achieved through the following technical solutions: the Chinese medicinal formulae of this kind orally taken for curing leukocytopenia, it is characterized in that, and make the raw materials of effective components medicine and be: Radix Angelicae Sinensis 15 grams by following weight, Rhizoma Chuanxiong 15 grams, Radix Codonopsis 15 grams, Caulis Spatholobi 30 grams, Radix Paeoniae Rubra 20 grams, Herba Epimedii 15 grams, Fructus Psoraleae 20 grams, the Radix Astragali 15 grams, Pericarpium Citri Reticulatae 10 grams, the Radix Rehmanniae 10 grams, Fructus Ligustri Lucidi 15 grams.
Usage: 1 dose of every day, be decocted in water for oral dose.2 weeks were a course of treatment.
Pharmacological action:
Radix Angelicae Sinensis: sweet Wen Zhirun, be the key medicine of enriching blood, enrich blood and invigorate blood circulation, holding concurrently again can dispersing cold for relieving pain.
Rhizoma Chuanxiong: warm in nature, acrid in the mouth.Function with blood-activating and qi-promoting, wind-expelling pain-stopping.Control air-cooled headache revolve dizzy, the arthralgia due to cold clonic spasm of the muscle.
Radix Codonopsis: invigorating the spleen and replenishing QI, promote the production of body fluid, nourish blood.Be used for the empty asthenia of body of deficiency of QI in middle-JIAO, lung qi loses empty cough and asthma, and the two shallow complexions of losing of QI and blood, dizzy cardiopalmus etc.
Caulis Spatholobi: blood circulation promoting and blood stasis dispelling, it is warm in nature, and bitter in the mouth, sweet is returned liver, kidney channel.Have enrich blood, invigorate blood circulation, the effect of collateral dredging.
Radix Paeoniae Rubra: clots absorbing, pain relieving, removing heat from blood, detumescence.Control the stagnant amenorrhea of the stasis of blood, the hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle.
Herba Epimedii: kidney invigorating and YANG supporting, expelling wind and removing dampness.Control the sexual impotence erectile problem, dribbling urination, the muscles and bones contraction is anxious, hemiplegia, weakness of the waist and knees, rheumatic arthralgia, extremity are meciless.
Fructus Psoraleae: reinforcing the kidney and supporting YANG.Control the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.
The Radix Astragali: tonifying Qi and lifting yang, benefit are defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening, diuretic detumescent.Cure mainly weakness of the spleen and stomach, lack of appetite asthenia, deficiency of vital energy blood prostration, exterior deficiency spontaneous perspiration, night sweat.
Pericarpium Citri Reticulatae: preventing phlegm from forming and stopping coughing is arranged, mediation cardiovascular and cerebrovascular vessel, effects such as blood pressure lowering.
The Radix Rehmanniae: clearing up internal heat by using drugs of bitter in taste and cold in nature, Gan Hanzhi moistens yin nourishing, for the refrigerant product that moisten, is good at the nourishing YIN and clearing away heat removing heat from blood.The effect clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, intestine moistening.
Fructus Ligustri Lucidi: invigorating the liver and kidney, strong waist knee joint.Control interior-heat caused by deficiency of YIN, dizziness, the order flower, tinnitus, soreness of the waist and knees, black hair makes eye bright.
Medicine of the present invention has been obtained remarkable result through clinical trial in the therapeutic process of leukopenia.
1 clinical data
1.1 physical data
Among the 60 routine patients, male's 14 examples, women's 46 examples, the age between 19 years old～51 years old, 38 years old mean age.The shortest person of the course of disease 2 months, elder 14 years, average out to 2 years half.In 60 examples except that 10 examples for the first visit patient, all the other 50 examples were all once taken the invalid or curative effect of medicines such as leucogen, adenine phosphate, batilol and were held time less than half a year.Chemicals such as the long-term contact acids of 2 examples, alkali, 9 example long-term contact benzene and ether, 43 examples have long-term contact radar ray history, and 6 examples were all taken for a long time because of gastropathy and rheumatoid arthritis and were suppressed leukocytic medicine in addition, and 2 examples are not found inducement.
1.2 diagnosis basis
1. continuous three peripheral leukocytes are counted all＜4 * 109/L, and average as the level value of treatment proleukocyte counting.2. with infect, symptom or some chronic medical history such as weak, dizzy, poor appetite, stomachache, tinnitus.3. long-term contact strong acid, highly basic, benzene, ether and lonizing radiation history are arranged, once took medicines such as Radix Tripterygii Wilfordii, cimetidine.
1.3 cardinal symptom and sign
That the thin or shape of yellowish complexion shape is contained is impractical, low grade fever, shortness of breath and fatigue, dizzy headache, insomnia and dreamful sleep, abdominal distention poor appetite, cold physique loose stool, skin purpura, and a few patients has hepatosplenomegaly etc.
Before the treatment, 60 routine patients' Hb is 80～130g/L,＜100g/L person 18 examples, 100～130g/L person, 42 examples.The WBC of 60 examples adds up to 1.8～3.5 * 109/L, 1.8～2.0 * 109/L person, 17 examples, 2.0～3.0 * 109/L person, 35 examples, 3.0～3.5 * 109/L person, 18 examples.Platelet＜100 * 109/L person, 14 examples.
2 Therapeutic Method
This group case all adopts Drug therapy of the present invention.Substantially square: Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 15 grams, Radix Codonopsis 15 grams, Caulis Spatholobi 30 grams, Radix Paeoniae Rubra 20 grams, Herba Epimedii 15 grams, Fructus Psoraleae 20 grams, the Radix Astragali 15 grams, Pericarpium Citri Reticulatae 10 grams, the Radix Rehmanniae 10 grams, Fructus Ligustri Lucidi 15 grams.1 dose of every day, be decocted in water for oral dose.2 weeks were a course of treatment.
3 therapeutic outcomes
3.1 curative effect judging standard
The observed value of the meansigma methods of getting continuous three differential blood counts in treatment back after as treatment:
1. produce effects: after treating leukocyte than treatment before increase more than 50%, total white blood cells＞4 * 109/L, the clinical symptoms sign all disappears, and can keep person more than a year after the drug withdrawal.2. effective: after treatment, total white blood cells increases by 20～50% than treatment is preceding, and numeration of leukocyte＞4 * 109/L, clinical symptoms partly disappear, or numeration of leukocyte can not the Sustainer after the drug withdrawal.3. invalid: total white blood cells is than increasing below 20% or not increasing before treating after treating, and the clinical symptoms sign does not have the improver.
3.2 efficacy result
It is the shortest 14 days, the longest 6 months that this organized for 60 routine patient treatment times, and average 97 days, wherein obtain produce effects 26 examples, WBC increases by 54～85% than treatment is preceding, and recurrence more than 1 year is followed up a case by regular visits in drug withdrawal; Increase by 30～44% before effective 31 examples, WBC ratio are controlled, followed up a case by regular visits to 1 year, only partial symptoms does not disappear, and wherein 4 routine WBC can not keep, and obey medicine of the present invention once more and can reach above-mentioned level again.Invalid 3 examples, treatment are more than 1 month, sx only, and WBC does not see rising.Control preceding Hb＜100g/L person, equal＞100g/L after controlling; Control thromboblast＜100 * 109/L person, control the back all＞100 * 109/L, and clinical symptoms is all alleviated or is disappeared.
4 discuss
Leukopenia belongs to the traditional Chinese medical science " asthenia " category.Its pathogeny is thought because due to the asthenia of both the spleen and kidney more.According to patient's clinical manifestation, it is main disease that the deficiency of vital energy appears in most of patients, though " gas " is a notion very widely in Chinese medicine, " gas " effect in human body has determined to comprise the effect of leukocyte at human body.The traditional Chinese medical science is thought the QI and blood homology, gas carries that blood is capable, blood in gas, gas in blood, inseparable, reflected the composition and the function of the said blood of modern medicine in fact, therefore, Qi-tonifying drug has curative effect preferably to leukopenia, and drug main of the present invention to want constituent be QI invigorating class medicine.
Model case has:
Case one: separate certain, woman, 48 years old, people from Shanxi.Dizzy tired out, two lower limbs are heavy, and are weak, the soreness of waist, and inappetence year is surplus.The leukocyte of repeatedly having a blood test fluctuates in 3000/mm
3About, have only 1000/mm when low
3, once used various shengbai drugs, all there is not positive effect, took we continuously three months, symptom is significantly improved, and has received better effects.
Case two: Wang, woman, 48 years old, people from Henan.The time numb limbs and tense tendons discomfort, insomnia and dreamful sleep arranged.The weary pool of the dim Huang of complexion, body of the tongue is light red, white and thin fur, deep,thready and forceless pulse.Deficiency of both the heart and spleen, deficiency of kidney-QI.After taking we treatment five courses of treatment.Hemogram: leukocyte (WBC) 3.2 * 109/L, hemoglobin (HGB) 36g/L, platelet (PLT) 0/L.Continue to take medicine after half a year, it is normal that hemogram recovers.
Case three: Jiang, woman, 34 years old, people from Guangzhou.The patient checks hemogram to certain institute: leukocyte (WBC) 2.8 * 109/L, hemoglobin (HGB) 60g/L, platelet (PLT) 20 * 109/L because of pale complexion, weak two weeks.Give we and take, after four months treatment, leukocyte (WBC) 5.0 * 109/L, hemoglobin (HGB) 119g/L, platelet (PLT) 160 * 109/L follows up a case by regular visits to so far patient health in order.
The specific embodiment
Example one: a kind of Chinese medicinal formulae of orally taken for curing leukocytopenia, making the raw materials of effective components medicine by following weight is: Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 15 grams, Radix Codonopsis 15 grams, Caulis Spatholobi 30 grams, Radix Paeoniae Rubra 20 grams, Herba Epimedii 15 grams, Fructus Psoraleae 20 grams, the Radix Astragali 15 grams, Pericarpium Citri Reticulatae 10 grams, the Radix Rehmanniae 10 grams, Fructus Ligustri Lucidi 15 grams.
Usage: 1 dose of every day, be decocted in water for oral dose.2 weeks were a course of treatment.
Claims (1)
1. the Chinese medicinal formulae of an orally taken for curing leukocytopenia is characterized in that, makes the raw materials of effective components medicine by following weight to be: Radix Angelicae Sinensis 15 grams, Rhizoma Chuanxiong 15 grams, Radix Codonopsis 15 grams, Caulis Spatholobi 30 grams, Radix Paeoniae Rubra 20 grams, Herba Epimedii 15 grams, Fructus Psoraleae 20 grams, the Radix Astragali 15 grams, Pericarpium Citri Reticulatae 10 grams, the Radix Rehmanniae 10 grams, Fructus Ligustri Lucidi 15 grams.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380016A (en) * | 2011-11-22 | 2012-03-21 | 中国人民解放军第三军医大学第二附属医院 | Anti-radiation traditional Chinese medicine composition |
| CN102389511A (en) * | 2011-11-22 | 2012-03-28 | 中国人民解放军第三军医大学第二附属医院 | Anti-radiation Chinese medicine preparation and preparation method thereof |
| CN102885998A (en) * | 2012-11-05 | 2013-01-23 | 陈兴旺 | Medicine composition for preventing or treating bone marrow suppression caused by tumor radiotherapy |
| CN105853724A (en) * | 2016-06-06 | 2016-08-17 | 孙喜艳 | Chinese herbal preparation for treating leucopenia caused by chemoradiotherapy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1311812C (en) * | 2004-09-23 | 2007-04-25 | 内蒙古伊泰医药科技开发有限责任公司 | Preparation method of granular agent for raising leucocyte and its quality control method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102380016A (en) * | 2011-11-22 | 2012-03-21 | 中国人民解放军第三军医大学第二附属医院 | Anti-radiation traditional Chinese medicine composition |
| CN102389511A (en) * | 2011-11-22 | 2012-03-28 | 中国人民解放军第三军医大学第二附属医院 | Anti-radiation Chinese medicine preparation and preparation method thereof |
| CN102380016B (en) * | 2011-11-22 | 2013-09-04 | 中国人民解放军第三军医大学第二附属医院 | Anti-radiation traditional Chinese medicine composition |
| CN102885998A (en) * | 2012-11-05 | 2013-01-23 | 陈兴旺 | Medicine composition for preventing or treating bone marrow suppression caused by tumor radiotherapy |
| CN105853724A (en) * | 2016-06-06 | 2016-08-17 | 孙喜艳 | Chinese herbal preparation for treating leucopenia caused by chemoradiotherapy |
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|---|---|
| CN101181412B (en) | 2011-11-23 |
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