CN101178364B

CN101178364B - Concentration analyzer for urine biology marker based on image sensor

Info

Publication number: CN101178364B
Application number: CN200710044484XA
Authority: CN
Inventors: 袁景淇; 黄杰胜; 丁伟东
Original assignee: Shanghai Jiaotong University
Current assignee: Shanghai Jiaotong University
Priority date: 2007-08-02
Filing date: 2007-08-02
Publication date: 2010-04-14
Anticipated expiration: 2027-08-02
Also published as: CN101178364A

Abstract

The invention relates to a concentration analyzer of urine biological marker which is based on an image sensor, which pertains to the field of medical apparatus, a light source penetrates a sample to provide the transmission light to the image sensor, the image sensor, a keyboard controller and a memory are connected with a data pin and a clock signal pin which are arranged in a singlechip microcomputer, the image sensor is connected with the singlechip microcomputer, an I/O port which presents a state of the keyboard in the keyboard controller is connected with an I/O port of the singlechip microcomputer, an LCD, a printer controller and a clock manager are connected with the corresponding pin of the singlechip microcomputer, a power supply manager provides three lines of voltage, wherein, one line is connected with the image sensor, the second line is connected with the single-chip microcomputer and the image sensor, and the third line is connected with the single-chip microcomputer, the memory, the clock manager, the LCD, the image sensor, the keyboard controller and the printer controller. The invention has simple and compact structure, simple and easy operation and great storage capacity of the information.

Description

Concentration analyzer for urine biology marker based on imageing sensor

Technical field

The present invention relates to a kind of analyser of technical field of medical instruments, particularly a kind of concentration analyzer for urine biology marker based on imageing sensor.

Background technology

The detecting element of existing Urine Analyzer is a test paper, the specific reaction reagent of test paper surface spraying.Urine sample drips to the test paper surface, and biomarker material and reaction reagent contained in the sample play metachromasia, and Urine Analyzer detects the reflectivity of incident light on test paper by light intensity sensor and obtains urine biology marker matter concentration information.The required best monochromatic light light source of different test events is not exclusively the same, therefore needs a plurality of monochromatic light light sources, and needs to carry out light source according to different test events and switch.Used light intensity sensor is generally exported analog quantity, so the class Urine Analyzer has special-purpose analog to digital conversion circuit.Test result is exported in semiquantitative mode, promptly uses the array output feminine gender of unlike signs, positive degree.

Find by prior art documents, Shang Xinjuan is in " developing electro-mechanic product and innovation " (3,68-69,2007) write articles " development of novel Urine Analyzer " on, this article has been introduced a kind of Urine Analyzer, its measuring principle is to adopt silicon photocell measuring samples reflective light intensity, output voltage signal, through shaping filter, deliver to A/D (analog to digital converter), draw urine information by the microprocessor computing again, because the silicon photocell output signal is an analog quantity, need filter shape and carry out analog to digital conversion, cause the hardware and software cost to rise to a certain extent.On the other hand, this appliance requires selects the monochromatic light light source of coupling to carry out irradiating and detecting according to different biomarkers, and making the hardware configuration complexity has increased hardware cost.In addition, this instrument lacks historical test data query function, can not realize monitored for prolonged periods of time, tracking and contrast to user profile.

Summary of the invention

The objective of the invention is to overcome deficiency of the prior art, a kind of concentration analyzer for urine biology marker based on imageing sensor is provided, make it can finish collection of multiple urine biology marker concentration signal and data processing, history data store management and back track function are provided simultaneously.

The present invention is achieved by the following technical solutions, the present invention includes: one-chip computer, storer, timer manager, LCD, power supervisor, imageing sensor, keyboard controller, printer controller and light source, annexation is: light source provides transmitted light for imageing sensor, imageing sensor, keyboard controller links to each other with the clock signal pin with the one-chip computer data pin with storer, 13 pins of imageing sensor, the pin of expression keyboard state in the keyboard controller, 14 pins of LCD, three pins of printer controller, three pins of timer manager all link to each other with one-chip computer, power supervisor links to each other with each building block, and provides power supply for each building block.

Described data pin and clock signal pin are the P0.2 and the P0.3 pin of one-chip computer, and with SIO_C, the SIO_D pin of imageing sensor, SCL, the SDA pin of the SCL of keyboard controller, SDA pin and storer link to each other respectively.

13 I/O pins of described imageing sensor, be VSYNC, HREF, Y7, Y6, Y5, Y4, Y3, Y2, Y1, Y0, PCLK, SIO_D and SIO_C respectively with one-chip computer in I/O mouth P0.19, P0.18, P0.15, P0.14, P0.13, P0.12, P0.11, P0.10, P0.9, P0.8, P0.7, P0.3, P0.2 links to each other, Y7 wherein, Y6, Y5, Y4, Y3, Y2, Y1, Y0 is an imageing sensor color data delivery outlet, VSYNC is the frame signal delivery outlet, HREF is the row signal output, PCLK is the picture element signal delivery outlet, and SIO_D and SIO_C are employed data port of initialisation image sensor internal register and clock mouth; At the imageing sensor initial phase, by SIO_D and two pins of SIO_C the configuration parameter table is write the imageing sensor internal register, one frame image information is to gather by 480 row, every row is gathered 640 points, be in low level state behind high level pulse of VSYNC frame signal mouth output and represent that a two field picture begins transmission, the capable signal port output of HREF high level represents that data line begins transmission, high level state is maintained to delegation's color data output and finishes, and represents the stable Y7 that outputs to of data when PCLK picture element signal mouth is in the rising edge transitional states, Y6, Y5, Y4, Y3, Y2, Y1, Y0 parallel data delivery outlet.One-chip computer is judged the beginning of a frame and the beginning of delegation by inquiry VSYNC frame signal mouth and the capable signal port state of HREF, be in the moment of rising edge saltus step at PCLK picture element signal mouth, parallel sampling Y7, Y6, Y5, Y4, Y3, Y2, Y1, Y0 data, obtain color data, delegation reads next line according to the prompting of HREF signal after finishing again, read up to a frame signal and to finish, one-chip computer carries out data processing to the three primary colors data again.

Three I/O mouth pins of described timer manager, promptly REST, SCLK and I/O respectively with one-chip computer in I/O mouth P1.19, P1.20 link to each other with P1.21.

Three I/O mouth pins of described printer controller, promptly BUSY, T1IN link to each other with P0.1 with I/O mouth P0.21, the P0.0 of one-chip computer respectively with R1OUT.

14 I/O mouths of described LCD pin, promptly DB0, DB1, DB2, DB3, DB4, DB5, DB6, DB7, RES, CS1, CS2, D/I, E and R/W link to each other with P0.4 with I/O mouth P0.22, P0.23, P0.24, P0.25, P0.27, P0.28, P0.29, P0.30, P1.18, P1.17, P1.16, P0.6, the P0.5 of one-chip computer respectively.

The I/O mouth pin of expression keyboard state in the described keyboard controller, promptly INT links to each other with the I/O mouth P0.20 of one-chip computer.

Described one-chip computer is responsible for each module of control and deal with data.

Described imageing sensor is CMOS (complementary metal oxide semiconductor (CMOS)) imageing sensor, receives the instruction of one-chip computer, and images acquired three primary colors data are exported the three primary colors digital quantity, and send digital quantity to one-chip computer.

Described timer manager, after start in the system initialization process by the one-chip computer setting, real-time clock information is provided.

Described printer controller is accepted the instruction of one-chip computer, joins printer outside the control and prints operation, the output measurement result.

The various output informations of described liquid crystal display displays can show Chinese and English operation interface, test result.

Described keyboard controller is responsible for various information input one-chip computers are connected the 4*4 keyboard, realizes numerical value input, affirmation, page turning, deletion, exit function.

Described storer is accepted the instruction of one-chip computer, preserves measurement data and supports data to recall.

Described power supervisor provides three-way power, wherein one the tunnel links to each other with imageing sensor, the second the tunnel links to each other with one-chip computer, imageing sensor, and Third Road links to each other with one-chip computer, storer, timer manager, LCD, imageing sensor, keyboard controller and printer controller.

Described light source adopts the cool white light source, the irradiation testing sample, and its transmitted light is gathered by imageing sensor.

When the present invention works, start at first plugs in, start back system is at first to LCD, timer manager, storer carries out initialization, time state to be adjusted such as then be in, the user can revise the time on date by keyboard operation as required, one-chip computer will be reset timer manager according to user's input, then enter the imageing sensor initial phase, one-chip computer is provided with the imageing sensor internal register, mainly comprise frame frequency, data layout and image sensor design become gathered the three primary colors data pattern, after initialization finishes, to be tested or the inquiry of historical data stage such as enter, if the user person of choosing enters the inquiry of historical data link, one-chip computer will be searched in storer according to the user number of user's input, and be exported this user's test result by LCD; If the user selects to enter the test link, with single white light source irradiation testing sample, testing sample is the potpourri of urine liquid and reaction reagent, one-chip computer sends instruction from the trend imageing sensor, start imageing sensor and gather the three primary colors data of urine image, collection finishes and draw corresponding urine biology marker concentration information after one-chip computer comparison standard colour chart and data correction, by LCD urine information is shown, the instruction that one-chip computer sends print result to printer controller is preserved test result to storer according to user's needs at last.

The present invention has mainly adopted four technical measures: 1) under the irradiation of white light source, utilize imageing sensor to gather the three primary colors data of urine and reagent colour development reaction back image, obtain biomarker concentration information in the urine by comparison standard colour chart and data correction; 2) a series of software and hardware optimization means such as storage space by setting up zone bit, allocated size to equate realize the fast data library management under hardware store finite capacity prerequisite; 3) provide Chinese and English operation interface demonstration, Multi-Function Keyboard, field print and multiple historical data trace back mode; 4) realizing under the prerequisite of required function, adopting that function is strong, compact conformation and cheap components and parts.

Compared with prior art, the advantage that the present invention has is simple and compact for structure, easy and simple to handle, information storage is big can quantitatively be finished collection of urine biology marker concentration signal and data processing in 20 seconds, history data store and back track function are provided.

Description of drawings

Fig. 1 structural representation of the present invention

Embodiment

Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment is being to implement under the prerequisite with the technical solution of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.

As shown in Figure 1, present embodiment comprises: one-chip computer 1, imageing sensor 2, timer manager 3, printer controller 4, LCD 5, keyboard controller 6, storer 7, power supervisor 8, light source 9.

Annexation is: light source 9 provides transmitted light for imageing sensor 2, the data pin P0.2 of one-chip computer 1 and clock signal pin P0.3 pin, respectively with the SIO_C of imageing sensor 2, the SIO_D pin, the SCL of keyboard controller 6, the SCL of SDA pin and storer 7, the SDA pin links to each other, 13 I/O pins of imageing sensor 2, be VSYNC, HREF, Y7, Y6, Y5, Y4, Y3, Y2, Y1, Y0, PCLK, SIO_D and SIO_C respectively with one-chip computer 1 in I/O mouth P0.19, P0.18, P0.15, P0.14, P0.13, P0.12, P0.11, P0.10, P0.9, P0.8, P0.7, P0.3, P0.2 links to each other, the I/O mouth pin of expression keyboard state in the keyboard controller 6, be that INT links to each other with the I/O mouth P0.20 of one-chip computer 1,50 four I/O mouths of LCD pin, be DB0, DB1, DB2, DB3, DB4, DB5, DB6, DB7, RES, CS1, CS2, D/I, E and R/W respectively with the I/O mouth P0.22 of one-chip computer 1, P0.23, P0.24, P0.25, P0.27, P0.28, P0.29, P0.30, P1.18, P1.17, P1.16, P0.6, P0.5 links to each other with P0.4, three I/O mouth pins of printer controller 4, be BUSY, T1IN and R1OUT respectively with the I/O mouth P0.21 of one-chip computer 1, P0.0 links to each other with P0.1, three I/O mouth pins of timer manager 3, be REST, SCLK and I/O respectively with one-chip computer 1 in I/O mouth P1.19, P1.20 links to each other with P1.21, power supervisor 8 links to each other with each building block, and provides power supply for each building block.

Described one-chip computer 1 is responsible for each module of control and deal with data, adopts the LPC2144FB064 cake core.

Described imageing sensor 2, its Y7, Y6, Y5, Y4, Y3, Y2, Y1, Y0 pin are imageing sensor 2 color data delivery outlets, VSYNC is the frame signal delivery outlet, HREF is the row signal output, PCLK is the picture element signal delivery outlet, and SIO_D and SIO_C are employed data port of initialisation image sensor 2 internal registers and clock mouth; At imageing sensor 2 initial phases, by SIO_D and two pins of SIO_C the configuration parameter table is write imageing sensor 2 internal registers, one frame image information is to gather by 480 row, every row is gathered 640 points, be in low level state behind high level pulse of VSYNC frame signal mouth output and represent that a two field picture begins transmission, the capable signal port output of HREF high level represents that data line begins transmission, high level state is maintained to delegation's color data output and finishes, and represents the stable Y7 that outputs to of data when PCLK picture element signal mouth is in the rising edge transitional states, Y6, Y5, Y4, Y3, Y2, Y1, Y0 parallel data delivery outlet.One-chip computer 1 is judged the beginning of a frame and the beginning of delegation by inquiry VSYNC frame signal mouth and the capable signal port state of HREF, be in the moment of rising edge saltus step at PCLK picture element signal mouth, parallel sampling Y7, Y6, Y5, Y4, Y3, Y2, Y1, Y0 data, obtain color data, delegation reads next line according to the prompting of HREF signal after finishing again, read up to a frame signal and to finish, one-chip computer 1 carries out data processing to the three primary colors data again.

Described imageing sensor 2 is CMOS (complementary metal oxide semiconductor (CMOS)) imageing sensor, receive the instruction of one-chip computer 1, images acquired three primary colors data, output three primary colors digital quantity, and give one-chip computer 1 with the data of gathering, imageing sensor 2 adopts the 0V9620 cake cores.

Described timer manager 3 is provided with by one-chip computer 1 in the system initialization process after start, and real-time clock information is provided, and timer manager 3 adopts the HT1381 cake core.

Described printer controller 4 is accepted the instruction of one-chip computer 1, and join printer outside the control and print operation, the output measurement result, printer controller 4 adopts sp3232EEN type control chips.

Described LCD 5 shows various output informations, can show Chinese and English operation interface, test result, and LCD 5 adopts 12864-3 dot matrix display module.

Described keyboard controller 6 is with various information input one-chip computers 1, and keyboard controller 6 adopts the zlg7290cs cake core, connects the 4*4 keyboard, realizes numerical value input, affirmation, page turning, deletion, exit function.

Described storer 7 is accepted the instruction of one-chip computer 1, preserves measurement data and supports data to recall, and storer 7 adopts the CSI24C256WI cake core.

Described power supervisor 8 provides three-way power, wherein one road V1 links to each other with imageing sensor 2, the second road V2 links to each other with one-chip computer 1, imageing sensor 2, and Third Road V3 links to each other with one-chip computer 1, storer 7, timer manager 3, LCD 5, imageing sensor 2, keyboard controller 6 and printer controller 4.

Described light source 9 adopts the cool white light source, and brightness is 1150 milli candelas, the irradiation testing sample, and its transmitted light is gathered by imageing sensor 2.

During present embodiment work, start at first plugs in, start back system is at first to LCD 5, timer manager 3, storer 7 carries out initialization, time state to be adjusted such as then be in, the user can revise the time on date by keyboard operation as required, one-chip computer 1 will be reset timer manager 3 according to user's input, then enter imageing sensor 2 initial phases, 1 pair of imageing sensor 2 internal register of one-chip computer are provided with, mainly comprise frame frequency, data layout and imageing sensor 2 is designed to gather the three primary colors data pattern, after initialization finishes, to be tested or the inquiry of historical data stage such as enter, if the user person of choosing enters the inquiry of historical data link, one-chip computer 1 will be searched in storer 7 according to the user number of user's input, and be exported these users' test result by LCD 5; If the user selects to enter the test link, with single white light source irradiation testing sample, testing sample is the potpourri of urine liquid and reaction reagent, one-chip computer 1 sends instruction from trend imageing sensor 2, start the three primary colors data that imageing sensor 2 is gathered the urine image, collection finishes and draw corresponding urine biology marker concentration information after one-chip computer 1 comparison standard colour chart and data correction, by LCD 5 urine information is shown, the instruction that one-chip computer 1 sends print result to printer controller 4 is preserved test result to storer 7 according to user's needs at last.

Claims

1. concentration analyzer for urine biology marker based on imageing sensor, comprise: one-chip computer (1), imageing sensor (2), LCD (5), power supervisor (8) and light source (9), it is characterized in that, also comprise: timer manager (3), printer controller (4), keyboard controller (6) and storer (7), annexation is: light source (9) provides transmitted light for imageing sensor (2), imageing sensor (2), keyboard controller (6) links to each other with the clock signal pin with the data pin of one-chip computer (1) with storer (7), 13 pins of imageing sensor (2), the pin of expression keyboard state in the keyboard controller (6), 14 pins of LCD (5), (3) three pins of (4) three pins of printer controller and timer manager all link to each other with one-chip computer (1), power supervisor (8) links to each other with each building block, and provide power supply for each building block

Described data pin and clock signal pin, be respectively the P0.2 and the P0.3 pin of one-chip computer (1), the SIO_C pin of the P0.2 pin of one-chip computer (1) and imageing sensor (2), the SCL pin of keyboard controller (6) links to each other with the SCL pin of storer (7), the SIO_D pin of the P0.3 pin of one-chip computer (1) and imageing sensor (2), the SDA pin of keyboard controller (6) links to each other with the SDA pin of storer (7), 13 I/O pins of described imageing sensor (2), be VSYNC, HREF, Y7, Y6, Y5, Y4, Y3, Y2, Y1, Y0, PCLK, SIO_D and SIO_C respectively with one-chip computer (1) in I/O mouth P0.19, P0.18, P0.15, P0.14, P0.13, P0.12, P0.11, P0.10, P0.9, P0.8, P0.7, P0.3, the P0.2 correspondence links to each other one by one, Y7 wherein, Y6, Y5, Y4, Y3, Y2, Y1 and Y0 are imageing sensor (2) color data delivery outlets, VSYNC is the frame signal delivery outlet, HREF is the row signal output, PCLK is the picture element signal delivery outlet, SIO_D and SIO_C are respectively employed data port of initialisation image sensor (2) internal register and clock mouth, at imageing sensor (2) initial phase, by SIO_D and two pins of SIO_C the configuration parameter table is write imageing sensor (2) internal register, one frame image information is to gather by 480 row, every row is gathered 640 points, be in low level state behind high level pulse of VSYNC frame signal mouth output and represent that a two field picture begins transmission, the capable signal port output of HREF high level represents that data line begins transmission, high level state is maintained to delegation's color data output and finishes, when being in the rising edge transitional states, PCLK picture element signal mouth represents the stable Y7 that outputs to of data, Y6, Y5, Y4, Y3, Y2, Y1 and Y0 parallel data delivery outlet, one-chip computer (1) is judged the beginning of a frame and the beginning of delegation by inquiry VSYNC frame signal mouth and the capable signal port state of HREF, be in the moment of rising edge saltus step at PCLK picture element signal mouth, parallel sampling Y7, Y6, Y5, Y4, Y3, Y2, Y1 and Y0 data, obtain color data, delegation reads next line according to the prompting of HREF signal after finishing again, read up to a frame signal and to finish, one-chip computer (1) carries out data processing to the three primary colors data again.

2. the concentration analyzer for urine biology marker based on imageing sensor according to claim 1, it is characterized in that, described imageing sensor (2) is a cmos image sensor, receive the instruction of one-chip computer (1), images acquired three primary colors data, export the three primary colors digital quantity, and give one-chip computer (1) the data of gathering.

3. the concentration analyzer for urine biology marker based on imageing sensor according to claim 1, it is characterized in that, three I/O mouth pins of described timer manager (3), promptly REST, SCLK and I/O respectively with one-chip computer (1) in I/O mouth P1.19, P1.20 correspondingly with P1.21 link to each other one by one.

4. the concentration analyzer for urine biology marker based on imageing sensor according to claim 1, it is characterized in that, three I/O mouth pins of described printer controller (4), promptly BUSY, T1IN and R1OUT link to each other one by one with I/O mouth P0.21, the P0.0 of one-chip computer (1) is corresponding with P0.1 respectively.

5. the concentration analyzer for urine biology marker based on imageing sensor according to claim 1, it is characterized in that, 14 I/O mouth pins of described LCD (5), promptly DB0, DB1, DB2, DB3, DB4, DB5, DB6, DB7, RES, CS1, CS2, D/I, E and R/W link to each other one by one with I/O mouth P0.22, P0.23, P0.24, P0.25, P0.27, P0.28, P0.29, P0.30, P1.18, P1.17, P1.16, P0.6, the P0.5 of one-chip computer (1) is corresponding with P0.4 respectively.

6. the concentration analyzer for urine biology marker based on imageing sensor according to claim 1 is characterized in that, the I/O mouth pin of expression keyboard state in the described keyboard controller (6), and promptly INT links to each other with the I/O mouth P0.20 of one-chip computer (1).

7. the concentration analyzer for urine biology marker based on imageing sensor according to claim 1, it is characterized in that, described power supervisor (8) provides three-way power, wherein one the tunnel links to each other with imageing sensor (2), the second the tunnel links to each other with imageing sensor (2) with one-chip computer (1), and Third Road links to each other with one-chip computer (1), storer (7), timer manager (3), LCD (5), imageing sensor (2), keyboard controller (6) and printer controller (4).