CN101143011B - Method for improving iron bioavailability in food - Google Patents
Method for improving iron bioavailability in food Download PDFInfo
- Publication number
- CN101143011B CN101143011B CN2007100715678A CN200710071567A CN101143011B CN 101143011 B CN101143011 B CN 101143011B CN 2007100715678 A CN2007100715678 A CN 2007100715678A CN 200710071567 A CN200710071567 A CN 200710071567A CN 101143011 B CN101143011 B CN 101143011B
- Authority
- CN
- China
- Prior art keywords
- food
- iron
- niacinamide
- bioavailability
- iron bioavailability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 235000013305 food Nutrition 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 title claims abstract description 20
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims description 59
- 229910052742 iron Inorganic materials 0.000 title claims description 29
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 30
- 241001465754 Metazoa Species 0.000 claims abstract description 7
- 229960003966 nicotinamide Drugs 0.000 claims description 26
- 235000005152 nicotinamide Nutrition 0.000 claims description 26
- 239000011570 nicotinamide Substances 0.000 claims description 26
- 241000282414 Homo sapiens Species 0.000 abstract description 7
- 229910000859 α-Fe Inorganic materials 0.000 abstract 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 14
- 208000007502 anemia Diseases 0.000 description 9
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 7
- 229930003268 Vitamin C Natural products 0.000 description 7
- 235000019154 vitamin C Nutrition 0.000 description 7
- 239000011718 vitamin C Substances 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 6
- 240000008042 Zea mays Species 0.000 description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 6
- 239000011790 ferrous sulphate Substances 0.000 description 6
- 235000003891 ferrous sulphate Nutrition 0.000 description 6
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 6
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 6
- 206010022971 Iron Deficiencies Diseases 0.000 description 5
- 239000008267 milk Substances 0.000 description 5
- 235000013336 milk Nutrition 0.000 description 5
- 210000004080 milk Anatomy 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 241000282887 Suidae Species 0.000 description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 235000005822 corn Nutrition 0.000 description 4
- 102000008857 Ferritin Human genes 0.000 description 3
- 238000008416 Ferritin Methods 0.000 description 3
- 108050000784 Ferritin Proteins 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 2
- 206010048259 Zinc deficiency Diseases 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- KFZAUHNPPZCSCR-UHFFFAOYSA-N iron zinc Chemical compound [Fe].[Zn] KFZAUHNPPZCSCR-UHFFFAOYSA-N 0.000 description 2
- 235000009973 maize Nutrition 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 208000027219 Deficiency disease Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010021929 Infertility male Diseases 0.000 description 1
- 208000007466 Male Infertility Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
Images
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a method for improving the effectiveness of ferrite in food. The method is to add nicotinic amide to food. Specifically, 1 to 20 mg of nicotinic amide is added to every kilogram of food. The method of the invention makes the ferrite in the food much easier absorbed by human body (or animal body).
Description
Technical field
The present invention relates to a kind of method that improves iron bioavailability in the food.
Background technology
Iron is the trace element of needed by human, and its major function is to combine with hemoglobin and myoglobins to form red blood cell, the transhipment and the exchange of oxygen and carbon dioxide in participating in organizing.Iron deficiency can cause the generation of hypoferric anemia and bad pregnancy etc.The WHO data show that nearly 3,700,000,000 population iron deficiencies are arranged in the world, and iron deficiency has become the influence serious nutrition problem of 30% population in the world, and especially those are the countries and regions of main food with plant food.Although by food additives with take in the shortage that tablet medicine can effectively be controlled iron, because relevant too high being difficult to of expense implements in developing country.Though iron microelement content is very little, be the constituent of the enzyme of human body 50%-70%, in keeping the normal activities process, served as irreplaceable effect.Because irrational dietary structure and life style, iron zinc micronutrient element deficiency disease has become the key factor that influences human health, is called as " second hunger ".It is reported that may there be asiderosis in 66%～80% of world population, wherein 2,000,000,000 people are anaemias, are mainly caused by the plain shortage of iron
[1,2], the intelligence that hypoferric anemia can cause bad pregnancy, mother and baby's the death rate to improve, influence the baby is grown, is reduced immunologic function, increases sense of fatigue and make inefficiency inferior, and human beings'health is caused very big threat.Zinc deficiency also is very general in developing country, affects about 2,000,000,000 populations, and zinc deficiency can cause dwarf, male sterility and immunologic function reduction etc.The data of announcing recently according to the Chinese government show that the children below 5 years old of China present 22% suffer from the anemia that is caused by iron deficiency, and the baby below 6 months up to 50% suffers from the anemia that iron deficiency causes in the rural area.The disease that causes owing to trace elements such as lacking zinc is also constantly spreading simultaneously.According to State Statistics Bureau's investigation data, the annual loss that the malnutrition that causes because of microelement deficiencies such as iron zinc causes accounts for the 3%-4% of gross national product up to 30,000,000,000 RMB (being equivalent to 3,600,000,000 dollars).Therefore, micro-enriched nutritive is most important to keeping crowd's health.
Above-mentioned list of references is specific as follows:
[1].WHO.(2003)(http://www.who.int/nut/malnutrition_worldwide.htm#ida).
[2].Frossard?E，Bucher?M，Machler?F，Mozafar?A，Hurrell?R(2000).Potential?for?increasing?thecontent?and?bioavailability?of?Fe，Zn，and?Ca?in?plants?for?human?nutrition.J?Sci?Food?Agric80：861-879.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of method that can improve iron bioavailability in the food, uses this method can make that ferro element in the food is easier to be absorbed by human body (or animal body).
In order to solve the problems of the technologies described above, the invention provides a kind of method that improves iron bioavailability in the food: in food, add niacinamide.
Improvement as the method for iron bioavailability in the raising food of the present invention: the niacinamide that adds 1～20mg in every kg food.In particular: the niacinamide that adds 1～10mg in every kg animal food; Add the niacinamide of 2～20mg in every kg plant food.
In order to prove that niacinamide (NA) has the function that can improve iron bioavailability in the food, the inventor has done following contrast experiment:
1, the niacinamide with different proportion adds in the ferrous sulfate, carries out the biological effectiveness analysis.Invention group 1 is that ferrous sulfate and NA mix with mole (molecule) ratio of 1: 1, and invention group 2 is ferrous sulfate and the NA mixing with 1: 4 mole of (molecule) ratio.When handling the CaCo-2 cell with invention group 1 and invention group 2 respectively, ferritin obviously increases in this clone, reaches every milligram of albumen 625 and 440 nanograms (as shown in Figure 1) respectively.Only do not add the group in contrast 1 of any NA for ferrous sulfate, handle the CaCo-2 cell with control group 1, the ferritin content in this clone only is every milligram of albumen 135 nanograms.Therefore invention group 1 and invention group 2 are respectively 4.63 times and 3.26 times of control group 1.
2, the promoter that absorbs as a kind of known iron of vitamin C (VC), when ferrous sulfate and vitamin C mix with mole (molecule) ratio of 1: 1, organize 2 in contrast, when ferrous sulfate and vitamin C mix with mole (molecule) ratio of 1: 4, organize 3 in contrast.Handle the CaCo-2 cell with control group 2 and control group 3 respectively, the ferritin content in this clone is every milligram of albumen 270 and 380 nanograms (as shown in Figure 1).That is, under the situation of identical addition, niacinamide is far longer than vitamin C to the facilitation that iron absorbs.
Therefore, we may safely draw the conclusion: niacinamide can be used as a kind of brand-new absorbing additives of iron efficiently, and the facilitation that niacinamide absorbs iron is far longer than iron promoter (the iron bioavalability enhancer) vitamin C of generally acknowledging at present.
Description of drawings
Fig. 1 is the comparison diagram that NA and VC influence CaCO-2 cell iron absorption efficiency.
The specific embodiment
Substantially 20 anaemic sucking pigs that equate with size, specification are experimental subjects, and invention group and control group are respectively established 10 anaemic sucking pigs.On the feeding basis of low iron content pig feed, the invention group is additional food with the milk powder of the niacinamide that added aforementioned proportion, and control group be to add food with simple milk powder.Under the prerequisite of identical pig feed and milk powder feeding volume, after feeding for 5 week, find after testing: (Hemoglobin RepletionEfficiency: the average level indication parameter of iron biological effectiveness) is 24.8% to the full rate of hemochrome, and the average level of the full rate of hemochrome is 33.5% in the invention group clone in the cellular control unit system.
Embodiment 2, a kind of method that improves iron bioavailability in the food as plant food, are added the niacinamide of 10mg with corn in every kg corn.
Substantially 20 anaemic adult pigs that equate with size, specification are experimental subjects, and invention group and control group are respectively established 10 anaemic adult pigs.The invention group is a food with the corn that has added the aforementioned proportion niacinamide, and control group is a food with simple corn.Under the prerequisite of identical feeding volume, fed for 6 weeks after, find after testing: the average level of the full rate of hemochrome is 26.6% in the cellular control unit system, and the average level of the full rate of hemochrome is 31.3% in the invention group clone.
Embodiment 3, a kind of method that improves iron bioavailability in the food as animal food, are added the niacinamide of 2mg with beef in every kg beef.
Embodiment 5, a kind of method that improves iron bioavailability in the food as plant food, are added the niacinamide of 20mg with rice in every kg rice.
Embodiment 6, a kind of method that improves iron bioavailability in the food as plant food, are added the niacinamide of 3mg with maize in every kg maize.
At last, it is also to be noted that what more than enumerate only is several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, many distortion can also be arranged.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.
Claims (3)
1. a method that improves iron bioavailability in the food is characterized in that: add niacinamide in food, add the niacinamide of 1～20mg in every kg food.
2. the method for iron bioavailability in the raising food according to claim 1 is characterized in that: the niacinamide that adds 1～10mg in every kg animal food.
3. the method for iron bioavailability in the raising food according to claim 1 is characterized in that: the niacinamide that adds 2～20mg in every kg plant food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100715678A CN101143011B (en) | 2007-10-09 | 2007-10-09 | Method for improving iron bioavailability in food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100715678A CN101143011B (en) | 2007-10-09 | 2007-10-09 | Method for improving iron bioavailability in food |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101143011A CN101143011A (en) | 2008-03-19 |
| CN101143011B true CN101143011B (en) | 2011-06-22 |
Family
ID=39205878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100715678A Expired - Fee Related CN101143011B (en) | 2007-10-09 | 2007-10-09 | Method for improving iron bioavailability in food |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101143011B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101376612B (en) * | 2008-10-10 | 2011-04-27 | 浙江大学 | Aminoacid foliar fertilizer and use thereof |
| GB201416293D0 (en) | 2014-09-15 | 2014-10-29 | Solvotrin Therapeutics Ltd | Methods and preparations |
| BR112018068571A2 (en) | 2016-03-15 | 2019-04-16 | Solvotrin Therapeutics Ltd | composition, method for increasing serum iron in a mammal, and process for producing a dry iron delivery material. |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195700A (en) * | 1997-02-21 | 1998-10-14 | 住友化学工业株式会社 | Nicotianamine aminotransferase and gene therefor |
-
2007
- 2007-10-09 CN CN2007100715678A patent/CN101143011B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1195700A (en) * | 1997-02-21 | 1998-10-14 | 住友化学工业株式会社 | Nicotianamine aminotransferase and gene therefor |
Non-Patent Citations (2)
| Title |
|---|
| 印莉萍,孙铭明,刘祥林,邱泽生.铁转运机制与相关基因的研究进展.植物学通报.1999,(06),全文. * |
| 李钟玉,李临生.烟酸、烟酰胺的研究进展.化工时刊.2003,(02),全文. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101143011A (en) | 2008-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Lyons et al. | High-selenium wheat: biofortification for better health | |
| Nieder et al. | Microelements and their role in human health | |
| Prasad | Zinc biofortification of food grains in relation to food security and alleviation of zinc malnutrition | |
| Henry et al. | Relative bioavailability of manganese in a manganese-methionine complex for broiler chicks | |
| CN106212952A (en) | A kind of ablactational baby pig premixed feed | |
| CN102742737A (en) | Selenium-rich total mixed ration for fattening sheep, and production method thereof | |
| CN102919583A (en) | Antimicrobial-free feed for young rex rabbits | |
| CN107223779A (en) | A kind of beef ox fattening early stage diet recipe and preparation method thereof | |
| CN101143011B (en) | Method for improving iron bioavailability in food | |
| CN103750054B (en) | A kind of organic sheep feed | |
| CN105341392A (en) | Active biological compound feed for cows and sheep and production method thereof | |
| CN105941869A (en) | Selenium-enriched feed additive and production process thereof | |
| Klusmeyer et al. | Effects of feed processing and frequency of feeding on ruminal fermentation, milk production, and milk composition | |
| CN104982738A (en) | Mixed feed for boer goats | |
| CN101779737A (en) | Straw feed with health-care function special for cattle and sheep | |
| Swain et al. | Effect of nanozinc supplementation on haematological and blood biochemical profiles in goats | |
| CN105995010A (en) | Complete feed used for pregnant sow and capable of reducing malformation of newborn piglets and preparation method | |
| CN103355541A (en) | Selenium-rich feed for cattle and feeding method thereof | |
| CN102511657B (en) | Lactobacillus grass meal biological feed formula and preparation method for feed | |
| CN103461650A (en) | Feed additive and feed applying same | |
| Currier et al. | Daily and alternate-day supplementation of urea or biuret to ruminants consuming low-quality forage: II. Effects on site of digestion and microbial efficiency in steers | |
| Gibson et al. | The adequacy of micronutrients in complementary foods | |
| CN104543524B (en) | Growing-finishing pig compound feed for reducing concentration of ammonia gas in pigsty | |
| Chandrasekharaiah et al. | Effect of different rumen degradable nitrogen levels on microbial protein synthesis and digestibility in sheep fed on finger millet straw (Eleucine coracana) based diet | |
| Ershow et al. | Databases of iodine content of foods and dietary supplements–Availability of new and updated resources |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110622 Termination date: 20131009 |