CN105534993A - Triamcinolone acetonide econazole cream and preparation method of triamcinolone acetonide econazole cream - Google Patents

Triamcinolone acetonide econazole cream and preparation method of triamcinolone acetonide econazole cream Download PDF

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CN105534993A
CN105534993A CN201510978610.3A CN201510978610A CN105534993A CN 105534993 A CN105534993 A CN 105534993A CN 201510978610 A CN201510978610 A CN 201510978610A CN 105534993 A CN105534993 A CN 105534993A
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triamcinolone acetonide
mannitol
econazole
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CN105534993B (en
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梅璇
王志敏
闫德莲
郭盛合
叶帮伟
刘润金
吴燕
廖光秀
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China Resources Sanjiu Nanchang Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses triamcinolone acetonide econazole cream and a preparation method of the triamcinolone acetonide econazole cream. After benzyl propionate, mannitol and sucrose stearate are specially proportioned, the skin permeability of the triamcinolone acetonide econazole cream can be improved, and the accumulated releasing amount and the permeation rate are improved, so that drug absorption is facilitated and the pharmacological effect is sufficiently expressed; a specific production process provided by the invention is combined so that the stability problem of the product can be solved; the product does not have a color changing phenomenon within a validity period of the product, and the content of effective components also accords with regulations of pharmacopeia.

Description

A kind of triamcinolone acetonide econazole cream and preparation method thereof
Technical field
The present invention relates to a kind of triamcinolone acetonide econazole cream and preparation method thereof, belong to field of medicaments.
Background technology
Triamcinolone acetonide econazole cream is white emulsifiable paste, compound preparation, for the fungal infection and eczema etc. of skin, mucosa, is a kind of common medicine.
We also find existing triamcinolone acetonide econazole cream less stable, and store 4-6 month and namely become yellow, it is very fast that active constituent content also declines, and had a strong impact on the drug effect of triamcinolone acetonide econazole cream.
Summary of the invention
The object of this invention is to provide a kind of triamcinolone acetonide econazole cream and preparation method thereof, benzyl propionate, mannitol, sucrose stearate can improve the percutaneous permeability of triamcinolone acetonide econazole cream after special proportioning of the present invention, improve cumulative release amount and infiltration rate, be conducive to drug absorption and give full play to drug effect, again in conjunction with specific production technology of the present invention, the said goods stability problem can be solved, metachromatism can not occur in keeping life, active constituent content also meets the regulation of pharmacopeia.
A kind of triamcinolone acetonide econazole cream, comprises the raw material of following weight portion:
Triamcinolone acetonide 1 part, econazole nitrate 10 parts, white vaseline 10 parts, single, double tristerin 30 parts, cetostearyl alcohol 70 parts, light liquid petrolatum 60 parts, polyoxyl stearate 60 parts, 2 parts, benzoic acid, glycerol 150 parts, disodium edetate 0.5 part, dibenzylatiooluene 0.5 part, purified water 602.4-604.6 part, benzyl propionate 0.1-0.9 part, mannitol 1.2-2.4 part, sucrose stearate 0.1-0.3 part;
Its preparation technology is as follows:
1) oil phase: by white vaseline, light liquid petrolatum, cetostearyl alcohol; single, double tristerin, polyoxyl stearate drops in oil phase reaction pot, heating; stir, the complete melting of material in oil phase, then add dibenzylatiooluene; stir; make it dissolve completely, when temperature reaches 80 ~ 85 DEG C, add benzyl propionate; cross 150 mesh sieves after 2-3h, be incubated for subsequent use;
2) aqueous phase: by the mannitol of purified water, glycerol, disodium edetate, benzoic acid and 60% formula ratio, drops into aqueous phase pot, heating, stirring and dissolving, and temperature reaches 80 ~ 85 DEG C of mistake 150 mesh sieves, is incubated for subsequent use;
3) get step 2) described aqueous phase 10% by triamcinolone acetonide, econazole nitrate mixing, then add the mannitol of 40% formula ratio, after mixing, cross 150 mesh sieves, for subsequent use;
4) when oil, the biphase temperature of water are 80 ~ 85 DEG C, oil phase is under agitation slowly poured in aqueous phase, add sucrose stearate again, abundant stirring, makes to react completely, puts cooling water, when being stirred to 55 ~ 60 DEG C, the mixed liquor of the triamcinolone acetonide described in step 3), econazole nitrate and mannitol is slowly added in emulsifying pot, continues to be stirred to mastic and be shaped, to obtain final product.
10% of aqueous phase described in step 3) is volume fraction.
The invention has the advantages that: the percutaneous permeability 1, improving triamcinolone acetonide econazole cream, improve cumulative release amount and infiltration rate, be conducive to drug absorption and give full play to drug effect, improve curative effect; 2, improve the stability of triamcinolone acetonide econazole cream, metachromatism can not occur before the deadline.
Detailed description of the invention:
Embodiment 1:
A kind of triamcinolone acetonide econazole cream, comprises the raw material of following weight portion:
Triamcinolone acetonide 1 part, econazole nitrate 10 parts, white vaseline 10 parts, single, double tristerin 30 parts, cetostearyl alcohol 70 parts, light liquid petrolatum 60 parts, polyoxyl stearate 60 parts, 2 parts, benzoic acid, glycerol 150 parts, disodium edetate 0.5 part, dibenzylatiooluene 0.5 part, purified water 602.4 parts, benzyl propionate 0.1 part, 1.2 parts, mannitol, sucrose stearate 0.1 part;
Its preparation technology is as follows:
1) oil phase: by white vaseline, light liquid petrolatum, cetostearyl alcohol; single, double tristerin, polyoxyl stearate drops in oil phase reaction pot, heating; stir, the complete melting of material in oil phase, then add dibenzylatiooluene; stir; make it dissolve completely, when temperature reaches 80 DEG C, add benzyl propionate; cross 150 mesh sieves after 2h, be incubated for subsequent use;
2) aqueous phase: by the mannitol of purified water, glycerol, disodium edetate, benzoic acid and 60% formula ratio, drops into aqueous phase pot, heating, stirring and dissolving, and temperature reaches 80 DEG C of mistake 150 mesh sieves, is incubated for subsequent use;
3) get step 2) described aqueous phase 10% by triamcinolone acetonide, econazole nitrate mixing, then add the mannitol of 40% formula ratio, after mixing, cross 150 mesh sieves, for subsequent use;
4) when oil, the biphase temperature of water are 80 DEG C, oil phase is under agitation slowly poured in aqueous phase, add sucrose stearate again, abundant stirring, makes to react completely, puts cooling water, when being stirred to 55 DEG C, the mixed liquor of the triamcinolone acetonide described in step 3), econazole nitrate and mannitol is slowly added in emulsifying pot, continues to be stirred to mastic and be shaped, to obtain final product.
Embodiment 2:
A kind of triamcinolone acetonide econazole cream, comprises the raw material of following weight portion:
Triamcinolone acetonide 1 part, econazole nitrate 10 parts, white vaseline 10 parts, single, double tristerin 30 parts, cetostearyl alcohol 70 parts, light liquid petrolatum 60 parts, polyoxyl stearate 60 parts, 2 parts, benzoic acid, glycerol 150 parts, disodium edetate 0.5 part, dibenzylatiooluene 0.5 part, purified water 603.5 parts, benzyl propionate 0.5 part, 1.8 parts, mannitol, sucrose stearate 0.2 part;
Its preparation technology is as follows:
1) oil phase: by white vaseline, light liquid petrolatum, cetostearyl alcohol; single, double tristerin, polyoxyl stearate drops in oil phase reaction pot, heating; stir, the complete melting of material in oil phase, then add dibenzylatiooluene; stir; make it dissolve completely, when temperature reaches 82 DEG C, add benzyl propionate; cross 150 mesh sieves after 2.5h, be incubated for subsequent use;
2) aqueous phase: by the mannitol of purified water, glycerol, disodium edetate, benzoic acid and 60% formula ratio, drops into aqueous phase pot, heating, stirring and dissolving, and temperature reaches 82 DEG C of mistake 150 mesh sieves, is incubated for subsequent use;
3) get step 2) described aqueous phase 10% by triamcinolone acetonide, econazole nitrate mixing, then add the mannitol of 40% formula ratio, after mixing, cross 150 mesh sieves, for subsequent use;
4) when oil, the biphase temperature of water are 82 DEG C, oil phase is under agitation slowly poured in aqueous phase, add sucrose stearate again, abundant stirring, makes to react completely, puts cooling water, when being stirred to 58 DEG C, the mixed liquor of the triamcinolone acetonide described in step 3), econazole nitrate and mannitol is slowly added in emulsifying pot, continues to be stirred to mastic and be shaped, to obtain final product.
Embodiment 3:
A kind of triamcinolone acetonide econazole cream, comprises the raw material of following weight portion:
Triamcinolone acetonide 1 part, econazole nitrate 10 parts, white vaseline 10 parts, single, double tristerin 30 parts, cetostearyl alcohol 70 parts, light liquid petrolatum 60 parts, polyoxyl stearate 60 parts, 2 parts, benzoic acid, glycerol 150 parts, disodium edetate 0.5 part, dibenzylatiooluene 0.5 part, purified water 604.6 parts, benzyl propionate 0.9 part, 2.4 parts, mannitol, sucrose stearate 0.3 part;
Its preparation technology is as follows:
1) oil phase: by white vaseline, light liquid petrolatum, cetostearyl alcohol; single, double tristerin, polyoxyl stearate drops in oil phase reaction pot, heating; stir, the complete melting of material in oil phase, then add dibenzylatiooluene; stir; make it dissolve completely, when temperature reaches 85 DEG C, add benzyl propionate; cross 150 mesh sieves after 3h, be incubated for subsequent use;
2) aqueous phase: by the mannitol of purified water, glycerol, disodium edetate, benzoic acid and 60% formula ratio, drops into aqueous phase pot, heating, stirring and dissolving, and temperature reaches 85 DEG C of mistake 150 mesh sieves, is incubated for subsequent use;
3) get step 2) described aqueous phase 10% by triamcinolone acetonide, econazole nitrate mixing, then add the mannitol of 40% formula ratio, after mixing, cross 150 mesh sieves, for subsequent use;
4) when oil, the biphase temperature of water are 85 DEG C, oil phase is under agitation slowly poured in aqueous phase, add sucrose stearate again, abundant stirring, makes to react completely, puts cooling water, when being stirred to 60 DEG C, the mixed liquor of the triamcinolone acetonide described in step 3), econazole nitrate and mannitol is slowly added in emulsifying pot, continues to be stirred to mastic and be shaped, to obtain final product.
Comparative example 1:
A kind of triamcinolone acetonide econazole cream, comprises the raw material of following weight portion:
Triamcinolone acetonide 1 part, econazole nitrate 10 parts, white vaseline 10 parts, single, double tristerin 30 parts, cetostearyl alcohol 70 parts, light liquid petrolatum 60 parts, polyoxyl stearate 60 parts, 2 parts, benzoic acid, glycerol 150 parts, disodium edetate 0.5 part, dibenzylatiooluene 0.5 part, purified water 600 parts, benzyl propionate 1.0 parts, 1.0 parts, mannitol, sucrose stearate 0.5 part;
Its preparation technology is as follows:
1) oil phase: by white vaseline, light liquid petrolatum, cetostearyl alcohol; single, double tristerin, polyoxyl stearate drops in oil phase reaction pot, heating; stir, the complete melting of material in oil phase, then add dibenzylatiooluene; stir; make it dissolve completely, when temperature reaches 90 DEG C, add benzyl propionate; cross 150 mesh sieves after 4h, be incubated for subsequent use;
2) aqueous phase: by the mannitol of purified water, glycerol, disodium edetate, benzoic acid and 60% formula ratio, drops into aqueous phase pot, heating, stirring and dissolving, and temperature reaches 75 DEG C of mistake 150 mesh sieves, is incubated for subsequent use;
3) get step 2) described aqueous phase 10% by triamcinolone acetonide, econazole nitrate mixing, then add the mannitol of 40% formula ratio, after mixing, cross 150 mesh sieves, for subsequent use;
4) when oil, the biphase temperature of water are 90 DEG C, oil phase is under agitation slowly poured in aqueous phase, add sucrose stearate again, abundant stirring, makes to react completely, puts cooling water, when being stirred to 50 DEG C, the mixed liquor of the triamcinolone acetonide described in step 3), econazole nitrate and mannitol is slowly added in emulsifying pot, continues to be stirred to mastic and be shaped, to obtain final product.
Comparative example 2:
A kind of triamcinolone acetonide econazole cream, comprises the raw material of following weight portion:
Triamcinolone acetonide 1 part, econazole nitrate 10 parts, white vaseline 10 parts, single, double tristerin 30 parts, cetostearyl alcohol 70 parts, light liquid petrolatum 60 parts, polyoxyl stearate 60 parts, 2 parts, benzoic acid, glycerol 150 parts, disodium edetate 0.5 part, dibenzylatiooluene 0.5 part, purified water 603 parts, 1.5 parts, mannitol, sucrose stearate 0.1 part;
All the other are with embodiment 1.
Comparative example 3:
A kind of triamcinolone acetonide econazole cream, comprises the raw material of following weight portion:
Triamcinolone acetonide 1 part, econazole nitrate 10 parts, white vaseline 10 parts, single, double tristerin 30 parts, cetostearyl alcohol 70 parts, light liquid petrolatum 60 parts, polyoxyl stearate 60 parts, 2 parts, benzoic acid, glycerol 150 parts, disodium edetate 0.5 part, dibenzylatiooluene 0.5 part, purified water 604 parts, benzyl propionate 0.4 part, sucrose stearate 0.2 part;
All the other are with embodiment 2.
Clinical trial:
Choose eczema of external ear patient 105 example, man 59 example, female 46 example, age 10-75 year, average 38.4 ± 5.3 years old, the course of disease 10 days-6 months, average 3.4 ± 0.8 months, acute eczema 37 example, chronic eczema 19 example; One-sided ear eczema 27 example, bilateral ear eczema 22 example, all shows as auricle in various degree, external auditory meatus gill surrounding skin flushing, casts off a skin, rotten to the corn, sepage and incrustation etc., and with violent pruritus.On average patient is divided into matched group, embodiment 1-3 group at random, comparative example 1-3 group, totally 7 groups, often organize 15 people, matched group not administration, embodiment 1-3 group gives the obtained medicine of embodiment 1-3 respectively, comparative example 1-3 group gives the obtained medicine of comparative example 1-3 respectively, 2 times/day, treats 2 weeks.
Curative effect determinate standard
Effective: Clinical symptom and sign disappears completely, ear week and skin of external auditory canal recover normal; Effective: Clinical symptom and sign obviously improves, ear week and skin of external auditory canal improving situation; Invalid: Clinical symptom and sign and trouble ear place skin conditions do not take a turn for the better.
Upper table data can be found out, the curative effect of the triamcinolone acetonide econazole cream that embodiment of the present invention 1-3 obtains obviously is better than comparative example 1(technological parameter not within the scope of the present invention), do not add benzyl propionate in comparative example 2(raw material) and comparative example 3(raw material in do not add mannitol), visible the present invention adds benzyl propionate, mannitol, sucrose stearate again after special proportioning of the present invention, improve the percutaneous permeability of triamcinolone acetonide econazole cream, improve cumulative release amount and infiltration rate, be conducive to drug absorption and give full play to drug effect, improve curative effect.
Upper table data can be found out, the Acceleration study successful of the triamcinolone acetonide econazole cream that embodiment of the present invention 1-3 obtains is better than comparative example 1(technological parameter not within the scope of the present invention), do not add benzyl propionate in comparative example 2(raw material) and comparative example 3(raw material in do not add mannitol), visible the present invention adds benzyl propionate, mannitol, sucrose stearate again after special proportioning of the present invention, improve the stability of triamcinolone acetonide econazole cream, metachromatism can not occur before the deadline.

Claims (3)

1. a triamcinolone acetonide econazole cream, is characterized by: comprise following raw material: triamcinolone acetonide, econazole nitrate, white vaseline, single, double tristerin, cetostearyl alcohol, light liquid petrolatum, polyoxyl stearate, benzoic acid, glycerol, disodium edetate, dibenzylatiooluene, purified water, benzyl propionate, mannitol, sucrose stearate.
2. a triamcinolone acetonide econazole cream, is characterized by: the raw material comprising following weight portion:
Triamcinolone acetonide 1 part, econazole nitrate 10 parts, white vaseline 10 parts, single, double tristerin 30 parts, cetostearyl alcohol 70 parts, light liquid petrolatum 60 parts, polyoxyl stearate 60 parts, 2 parts, benzoic acid, glycerol 150 parts, disodium edetate 0.5 part, dibenzylatiooluene 0.5 part, purified water 602.4-604.6 part, benzyl propionate 0.1-0.9 part, mannitol 1.2-2.4 part, sucrose stearate 0.1-0.3 part.
3. a kind of triamcinolone acetonide econazole cream as claimed in claim 2, is characterized by: its preparation technology is as follows:
1) oil phase: by white vaseline, light liquid petrolatum, cetostearyl alcohol; single, double tristerin, polyoxyl stearate drops in oil phase reaction pot, heating; stir, the complete melting of material in oil phase, then add dibenzylatiooluene; stir; make it dissolve completely, when temperature reaches 80 ~ 85 DEG C, add benzyl propionate; cross 150 mesh sieves after 2-3h, be incubated for subsequent use;
2) aqueous phase: by the mannitol of purified water, glycerol, disodium edetate, benzoic acid and 60% formula ratio, drops into aqueous phase pot, heating, stirring and dissolving, and temperature reaches 80 ~ 85 DEG C of mistake 150 mesh sieves, is incubated for subsequent use;
3) get step 2) described aqueous phase 10% by triamcinolone acetonide, econazole nitrate mixing, then add the mannitol of 40% formula ratio, after mixing, cross 150 mesh sieves, for subsequent use;
4) when oil, the biphase temperature of water are 80 ~ 85 DEG C, oil phase is under agitation slowly poured in aqueous phase, add sucrose stearate again, abundant stirring, makes to react completely, puts cooling water, when being stirred to 55 ~ 60 DEG C, the mixed liquor of the triamcinolone acetonide described in step 3), econazole nitrate and mannitol is slowly added in emulsifying pot, continues to be stirred to mastic and be shaped, to obtain final product.
CN201510978610.3A 2015-12-24 2015-12-24 Triamcinolone acetonide econazole cream and preparation method of triamcinolone acetonide econazole cream Active CN105534993B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108125969A (en) * 2017-11-10 2018-06-08 牛云飞 A kind of ointment for treating dermatophytid infection and preparation method thereof
CN111249221A (en) * 2020-02-28 2020-06-09 天津金耀药业有限公司 Diflucolone cream ester and preparation method thereof
CN112535711A (en) * 2020-12-29 2021-03-23 张德斌 Plaster for treating beriberi and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101239066A (en) * 2008-03-11 2008-08-13 刘全胜 Triamcinolone acetonide econazole cream
CN103860566A (en) * 2014-04-08 2014-06-18 白玲强 Triamcinolone acetonide and econazole cream and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101239066A (en) * 2008-03-11 2008-08-13 刘全胜 Triamcinolone acetonide econazole cream
CN103860566A (en) * 2014-04-08 2014-06-18 白玲强 Triamcinolone acetonide and econazole cream and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
顾孝红等: "复方硝酸益康唑软膏制备工艺与质量标准研究", 《江西中医学院学报》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108125969A (en) * 2017-11-10 2018-06-08 牛云飞 A kind of ointment for treating dermatophytid infection and preparation method thereof
CN111249221A (en) * 2020-02-28 2020-06-09 天津金耀药业有限公司 Diflucolone cream ester and preparation method thereof
CN112535711A (en) * 2020-12-29 2021-03-23 张德斌 Plaster for treating beriberi and preparation method thereof

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