CN101177540B - Method for preparing lutein water-soluble dry powder - Google Patents
Method for preparing lutein water-soluble dry powder Download PDFInfo
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Abstract
The invention discloses a preparation method of a food grade phylloxanthin water-soluble dry powder. The content of the all-trans isomer of the active ingredient of the product obtained by means of the prior method is low with an amorphous structure, so that the coloring effect or bioavailability of the product is affected. The procedures of the invention are as follows: when a phylloxanthin crystal is mixed with a low boiling point and volatile organic solvent which has a big solubility to the phylloxanthin crystal, and then the mixer is heated and dissolved so as to get an oil phase; a modified starch is mixed with water, and the mixer is warmed up and dissolved, then is cooled so as to get a water phase; the oil phase is slowly added into the water phase after mixed around, so that an emulsive mixed liquor is gotten; the emulsive mixed liquor is uniform through a high-pressure uniform machine, thereby the latex grain diameter can reach the nanometer level; the organic solvent in the latex system can be removed by a conventional separation method; the normal water in the latex can be removed to get the dry powder by a spray drying process or spray starch fluidized bed drying process. The invention can greatly improve the all-trans content of the active ingredient of the termination product in amorphous form, thereby the invention has the advantages of good coloring and nutrition strengthening effects.
Description
Technical field
The natural pigment that the present invention relates to eat, specifically a kind of is the preparation method of the food grade products lutein water-soluble dry powder of raw material extraction with the Flower of Aztec Marigold.
Background technology
Xenthophylls has another name called " plant lutein ", is a kind of natural pigment that extensively is present in vegetables, flowers, fruit and some biology, belongs to carotenoids, molecular formula C
40H
56O
2, molecular weight 568.85 is a kind of natural antioxidants, tinting material and nutritious supplementary of excellent performance.Modern medicine studies confirm that: a certain amount of xenthophylls, and can resist cell and organ senescence that free radical causes, thereby can prevent because of cardiovascular diseases, tumour and visual deterioration that organ senescence causes and disease such as blind.In addition, confirmed also in recent years in xenthophylls and the human body that " because age cause look macular degeneration (ARMD) " disease is relevant, xenthophylls and its isomers zeaxanthin are two kinds of carotenoid of unique existence in the human eye, they have constituted the macular pigment of human eye jointly, macular pigment can filter out the blue light on infringement sight sensor and the retinochrome, and eyes are protected; And many discovering, xenthophylls is relevant with human lenticular readability.A large amount of food that contain carotenoid of taking in can reduce cataractous generation.The content of xenthophylls and cataractous sickness rate are negative correlation in the intake of xenthophylls and the blood.If take in the xenthophylls and the zeaxanthin of q.s, the women suffers from cataractous risk can reduce by 22%; The male sex can reduce by 19%.Simultaneously, newest research results shows: xenthophylls has restraining effect to multiple cancer (as mammary cancer, prostate cancer, the rectum cancer, colorectal carcinoma, skin carcinoma etc.).In vitro study also shows: xenthophylls is more effective than β-Hu Luobusu aspect inhibition cytolemma lipid autoxidation and inducing cell damage.The xenthophylls monomer can be made into multiple skincare product and makeup, is used for protecting the health of skin, prevents skin damage.
The main application of xenthophylls was as livestock fodder additives in the past, usually added in the animal-feed as tinting material.Be mainly used in laying hen and the broiler fodder, to increase yolk and cock skin, beak, pin shin color and luster.But, caused the interest that people are increasing based on the xenthophylls special physiological properties.U.S. FDA nineteen ninety-five with regard to approved xenthophylls be used for food as food supplement, to improve its nutritive value.As be used for benefit and look beverage and infant or baby food.The result of a large amount of clinical detection shows: the recommended intake of human body every day is 6mg, and under this intake, the xenthophylls concentration after 45 days in the blood reaches the highest.
The rules problem that domestic xenthophylls is used in food can be resolved very soon, and xenthophylls just can be used as a kind of nutrition-fortifying agent or tinting material is applied in the food.But xenthophylls is a kind of carotenoid, has the two keys more than nine in the molecular structure, and is very responsive to environment such as light, heat, oxygen, very easily oxidized destruction.And xenthophylls is water-fast, and the solubleness in fat or oil is also very low.These character of xenthophylls such as limited solubleness and oxidation extremely sensitive limited it in food and independent direct application, particularly to those water-based food such as beverage, jelly and jam food, frozen product and bakery product class, because xenthophylls is insoluble at all therein, and, when lutein crystal was directly used, the existence of coarse crystallization form can have influence on animal body or absorption by human body and the coloring effect when using greatly.
CN1; 101; 425C has described the preparation method that the stable water dispersion of a kind of xenthophylls and stable water can disperse dried powder; in order to prevent to produce xenthophylls floss precipitation in process of production; with the mixture that contains a kind of lower molecular weight non-gelling proteolysate and at least a high molecular gel gelatin at least as protective colloid; it makes water-soluble dry powder again with after the aqueous isopropanol of lutein crystal mixes.In this technology, use the TRANSIENT HIGH TEMPERATURE high-tension apparatus, difficult operation in the production, the solvent boiling point that uses is higher, causes in the finished product in the xenthophylls aqueous dispersions system that the alltrans content of isomer has only 50% in the active compound, has influence on the biological activity of product.
CN1; 125; 145C relates to can the loose preparation method of dry powder powder of a kind of xenthophylls stable aqueous dispersion and stable water; the protective colloid that uses in the method is sodium-caseinate or casein; but as CN1; 101; that mentions among the 425C is such; use higher solvent of boiling point such as Virahol in the technology; the process top temperature reaches 240 ℃; the alltrans content of isomer that causes active ingredient in the finished product about 50%, this for be applied to xenthophylls in the foodstuff additive or when Food fortification or medicine bioactive raising be far from being enough, and use high-tension apparatus in the process.
In a word, operational condition is had relatively high expectations among the preparation method of the lutein water-soluble preparation that above-mentioned these known technologies disclose, and suitability for industrialized production is difficult; Lutein crystal is not carried out good embedding protection, and the stability of product is not good; The content of the alltrans isomer of active ingredient is low in the finished product, generally about 50%, and undefined structure, thus influenced the coloring effect or the bioavailability of product.
Summary of the invention
Technical problem to be solved by this invention is to overcome the defective that above-mentioned prior art exists, a kind of preparation method who is easy to the lutein water-soluble dry powder of suitability for industrialized production is provided, alltrans content of isomer height in the product that obtains, complete is unformed, and the coloring effect when using to improve xenthophylls also increases optical density or bioavailability.
For this reason, the present invention adopts following technical scheme: the preparation method of lutein water-soluble dry powder, and its step is as follows:
A) xenthophylls cellulose crystal and lower boiling, volatile and the big organic solvent of xenthophylls cellulose crystal solubleness mixed after, heating for dissolving, get oil phase, the organic solvent boiling point that uses is low and volatile, but big to the solubleness of lutein crystal, so solvent temperature is lower, generally be no more than 100 ℃, this is quite important for the ratio that keeps alltrans isomer in the raw material xenthophylls, and in follow-up process, organic solvent ratio in the emulsion system is easier to remove, and dissolvent residual is low in the product;
B) modified starch is mixed with water, rising temperature for dissolving, cool off again water, modified starch carries out good embedding protection, good stability of products to lutein crystal; Modified starch is different from the proteic plyability colloid that relates in the existing method, and this is popular concerning the more sensitive human consumer of animal colloid to some;
C) oil phase is under agitation slowly joined aqueous phase, the mixed solution after the emulsification;
D) mixed solution after the emulsification is even by the high-pressure uniform machine, make emulsion particle diameter reach nano level, it is even to carry out secondary as required, and emulsion particle diameter can reach the ideal fineness, and this can overcome in the conventional method the defective that active compound in the emulsion described or the dry powder easily is cross-linked to form flocculation;
E) remove the organic solvent in the emulsion system by conventional separation method as distillation, concentrating under reduced pressure, the organic solvent of recovery can be applied mechanically when producing next time, has so reduced production cost, can reduce environmental protection pressure again;
F) remove moisture content in the emulsion with spray-drying process or spraying-starch fluid-bed drying, get free flowable dry powder.Moisture content is removed with spraying-starch fluidized-bed dry technology, and what obtain is the bigger xenthophylls particulate of grain diameter, this particulate good fluidity, and dust is few, is easier to add in food.
The xenthophylls dry powder that the present invention obtains is water-soluble good, and wherein active ingredient alltrans content height reaches more than 90%, and is unformed entirely, be re-dubbed in the aqueous solution after, emulsion particle diameter is between 100-300nm.Product can be directly with dry powder form or be made into certain density stock solution and be applied to bakery product, frozen product, beverage, jelly and jam food etc., physical stability and chemical stability are all better in processing and storage process, has good painted and nutritional fortification function, aspect coloring effect, it is more bright-coloured more tempting than β-Hu Luobusu, and more lasting.
The preparation method of described lutein water-soluble dry powder, organic solvent is ketone, ester class or heterocyclic solvent, and ketones solvent is acetone or butanone, and esters solvent is ethyl acetate, propyl acetate or isobutyl acetate, and the heterocyclic solvent is a tetrahydrofuran (THF).These organic solvent boiling points are low and volatile, and big to the solubleness of lutein crystal, solvent temperature is lower, generally are no more than 100 ℃.
The preparation method of described lutein water-soluble dry powder, the add-on of organic solvent are 15-25 times of lutein crystal add-on, and xenthophylls is dissolved in organic solvent fully.
The preparation method of described lutein water-soluble dry powder, the add-on of modified starch are the 30-60% of the finished product dry powder weight.
The preparation method of described lutein water-soluble dry powder in step a), has added any or the mixture more than two kinds in emulsifying agent, antioxidant, the vegetables oil in oil phase, to guarantee emulsion preparation or the stability of power-product in storage process.
The preparation method of described lutein water-soluble dry powder, described emulsifying agent is a fatty acid esters of sorbitan, Ascorbyl Palmitate, sapn or tween, its add-on is the 2-8% of the finished product dry powder weight; Described antioxidant is a vitamin-E, and the tertiary butyl is to cresorcin or butylhydroxy anisole, and its add-on is the 2-5% of the finished product dry powder weight; Described vegetables oil is sunflower seed oil, rapeseed oil, soybean oil or Semen Maydis oil, and its add-on is the 10-25% of the finished product dry powder weight.
The preparation method of described lutein water-soluble dry powder in step b), has added weighting agent at aqueous phase, and described weighting agent is sucrose, lactose, glucose, dextrin, glycerine or N.F,USP MANNITOL, and its add-on is the 20-45% of the finished product dry powder weight.
The preparation method of described lutein water-soluble dry powder, in step a), the temperature during dissolving is 50-110 ℃; In step b), the temperature during dissolving is 70-90 ℃, and cooling temperature is at 30-50 ℃.
The preparation method of described lutein water-soluble dry powder, the uniform pressure during high-pressure uniform is 10-60MPa, is the emulsion of wall material with the modified starch, after high-pressure uniform, emulsion particle diameter can reach the ideal fineness, is nano level.
The present invention has following beneficial effect: the protectiveness wall material that 1) uses is the single-material modified starch, rather than the proteic plyability colloid in the existing method, and this is popular concerning the more sensitive human consumer of animal colloid to some; 2) organic solvent of Shi Yonging is big to the solubleness of lutein crystal, and required solvent multiple is little, and solvent temperature is low, has improved the content of the alltrans of active ingredient in the finished product greatly; 3) use the high-pressure uniform process in present method, make the emulsion particle diameter that obtains less, reach the sodium meter level, and can not form intergranular flocculation, overcome the defective in the existing method; 4) the xenthophylls particulate good fluidity that uses spraying-starch bed fluidized drying technology drying to obtain, dust is few, is easy to add in food; 5) xenthophylls dry powder is applied in the food, is that physical stability or chemical stability are all better, and good painted and nutritional fortification effect is arranged.
Invention is applied in the food with natural pigment, in food such as orange beverage, milk-contained drink, milk tea, jelly, ice-creams, bakery product, investigates stability, comprises physical stability and chemical stability.Addition manner is made the certain density aqueous solution for earlier the natural pigment of invention usefulness being dissolved in a certain amount of water, add according to the actual production processing requirement, also can directly make an addition to dry powder in the food; Condition of storage normal temperature, natural light; Storage time makes a living 1 week of postpartum, 2 weeks, 4 weeks, 2 months, 3 months, 6 months; Whether physical stability investigates that index comprises that color and luster changes, whether precipitation is arranged, whether has that floss is separated out, whether layering, separate out or the like; The content that adopts high-efficient liquid phase technique to measure natural pigment is investigated its chemical stability in food.
The present invention can illustrate with the following example, but the present invention is not limited by listed embodiment.
Embodiment
Embodiment 1
The thorough mixing in the 1000ml there-necked flask with 30g lutein crystal and 650g acetone adds the 6.0g mixed tocopherol again, and the 3.0g fatty acid esters of sorbitan is warmed up to 60 ℃ of following insulation dissolving 0.5hr with mixed solution after mixing and makes oil phase.75.0g modified starch and 136.0g glucose dissolve 0.5hr down at 80 ℃ in the 600ml deionized water, cool to 40 ℃ again, and is stand-by.
Under the high speed shear situation, oil phase is slowly joined the aqueous phase mixing and emulsifying, after with emulsion through high pressure homogenizer even, used pressure is 45MPa, the homogeneous secondary reaches about 250nm final emulsion particle diameter.Boil off organic solvent-acetone and part moisture under the decompression situation, make in the final emulsion solid content about 40%, remove remaining exhausted most moisture and emulsion is become dry powder particle by spray-drying process.
Obtain 236.8g orange xenthophylls dry powder powder at last, wherein the content of xenthophylls is 10.2%, and dry powder is water-soluble fine, the median size of back active ingredient in water of redissolving is 285nm, active ingredient alltrans content of isomer reaches 91.2%, and is unformed entirely, the biological activity height.
Embodiment 2
The thorough mixing in reactor with 18kg lutein crystal and 450kg ethyl acetate adds the 10kg mixed tocopherol, the 5.0kg Quicifal again, 8.0kg sunflower seed oil, mix the back at 80 ℃ of following stirring and dissolving 0.5hr, form clear solution, be oil phase.75.0kg modified starch is scattered in the 200kg water, adds 120.0kg sucrose, mixes the back and dissolves fully down in 80 ℃, is cooled to 45 ℃, and is standby as water.
Under the high speed shear situation, oil phase is slowly joined the aqueous phase mixing and emulsifying, after with emulsion through high pressure homogenizer even, used pressure is 60MPa, the homogeneous secondary reaches about 170nm final emulsion particle diameter.Organic solvent ethyl acetate and deionized water are partly sloughed in decompression, make that solid content becomes emulsion into particulate by spraying-starch bed fluidized drying method in the final emulsion about 55%.
Obtain 225.3g orange xenthophylls dry powder particulate at last, wherein the content of xenthophylls is 5.56%, and dry powder is water-soluble fine, the median size of back active ingredient in water of redissolving is 186nm, active ingredient alltrans content of isomer reaches 92.4%, and is unformed entirely, the biological activity height.
Embodiment 3-5 changes reaction conditions, reactive material and consumption thereof, and its preparation method is identical with embodiment 1-2.
The results are shown in Table 1 for the reaction conditions of embodiment 1-5 and gained.
Table 1
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| The xenthophylls amount | 30g | 18kg | 20kg | 54g | 25kg |
| Solvent species and quantity | Acetone 650g | Ethyl acetate 450kg | Tetrahydrofuran (THF) 340kg | Butanone 970g | Isobutyl acetate 375kg |
| Antioxidant kind and quantity | Mixed tocopherol 6.0g | Mixed tocopherol 10.0kg | The tertiary butyl is to cresorcin 5.0kg | Mixed tocopherol 10.0g | Butylhydroxy anisole 4.0kg |
| Project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Emulsifying agent kind and quantity | Fatty acid esters of sorbitan 3.0g | Quicifal 5.0kg | Span 40 4.0kg | Tween 80 3.6g | Fatty acid esters of sorbitan 3.0kg |
| Modified starch quantity | 75.0g | 75.0kg | 80.0kg | 268.0g | 94.0kg |
| Weighting material kind and quantity | Glucose 136g | Sucrose 120.0kg | N.F,USP MANNITOL 122kg | Dextrin 454.0g | Lactose 150.0kg |
| Homogenization pressure | 45MPa | 60MPa | 55MPa | 38MPa | 75MPa |
| Dry powder quantity | 236.8g | 225.3kg | 210kg | 680.5g | 236.5kg |
| Lutein content in the dry powder | 10.2％ | 5.56％ | 8.45％ | 6.23％ | 10.8％ |
| Emulsion particle diameter | 285nm | 186nm | 209nm | 298nm | 179nm |
| Alltrans content | 91.2％ | 92.4％ | 93.1％ | 92.6％ | 91.9％ |
Embodiment 6
The application of xenthophylls dry powder in orange beverage
(1) orange beverage prescription
| Composition | Addition (g) |
| Concentrated orange juice | 20 |
| White sugar | 80 |
| High ester pectin | 0.5 |
| Citric acid | 1.5 |
| Different Vc sodium | 0.4 |
| Xenthophylls dry powder | 0.2 |
| Water | Add to 1000 |
(2) technical process:, mix with the composition dissolving; Homogeneous; Be heated to about 85 ℃ hot canning.Xenthophylls addition: 10mg/kg wherein.According to nutritional fortification and chroma color requirement, the addition of xenthophylls can suitably increase and decrease in the production.
(3) physical stability of orange beverage and chemical stability
Add the physical stability of xenthophylls orange beverage and chemical stability and seen Table 2 and table 3 respectively.
Embodiment 7
The application of xenthophylls dry powder in milk-contained drink
(1) milk-contained drink prescription
| Composition | Addition (g) |
| Whole milk powder | 40 |
| White sugar | 80 |
| CMC(FH9) | 4 |
| Tripoly phosphate sodium STPP | 0.5 |
| Trisodium Citrate | 0.5 |
| Xenthophylls 5%CWS | 0.4 |
| Water | Add to 1000 |
(2) technical process:, mix with the composition dissolving; Homogeneous; Be heated to about 85 ℃ hot canning.Xenthophylls addition: 20mg/kg wherein.According to nutritional fortification and chroma color requirement, the addition of xenthophylls can suitably increase and decrease in the production.
(3) physical stability of milk-contained drink and chemical stability
Add the physical stability of xenthophylls milk-contained drink and chemical stability and seen Table 2 and table 3 respectively.
Embodiment 8
The application of xenthophylls dry powder in milk tea
(1) milk tea beverage prescription
| Composition | Addition (g) |
| Milk powder | 45 |
| Sucrose | 55 |
| The tea powder | 1 |
| Emulsion stabilizer | 2 |
| Xenthophylls 5%CWS | 0.3 |
| Water | Add to 1000 |
(2) processing method: composition is mixed soluble in water, is heated to about 60 ℃, stir, homogeneous, be heated to 90 ℃ after, hot canning.Xenthophylls addition: 15mg/kg.According to nutritional fortification and chroma color requirement, the addition of xenthophylls can suitably increase and decrease in the production.
(3) physical stability of milk tea beverage and chemical stability
Add the physical stability of xenthophylls milk tea beverage and chemical stability and seen Table 2 and table 3 respectively.
Embodiment 9
The application of xenthophylls dry powder in soda pop
(1) soda pop prescription
| Composition | Addition (g) |
| White sugar | 60 |
| Trisodium Citrate | 0.38 |
| Essence | 0.9625L |
| Sodium Benzoate | 0.175 |
| Citric Acid, usp, Anhydrous Powder | 2.28 |
| Carbonic acid gas | In right amount |
| Xenthophylls 5%CWS | 0.3 |
| Water | Add to 1000 |
(2) processing method:, and then pour in the bottled salt soda water earlier with small amounts of salts carbonated drink dissolve lutein CWS.Lutein content is 15mg/kg in the experimental formula, and according to nutritional fortification and chroma color requirement, the addition of xenthophylls can suitably increase and decrease in the production.
(3) physical stability of soda pop and chemical stability
Add the physical stability of xenthophylls soda pop and chemical stability and seen Table 2 and table 3 respectively.
Embodiment 10
The application of lutein water-soluble dry powder in jelly
(1) prescription of jelly
| Composition | Addition (g) |
| Fruit juice gel B | 8 |
| White sugar | 200 |
| Composition | Addition (g) |
| Calcium lactate | 1 |
| Citric acid | 1.5 |
| Xenthophylls 5%CWS | 0.5 |
| Water | 1000 |
(2) processing method: after fruit juice gel and white sugar be dissolved in the water, successively add calcium lactate and citric acid, fully shake up after the dissolving, injection molding while hot, sterilization.Xenthophylls addition: 25mg/kg.According to nutritional fortification and chroma color requirement, the addition of xenthophylls can suitably increase and decrease in the production.
(3) chemical stability of xenthophylls in the jelly
The chemical stability table 3 of xenthophylls in the jelly.
Embodiment 11
The application of xenthophylls dry powder in ice-creams
(1) ice-cream prescription
| Composition | Addition (g) |
| Gelatin (powder) | 5 |
| White sugar | 160 |
| Whole milk powder | 100 |
| Skim-milk | 20 |
| Mono-glycerides | 4 |
| Essence | 1 |
| Xenthophylls dry powder | 0.3 |
| Water | 1000 |
(2) ice-creams simple process flow
Batching → homogeneous → sterilization → cool aging → add essence and xenthophylls solution → congeal → can → sclerosis → finished product.The xenthophylls addition is 15mg/kg in the experimental formula, and according to nutritional fortification and chroma color requirement, the xenthophylls addition can suitably increase and decrease in the production.
(3) chemical stability of xenthophylls in the ice-creams
The chemical stability table 3 of xenthophylls in the ice-creams.
Embodiment 12
The application of xenthophylls in bread
(1) prescription of bread
| Composition | Addition (g) |
| Middle Strong flour | 1000 |
| White sugar | 200 |
| The stirring butter | 20 |
| Yeast | 12 |
| Bread improver | 10 |
| Xenthophylls 5%CWS | 0.5 |
| Water | 400 |
(2) bread simple process flow
Batching (flour, sugar, yeast, xenthophylls solution, butter) → mix → roll forming → proof → toast → cool off → pack → finished product. the xenthophylls addition is 25mg/kg in the experimental formula, according to nutritional fortification and chroma color requirement, the xenthophylls addition can suitably increase and decrease in the production.
(3) chemical stability of xenthophylls in the bread
The chemical stability table 3 of xenthophylls in the bread.
The physical stability of xenthophylls in table 2 milk tea
| Sample | After the production | 1 week | 2 weeks | 4 weeks | February | March | June |
| Orange beverage | Stable | Stable | Stable | Stable | Stable | Stable | Stable |
| Milk-contained drink | Stable | Stable | Stable | Stable | Stable | Stable | Slight ring |
| Milk tea | Stable | Stable | Stable | Stable | Stable | Stable | Come-up is arranged slightly |
| Soda pop | Stable | Stable | Stable | Stable | Stable | Slight ring, little brown throw out | Slight ring, little brown throw out |
The chemical stability of xenthophylls in table 3 food
Claims (8)
1. the preparation method of lutein water-soluble dry powder, its step is as follows:
A) lutein crystal and lower boiling, volatile and the big organic solvent of lutein crystal solubleness mixed after, heating for dissolving, oil phase;
B) modified starch is mixed with water, rising temperature for dissolving, cool off again water;
C) oil phase is under agitation slowly joined aqueous phase, the mixed solution after the emulsification;
D) mixed solution after the emulsification is even by the high-pressure uniform machine, makes emulsion particle diameter reach nano level;
E) by the organic solvent in the conventional separation method removal emulsion system;
F) remove moisture content in the emulsion with spray-drying process or spraying-starch fluid-bed drying, get free flowable dry powder;
Described organic solvent is acetone, butanone, ethyl acetate, propyl acetate, isobutyl acetate or tetrahydrofuran (THF).
2. the preparation method of lutein water-soluble dry powder according to claim 1, the add-on that it is characterized in that organic solvent be the lutein crystal add-on 15-25 doubly.
3. the preparation method of lutein water-soluble dry powder according to claim 2, the add-on that it is characterized in that modified starch is the 30-60% of the finished product dry powder weight.
4. the preparation method of lutein water-soluble dry powder according to claim 2 is characterized in that in step a), has added any or the mixture more than two kinds in emulsifying agent, antioxidant, the vegetables oil in oil phase.
5. the preparation method of lutein water-soluble dry powder according to claim 4 is characterized in that described emulsifying agent is a fatty acid esters of sorbitan, Ascorbyl Palmitate, and sapn or tween, its add-on is the 2-8% of the finished product dry powder weight; Described antioxidant is a vitamin-E, and the tertiary butyl is to cresorcin or tert-butylation BHA, and its add-on is the 2-5% of the finished product dry powder weight; Described vegetables oil is sunflower seed oil, rapeseed oil, soybean oil or Semen Maydis oil, and its add-on is the 10-25% of the finished product dry powder weight.
6. the preparation method of lutein water-soluble dry powder according to claim 2, it is characterized in that in step b), added weighting agent at aqueous phase, described weighting agent is sucrose, lactose, glucose, dextrin, glycerine or N.F,USP MANNITOL, and its add-on is the 20-45% of the finished product dry powder weight.
7. the preparation method of lutein water-soluble dry powder according to claim 2 is characterized in that in step a), and the temperature during dissolving is 50-110 ℃; In step b), the temperature during dissolving is 70-90 ℃, and cooling temperature is at 30-50 ℃.
8. the preparation method of lutein water-soluble dry powder according to claim 2, the uniform pressure when it is characterized in that high-pressure uniform is 10-60MPa.
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| CN104116019A (en) * | 2014-06-25 | 2014-10-29 | 安阳工学院 | Xanthophyll jelly and preparation method thereof |
| WO2016119143A1 (en) | 2015-01-28 | 2016-08-04 | 晨光生物科技集团股份有限公司 | Lutein microcapsule preparation and preparation method |
| CN105053556B (en) * | 2015-07-09 | 2018-07-17 | 浙江新维普添加剂有限公司 | A kind of preparation method of lutein feed addictive |
| CN107897915A (en) * | 2017-11-21 | 2018-04-13 | 南京师范大学 | A kind of lotus seed protein pectin complex emulsions for loading curcumin and its preparation method and application |
| CN108634169B (en) * | 2018-05-14 | 2021-07-30 | 上海交通大学 | Preparation method of lutein nano emulsion |
| CN110693027A (en) * | 2019-10-14 | 2020-01-17 | 桂林莱茵生物科技股份有限公司 | Water-dispersible cannabidiol product and preparation method thereof |
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| CN1239977A (en) * | 1996-12-12 | 1999-12-29 | Basf公司 | Stable aqueous dispersions and stable water-dispersible dry xanthophyll powder, their production and use |
| CN1348483A (en) * | 1999-04-29 | 2002-05-08 | Basf公司 | Stable, aqueous dispersions and stable, water-dispersible dry powders of xanthophylls, and production and use of the same |
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| WO2015043112A1 (en) | 2013-09-24 | 2015-04-02 | 浙江医药股份有限公司新昌制药厂 | Carotenoid compound coming from plant and containing natural astaxanthin, preparation method therefor, and composition |
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