CN101119739A - Methods for use of oral care compositions containing free-b-ring flavonoid anti-oxidants - Google Patents
Methods for use of oral care compositions containing free-b-ring flavonoid anti-oxidants Download PDFInfo
- Publication number
- CN101119739A CN101119739A CNA2005800482889A CN200580048288A CN101119739A CN 101119739 A CN101119739 A CN 101119739A CN A2005800482889 A CNA2005800482889 A CN A2005800482889A CN 200580048288 A CN200580048288 A CN 200580048288A CN 101119739 A CN101119739 A CN 101119739A
- Authority
- CN
- China
- Prior art keywords
- composition
- oral cavity
- agent
- oral
- antioxidant activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The present invention relates to a method for providing an anti-oxidant to an oral cavity of a mammalian subject. An oral composition comprising an anti-oxidant active ingredient comprising a free-B-ring flavonoid and an orally acceptable carrier is contacted with oral tissue in the oral cavity. The anti-oxidant active ingredient reduces one or more reactive oxygen species, or free radicals in the oral cavity. Methods are also provided for preparing the anti-oxidant containing oral composition.
Description
The cross reference of related application
The application requires the priority of the U.S. Provisional Patent Application 60/639,329 of December in 2004 submission on the 22nd, and it is hereby incorporated by.
Background of invention
Produce reactive oxygen species (ROS) between various Biochemical processes, described reactive oxygen species comprises superoxide anion, hydrogen peroxide and hydroxyl radical free radical.The part that the generation of ROS can be used as many cellular process produces, and described cellular process comprises the metabolism of radiation, medicine and other chemicals in mitochondrial respiratory, immune cell responses, cell injury, heating, many sources.ROS has very high reactivity and changes important cellular macromolecules.ROS causes or the acceleration disease process.
In an example, ROS is producing by engulfing in the inflammatory process that leukocyte (for example producing the activatory neutrophil of superoxide radical " oxidative burst ") causes, thinks to produce the key element of the cytotoxic effect of activation neutrophil.In addition, superoxides can be produced by endotheliocyte and being reflected on the physiology of nitrogen oxide (physiological regulation agent), forms peroxynitrite ONOO
-, it can decay and produce hydroxyl radical free radical OH.The other source of oxyradical is that electronics " leakage ", the prostaglandin of break line plastochondria or the netted electron transport chain of endoplasmic reticulum is synthetic, the oxidation and the platelet activation of catecholamine.
Think that ROS relates to nearly all lysis and ageing process.Think that the ROS formation meeting that increases under the pathological state causes primary cellular defect by these high response molecular actions that produced by crosslinking protein, mutagenic treatment DNA and peroxide lipid.
People's periodontal is an inflammatory diseases, and it is a complicated results of interaction between periodontal disease substance and the host immune response.Think exist two with periodontal disease development related aspect, first is that the activation of host immune system and second are the generations of oxygen-derived free radicals and their associated metabolic products.The oxygen-derived free radicals that increases produces can help response to oxidative stress, thinks that it is relevant with periodontal disease.
Gingivitis is the inflammation or the infection of the gingiva and the alveolar bone of supports tooth.It has been generally acknowledged that gingivitis is by the antibacterial in the oral cavity (particularly luring the antibacterial that plaque forms into) and caused from the toxin that described antibacterial forms as by-product.Think that described toxin lures intraoral oral tissue inflammation into.Compare with gingivitis, periodontitis is the state that runs down, and various focusing depths represented also begins to shrink back and form recess betwixt from tooth, finally can cause bone and periodontal ligament to destroy.Therefore, chronic infection and inflammation cause tooth loss subsequently potentially.In addition, oral tissue inflammation can be by operation, local damage, wound is downright bad or various systemic origins causes.
Generally believe that the cellular component that relates to these diseases and disease comprises epithelial tissue, gums fibroblast and circulating leukocyte, these components all promote the host to the reaction by bacteriogenic paathogenic factor.Therefore, the bacterial infection of oral cavity tissue spreads to host's immunoreation and reduces by free radical ROS material and the agglutination that produces to the adjusted mediator of inflammation, and it causes tangible tissue injury.
Need a kind of method for the treatment of the mammalian subject that primary cellular defect is arranged in the oral cavity tissue, described in some cases primary cellular defect is caused that by oral tissue inflammation described method reduces the level of cellular damage of oral cavity tissue and promotes healing by reducing the radical reaction oxygen species.
The invention summary
In various embodiments of the present invention, be provided for reducing the method for one or more free radical materials in the mammalian subject oral cavity.Described method comprises that contact contains the composition for oral cavity that carrier can be accepted in antioxidant activity composition and oral cavity.Described antioxidant activity composition comprises at least a dissociating-B-lopps flavone and mammalian subject oral surfaces acceptable carrier.
In other embodiments, the method that antioxidant is provided to the mammalian subject oral cavity is disclosed.Described method comprises that described compositions contains antioxidant activity composition and the oral cavity acceptable carrier that comprises free-B-lopps flavone with the oral cavity tissue in the composition for oral cavity contact mammalian subject oral cavity.
In other other embodiment, the method for preparing the antioxidant composition for oral cavity is provided, described method comprises that the antioxidant composition that will contain at least a dissociating-B-lopps flavone mixes with the acceptable oral composition carrier in oral cavity.
Have now found that the compositions and methods of the invention are better than the composition for oral cavity of prior art, oral care composition provided by the present invention be safety, stable, and as antioxidant therapy be very effective as the gingivitis oral tissue inflammation relevant with this class disease of periodontitis.Described antioxidant composition comprises chemical compound safe and that obtained by natural plants source (for example Scutellaria baicalensis).
Detailed Description Of The Invention
Various embodiments of the present invention provide a kind of method that reduces one or more free radical materials in the mammalian subject oral cavity.This method comprises that contact contains the composition for oral cavity that carrier can be accepted in antioxidant activity composition and oral cavity.Described antioxidant activity composition comprises at least a dissociating-B-lopps flavone and mammalian subject oral surfaces acceptable carrier.
In other embodiments, provide the method for antioxidant to comprise that described composition for oral cavity contains antioxidant activity composition and the oral cavity acceptable carrier that comprises free-B-lopps flavone with the oral cavity tissue in the composition for oral cavity contact mammalian subject oral cavity to the mammalian subject oral cavity.
The oral cavity tissue of mammalian subject contacts with antioxidant in the composition for oral cavity and is used for alleviating the infringement that is caused by the radical reaction oxygen species, determine that except that previous alternative route (minimize by making the infringement from the free radical material, rather than the previous inhibition pro-inflammatory cytokine of determining producing) the approach reduces oral tissue inflammation with in the mechanism of following, being used in the reduce oral tissue.Therefore described method reduces inflammation and promotes healing by the infringement that reduces from the free radical material.
" safety and the effective dose " of active component is meant and (for example reaches targeted activity in various embodiments of the present invention, antioxidant activity in the host's that will treat target location), and do not have over-drastic adverse side effect (for example toxicity, stimulation or allergy), when using in mode of the present invention with reasonably, be benefited/risk is than the amount that matches.Concrete " safety and effective dose " will with the excipient of the character (if any) of the disease that for example will treat, patient's body state, treatment persistent period, treatment simultaneously, used concrete dosage form, use, wherein the dissolubility of active component and the factor of the dosage regimen that described composition for oral cavity requires change.
" inflammation " general reference of oral cavity tissue is used for destroying, dilutes or isolates harmful reagent and wounded tissue by the localised protection reaction that tissue injury or destruction cause.Being characterized as pain, generating heat, reddening of acute form, swelling and loss function.Chronic inflammatory disease is that a kind of slow process and its principal character are the new connective tissue of formation.Chronic inflammatory disease usually is the mild inflammation form (for example relevant with periodontitis or gingivitis inflammation form) of acutely inflamed continuity or delay and causes persistent histologic lesion usually.Histological inflammation comprises the complex series of certain situation, and these situations comprise small artery, capillary tube and venule expansion, the permeability and the blood flow that increase; The liquid that comprises plasma protein oozes out and leucocyte migration enters the inflammation position.Inflammation is corresponding to the short inflammatory cellular mediators level that improves and the free radical material or the reactive oxygen species (ROS) that discharge from cell, for example as antigen and antibody interaction or by the result of antigen and primed lymphocyte effect.
The source of oral tissue inflammation comprises bacterial infection, operation, local damage, wound or necrosis or various systemic origins.Oral disease, disease and comprise gingivitis, periodontitis with the non-limitative example of the active diseases associated of the inflammatory cell amboceptor that increases, because neutrophilic leukocyte reduces wound healing, the infringement of periodontal bone and the acute and chronic mandibular bone osteomyelitis of the loss of tooth, dental pulp disease and the sequela thereof that cause, acute and chronic stomatocace, acute necrotizing ulcerative gingivitis, dental caries, delay.In certain embodiments, the inflammatory diseases that treat or disease are gingivitis or periodontitis.
The various forms of oxygen and the radical pair biosystem of the excessive concentrations that is produced by Inflamed tissue and host immune response have serious adverse, comprise oxidation of other responsive part in the hydroxylating of peroxidating, nucleic acid base of film fat and sulfydryl and the albumen.If uncontrolled, then cause sudden change and cell death.
Aerobic cell contains in a large number the defense to the illeffects of antioxidant radical and their product.For example, biological anti-oxidant is present in the various cells, comprises enzyme, as superoxide dismutase, catalyzing enzyme, selenium glutathion peroxidase and phospholipid hydroperoxide glutathione peroxidase; With the biological anti-oxidant of non-enzymatic catalysis, comprise tocopherol and tocotrienol, carotenoid, quinone, bilirubin, ascorbic acid, uric acid and metal-conjugated protein.Though every kind of concrete antioxidant is the distribution situation of indicating characteristic usually, find to have various lipids and water miscible antioxidant in the various piece of cell and tissue.Yet, in oral cavity tissue, oral cavity tissue is (for example around for the mammalian subject that supportive (mounting) evidence explanation suffers from various gum disease forms, in gum seam liquid etc.) in have unusual low-level antioxidant (as glutathion), and the mammalian subject with healthy gingiva has very high-caliber antioxidant.
Though the present invention is not bound by the theory of limitting, think that forming some flavonoids of back at free radical compounds in the oral cavity can prevent oxygen-derived free radicals-inductive infringement by removing free radical compounds (ROS).The invention provides a kind of antioxidant activity composition that is used for composition for oral cavity, its consumption safety is effectively removed dangerous oxygen-derived free radicals, particularly superoxides and hydrogen peroxide, and is stable and effective in the composition for oral cavity of being convenient to relatively produce.
In certain embodiments, it is aging that the present invention is used for prevent disease development or prevention cell death and oral cavity tissue.Term " prevention " belongs to the prophylactic treatment in mammalian subject oral cavity as used herein, and the composition for oral cavity by containing antioxidant composition contacts with aging, death or inflammation, oral cavity tissue ill or the infringement tendency are arranged.
In certain embodiments, provide a kind of method that is used for the treatment of oral disease and disease and the situation relevant with the elevated levels of inflammation, infection and one or more reactive oxygen species." treatment " is included in owing to after the development or physical manifestations that the inflammatory reaction of disease or situation and free radical material produce, use the composition for oral cavity that contains oxidant free-B-lopps flavone.When treatment Inflamed tissue, improve inflammation, disease or situation or prevent to deteriorate into and destroy the degradation mode that oral cavity tissue causes by free radical.For example, use " treatment " that free-b-ring flavonoid anti-oxidants comprises described disease or inflammatory/infectious symptom in inflammatory cascade development back.
In certain embodiments, described Therapeutic Method is included in the recurrence interval in one period, from a week until throughout one's life, treat the composition for oral cavity of useful amount, described composition for oral cavity contains the antioxidant that comprises free-B-lopps flavone.For example, the comprehensive preventative-therapeutic typical method that is used for the treatment of described oral disease, situation and disease and slows down ageing process comprises by calculating the composition for oral cavity that contains free-b-ring flavonoid anti-oxidants for the treatment of useful amount every day.
In various embodiments, can be by washing, smear, brush or using suitable dressing layering to finish and use or contact.In various embodiments, use described compositions and comprise the use application apparatus, the antioxidant activity composition that this equipment helps to keep to comprise free-b-ring flavonoid anti-oxidants contacts time enough with target tissue so that allow in the oral cavity tissue and the reactive oxygen species of access hole cavity tissue suppresses or reduces on the pharmacology.
In various embodiments of the present invention, described composition for oral cavity comprises the antioxidant activity composition that reduces one or more free radicals or reactive oxygen species.In a preferred embodiment of the invention, described composition for oral cavity comprises free-b-ring flavonoid anti-oxidants.
The invention provides oral care composition and give or use, or use the method for described oral care composition to people or other animal subjects.As mentioned herein, oral care composition is any compositions that is fit to give or be applied to health, health or appearance that human or animal's subject oral cavity is used to improve the experimenter, preferably provides such benefit: other of prevention or treatment tooth, gingiva, mucosa or oral cavity situation or disease hard or soft tissue; Prevention or treatment general situation or disease; Sensation, modification or cosmetic benefits are provided; With and the combination.In various preferred embodiments, can not deliberately swallow oral care composition, but described compositions should be kept being enough to play in the oral cavity time of predetermined effect.Preferably, therefore be used for concrete material of the present invention and composition be pharmaceutically or cosmetics acceptable.As used herein, " pharmaceutically acceptable " like this or " acceptable in the cosmetics " component are to be applicable to that people and/or animal are to provide the benefit of required treatment, prevention, sensation, modification or cosmetic, and do not have over-drastic adverse side effect (as toxicity, stimulation and allergy), with the component that rational being benefited/risk ratio matches.
In preferred embodiments, the antioxidant composition of composition for oral cavity of the present invention comprises at least a dissociating-B-lopps flavone.Flavonoid is to have one group of chemical compound of identical general structure and be found in the higher plant.The term flavonoid comprise as flavone, flavane, flavonol, flavanonol (dihydroflanonol), flavanone with and derivant the chemical compound of classification.
In various embodiments of the present invention, the antioxidant activity composition comprises free-B-lopps flavone, it is meant on aromatic series " B " ring without any substituent flavonoids, shown in following structure.
Free-B-lopps flavone constitutes one group and contains 2 usually, two keys of 3-and/or 4-oxo base, but on aromatic series B ring, do not have substituent flavonoid.Free B lopps flavone is rare relatively and can separates from various plant part that described plant part includes but not limited to stem, peel of stem, trunk, trunk bark, sprig, tuber, root, root bark, twig, tissue, seed, rhizome, flower and other organ of multiplication, leaf and other gas first portion.In various embodiments, free-B-lopps flavone separates from Lamiaceae section plant.In various embodiments, free-B-lopps flavone separates from the Scutellarioideae subfamily plant.In various embodiments, free-B-lopps flavone separates from the Scutellaria plant.In certain embodiments, the free-B-lopps flavone that is used as antioxidant in oral care composition of the present invention separates from Scutellaria baicalensis species.Chinese medicinal plant Scutellaria baicalensis contains a large amount of free-B-lopps flavone, comprises Radix Scutellariae aglycon (baicalein), baicalin (baicalin), wogonin (wogonin) and baicalenoside.Term as used herein " free-B-lopps flavone " also comprises the synthetic or semisynthetic equivalent of this type of natural extract or its active component.Contain that the compositions of free-B-lopps flavone is former to show the general activity that suppresses cyclo-oxygenase COX-2, yet formerly do not recognize that they are used in anti-oxidant properties in the oral care composition.In preferred embodiments, the antioxidant activity composition contains one of isolating two kinds of effective and useful especially flavonoid from S.Baicalensis.
The baicalin noroxylin
Baicalin (being also referred to as Chinese " baicalin ") is 5,6-dihydroxyflavone-7-O-glucoside, and noroxylin (being also referred to as Chinese " baicalin ") is a 5.In various embodiments, the antioxidant activity composition of composition for oral cavity of the present invention can comprise baicalin, noroxylin or its mixture.
For example of the present invention free-the antioxidant activity composition of B-lopps flavone can reduce or in and free radical compounds, comprise reactive oxygen species (ROS), as superoxide anion, hydrogen peroxide and hydroxyl anion.In certain embodiments, the antioxidant activity composition Expected Results in vivo in the composition for oral cavity can be measured in the ability of external remarkable minimizing lipid peroxidase oxidation by described compositions.Lipid peroxide (LPO) level is the index by the caused cell membrane infringement of free radical effect.For example, the film of described cell within a cell device (mitochondrion, lysosome and peroxisome) may be compromised.Because handle the antioxidant deficiency of response to oxidative stress/free radical level, memebrane protein, membrane lipid and cholesterol can be compromised.The rising of LPO is as the indication of the potential long term effect early warning of high free radical activity and response to oxidative stress.As described above, the result of long-term oxidative stress is a chronic degenerative disease.Therefore, antioxidant activity is represented in the obvious minimizing of LPO contrast tester.Such mensuration can be undertaken by commercially available mensuration, for example the biomedical test kit of LPO-CC Kamiya.Especially, importantly the antioxidant composition for oral cavity is mixed with the stabilization formulations form, and it has proved the antioxidant effect of described active component in composition for oral cavity, and no matter the effect of described chemical compound itself.
In addition, the concentration of antioxidant composition in oral care composition depends on the relative concentration of reactive compound in the extract or the purity of specific examples of such components, and can be changed by the mode that those skilled in the art determines.In addition, the concentration of active component depends on the form of composition for oral cavity usually.For example, collutory has the active component of relative low concentration usually, and dentifrice, gel or dentifrice have higher concentration to reach based on being convenient to dispersive identical dosage delivered.Equally, confectionery composition has the active component of relative wide range of concentrations usually so that can be enough to disperse when their dissolve or are chewed.
In various embodiments of the present invention, the antioxidant activity composition is present in the composition for oral cavity with the concentration of about 0.001-about 10%.In other embodiments, there is about 0.01-about 5% in the antioxidant activity composition.In certain embodiments, there is about 0.1-about 3% in the antioxidant activity composition.In other embodiments, there is about 0.1-about 1% in the antioxidant activity composition.In certain embodiments, the antioxidant activity composition is selected from free-B-lopps flavone (flavone), it is selected from baicalin, noroxylin or its mixture.Antioxidant contains in the embodiment of baicalin therein, and baicalin preferably exists with the concentration greater than about 0.2%.In other embodiments, wherein the antioxidant activity composition contains noroxylin, and noroxylin exists greater than about 0.1%.Certain embodiments of the present invention comprise mixture with baicalin and noroxylin as active component, and wherein free-B-lopps chromocor compound exists greater than 1%.
In one embodiment, come separated free from Scutellaria baicalensis-B-lopps flavone by using appropriate solvent to extract exsiccant.Preferred solvent comprises methanol, ethanol, dichloromethane, hexane, cyclohexane extraction, pentane, petroleum ether, chloroform, hydrochloric acid, dichloroethanes, methanol: THF and hydrofluoroalkane, for example 1,1,1, and 2-tetrafluoroethane or HFA-13A.Usually, a plant tissue (butt) is with about 5 to about 50 parts, preferably approximately 15 parts of extremely about 30 parts of solvents use extractor to extract, solvent contacts with bark to obtain spissated paste in extractor, then with spissated paste through one or more additional extraction steps with different solvents with further in the persistent period, preferably approximately 6 hours to approximately 1-2 days, concentrate the paste that obtains at first in more preferably about 1 day.In preferred embodiments, the natural extract active component that is used for oral care composition is renewable, stable and has microbiological safety.In one embodiment of the invention, described extract is the use carbon dioxide (CO that confirms by by those skilled in the art
2) supercritical extraction (SFE) or by steam distillation isolating.Other plant origin of noticing free-B-lopps flavone (particularly preferred baicalin or noroxylin chemical compound) also is applicable to the present invention.
Suitable excipient or carrier comprise solid or liquid filling agent, diluent, the excipient that one or more can mate or form capsular material that they are suitable for topical to oral tissue surfaces.Preferably oral acceptable carrier does not cause stimulation, swelling or pain and does not produce atopic reaction or untoward reaction usually, for example regurgitation, nauseating or dizzy.The selection of concrete carrier component depends on required product form, comprises dentifrice, toothpaste, dentifrice, preventative paste, collutory, lozenge, natural gum, gel, pigment, livestock products or the like.
In various embodiments, for example toothpaste, ointment and gel, described composition for oral cavity contains natural or synthetic thickening agent or gel, and it is different from silicon dioxide thickening agents, comprises natural and synthetic natural gum and colloid.This type of suitable thickening comprises naturally occurring polymer, for example carrageenin, xanthan gum; Synthetic thickening agent, for example polyglycols and the cellulosic polymer of the different molecular weight of selling with trade name Polyox, for example hydroxyethyl-cellulose and hydroxypropyl cellulose.Other inorganic thickening agent comprises natural and synthetic clay, for example HECTABRITE DP, lithium magnesium silicate (laponite) and Magnesiumaluminumsilicate (Veegum).Other suitable thickening is synthetic Strese Hofmann's hectorite., a kind of synthetic colloidal magnesium alkali silicate compound clay, for example the Laponite that can be sold by Laporte Industries Limited. (for example, CP, SP 2002 or D) obtain, Laponite D analyzes and shows about 58.00%SiO
2, 25.40%MgO, 3.05%Na
2O, 0.98%Li
2O and some water and trace metal, and true specific gravity be 2.53 and apparent bulk density be 1.0 (g/mL, 8% humidity).In certain embodiments, described thickening agent is about 10% with about 0.1-, and preferably approximately the amount of 0.5-about 5.0% is present in the dentifrice composition.
Other suitable thickening (for example comprises Irish moss, tragakanta, starch, polyvinylpyrrolidone, ethoxy propyl cellulose, hydroxy butyl methyl cellulose, hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, can NATROSOL1 obtain), sodium carboxymethyl cellulose and cabosil, as the SYLOID that grinds very carefully (for example, 244).
The various embodiments of the present invention also comprises surfactant, surfactant can play the effect of surfactant, emulsifying agent and/or foam modifier.Surfactant is usually by thoroughly being dispersed to the prophylactic action that the oral cavity reaches raising everywhere with active component.Suitable emulsifying agent be reasonably stability and all producing foamy emulsifying agent in the pH value scope widely, comprise non-soap anionic, nonionic, amphion and both sexes synthetic organic detergent.In addition, surface active ingredient preferably makes and promptly can accept on cosmetics more with compositions.Organic surface-active material is at preferably anion, nonionic or amphoteric in nature, and preferably gives the cleaning substance of the compositions cleaning and the character that spumes.In certain embodiments, one or more surfactants are with about 0.001% to about 5%, and preferably approximately 0.5% to about 2.5% scope is present in the composition for oral cavity of the present invention.
The ionic surfactant pack that is used for the present composition is drawn together the chemical compound that is produced by alkylene oxide (especially oxirane) and organic hydrophobic compound condensation, and its character can be aliphatic or alkyl aromatic.The one group of surfactant that is called as " ethoxamers " is the condensation product of oxirane and fatty acid, aliphatic alcohol, fatty acid amide, polyhydric alcohol (for example monostearate Isosorbide Dinitrate) etc." Polysorbate " is the title that gives the non-ionic surface active agent that a class prepares by the free hydroxyl group ethoxylation with anhydro sorbitol-fatty acid ester.They are commercially available, for example with the TWEEN of ICI
Surfactant obtains.Non-limitative example comprises polysorbate 20 (polyoxyethylene 20 Arlacel-20s, Tween
20) and polyoxyethylene sorbitan monoleate (polyoxyethylene 20 Arlacel-80s, TWEEN
80).Preferred Polysorbate comprises that every mole of Isosorbide Dinitrate has the Polysorbate of about 20 to 60 moles of ethylene oxide.
Other suitable ionic surfactant pack is drawn together poly-(oxygen ethylene) and the triblock polymer that gathers (oxypropylene) of a block of poly-(oxygen ethylene)-poly-(oxypropylene) block copolymer, especially the type and diblock.This analog copolymer is at commercial employing nonproprietary name poloxamer, and this title and numeric suffix logotype are to indicate the individual marking of each copolymer.Poloxamer can have the oxirane and the expoxy propane of different content, and this can produce various chemical constitutions and molecular weight.A kind of preferred poloxamer is a poloxamer 407.It is generally available, for example with the trade name PLURONIC of BASF AG
F127 obtains.
The non-limitative example of the non-ionic surface active agent that other is suitable comprises the product that is obtained by condensations such as the product of oxirane and expoxy propane and ethylenediamine, long chain tertiary amine oxide, long chain tertiary phosphine oxide, long-chain dialkyl sulphoxides.
Other surfactant that is used for the various embodiments of the present invention comprises the amphion synthetic surfactant.Some this type of surfactant can be described as widely the derivant of aliphatic quaternary ammonium, phosphorus and sulfonium compound, wherein aliphatic group can be a straight or branched, and one of them aliphatic substituent group contains 8-18 carbon atom and one and contains anionic water-solubilizing group, for example carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.A kind of example of suitable zwitterionic surfactant is 4-(N, N-two (2-ethoxy)-N-octadecyl ammonium)-butane-1-carboxylate.
Other suitable zwitterionic surfactant comprises that 577 beet alkali surface activator is hereby incorporated by its content as being disclosed in U.S. Pat 5,180.Typical alkyl dimethyl betanin comprises decyl betaine 2-(N-decyl-N, N-Dimethyl Ammonium) acetate, coco betaine, myristyl betaine, palmityl betaine, lauryl betaine, cetyl betaine, stearyl betaine, or the like.Illustrate amido betaines by cocoamidoethyl betanin, cocoamidopropyl, lauramido propyl betaine etc.Useful especially beet alkali surface activator comprises cocos nucifera oil acyl aminopropyl betanin and lauramide CAB.
The suitable example of anion surfactant is the water soluble salt of higher fatty acids monoglyceride monosulfate such as hydrogenation fatty acid distribution of coconut oil monoglyceride sulfate mono sodium salt, higher alkyl sulfates such as sodium lauryl sulphate (SLS), alkylaryl sulfonates such as dodecylbenzene sodium sulfonate, senior alkyl sulfosalicylic acetate, 1; the high-grade aliphatic ester of 2-dihydroxypropane sulfonate; and the saturated substantially higher aliphatic acyl group amide of lower aliphatic amino carboxylic acid compounds, have 12-16 carbon compound as fatty acid, alkyl or acyl group etc.The example of last-mentioned amide is the N-lauroyl sarcosine, and the sodium salt, potassium salt and the ethanolamine salt that preferably do not have N-lauroyl, N-myristoyl or the N-palmitoyl sarcosine of soap class or similar higher fatty acids material basically.
In various embodiments of the present invention, the carrier of oral care composition is solid or pastel, and described composition for oral cavity preferably contains the acceptable grinding-material of tooth, and described grinding-material can be used to polish enamel or the effect that bleaches is provided.
In the preparation of dentifrice composition, the grinding agent that can be used for the present invention's practice comprises silica abrasive, is at most about 20 microns precipitated silica as particle mean size, as the Zeodent115 that is sold by J.M.Huber.A kind of useful grinding agent is sold with trade name Zeodent105 by J.M Huber Co, and this grinding agent has low abrasiveness to enamel, and is about 7 precipitated silicas to about 10 micron diameters, has 390m
2The BET surface area of/g silicon dioxide and less than 70cm
3The oil absorption of/100g silicon dioxide.Other useful dentifrice abrasives comprises Polymeric sodium metaphosphate., potassium metaphosphate, tricalcium phosphate, Tri-Compress, anhydrous dicalcium phosphate, aluminium silicate, calcined alumina, bentonite or other siliceous material, or its combination.
In other embodiments of the present invention, the useful abrasive materials that is used to prepare dentifrice composition comprises having less than 100cm
3/ 100g silicon dioxide, preferably approximately 45cm
3/ 100 grams are extremely less than about 70cm
3The silica dioxide gel of the oil factor of/100g silicon dioxide and sedimentary amorphous silica.Use ASTA Rub-Out Method D281 to measure oil factor.These silicon dioxide be particle mean size from about 3 microns to about 12 microns, more preferably pH value is 4-10 between about 5 to about 10 microns and at the serosity of measuring 5% time, the micelle of preferred 6-9.A kind of useful grinding agent is sold with trade name Zeodent105 by J.M Huber Co, and this grinding agent has low abrasiveness to enamel, and is about 7 precipitated silicas to about 10 micron diameters, has 390m
2The BET surface area of/g silicon dioxide and less than 70cm
3The oil absorption of/100g silicon dioxide.The other suitable grinding agent that is used for the various embodiments of the present invention is the silica abrasive of low oil suction, as by DavisonChemical Division of W.R.Grace﹠amp; Co., Baltimore, the silica abrasive that Md.21203 sells with trade name Sylodent XWA or Sylodent 783.SylodentXWA 650 is a kind of silica hydrogels of being made up of the colloidal silica particles with 29% water content, its diameter on average from about 7 to about 10 microns and oil absorption less than 70cm
3/ 100g silicon dioxide, it is the preferred example that is used for the low oil absorption silica abrasive of the present invention's practice.Described grinding agent is present in the dentifrice composition of the present invention with about 10 to about 40% and preferably approximately 15 to about 30% concentration.
Other suitable polishing material comprises the graininess thermosetting resin, as tripolycyanamide, phenolic resins and urea-formaldehyde, and crosslinked polyepoxide and polyester.Preferred polishing material comprises that granularity is at most about 5 microns, and particle mean size is at most 1.1 microns, and surface area be at most about 50,000cm
2The crystalline silica of/g, silica gel or colloidal silica, and compound amorphous alkali metal aluminosilicate.
Comprise Tri-Compress, anhydrous dicalcium phosphate, winnofil or its combination according to the particularly preferred grinding agent of certain embodiments of the present invention.
At dentifrice is in the embodiment of clarification or clear gel, be useful especially for example, because their refractive index approaches to be generally used for the refractive index of gel-liquid (comprising water and/or wetting agent) system of dentifrice with trade mark SYLOID such as Syloid 72 and Syloid 74 or the colloidal silica buffing compound sold with trade mark SANTOCEL such as Santocel 100 composite alkali aluminums-silicate composite.
In certain embodiments, grinding agent also can comprise the abrasive grains that brightens, and it comprises for example metal-oxide.Described metal-oxide can comprise any metal-oxide that white is provided, for example titanium dioxide, aluminium oxide, stannum oxide, calcium oxide, magnesium oxide, Barium monoxide or its combination.Some grinding agent that brightens also is a pearlescent particles, and it comprises single mineral or chemical substance, for example silicate such as Muscovitum or bismuth oxychloride." Muscovitum " is meant any hydrous aluminum silicate minerals with platy morphology and perfect basis (Muscovitum shape) crackle.Muscovitum can be for example sheet mica, scrap mica or thin slice Muscovitum, is illustrated by white mica, biotite or phlogopite type Muscovitum.In some embodiments, pearlescent particles can comprise the complex that contains above a kind of mineral or chemical substance, for example scribbles the Muscovitum of metal-oxide (as titanium dioxide).
At dentifrice is in the embodiment of solid or pasty state, and described grinding-material is present in the described composition for oral cavity with about 10% to about 99% usually.In certain embodiments, polishing material is present in the toothpaste with about 10% to about 75% amount, and is present in the dentifrice with about 70% to about 99% amount.
As above mention, in various embodiments of the present invention, water also is present in the described composition for oral cavity.The water that is used to prepare commercial suitable toothpaste, gel and collutory should water preferably deionized, that UV treatment is crossed and that do not contain organic impurity.Water accounts for the about 10% to 50% of this paper dentifrice composition usually, and preferably approximately 20% to 40%.Described water is except introducing with other material, for example the free water that adds beyond the water that sorbitol adds.
In various embodiments, oral care composition of the present invention contains flavoring agent.The flavoring agent that is used for the present invention's practice comprises the aldehyde of quintessence oil and various seasonings, ester, pure and mild similar material.Also can use any suitable flavoring agent or sweeting agent material.The example of suitable flavor ingredients is the oils of seasoning, for example oil of Herba Menthae Rotundifoliae, Herba Menthae, Herba pyrolae japonicae, yellow Camphor tree, Flos Caryophylli, Salvia farinacea, Eucalyptus, Origanum majorana, Cortex Cinnamomi, Fructus Citri Limoniae, sour Fructus Citri grandis, Fructus Citri tangerinae, grapefruit, and methyl salicylate.This type of chemicals equally usefully is as menthol, carvone and anethole.Suitable sweeting agent comprises sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, perillartine, AMP (aspartyl phenylalanine, methyl ester), glucide or the like.Described flavoring agent and sweeting agent approximately 0.001-about 5% and preferably approximately the concentration of 0.5-about 2% be incorporated into composition for oral cavity separately or jointly.
As is known to the person skilled in the art, compositions of the present invention can be incorporated into chew article or the toy that forms with various patterns and size, and preferably provide to a certain degree with tooth and gingival surface the interaction of physics is arranged, promote the particle release under gingival irritation and/or the gingiva.The example of this type toy can be bone, ball and rope.In addition, preferred described chew toys can for example pass through interior reservoir, enter material or be coated onto on the toy surface by dipping and carry active component.The chew article of embodiment of the present invention is preferably formed by nontoxic edible material, and described material comprises for example rawhide or polymer, as polyester or polyisoprene.
The food and the fill-in that are used for animal are known in the art and preferably use any suitable dough preparation.Food supplement dough contains at least a flour, coarse powder, fat, water and randomly granulate protein granule (being used for decorative pattern) and flavoring agent usually.For example, when required product is cookies, can use conventional dough/pasta, randomly contain the discrete particles of meat and/or meat by-products or flour material.The example that is used for producing the suitable dough/pasta of hard and soft (comprising the wetting agent that is used for moisture Control) animal crackers is disclosed in people's such as Richar U.S. Patent No. 5,405,836; People's such as Scaglione U.S. Patent No. 5,000,943; People's such as Gellman U.S. Patent No. 4,454,163 and 4,454,164.Preferably cure this based composition.Described active component can add with flavoring agent, be included in the interior reservoir with soft center or be coated on the surface of bakery fill-in by dipping or spraying.Being used for known to those skilled in the art also estimated by the present invention to any other suitable method of animal delivering active ingredients.
Compositions for use randomly comprises the optional active substance except that oxidant free-B-lopps flavone active component according to the present invention.Additional like this mouth care active component can prevent or treat oral cavity hard or soft tissue situation or disease, prevents or treatment physiological disorder or situation, or reaches the benefit of cosmetic.In such embodiments, one or more additional activity compositions can not suppress the effect of above-described antioxidant composition.
In various embodiments, described active matter is " the systemic active thing " that can treat or prevent disease, described disease generally or the part on be not oral condition.In various embodiments, described active matter is " oral care actives " that can treat or prevent disease or (for example, to tooth, gums or oral cavity other hard or soft tissue) cosmetic benefits is provided in the oral cavity.Comprise anticalculus agent, antibacterial, antiinflammatory, anti-caries agent, brightening agent, desensitizer, vitamin, compatible enzyme, chlorophyll compound, periodontal actives, flavorants, stench controlling agent, saliva stimulant and combination thereof in this useful optional oral care actives among those, these are well-known to those skilled in the art.Though the general property of the active matter of certain each mentioned kind meeting difference can have some common attributes to open and any material that provides can be used as the interior multipurpose of two or more these type of active matters.
Compositions of the present invention also can be used for treatment or prevention of systemic disorders, as improve comprehensive general health, it is characterized by the danger that reduces the systemic disease development, described systemic disease for example is the mortality risk of the increase of cardiovascular disease, apoplexy, diabetes, serious respiratory tract infection, premature labor and LBWI (the branch puerperium malfunction that comprises related nerve/growth function) and association).Such method and additional activity composition can be used for treating those disclosed disease in the U.S. Patent Publication 2003/0206874 (announcement on November 6th, 2003) people such as Doyle.Also be disclosed in people's such as Durga U.S. Pat .6 at this useful active matter, the U.S. Pat .6 of 290,933 (calendar year 2001s JIUYUE authorized in 18th) and Lawlor, 685,921 (mandates on February 3rd, 2004).Randomly be present in the compositions of the present invention with safety and effective amount at this useful active matter.
Composition for oral cavity of the present invention can comprise anti-caries agent, for example fluoride ion source or the component of fluorine is provided.In various embodiments, so that about 25ppm to 5 enough to be provided, the amount of 000ppm fluoride ion exists based on the fluoride of anti-caries agent.Useful anti-caries agent comprises inorganic fluoride salts, for example the alkali metal salt of solubility.For example, the preferred fluoride source that is used for described composition for oral cavity is sodium fluoride, potassium fluoride, prodan, ammonium fluosilicate, sodium monofluorophosphate (MFP) and amine fluoride, comprise olaflur (olaflur) (N '-octadecyltrimethylen-iamine-N, N, N '-three (2-ethanol)-dihydrofluoride).The tinbase chemical compound that comprises stannous fluoride and stannous chloride also is useful at this.In certain embodiments, sodium fluoride or MFP are preferably as anti-dental caries composition.
In various embodiments, composition for oral cavity of the present invention comprises anticalculus agent to prevent and/or to make the formation of calculus reduce to minimum.Can there be one or more such reagent.
Suitable antilithic includes but not limited to: phosphate and Quadrafos.Phosphate and Quadrafos are used with the form of their neutral wholly or in part water-soluble cationic materials (for example, potassium, sodium or ammonium salt with and any mixture) usually.Therefore, useful inorganic phosphate and Quadrafos illustrative ground comprises monobasic, binary and the ternary phosphates of monovalent cation; Tripolyphosphate and four Quadrafos; Single-, two-, three-and four-pyrophosphate; And PC (being also referred to as " metaphosphate " in the art usually).For example, this type of phosphatic useful monovalent cation comprises hydrogen, comprises alkali-metal monovalent metal and ammonium.
The example of useful anticalculus agent comprises Na
5P
3O
10(sodium tripolyphosphate or STPP), four alkali metal pyrophosphates are Na for example
4P
2O
7(tetrasodium pyrophosphate or TSPP), K
4P
2O
7(tetrapotassium pyrophosphate), Na
2K
2P
2O
7(disodium pyrophosphate dipotassium), Na
2H
2P
2O
7(Sodium Acid Pyrophosphate) and K
2H
2P
2O
7(pyrophosphoric acid dihydro dipotassium).The PC that is commonly referred to " metaphosphate " is cyclic phosphate anion chemical compound.Be suitable for those materials of making the tartar controlling agent and comprise for example sodium hexameta phosphate and sodium trimetaphosphate.In one embodiment, the active anticalculus system contains sodium tripolyphosphate (STPP) and/or tetrasodium pyrophosphate (TSPP).
Other suitable tartar controlling agent comprises poly-amino propane sulfonic acid (AMPS), three hydration zinc citrates, polypeptide such as poly-aspartate and polyglutamic acid, polyolefin sulfonate, polyolefin phosphate, diphosphate such as azacycloalkyl-2, the 2-diphosphate (for example, azepan-2, the 2-di 2 ethylhexyl phosphonic acid), N-methyl aza-cyclopentane-2,3-di 2 ethylhexyl phosphonic acid, ethane-1-hydroxyl-1,1-di 2 ethylhexyl phosphonic acid (EHDP) and ethane-1-amino-1, the salt of 1-diphosphate, phosphono alkane carboxylic acid and any of these reagent, for example their alkali metal salt and ammonium salt.
In the various embodiments that described calculus/anti-calculus active component exists in composition for oral cavity, their concentration range by weight from about 0.01 to about 10%, more preferably by weight about 1 to about 5%.
In addition, various embodiments of the present invention comprise the anticalculus system that further contains synthetic anionic linear polycarboxylate polymer.Described anionic linear polycarboxylate utilizes the alkene formula or the ethylenically unsaturated carboxylic acids that contain the two keys of activated carbon-carbene formula and at least one carboxyl to synthesize usually.Described acid contains the two keys of the alkene formula that works easily in polyreaction, because the two keys of alkene formula exist in monomer molecule or in the alpha-beta position of carboxyl relatively or exist as the part of terminal methylene.This type of sour example is acrylic acid, methacrylic acid, ethylacrylic acid, α-Lv Bingxisuan .beta.-methylacrylic acid, β-acryloxy propionic, sorbic acid, α-chlorine sorbic acid, cinnamic acid, β-styrene acrylic (styrilacrylic), muconic acid, itaconic acid, citraconic acid, mesaconic acid, glutaconate, equisetic acid, atropic acid, 2 benzyl acrylic acid, 2-cyclohexyl acrylic acid, angelic acid, umbellic acid, fumaric acid, maleic acid and anhydride.But comprise vinyl acetate, vinyl chloride, dimethyl maleate etc. with other alkene formula monomer of this type of carboxylic monomer copolymerization.Synthetic anionic linear multi-carboxylate polymer's component mainly is to have optional halogen and contain the O substituent group and be present in for example hydrocarbon that is connected of ester, ether and OH base.Described copolymer preferably contains is enough to reach water miscible carboxylate groups.Term " synthetic " and " straight chain " do not comprise known thickening agent or the gel that contains other derivant of carboxymethyl cellulose and cellulose and natural gum, do not comprise the carbomer (Carbopols) that has the dissolubility of reduction owing to crosslinked yet.
Preferably 1: 4 of maleic anhydride or maleic acid and another kind of polymerisable ethylenically unsaturated monomer to 4: 1 copolymers preferably have about 30,000 methyl vinyl ethers (methoxy-ethylene) to about 2,500,000 molecular weight (M.W.).These copolymers are commercially available, for example obtain with Gantrez AN-139 (M.W.1,100,000), AN-119 (M.W.200,000) and S-97 solution (M.W.1,500,000) from ISP company.
In various embodiments, described anti-calculus/anticalculus system contains the synthetic anionic polycarboxylates of the about 5 weight % of 0.001-preferably approximately.In another embodiment, described synthetic anionic polycarboxylates is with the about 1.5 weight % of the about 0.5-that accounts for oral care composition, and most preferably about 1 weight % exists.In according to one embodiment of the invention, described anticalculus system contains the copolymer of maleic anhydride and methyl vinyl ether, for example above-mentioned Gantrez S-97 product that discusses.In one embodiment, the anti-calculus active component system of oral care composition contain by weight TSPP at about 0.5-about 1.5%, by weight at the STPP of about 1-about 10% and by weight at the approximately maleic anhydride of 0.5-about 1.5% and the copolymer of methyl vinyl ether.
The synergist that synthetic anionic polycarboxylates also can be used as some active component is used for dentifrice composition of the present invention, and described active component comprises antibacterial, anticalculus agent (as discussed above) or other activating agent in the composition for oral cavity.This type of anionic polycarboxylates is usually with their free acid or the preferably partly form application of neutralization or more preferably complete neutral water-soluble alkali (for example, potassium and preferred sodium) or ammonium salt.As discussed above, preferred copolymer is from maleic anhydride or maleic acid and another kind of polymerisable ethylenically unsaturated monomer, preferably have about 30,000 to about 2,500,000, most preferably about 30,000 methyl vinyl ether/maleic anhydride to about approximate molecular weight of 2,000,000 (M.W.).The example of these copolymers can be from ISP company with trade name Gantrez, for example AN 139 (M.W.1,100,000), AN 119 (M.W.200,000); S-97 pharmaceutical grade (M.W.1,500,000), AN 169 (M.W.2,000,000) and AN 179 (M.W.2,400,000) obtain; Wherein preferred copolymer is S-97 pharmaceutical grade (M.W.1,500,000).
Described anionic polycarboxylates is used for some embodiment with the amount that effectively reaches antibacterial, anticalculus agent or the required potentiation of other activating agent in the dentifrice composition.Usually, described anionic polycarboxylates is by weight from about 0.05% to about 5%, preferably from about 0.5% to about 2.5% is present in the described dentifrice composition by weight.
Various optional oral care actives can be included in the composition for oral cavity of the present invention, these active matters comprise above-described, and for example antibacterial, ascoxal, antiblocking agent (the prevention bacterial plaque is to the adhesion of enamel surface), antioxidant (as vitamin E or coenzyme Q10), anti-caries agent, desensitizer (as potassium citrate, Soluble tartar., potassium chloride, potassium sulfate and potassium nitrate), brightening agent are (as urea peroxide, SODIUM PERCARBONATE, Dexol and polyvinylpyrrolidone-H
2O
2); Compatible enzyme; Antiinflammatory (for example, steroidal class antiinflammatory comprises fluocinonide (flucinolone) and hydrocortisone, and non-steroidal anti-inflammatory agent (NSAID)), the tartar controlling agent, periodontal actives, chlorophyll compound, nutrient is (as vitamin, mineral and aminoacid, lipotropic, fish oil, coenzyme etc.), grinding agent, flavorants/stench controlling agent (zinc salt for example, as zinc gluconate, zinc citrate, zinc chlorite and α-Zi Luolantong), and saliva stimulant (citric acid for example, lactic acid, malic acid, succinic acid, ascorbic acid, adipic acid, fumaric acid and tartaric acid); And any other appropriate ingredients that is used for mouth care known to those skilled in the art.When these additives existed, they were typically about the concentration of 0.001-about 10% can required character and characteristic there be the amount of adverse effect basically, are incorporated into described dentifrice composition.
Various other materials can be incorporated into composition for oral cavity of the present invention, and described material comprises for example antiseptic such as sodium benzoate and polysiloxanes.When these auxiliary agents existed, they were incorporated into described compositions with the amount that can influence required character and characteristic basically sharply.
Example I
Prepare dentifrice composition by the following method with ingredients listed in the Table I.Baicalin is isolating from the extract of S.Baicalensis.
Be dispersed in saccharin sodium, sodium monofluorophosphate, TSPP and any other salt in the water and under agitation in the blender of routine, mix.Under agitation, wetting agent (for example, glycerol and sorbitol) is added aqueous mixture.Add organic thickening agent then, as carrageenin (carageenan) and any polymer.The mixture that stirring obtains is up to forming the even gel phase.Change mixture over to high-speed vacuum mixer then; Add the dicalcium phosphate grinding agent therein.Then at about 20-50 millimetres of mercury, preferably approximately under the vacuum of 30 millimetress of mercury, with mixture with mixed at high speed 5 to 30 minutes.Weigh up flavored oils, then baicalin is added in the flavored oils.The mixture of flavored oils and flavonoid is added mixture.At last, surfactant is packed into as sodium lauryl sulphate (SLS) as described in blender.The product that obtains be uniformly, semi-solid, extrudable paste or gel products.
| Table I | |
| Composition % | Final weight |
| Baicalin | 0.6 |
| Sorbitol | 14.0 |
| Glycerol | 10.8 |
| Sodium monofluorophosphate | 0.8 |
| Saccharin sodium | 0.1 |
| Tetrasodium pyrophosphate (TSPP) | 0.3 |
| Carrageenin (Viscarin) | 0.9 |
| Anhydrous dicalcium phosphate | 3.9 |
| Dicalcium phosphate dihydrate | 45.2 |
| Sodium lauryl sulphate | 1.5 |
| Flavoring agent | 1.0 |
| Blue 0.05 | Solution |
| The deionization and the water yield of handling through UV | Suitable |
Example II
Prepare dentifrice composition by the following method with ingredients listed in the Table II.Noroxylin is isolating from the extract of S.Baicalensis.Be dispersed in saccharin sodium, sodium monofluorophosphate, TSPP and any other salt in the water and under agitation in the blender of routine, mix.Under agitation, wetting agent (for example, glycerol and sorbitol) is added aqueous mixture.Add organic thickening agent then, as carrageenin.The mixture that stirring obtains is up to forming the even gel phase.Change mixture over to high-speed vacuum mixer then; Add the dicalcium phosphate grinding agent therein.Then at about 20-50 millimetres of mercury, preferably approximately under the vacuum of 30 millimetress of mercury, with mixture with mixed at high speed 5 to 30 minutes.
Weigh up flavored oils, then noroxylin is added described flavored oils.The mixture of flavored oils and flavonoid is joined in the mixture.Then sodium lauryl sulphate (SLS) is added described blender.The product that obtains be uniformly, semi-solid, extrudable paste or gel products.
| Table II | |
| Composition % | Final weight |
| Noroxylin | 0.2 |
| Sorbitol | 14.0 |
| Glycerol | 10.8 |
| Sodium monofluorophosphate | 0.8 |
| Saccharin sodium | 0.1 |
| Tetrasodium pyrophosphate (TSPP) | 0.3 |
| Carrageenin (Viscarin) | 0.9 |
| Anhydrous dicalcium phosphate | 3.9 |
| Dicalcium phosphate dihydrate | 45.2 |
| Sodium lauryl sulphate | 1.5 |
| Flavoring agent | 1.0 |
| Blue solution | 0.05 |
| Deionization and the water of handling through UV | In right amount |
EXAMPLE III
Prepare dentifrice composition by the following method with ingredients listed in the Table III.Noroxylin and baicalin are isolating from the extract of S.Baicalensis.Be dispersed in saccharin sodium, sodium monofluorophosphate, TSPP and any other salt in the water and under agitation in the blender of routine, mix.Under agitation, wetting agent (for example, glycerol and sorbitol) and polymer are added aqueous mixture.Add organic thickening agent then, as carrageenin.The mixture that stirring obtains is up to forming the even gel phase.Change mixture over to high-speed vacuum mixer then; Add the dicalcium phosphate grinding agent therein.Then at about 20-50 millimetres of mercury, preferably approximately under the vacuum of 30 millimetress of mercury, with mixture with mixed at high speed 5 to 30 minutes.
Weigh up flavored oils, then baicalin/baicalein is added in the flavored oils.The mixture that adds flavored oils and flavonoid.Then sodium lauryl sulphate (SLS) is added described blender.The product that obtains be uniformly, semi-solid, extrudable paste or gel products.The product that obtains be uniformly, semi-solid, extrudable paste or gel products.
| Table III | |
| Composition % | Final weight |
| Noroxylin | 0.2 |
| Baicalin | 0.6 |
| Sorbitol | 14.0 |
| Glycerol | 10.8 |
| Sodium monofluorophosphate | 0.8 |
| Saccharin sodium | 0.1 |
| Tetrasodium pyrophosphate (TSPP) | 0.3 |
| Carrageenin (Viscarin) | 0.9 |
| Anhydrous dicalcium phosphate | 3.9 |
| Dicalcium phosphate dihydrate | 45.2 |
| Sodium lauryl sulphate | 1.5 |
| Flavoring agent | 1.0 |
| Blue solution | 0.05 |
| Deionization and the water of handling through UV | In right amount |
Embodiment described here and other embodiment are exemplary and are not intended to the present composition that is limited to description and the four corner of method.The equivalence that can carry out specific embodiment, material, compositions and method within the scope of the present invention changes, changes and change, has substantially similar result.
Claims (23)
1. reduce the method for one or more free radical materials in the mammalian subject oral cavity, described method comprises makes composition for oral cavity contact with the oral surfaces of mammalian subject, and described composition for oral cavity contains antioxidant activity composition and the oral cavity acceptable carrier that comprises at least a dissociating-B-lopps flavone.
2. according to the process of claim 1 wherein that the concentration of the described antioxidant activity composition in the described composition for oral cavity is between about 0.001-about 10%.
3. according to the process of claim 1 wherein that the concentration of the described antioxidant activity composition in the described composition for oral cavity is between about 0.01-about 3%.
4. according to the process of claim 1 wherein that the concentration of the described antioxidant activity composition in the described composition for oral cavity is between about 0.1-about 1%.
According to the process of claim 1 wherein described antioxidant activity composition be selected from baicalin, noroxylin with and composition thereof.
6. according to the process of claim 1 wherein that described oral cavity acceptable carrier comprises that one or more are selected from the orally active composition of anticalculus agent, antibacterial, antiinflammatory, anti-caries agent, brightening agent, desensitizer, vitamin, compatible enzyme, chlorophyll compound, periodontal actives, flavorants, stench controlling agent, saliva stimulant and combination thereof.
According to the process of claim 1 wherein described oral cavity acceptable carrier comprise one or more be selected from viscosity modifier, diluent, surfactant, pH value regulator, grinding agent, wetting agent, oral sensation agent, sweeting agent, flavoring agent, coloring agent, antiseptic with and the component of combination.
8. according to the process of claim 1 wherein that free radical is owing to the immunoreation to the oral cavity pathogen produces in the mammalian subject oral cavity.
9. method according to Claim 8, wherein said immunoreation is relevant with the situation that is selected from gingivitis and periodontitis.
10. according to the process of claim 1 wherein that described contact is repeated many days.
11. method that antioxidant is provided to the mammalian subject oral cavity, described method comprises that described compositions contains antioxidant activity composition and the oral cavity acceptable carrier that comprises free-B-lopps flavone with the oral cavity tissue in the composition for oral cavity contact oral cavity.
12. according to the method for claim 11, the concentration of the described antioxidant activity composition in the wherein said composition for oral cavity is between about 0.001-about 10%.
13. according to the method for claim 11, the concentration of the described antioxidant activity composition in the wherein said composition for oral cavity is between about 0.1-about 3%.
14. according to the method for claim 11, wherein said antioxidant activity composition be selected from baicalin, noroxylin with and composition thereof.
15. according to the method for claim 11, wherein said oral cavity acceptable carrier comprises that one or more are selected from the orally active composition of anticalculus agent, antibacterial, antiinflammatory, anti-caries agent, brightening agent, desensitizer, vitamin, compatible enzyme, chlorophyll compound, periodontal actives, flavorants, stench controlling agent, saliva stimulant and combination thereof.
16. according to the method for claim 11, wherein said oral cavity acceptable carrier comprise one or more be selected from viscosity modifier, diluent, surfactant, pH value regulator, grinding agent, wetting agent, oral sensation agent, sweeting agent, flavoring agent, coloring agent, antiseptic with and the component of combination.
17. according to the method for claim 11, wherein said contact is repeated many days.
18. a method for preparing the antioxidant composition for oral cavity, described method comprise that the antioxidant composition that will comprise at least a dissociating-B-lopps flavone mixes with the acceptable oral composition carrier in oral cavity.
19. according to the method for claim 18, wherein said antioxidant composition comprise at least a be selected from baicalin, noroxylin with and composition thereof free-B-lopps flavone.
20. according to the method for claim 18, wherein said antioxidant activity composition is present in the described composition for oral cavity with the concentration of about 0.001-about 10%.
21. according to the method for claim 18, wherein said oral cavity acceptable carrier comprises that one or more are selected from the orally active composition of anticalculus agent, antibacterial, antiinflammatory, anti-caries agent, brightening agent, desensitizer, vitamin, compatible enzyme, chlorophyll compound, periodontal actives, flavorants, stench controlling agent, saliva stimulant and combination thereof.
22. according to the method for claim 18, wherein said oral cavity acceptable carrier also comprise one or more be selected from viscosity modifier, diluent, surfactant, pH value regulator, grinding agent, wetting agent, oral sensation agent, sweeting agent, flavoring agent, coloring agent, antiseptic with and the component of combination.
23. according to the method for claim 18, wherein said oral care composition is to be selected from the oral care product form of collutory, powder, medicine, dentifrice, confection and animal product.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63932904P | 2004-12-22 | 2004-12-22 | |
| US60/639,329 | 2004-12-22 | ||
| US11/280,668 | 2005-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101119739A true CN101119739A (en) | 2008-02-06 |
Family
ID=39055527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2005800482889A Pending CN101119739A (en) | 2004-12-22 | 2005-12-15 | Methods for use of oral care compositions containing free-b-ring flavonoid anti-oxidants |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN101119739A (en) |
| ZA (1) | ZA200705994B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114796260A (en) * | 2022-06-28 | 2022-07-29 | 潍坊护理职业学院 | Oral care composition and preparation method thereof |
-
2005
- 2005-12-15 CN CNA2005800482889A patent/CN101119739A/en active Pending
-
2007
- 2007-07-19 ZA ZA200705994A patent/ZA200705994B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114796260A (en) * | 2022-06-28 | 2022-07-29 | 潍坊护理职业学院 | Oral care composition and preparation method thereof |
| CN114796260B (en) * | 2022-06-28 | 2022-09-27 | 潍坊护理职业学院 | Oral care composition and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200705994B (en) | 2009-03-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2005322191B2 (en) | Method of reducing oral tissue inflammation using magnolia extract | |
| JP5883428B2 (en) | Combinations for obtaining oral compositions, their production and use | |
| TWI396569B (en) | Oregano oral care compositions and methods for use thereof | |
| CN105592892B (en) | Compositions comprising gallic acid esters and gallic acid amides | |
| JP5665888B2 (en) | Oral care composition | |
| MX2007007705A (en) | Antibacterial and anti-inflammatory oral care composition. | |
| CN103228248A (en) | Dentifrice compositions containing calcium silicate and a basic amino acid | |
| BRPI0620265B1 (en) | anti-plaque and desensitizing oral composition | |
| CN102626378A (en) | Oral care composition containing extract of unoxidized camellia | |
| JP2015212274A (en) | Oral care composition | |
| CN110636887A (en) | Oral care compositions and methods of use | |
| CN101132806A (en) | Method of reducing oral tissue inflammation using magnolia extract | |
| RU2457829C2 (en) | Mineral and vitamin complex for strengthening tooth enamel, composition for oral cavity hygiene and toothpaste | |
| KR19980013946A (en) | Oral composition of liquid type | |
| KR20200050801A (en) | Oral composition containing eugenol and bamboo salt | |
| KR20040046309A (en) | Oral care composition comprising nanoparticulated cinnamon extract | |
| CN101119739A (en) | Methods for use of oral care compositions containing free-b-ring flavonoid anti-oxidants | |
| US20060134015A1 (en) | Methods for use of oral care compositions containing free-B-ring flavonoid anti-oxidants | |
| KR20040081936A (en) | Dental composition for antiplaque and antigingivity | |
| EP2906179B1 (en) | Topical ubiquinol oral supplement compositions with amorphous calcium phosphate | |
| US11273122B2 (en) | Combination of cannabis, derivatives thereof and additives in oral care compositions | |
| JP3140412B2 (en) | Oral composition containing beef knee or yu white skin extract | |
| RU2068688C1 (en) | Curative-prophylactic dental paste | |
| CN114601760A (en) | Oral composition | |
| JP2023537868A (en) | Composition for treating and/or preventing oral disease |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080206 |