CN101120913B - Ftibamzone chrisma with PEG-200 as co-solvent - Google Patents
Ftibamzone chrisma with PEG-200 as co-solvent Download PDFInfo
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- CN101120913B CN101120913B CN2006101094020A CN200610109402A CN101120913B CN 101120913 B CN101120913 B CN 101120913B CN 2006101094020 A CN2006101094020 A CN 2006101094020A CN 200610109402 A CN200610109402 A CN 200610109402A CN 101120913 B CN101120913 B CN 101120913B
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Abstract
The present invention discloses a new phthiobuaone ointment. In the phthiobuaone ointment, the active component is phthiobuaone. The PEG-200 is the cosolvent. A new prescription comprises the octadecanol, the liquid paraffin, the albolene, the lauryl alcohol sodium sulfate, the nipagin acetic ester and the distilled water, which not only guarantee the effect and stability of the phthiobuaone ointment, but also overcome skin irritation of the phthiobuaone ointment taking PEG-200 as the cosolvent in current technology.
Description
Technical field
The present invention relates to a kind of new Ftibamzone Ointment.This Ftibamzone Ointment is an active component with the ftibamzone, is cosolvent with PEG-200, and and the new prescription of the common composition of octadecanol, liquid paraffin, white vaseline, sodium laurylsulfate, ethyl hydroxybenzoate and distilled water.
Background technology
Ftibamzone is a kind of novel antiviral medicine of the Chinese Academy of Medical Sciences's development seventies, is the treatment herpes zoster, also can be used for dermopathic ideal medicament such as condyloma acuminatum, molluscum contagiosum, verruca plana and verruca vulgaris.But Ftibamzone Ointment all is cosolvent with the dimethyl sulfoxide in the prior art, and dimethyl sulfoxide has certain skin irritation, forbids external in developed regions such as America and Europes.The Ftibamzone Ointment that applicant is produced is a cosolvent with the dimethyl sulfoxine also, is subjected to bigger restriction when entering American-European market.
Summary of the invention
The technical problem that the present invention will solve provides a kind of new Ftibamzone Ointment, drug effect that can guarantee Ftibamzone Ointment and stability, and can overcome again in the prior art with the dimethyl sulfoxide is the skin irritation that is had of the Ftibamzone Ointment of cosolvent.
Another technical problem that the present invention will solve provides the preparation method of this new Ftibamzone Ointment.
Another technical problem that the present invention will solve provides this new Ftibamzone Ointment in the application as the medicine for the treatment of herpes zoster, condyloma acuminatum, molluscum contagiosum, verruca plana and verruca vulgaris.
In order to solve technical problem of the present invention, adopt following technical scheme: the present invention is through repetition test repeatedly, and employing PEG-200 is a cosolvent, forms new prescription.
Ftibamzone Ointment of the present invention is made by following each component: (consumption is a weight portion, and total amount is in 1000 weight portions)
Ftibamzone 10
The PEG-200 that is used to dissolve ftibamzone is 200 weight portions
Oil water phase
Octadecanol 70-100 PEG-200 30-80
Liquid paraffin 40-80 sodium laurylsulfate 5-20
White vaseline 20-40 ethyl hydroxybenzoate 0.5-2
Distilled water surplus
Weight (part) ratio range for preparing the formula optimization of Ftibamzone Ointment of the present invention is (total amount is in 1000 weight portions):
Ftibamzone 10
The PEG-200 that is used to dissolve ftibamzone is 200 weight portions
Oil water phase
Octadecanol 80-95 PEG-200 40-70
Liquid paraffin 50-70 sodium laurylsulfate 5-15
White vaseline 25-40 ethyl hydroxybenzoate 0.5-2
Distilled water surplus
The preferred weight of prescription (part) ratio range for preparing Ftibamzone Ointment of the present invention is (total amount is in 1000 weight portions):
Ftibamzone 10
The PEG-200 that is used to dissolve ftibamzone is 200 weight portions
Oil water phase
Octadecanol 85-95 PEG-200 40-60
Liquid paraffin 55-65 sodium laurylsulfate 8-15
White vaseline 25-35 ethyl hydroxybenzoate 0.5-1.5
Distilled water surplus
Weight (part) proportioning (total amount is in 1000 weight portions) for preparing prescription the best of Ftibamzone Ointment of the present invention:
Ftibamzone 10
The PEG-200 that is used to dissolve ftibamzone is 200 weight portions
Oil water phase
Octadecanol 90 PEG-200 50
Liquid paraffin 60 sodium laurylsulfates 10
White vaseline 30 ethyl hydroxybenzoates 1
Distilled water 549
The preparation method of above-mentioned Ftibamzone Ointment also is provided according to the present invention.
Earlier the Ftibamzone raw material gradation is added after the PEG-200 heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in this step)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Ftibamzone Ointment of the present invention has following advantage:
Ftibamzone of the present invention does not contain dimethyl sulfoxide, drug effect that can guarantee Ftibamzone Ointment and stability, and can overcome again in the prior art with the dimethyl sulfoxide is the skin irritation that is had of the Ftibamzone Ointment of cosolvent.
The specific embodiment
The following examples further specify the present invention, but do not limit the present invention in any way.
Embodiment 1
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 2
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 3
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 4
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 5
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 6
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 7
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 8
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 9
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
| White vaseline | 35 | Ethyl hydroxybenzoate | 1.5 |
| Distilled water | 548.5 |
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 10
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 11
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
| Oil phase | Water |
| Octadecanol | 95 | PEG-200 | 60 |
| Liquid paraffin | 55 | Sodium laurylsulfate | 8 |
| White vaseline | 35 | Ethyl hydroxybenzoate | 1.5 |
| Distilled water | 535.5 |
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 12
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Embodiment 13
Step 1
Take by weighing Ftibamzone raw material 10 gram, gradation adds PEG-200 100 grams, and 50 grams, 50 grams amount to after the 200 gram heating for dissolving stand-by.(PEG-200 ratio in prescription accounts for 20% in the step 1)
Step 2 prescription (in 1000 gram Ftibamzone Ointments, unit of weight is gram)
Each composition takes by weighing by recipe quantity, and oil phase and water are respectively to the extremely dissolving of container internal heating.Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually.Pour stirring into having dissolved good ftibamzone solution in the step 1, along with the reduction formation mastic of temperature.In colloid mill 2-3 time repeatedly, make the ointment mastic fine and smooth more ointment.Packing, capping promptly gets Ftibamzone Ointment of the present invention, puts shady and cool place and preserves.
Claims (5)
1. a Ftibamzone Ointment is characterized in that, is to be made by each component of following weight proportioning, and total amount is in 1000 weight portions:
Ftibamzone 10
The PEG-200 that is used to dissolve ftibamzone is 200 weight portions
Oil water phase
Octadecanol 70-100 PEG-200 30-80
Liquid paraffin 40-80 sodium laurylsulfate 5-20
White vaseline 20-40 ethyl hydroxybenzoate 0.5-2
Distilled water surplus.
2. Ftibamzone Ointment according to claim 1 is characterized in that, is to be made by each component of following weight proportioning, and total amount is in 1000 weight portions:
Ftibamzone 10
The PEG-200 that is used to dissolve ftibamzone is 200 weight portions
Oil water phase
Octadecanol 80-95 PEG-200 40-70
Liquid paraffin 50-70 sodium laurylsulfate 5-15
White vaseline 25-40 ethyl hydroxybenzoate 0.5-2
Distilled water surplus.
3. Ftibamzone Ointment according to claim 2 is characterized in that, is to be made by each component of following weight proportioning, and total amount is in 1000 weight portions:
Ftibamzone 10
The PEG-200 that is used to dissolve ftibamzone is 200 weight portions
Oil water phase
Octadecanol 85-95 PEG-200 40-60
Liquid paraffin 55-65 sodium laurylsulfate 8-15
White vaseline 25-35 ethyl hydroxybenzoate 0.5-1.5
Distilled water surplus.
4. Ftibamzone Ointment according to claim 3 is characterized in that, is to be made by each component of following weight proportioning, and total amount is in 1000 weight portions:
Ftibamzone 10
The PEG-200 that is used to dissolve ftibamzone is 200 weight portions
Oil water phase
Octadecanol 90 PEG-200 50
Liquid paraffin 60 sodium laurylsulfates 10
White vaseline 30 ethyl hydroxybenzoates 1
Distilled water 549.
5. the preparation method of arbitrary described Ftibamzone Ointment among the claim 1-4 is characterized in that,
Add among 200 parts of PEG-200 10 parts of gradation of Ftibamzone raw material stand-by after the heating for dissolving earlier;
Take by weighing oil phase and each composition of water by recipe quantity, oil phase and water are respectively to the extremely dissolving of container internal heating; Water is poured in the oil phase rapidly, and quick stirring makes, and profit is biphase to be melted fully mutually; Pour stirring into dissolving good ftibamzone solution, along with the reduction formation mastic of temperature; Ointment in colloid mill 2-3 time repeatedly, is promptly got Ftibamzone Ointment of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101094020A CN101120913B (en) | 2006-08-11 | 2006-08-11 | Ftibamzone chrisma with PEG-200 as co-solvent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006101094020A CN101120913B (en) | 2006-08-11 | 2006-08-11 | Ftibamzone chrisma with PEG-200 as co-solvent |
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|---|---|
| CN101120913A CN101120913A (en) | 2008-02-13 |
| CN101120913B true CN101120913B (en) | 2011-04-20 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1041527A (en) * | 1989-11-21 | 1990-04-25 | 中国人民解放军军事医学科学院毒物药物研究所 | The preparation method of ftibamzone compound liniment |
| CN1732969A (en) * | 2005-08-24 | 2006-02-15 | 王卫阳 | Ointment with clindamycin and metronidazole and method for preparing the same |
-
2006
- 2006-08-11 CN CN2006101094020A patent/CN101120913B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1041527A (en) * | 1989-11-21 | 1990-04-25 | 中国人民解放军军事医学科学院毒物药物研究所 | The preparation method of ftibamzone compound liniment |
| CN1732969A (en) * | 2005-08-24 | 2006-02-15 | 王卫阳 | Ointment with clindamycin and metronidazole and method for preparing the same |
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| Publication number | Publication date |
|---|---|
| CN101120913A (en) | 2008-02-13 |
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Address after: 102600 building 7, 37 Yongwang Road, Daxing biomedical industrial base, Zhongguancun Science and Technology Park, Daxing District, Beijing Patentee after: Beijing Xiehe Pharmaceutical Co.,Ltd. Address before: 102600 Xingye Road, Daxing District, Beijing Patentee before: Beijing Union Pharmaceutical Factory |
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