CN101106998A - 有丝分裂驱动蛋白抑制剂 - Google Patents

有丝分裂驱动蛋白抑制剂 Download PDF

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Publication number
CN101106998A
CN101106998A CNA2006800025464A CN200680002546A CN101106998A CN 101106998 A CN101106998 A CN 101106998A CN A2006800025464 A CNA2006800025464 A CN A2006800025464A CN 200680002546 A CN200680002546 A CN 200680002546A CN 101106998 A CN101106998 A CN 101106998A
Authority
CN
China
Prior art keywords
alkyl
cancer
aryl
cycloalkyl
chemical compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2006800025464A
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English (en)
Chinese (zh)
Inventor
P·J·科尔曼
G·D·哈特曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CN101106998A publication Critical patent/CN101106998A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CNA2006800025464A 2005-01-19 2006-01-13 有丝分裂驱动蛋白抑制剂 Pending CN101106998A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64493405P 2005-01-19 2005-01-19
US60/644,934 2005-01-19

Publications (1)

Publication Number Publication Date
CN101106998A true CN101106998A (zh) 2008-01-16

Family

ID=36692770

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2006800025464A Pending CN101106998A (zh) 2005-01-19 2006-01-13 有丝分裂驱动蛋白抑制剂

Country Status (7)

Country Link
US (1) US20090124641A1 (https=)
EP (1) EP1855685A4 (https=)
JP (1) JP2008527041A (https=)
CN (1) CN101106998A (https=)
AU (1) AU2006206675A1 (https=)
CA (1) CA2593166A1 (https=)
WO (1) WO2006078598A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021213518A1 (zh) * 2020-04-23 2021-10-28 复旦大学 用于预防或治疗脂质代谢相关疾病的化合物

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110171172A1 (en) * 2007-11-07 2011-07-14 Siddiqui M Arshad Compounds for inhibiting ksp kinesin activity
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PT3052485T (pt) 2013-10-04 2021-10-22 Infinity Pharmaceuticals Inc Compostos heterocíclicos e suas utilizações
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX382033B (es) 2014-03-19 2025-03-13 Infinity Pharmaceuticals Inc Compuestos heterocíclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma.
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
WO2017048702A1 (en) 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183931A (en) * 1977-09-08 1980-01-15 Research Corporation 2-Ketoalkyl-4(3H)-quinazolinones
US5470975A (en) * 1990-10-16 1995-11-28 E.R. Squibb & Sons, Inc. Dihydropyrimidine derivatives
US6667300B2 (en) * 2000-04-25 2003-12-23 Icos Corporation Inhibitors of human phosphatidylinositol 3-kinase delta
WO2004064741A2 (en) * 2003-01-17 2004-08-05 Cytokinetics Inc. Compounds, compositions, and methods
JP2007510660A (ja) * 2003-11-07 2007-04-26 サイトキネティクス・インコーポレーテッド 化合物、組成物及び方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021213518A1 (zh) * 2020-04-23 2021-10-28 复旦大学 用于预防或治疗脂质代谢相关疾病的化合物
CN115427396A (zh) * 2020-04-23 2022-12-02 复旦大学 用于预防或治疗脂质代谢相关疾病的化合物
US12582720B2 (en) 2020-04-23 2026-03-24 Fudan University Compound for preventing or treating lipid metabolism-related diseases

Also Published As

Publication number Publication date
WO2006078598A2 (en) 2006-07-27
WO2006078598A3 (en) 2007-04-12
EP1855685A4 (en) 2009-12-23
CA2593166A1 (en) 2006-07-27
AU2006206675A1 (en) 2006-07-27
JP2008527041A (ja) 2008-07-24
EP1855685A2 (en) 2007-11-21
US20090124641A1 (en) 2009-05-14

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20080116