CN101113922A - Flow rate sensor calibrating method in medical respiration mechanics module - Google Patents
Flow rate sensor calibrating method in medical respiration mechanics module Download PDFInfo
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- CN101113922A CN101113922A CNA2006100619356A CN200610061935A CN101113922A CN 101113922 A CN101113922 A CN 101113922A CN A2006100619356 A CNA2006100619356 A CN A2006100619356A CN 200610061935 A CN200610061935 A CN 200610061935A CN 101113922 A CN101113922 A CN 101113922A
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Abstract
The invention discloses a flow sensor calibration method in a medical respiratory mechanics module, which comprises a zero point calibration and a linearity difference calibration, the linearity difference calibration comprises the steps that: a standard circuit board in the respiratory mechanics module is manufactured to obtain a board calibration coefficient, the board calibration coefficient is saved in a memorizer of the respiratory mechanics module; the standard circuit board is used for calibrating a flow sensor to gain a flow sensor calibration coefficient, the flow sensor calibration coefficient is recorded on a medium, which can be output with the flow sensor; when the respiratory mechanics module need to be measured, firstly the pressure difference value is measured; the pressure difference value is multiplied by the board calibration coefficient to get a first calibration pressure difference value; the first calibration pressure difference value is multiplied by the flow sensor calibration coefficient to get a second calibration pressure difference value, or according to the first calibration pressure difference calculating the flow, the flow is multiplied by the flow sensor calibration coefficient to get the calibration flow.
Description
[technical field]
The present invention relates to flow sensor calibration steps in a kind of medical respiration mechanics module.
[background technology]
In medical monitoring, breathing mechanics module is widely used in medical monitor, Anesthesia machine and the lung ventilator, and in respiratory mechanics monitor, flow sensor plays an important role.Because technological problems, the individual difference of flow sensor often is difficult to avoid, and its individual difference is quite big.Frequently change the breathing mechanics module of flow sensor for needs, such inconsistency has seriously influenced the result of respiratory mechanics monitor.With the diaphragm type differential pressure pickup is example, this sensor is mainly by inserting a plastic film in gas circuit, thereby and on diaphragm, leave the pore of given shape or air cleft forms pressure differential on the diaphragm both sides, measure magnitude of pressure differential with existing pressure-gradient transducer and measure flow size in the air flue indirectly.The geometric configuration of pore or air cleft directly determines the coordinate curve of pressure reduction to flow.Fig. 1 is the pressure reduction-flow curve of a certain diaphragm type differential pressure pickup.Ideally, this curve should be the straight line of two symmetries, and the coincidence of the characteristic curve of employed all flow sensors, so just can reach the consistance of measurement.But in the actual measurement, because the flow-pressure differential curve is very responsive to the change of the shape of gas circuit, and rule also is not easy to grasp.Even this difference that just causes between the flow sensor Different Individual of identical lot number also is appreciable.Fig. 2 is and same batch of another flow sensor of Fig. 1.Can calculate easily, the slope difference of the trend line of two curves has reached 12.18%.Therefore, can measure for doctor and patient provide accurately breathing mechanics parameters in order to make patient monitor, the calibration of flow sensor becomes most important.
Existing breathing mechanics flow sensor mainly contains hot wire type's flow sensor and differential flow sensor.Hot wire type's flow sensor is owing to the measuring principle difference, and individual difference relative pressure formula sensor cost is very high.The most important thing is, reach accurate measurement result.Even hot wire type's sensor can not be avoided the process of calibrating.Differential flow sensor comprises diaphragm type and venturi type flow sensor etc.Wherein, compare venturi type flow sensor pressure reduction-discharge characteristic linear relatively poor with the diaphragm type flow sensor.Fig. 3 is one group of relatively more typical venturi type flow sensor pressure reduction-flow curve.For pressure reduction-rating curve as shown in Figure 3, when carrying out the breathing mechanics module design, if adopt the AD converter of low resolution, the precision needs in the time of can guaranteeing high flow capacity, the precision needs when but being difficult to guarantee low discharge; If adopt high-resolution AD converter, the accuracy requirement in the time of can having guaranteed low discharge then is a kind of waste concerning high flow capacity.Therefore the respiratory mechanics monitoring system design generally trends towards using the flow sensor of strictness of Linearity.Calibration steps to capsule has three kinds at present.One is to use normal flow generation equipment (normally making frock by oneself) and high-precision flow checkout equipment to carry out the exhaustive pointwise demarcates.This method writes down all flow-pressure differential calibration points, with linking to each other with straight line between all points, forms the characteristic curve at some flow sensors again.The point of demarcating is many more, and then calibration result is accurate more.Its shortcoming is: 1) increased the development amount, if calibration is manually to carry out, for so many calibration point, be undoubtedly very large workload; If carry out automatically, then need to make especially the communication program and the automatic calibration procedure of flow reference equipment, also be a no small task.2) expense costliness adds that the flow generating means is just especially one than expensive expense.For the terminal user of small purchases respiratory mechanics monitor equipment, this calibration steps is obviously inapplicable.The 2nd, carry out the linear calibration of single-point type with special constant current equipment.Its shortcoming is: need to introduce constant current equipment, and when fluctuations in discharge that constant current equipment provides, be not easy timely discovery, thereby cause alignment error.The 3rd, some Anesthesia machines and lung ventilator be an integrated permanent type flow sensor in machine, produces constant current by Anesthesia machine or lung ventilator self during calibration, thereby the measurement result contrast of the flow sensor that measurement result and inside is integrated reaches the purpose of calibration.Its shortcoming is: only be applicable to this heavy mechanical equipment that can oneself produce flow of Anesthesia machine and lung ventilator, for patient monitor or common breathing mechanics module, this method can not be suitable for.
[summary of the invention]
Fundamental purpose of the present invention is exactly in order to address the above problem, flow sensor calibration steps in a kind of medical respiration mechanics module is provided, flow sensor is carried out low cost, convenience, simple calibration, not only be applicable to heavy mechanical equipments such as Anesthesia machine and lung ventilator, and be applicable to and self produce the patient monitor or the common breathing mechanics module of constant current.
For achieving the above object, the present invention proposes flow sensor calibration steps in a kind of medical respiration mechanics module, comprises the linear differences calibration, and described linear differences calibration may further comprise the steps:
The preferred circuit integrated circuit board of A1, making breathing mechanics module draws the integrated circuit board calibration factor;
B1, usefulness preferred circuit integrated circuit board calibrated fluxes sensor draw the flow sensor calibration factor.
Wherein, above-mentioned steps A1 may further comprise the steps:
A11, the circuit-board card of breathing mechanics module is carried out zero point correction;
A12, utilize normal pressure equipment that the differential pressure pickup in the circuit-board card is carried out the input of slow scale pressure, measure pressure reduction or flow;
A13, the result that circuit-board card in the result of reference device measuring and the steps A 12 is measured compare, and draw the integrated circuit board calibration factor, and the integrated circuit board calibration factor are stored in the storer of breathing mechanics module;
A14, once more circuit-board card is carried out zero point correction, obtain the preferred circuit integrated circuit board.
Wherein, above-mentioned steps B1 may further comprise the steps:
B11, flow sensor to be calibrated is arranged on the relevant position of preferred circuit integrated circuit board;
B12, the flow that utilizes constant current equipment to be produced trigger the flow sensor perception and measure pressure reduction or flow;
B13, the result who measures among the result of reference device measuring and the step B12 is compared, draw the flow sensor calibration factor.
Wherein, the flow sensor calibration factor among the above-mentioned steps B13 is two, is respectively applied for the positive axis and the negative semiaxis of calibrating-flow curve.
Further comprising the steps of after the step B13:
B14, the flow sensor calibration factor is recorded on visual media or the computer-readable medium, and with the flow sensor shipment, the calibration factor of the flow sensor after after changing flow sensor, the flow sensor calibration factor in the breathing mechanics module being updated to replacing for the terminal user.
For achieving the above object, the present invention also proposes flow sensor calibration steps in a kind of medical respiration mechanics module, comprises the linear differences calibration, and described linear differences calibration may further comprise the steps:
A2, breathing mechanics module are measured the pressure difference that is directly obtained by flow sensor earlier;
B2, pressure difference be multiply by the integrated circuit board calibration factor obtain calibration back pressure difference for the first time;
Pressure difference multiply by the flow sensor calibration factor and obtains calibration back pressure difference for the second time after C2, the calibration for the first time, or calculates flow according to calibrating the back pressure difference for the first time, flow be multiply by the flow sensor calibration factor obtain calibrating the back flow.
Wherein, according to calibrating positive axis or the negative semiaxis that the back pressure difference is positioned at pressure reduction-flow curve for the first time, the back pressure difference multiply by and the positive axis or the corresponding flow sensor calibration factor of negative semiaxis of pressure reduction-flow curve with calibrating for the first time in step C2; Be positioned at the positive axis or the negative semiaxis of pressure reduction-flow curve according to flow, flow be multiply by positive axis or the corresponding flow sensor calibration factor of negative semiaxis with pressure reduction-flow curve.
For achieving the above object, the present invention also proposes flow sensor calibration steps in a kind of medical respiration mechanics module, comprises the calibration of zero point correction and linear differences, and described linear differences calibration may further comprise the steps:
The preferred circuit integrated circuit board of A3, making breathing mechanics module draws the integrated circuit board calibration factor, and the integrated circuit board calibration factor is stored in the storer of breathing mechanics module;
B3, usefulness preferred circuit integrated circuit board calibrated fluxes sensor, draw the flow sensor calibration factor, and the flow sensor calibration factor is recorded on visual media or the computer-readable medium, with the flow sensor shipment, the calibration factor of the flow sensor after after changing flow sensor, the flow sensor calibration factor in the breathing mechanics module being updated to replacing for the terminal user;
C3, when breathing mechanics module need be measured, measure the pressure difference that directly obtains earlier by flow sensor;
D3, pressure difference be multiply by the integrated circuit board calibration factor obtain calibration back pressure difference for the first time;
Pressure difference multiply by the flow sensor calibration factor and obtains calibration back pressure difference for the second time after E3, the calibration for the first time, or calculates flow according to calibrating the back pressure difference for the first time, flow be multiply by the flow sensor calibration factor obtain calibrating the back flow.
Wherein, above-mentioned steps A3 may further comprise the steps:
A31, the circuit-board card of breathing mechanics module is carried out zero point correction;
A32, utilize normal pressure equipment that the differential pressure pickup in the circuit-board card is carried out the input of slow scale pressure, measure pressure reduction or flow;
A33, the result that circuit-board card in the result of reference device measuring and the steps A 32 is measured compare, and draw the integrated circuit board calibration factor, and the integrated circuit board calibration factor are stored in the storer of breathing mechanics module;
A34, once more circuit-board card is carried out zero point correction, obtain the preferred circuit integrated circuit board;
Step B3 may further comprise the steps:
B31, flow sensor to be calibrated is arranged on the relevant position of preferred circuit integrated circuit board;
B32, the flow that utilizes constant current equipment to be produced trigger the flow sensor perception and measure pressure reduction or flow;
B33, the result who measures among the result of reference device measuring and the step B32 is compared, draw the flow sensor calibration factor.
Wherein, the flow sensor calibration factor among the above-mentioned steps B33 is two, is respectively applied for the positive axis and the negative semiaxis of calibrating-flow curve; According to calibrating positive axis or the negative semiaxis that the back pressure difference is positioned at pressure reduction-flow curve for the first time, the back pressure difference multiply by and the positive axis or the corresponding flow sensor calibration factor of negative semiaxis of pressure reduction-flow curve with calibrating for the first time in step e 3; Be positioned at the positive axis or the negative semiaxis of pressure reduction-flow curve according to flow, flow be multiply by positive axis or the corresponding flow sensor calibration factor of negative semiaxis with pressure reduction-flow curve.
The invention has the beneficial effects as follows: the terminal user does not need to buy in addition any correcting device, by easy zero point correction and the calibration of linear difference, has obtained quite or better to calibrate effect with existing calibration steps.
Feature of the present invention and advantage will be elaborated in conjunction with the accompanying drawings by embodiment.
[description of drawings]
Fig. 1, Fig. 2 are the pressure reduction-flow curve of two flow sensors of same batch;
Fig. 3 is the pressure reduction-flow curve of venturi type flow sensor;
Fig. 4 is the breathing mechanics module calibration factor calculation process of an embodiment of the present invention;
Fig. 5 is the breathing mechanics measurement result calibration flow process of an embodiment of the present invention.
[embodiment]
By carrying out a large amount of experiments and a large amount of experimental datas are handled and analyzed, the individual pressure reduction-discharge characteristic difference that found that flow sensor is embodied on the curve shape and is not obvious, and is the difference of its linear gain entirely.(as depicted in figs. 1 and 2.) if linear gain difference can be calibrated, the difference of its shape can be ignored fully so.Like this, calibration needs the just remaining zero point drift (offset excursion) of problem and the linear differences (gain/linearity difference) of solution.
For zero point drift, this calibration steps takes the method for traditional zero point correction to solve.Promptly before carrying out factory level calibration and actual measurement and carry out zero point correction in the measuring process.
For linear differences, by the method solution of factory calibrated and user class calibration combination.Aspect factory, at first carry out the calibration of integrated circuit board level, make the preferred circuit integrated circuit board of breathing mechanics module.Mass data in the integrated circuit board test confirms that the pressure reduction-electric pressure converter that is adopted (differential pressure pickup) can keep tight linearity usually when carrying out transducing.Therefore, the integrated circuit board level in factory calibrated calibration is primarily aimed at is that the amplifying circuit in the breathing mechanics module and the linear gain of this total system of differential pressure pickup are regulated.The purpose of this calibration is: 1. carry out the calibration that absolute pressure is measured, guarantee the accuracy that absolute pressure is measured; 2. guarantee the breathing mechanics module circuit-board card the produced consistance to differential pressure measurement, the calibration factor of calibrating the flow sensor that obtains with the standard integrated circuit board just can be applicable to each piece integrated circuit board like this.The calibration steps of integrated circuit board level calibration may further comprise the steps as shown in Figure 4:
In step 11, circuit-board card is carried out zero point correction, carry out step 12 then, use normal pressure equipment (as DPI610) that differential pressure pickup is carried out slow scale pressure input, measure pressure reduction or flow.For example, be respectively 120cmH for pressure and pressure reduction full scale
2O and 5cmH
2The system of O, general tonometric calibration point is at 110-120cmH
2O, the pressure reduction calibration point is at 4.5-5cmH
2O.Carry out step 13 then, with reference equipment (when comparative parameter is pressure, reference equipment is the normal pressure meter, when comparative parameter is flow, reference equipment is proving flowmeter) pressure reduction measured or flow compare with the pressure reduction or the flow of circuit-board card measurement before, it is the flow that circuit-board card is measured on the throughput ratio of the pressure reduction measured than last circuit-board card of the pressure reduction of reference device measuring or reference device measuring, draw integrated circuit board calibration factor k, and integrated circuit board calibration factor k is stored in the storer (for example EEPROM or Flash) of breathing mechanics module and forever preserves, up to new calibration factor it is upgraded; Carry out step 14 at last, once more circuit-board card is carried out zero point correction, obtain the preferred circuit integrated circuit board.
After obtaining the preferred circuit integrated circuit board, utilize this preferred circuit integrated circuit board flow sensor to calibrate, the calibration steps of flow sensor may further comprise the steps as shown in Figure 4:
In step 21, flow sensor to be calibrated is arranged on the relevant position of preferred circuit integrated circuit board, the flow that utilizes constant current equipment to be produced triggers the flow sensor perception and measures pressure reduction or flow; Carry out step 22 then, the result who measures among the result of reference device measuring and the step B12 is compared, draw flow sensor calibration factor k1, k2, flow sensor calibration factor k1, k2 are respectively applied for the positive axis and the negative semiaxis of calibrating-flow curve; Because the characteristic of sensor determines its flow experienced and the pressure differential that is produced to be substantially linear, so equal substantially with the k1 value that obtains by contrast pressure reduction by the k1 that unit rate of flow is obtained; Carry out step 23 then, flow sensor calibration factor k1, k2 are recorded on visual media or the computer-readable medium, visual media and computer-readable medium comprise the medium of various materials, for example label, instructions, packing, floppy disk, CD, or even product itself, and with the flow sensor shipment, flow sensor can be that installation is sold to the user with circuit-board card, also can be sold to the user separately.The calibration factor of the flow sensor flow sensor calibration factor k1, k2 are updated to replacing with the flow sensor calibration factor in the breathing mechanics module for the terminal user after changing flow sensor after.
At customer-side, what the user obtained is a whole set of breathing mechanics module or single flow sensor, after the user is changing flow sensor, in flow sensor calibration factor k1, k2 load module, or read flow sensor calibration factor k1, k2 on the computer-readable medium (for example floppy disk, CD) by computing machine, directly cover the former flow sensor calibration factor in the breathing mechanics module.Carry out measurement result with integrated circuit board calibration factor k and flow sensor calibration factor k1 below and be calibrated to example and describe, its flow process may further comprise the steps as shown in Figure 5:
In step 31, directly obtain pressure difference dp by measuring; Carry out step 32 then, from the storer of breathing mechanics module, read integrated circuit board calibration factor k, utilize the pressure difference dp1:dp1=dp*k after integrated circuit board calibration factor k calculates calibration for the first time, carry out step 33 or step 34 then;
In step 33, reading flow quantity sensor calibration factor k1 from the storer of breathing mechanics module utilizes the pressure difference dp2:dp2=dp1*k1 after flow sensor calibration factor k1 calculates calibration for the second time.
In step 34,, carry out step 35 then by flow rate calculation formula calculated flow rate flow:flow=f (dp1);
In step 35, reading flow quantity sensor calibration factor k1 from the storer of breathing mechanics module utilizes flow sensor calibration factor k1 to calculate calibration back flow flow1:flow1=flow*k1.
Above-mentioned is pressure reduction and flow to be positioned under the situation of pressure reduction-flow curve positive axis calibrate flow process, be positioned under the situation of the negative semiaxis of pressure reduction-flow curve for pressure reduction and flow, only need be in step 33 and 35 from the storer of breathing mechanics module reading flow quantity sensor calibration factor k2, utilize pressure difference dp2 and calibration back flow flow1:dp2=dp1*k2 after flow sensor calibration factor k2 calculates calibration for the second time, flow1=flow*k2.
In sum, the characteristics that The present invention be directed to the flow sensor individual difference are tested laggard line data analysis in a large number and are summed up the very easy calibration steps of a kind of operation that the back is designed, this calibration steps not only comprises conventional zero point correction, also comprises factory calibrated and user calibration.Utilize calibration steps of the present invention can also calibrate flow sensor in other modules, only need select for use corresponding circuit-board card to get final product.
Claims (10)
1. flow sensor calibration steps in the medical respiration mechanics module is characterized in that comprising the linear differences calibration, and described linear differences calibration may further comprise the steps:
The preferred circuit integrated circuit board of A1, making breathing mechanics module draws the integrated circuit board calibration factor;
B1, usefulness preferred circuit integrated circuit board calibrated fluxes sensor draw the flow sensor calibration factor.
2. flow sensor calibration steps in the medical respiration mechanics module as claimed in claim 1 is characterized in that steps A 1 may further comprise the steps:
A11, the circuit-board card of breathing mechanics module is carried out zero point correction;
A12, utilize normal pressure equipment that the differential pressure pickup in the circuit-board card is carried out the input of slow scale pressure, measure pressure reduction or flow;
A13, the result that circuit-board card in the result of reference device measuring and the steps A 12 is measured compare, and draw the integrated circuit board calibration factor, and the integrated circuit board calibration factor are stored in the storer of breathing mechanics module;
A14, once more circuit-board card is carried out zero point correction, obtain the preferred circuit integrated circuit board.
3. flow sensor calibration steps in the medical respiration mechanics module as claimed in claim 2, it is characterized in that: step B1 may further comprise the steps:
B11, flow sensor to be calibrated is arranged on the relevant position of preferred circuit integrated circuit board;
B12, the flow that utilizes constant current equipment to be produced trigger the flow sensor perception and measure pressure reduction or flow;
B13, the result who measures among the result of reference device measuring and the step B12 is compared, draw the flow sensor calibration factor.
4. flow sensor calibration steps in the medical respiration mechanics module as claimed in claim 3 is characterized in that the flow sensor calibration factor among the step B13 is two, is respectively applied for the positive axis and the negative semiaxis of calibrating-flow curve.
5. flow sensor calibration steps in the medical respiration mechanics module as claimed in claim 4 is characterized in that step B13 is afterwards further comprising the steps of:
B14, the flow sensor calibration factor is recorded on visual media or the computer-readable medium, and with the flow sensor shipment, the calibration factor of the flow sensor after after changing flow sensor, the flow sensor calibration factor in the breathing mechanics module being updated to replacing for the terminal user.
6. flow sensor calibration steps in the medical respiration mechanics module, it is characterized in that: comprise the linear differences calibration, described linear differences calibration may further comprise the steps:
A2, breathing mechanics module are measured the pressure difference that is directly obtained by flow sensor earlier;
B2, pressure difference be multiply by the integrated circuit board calibration factor obtain calibration back pressure difference for the first time;
Pressure difference multiply by the flow sensor calibration factor and obtains calibration back pressure difference for the second time after C2, the calibration for the first time, or calculates flow according to calibrating the back pressure difference for the first time, flow be multiply by the flow sensor calibration factor obtain calibrating the back flow.
7. flow sensor calibration steps in the medical respiration mechanics module as claimed in claim 6, it is characterized in that: according to calibrating positive axis or the negative semiaxis that the back pressure difference is positioned at pressure reduction-flow curve for the first time, the back pressure difference multiply by and the positive axis or the corresponding flow sensor calibration factor of negative semiaxis of pressure reduction-flow curve with calibrating for the first time in step C2; Be positioned at the positive axis or the negative semiaxis of pressure reduction-flow curve according to flow, flow be multiply by positive axis or the corresponding flow sensor calibration factor of negative semiaxis with pressure reduction-flow curve.
8. flow sensor calibration steps in the medical respiration mechanics module, it is characterized in that: comprise the calibration of zero point correction and linear differences, described linear differences calibration may further comprise the steps:
The preferred circuit integrated circuit board of A3, making breathing mechanics module draws the integrated circuit board calibration factor, and the integrated circuit board calibration factor is stored in the storer of breathing mechanics module;
B3, usefulness preferred circuit integrated circuit board calibrated fluxes sensor, draw the flow sensor calibration factor, and the flow sensor calibration factor is recorded on visual media or the computer-readable medium, with the flow sensor shipment, the calibration factor of the flow sensor after after changing flow sensor, the flow sensor calibration factor in the breathing mechanics module being updated to replacing for the terminal user;
C3, when breathing mechanics module need be measured, measure the pressure difference that directly obtains earlier by flow sensor;
D3, pressure difference be multiply by the integrated circuit board calibration factor obtain calibration back pressure difference for the first time;
Pressure difference multiply by the flow sensor calibration factor and obtains calibration back pressure difference for the second time after E3, the calibration for the first time, or calculates flow according to calibrating the back pressure difference for the first time, flow be multiply by the flow sensor calibration factor obtain calibrating the back flow.
9. flow sensor calibration steps in the medical respiration mechanics module as claimed in claim 8 is characterized in that: steps A 3 may further comprise the steps:
A31, the circuit-board card of breathing mechanics module is carried out zero point correction;
A32, utilize normal pressure equipment that the differential pressure pickup in the circuit-board card is carried out the input of slow scale pressure, measure pressure reduction or flow;
A33, the result that circuit-board card in the result of reference device measuring and the steps A 32 is measured compare, and draw the integrated circuit board calibration factor, and the integrated circuit board calibration factor are stored in the storer of breathing mechanics module;
A34, once more circuit-board card is carried out zero point correction, obtain the preferred circuit integrated circuit board;
Step B3 may further comprise the steps:
B31, flow sensor to be calibrated is arranged on the relevant position of preferred circuit integrated circuit board;
B32, the flow that utilizes constant current equipment to be produced trigger the flow sensor perception and measure pressure reduction or flow;
B33, the result who measures among the result of reference device measuring and the step B32 is compared, draw the flow sensor calibration factor.
10. flow sensor calibration steps in the medical respiration mechanics module as claimed in claim 9 is characterized in that: the flow sensor calibration factor among the step B33 is two, is respectively applied for the positive axis and the negative semiaxis of calibrating-flow curve; According to calibrating positive axis or the negative semiaxis that the back pressure difference is positioned at pressure reduction-flow curve for the first time, the back pressure difference multiply by and the positive axis or the corresponding flow sensor calibration factor of negative semiaxis of pressure reduction-flow curve with calibrating for the first time in step e 3; Be positioned at the positive axis or the negative semiaxis of pressure reduction-flow curve according to flow, flow be multiply by positive axis or the corresponding flow sensor calibration factor of negative semiaxis with pressure reduction-flow curve.
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