CN101156664A - Method for distilling fucoidin from sea tangle caustic refining liquid - Google Patents
Method for distilling fucoidin from sea tangle caustic refining liquid Download PDFInfo
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- CN101156664A CN101156664A CNA2007101706977A CN200710170697A CN101156664A CN 101156664 A CN101156664 A CN 101156664A CN A2007101706977 A CNA2007101706977 A CN A2007101706977A CN 200710170697 A CN200710170697 A CN 200710170697A CN 101156664 A CN101156664 A CN 101156664A
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Abstract
The invention discloses a process for extracting fucoidin. The invention adopts sea kelp iodine alkali refined liquid as the raw material which is separated and settled after being washed with tap water, the fucoidin solution is extracted by extracting agent, the impurity of heavy metal is removed through an ion exchange method, then the fucoidin is settled with precipitating agent, and finally the fucoidin is obtained through drying. The invention changes the traditional production process of the fucoidin, the used reagent is more practical and non-toxic, the adopted concentration method does not require complex equipment, and the cost is far lower than the membrane separation technology, no or only a small amount of alcohol is consumed, and the invention adopts simple and cheap extracting agent to extract the fucoidin from the sea kelp iodine alkali refined liquid, thereby the production cost of the fucoidin is greatly reduced.
Description
Technical field
The present invention relates to a kind of preparation method of polysaccharide, the present invention relates in particular a kind ofly put forward the iodine alkali refining liquid method of extracting fucoidin from sea-tangle.
Background technology
Fucoidin has purposes widely, this has been caused both at home and abroad widely to note, continually develops its new purposes.But, to produce at fucoidin both at home and abroad and have shortcomings such as cost height, equipment complexity, reagent consumption are big aspect the separating and purifying technology, the market price of product is high, has directly influenced the application of fucoidin.At present, the domestic production fucoidin mainly comprises ethanol separation and purification method step by step and membrane separation technique discolor element and inorganic molecules purifying concentration technique.The former will consume a large amount of alcohol, and the latter is subjected to the influence of factors such as membrane flux, and output is difficult to promote.
Summary of the invention
Technical problem to be solved by this invention provides a kind of cost well below membrane separation technique, does not need or only need consume minute quantity alcohol, adopts the sea-tangle of cheap and simple to put forward the method for extracting fucoidin in the iodine alkali refining liquid.
The technical solution used in the present invention: carrying iodine alkali refining liquid with sea-tangle is raw material, running water washing back precipitation separation extracts fucoidin with extractant, removes impurity such as heavy metal through ion-exchange, with precipitating reagent fucoidin is precipitated then, last drying obtains described fucoidin.
Described inorganic acid fluid is the mixed solution by the ammonium phosphomolybdate solution composition of 10% citric acid solution, 2% tartaric acid solution, 10% salpeter solution and 1%, the mixed solution that described precipitating reagent is made up of 2% ethanol, 2% edta solution, 5% acetone and 5% sodium carbonate liquor.
The mixed solution that described inorganic acid fluid is made up of the edta solution of 10% citric acid solution, 2% oxalic acid solution, 10% salpeter solution, 1% ammonium phosphomolybdate solution and 0.2%, the mixed solution that described precipitating reagent is made up of 0.1% shitosan, 2% edta solution and 5% sodium carbonate liquor.
Fucoidin after precipitating reagent separates adopts drying process with atomizing to carry out drying.
Beneficial effect of the present invention: the present invention has changed traditional fucoidin and has become production. art, employed reagent practical and non-toxic, residual quantity more is little, the concentration method that is adopted need not complex device, cost is well below membrane separation technique, do not need or seldom measure to consume alcohol, the inorganic solvent of employing cheap and simple is carried the iodine alkali refining liquid from sea-tangle and is extracted fucoidin, greatly reduces the production cost of fucoidin.
The specific embodiment
Below by embodiment the present invention is described in further detail, carrying iodine alkali refining liquid with sea-tangle is raw material, with a kind of solvent inorganic acid the fucoidin dissolving is extracted, after ion-exchange is removed impurity such as heavy metal, separates fucoidin with precipitating reagent.The main technique route is as follows: sea-tangle alkali refining liquid-----washing, centrifugation--------------precipitation-------drying that extract and separate concentrates.The present invention separates fucoidin with extractant, and it can be the mixed solution of citric acid, oxalic acid, sulfuric acid, tartaric acid, salpeter solution, ammonium phosphomolybdate solution composition.The fucoidin precipitating reagent of indication is a kind of inorganic precipitant or the compound precipitating reagent of organic-inorganic among the present invention, wherein can be ethanol, acetone, water, shitosan, sodium carbonate, sodium tartrate, EDTA disodium etc.
Embodiment 1
500 kilograms of sea-tangles are carried iodine alkali refining liquid, with about 250 kilograms running water washing, the employing disk plate centrifuge separates, and separating factor adds 10 kilograms of inorganic extractants more than 800 then, adopt the disk plate centrifuge of separating factor more than 800 to separate, gained filtrate adds 5 kilograms of precipitating reagents, and after the precipitate and separate, drying obtains product, product fucoidin content is 19%-29%, and total sugar content is 45%-65%.
A. used isolation technics adopts disk plate centrifuge, and separating factor is more than 800
B. the solvent that is adopted contains 10% citric acid solution, 2% tartaric acid, 10% salpeter solution and 1% ammonium phosphomolybdate
C. contain 2% ethanol in the precipitating reagent that is adopted, 2% EDTA, 5% acetone and 5% sodium carbonate liquor
D. the dry technology that is adopted is freeze drying
Embodiment 2
500 kilograms of sea-tangles are carried iodine alkali refining liquid, with about 250 kilograms running water washing, adopt the disk plate centrifuge precipitation separation, separating factor is more than 800, add 8 kilograms of inorganic extractants then, adopt the video disc machine of separating factor more than 800 centrifugal, gained filtrate adds 8 kilograms of precipitating reagents after removing heavy metal through ion-exchange, after the precipitate and separate, drying obtains product, product fucoidin content 27%-37%, and total sugar content is at 60%-79%.
A. used isolation technics adopts disk plate centrifuge, and separating factor is more than 800
B. the solvent that is adopted contains 15% citric acid solution, 2% oxalic acid, 10% salpeter solution and 1% ammonium phosphomolybdate and 0.2% EDTA
C. contain 0.1% shitosan in the precipitating reagent that is adopted, 2% EDTA and 5% sodium carbonate liquor
D. the dry technology that is adopted is a spray-drying
Above said content only is the basic explanation of the present invention under conceiving, and according to any equivalent transformation that technical scheme of the present invention is done, all should belong to protection scope of the present invention.
Claims (4)
1. put forward the method for extracting fucoidin the iodine alkali refining liquid from sea-tangle, comprise the following steps: that carrying iodine alkali refining liquid with sea-tangle is raw material, washing back precipitation separation, extract fucoidin with extractant, further remove impurity such as heavy metal again through ion-exchange, separate fucoidin with precipitating reagent then, last drying obtains described fucoidin.
2. put forward the method for extracting fucoidin the iodine alkali refining liquid according to claim 1 is described from sea-tangle, it is characterized in that: described extract is by the mixed solution of the ammonium phosphomolybdate solution composition of 10% citric acid solution, 2% tartaric acid solution, 10% salpeter solution, 0.2% edta solution and 1%, the mixed solution that described precipitating reagent is made up of 2% ethanol, 5% acetone, 2% disodium ethylene diamine tetra-acetic acid solution, 5% sodium tartrate and 5% sodium carbonate liquor.
3. put forward the method for extracting fucoidin the iodine alkali refining liquid according to claim 1 is described from sea-tangle, it is characterized in that: the mixed solution that described extractant is made up of the edta solution of 10% citric acid solution, 2% oxalic acid solution, 10% salpeter solution, 1% ammonium phosphomolybdate solution and 0.2%, the mixed solution that described precipitating reagent is made up of 0.1% shitosan, 2% edta solution and 5% sodium carbonate liquor.
4. put forward the method for extracting fucoidin the iodine alkali refining liquid according to claim 1 is described from sea-tangle, it is characterized in that: the fucoidin after precipitating reagent separates adopts drying process with atomizing to carry out drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101706977A CN101156664B (en) | 2007-11-21 | 2007-11-21 | Method for distilling fucoidin from sea tangle caustic refining liquid |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101706977A CN101156664B (en) | 2007-11-21 | 2007-11-21 | Method for distilling fucoidin from sea tangle caustic refining liquid |
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| Publication Number | Publication Date |
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| CN101156664A true CN101156664A (en) | 2008-04-09 |
| CN101156664B CN101156664B (en) | 2010-08-11 |
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| CN2007101706977A Expired - Fee Related CN101156664B (en) | 2007-11-21 | 2007-11-21 | Method for distilling fucoidin from sea tangle caustic refining liquid |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101891838A (en) * | 2010-07-29 | 2010-11-24 | 中国水产科学研究院黄海水产研究所 | Method for recovering residual algin from floating waste residue liquid in seaweed chemical production |
| CN103387622A (en) * | 2013-08-23 | 2013-11-13 | 福建华尔康生物科技有限公司 | Method for extracting fucoidan and removing heavy metals from kelps |
| CN108641008A (en) * | 2018-05-11 | 2018-10-12 | 大连工业大学 | The method that Undaria pinnatifida Suringar extracts fucoidan and removes heavy metal |
| WO2020019077A1 (en) * | 2018-07-27 | 2020-01-30 | Arc Medical Devices Inc. | Low endotoxin fucan compositions, systems and methods |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1344565A (en) * | 2001-10-19 | 2002-04-17 | 汤洁 | Fucoidin ester as antiviral immunoregulator and its prepn |
| CN100425622C (en) * | 2006-09-28 | 2008-10-15 | 青岛明月海藻集团有限公司 | Process of comprehensive utilization sea-tangle for extracting fucoidin |
-
2007
- 2007-11-21 CN CN2007101706977A patent/CN101156664B/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101891838A (en) * | 2010-07-29 | 2010-11-24 | 中国水产科学研究院黄海水产研究所 | Method for recovering residual algin from floating waste residue liquid in seaweed chemical production |
| CN103387622A (en) * | 2013-08-23 | 2013-11-13 | 福建华尔康生物科技有限公司 | Method for extracting fucoidan and removing heavy metals from kelps |
| CN103387622B (en) * | 2013-08-23 | 2015-07-01 | 福建华尔康生物科技有限公司 | Method for extracting fucoidan and removing heavy metals from kelps |
| CN108641008A (en) * | 2018-05-11 | 2018-10-12 | 大连工业大学 | The method that Undaria pinnatifida Suringar extracts fucoidan and removes heavy metal |
| CN108641008B (en) * | 2018-05-11 | 2020-07-24 | 大连工业大学 | Method for extracting fucosan sulfate and removing heavy metal from undaria pinnatifida sporophyll |
| WO2020019077A1 (en) * | 2018-07-27 | 2020-01-30 | Arc Medical Devices Inc. | Low endotoxin fucan compositions, systems and methods |
| JP2021532137A (en) * | 2018-07-27 | 2021-11-25 | エーアールシー メディカル デバイス，インク． | Low endotoxin fucan composition, system and method |
| US11628183B2 (en) | 2018-07-27 | 2023-04-18 | ARC Medical Ine. | Highly purified fucans for the treatment of fibrous adhesions |
| US11642368B2 (en) | 2018-07-27 | 2023-05-09 | ARC Medical Inc. | Highly purified and/or modified fucan compositions for the treatment of fibrous adhesions |
| JP7302831B2 (en) | 2018-07-27 | 2023-07-04 | エーアールシー メディカル デバイス，インク． | Low endotoxin fucan composition, system and method |
| US11938145B2 (en) | 2018-07-27 | 2024-03-26 | ARC Medical Inc. | Low endotoxin fucan compositions, systems, and methods |
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|---|---|
| CN101156664B (en) | 2010-08-11 |
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