CN101093211B - Transient drift field method in use for drift tube of ionic mobility spectrometer - Google Patents
Transient drift field method in use for drift tube of ionic mobility spectrometer Download PDFInfo
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Abstract
A method of using transient electric field to make shift electric field for shift tube of IMB includes utilizing transient electric field as shift electric field in shift tube of IMB, shifting all iongroups to region between shift electrode of m +1 and m +2 and m +3 at certain time slot, separately exerting proper voltages on three said shift electrodes at shift tube to satisfy certain conditionsand forming transient electric field with strength E at region between three said electrodes at shift tube.
Description
Technical field
The present invention relates to the detection technique field, belong to ion migration ratio spectrometer (IMS:Ion MobilitySpectrometer) technology, relate in particular to a kind of transient state drift field and transient state drift field production method that is used for the ion migration ratio spectrometer drift tube.
Background technology
Ion migration ratio spectrometer (ion mobility spectrometry) is a kind of new detection technique that grows up from later 1960s, it and flight time mass spectrum are similar a bit, but ion mobility spectrometry needs high vacuum condition unlike mass spectrum, but under atmospheric pressure works.The ion migration ratio spectrometer selectivity is good, and the detection sensitivity height is the effective tool that detects trace explosive, drugs, biochemical war agent.
Ion migration ratio spectrometer is to separate different material according to the difference of (the about 200V/cm magnitude) mobility in weak electric field of ion under the atmospheric pressure.It mainly is made up of drift tube and peripheral circuit and air-channel system, sampling system.Drift tube is the place that ion forms and drifts about, and is most important extraordinary device in the ion migration ratio spectrometer (IMS), and its performance has directly determined the index of whole ion migration ratio spectrometer; Air-channel system, sampling system provide the environment and the condition of ion migration ratio spectrometer work; Peripheral circuit is finished ion migration ratio spectrometer process control, signals collecting and data processing function.
Drift tube mainly is made up of four parts: ionization chamber 1; 2 ion drift districts; 3 ion control gates between ionization chamber and ion drift district; 4 faraday's dishes as ion detector.When using ion migration ratio spectrometer (IMS) test sample, at first make measured object (can be gas or particulate) form charged ion in the ionization of ionization chamber, ion enters the ion drift district by the ion control gate then, under electric field action, drift to faraday's dish, measure ion can calculate ion the required time by the ion drift district mobility through certain hour.Ion mobility is influenced by extraneous factors such as drift gas, temperature, pressure, and under certain condition, the mobility of small ion depends primarily on its molecular weight, and the mobility of heavy ion is mainly determined by collision cross-section.Because the mobility of various substance ions is different under certain condition, measures and to obtain sample indirectly for information about drift time.
Compare with general chemical analysis instrument, ion migration ratio spectrometer (IMS) has volume advantage little, in light weight, low in energy consumption, it to the detection sensitivity of materials such as explosive, drugs up to 10
-8-10
-14G or ppb (10
-9)-ppt (10
-12) magnitude, be particularly suitable for the real-time detection that luggage wraps up.
In ion migration ratio spectrometer shown in Figure 1 (IMS) schematic diagram, a plurality of drift electrodes are arranged in the ion drift district, the ion migration ratio spectrometer of traditional structure (IMS) instrument is to add constant voltage at each drift electrode, set up the drift field of the about 200V/cm of desirable strength in the whole space of drift region, this just needs to use the high-voltage power supply of 1000V magnitude, circuit is not easy of integration, more is difficult to utilize the IC technology of comparative maturity to realize.
Summary of the invention
The purpose of this invention is to provide a kind of transient state drift field thought of ion migration ratio spectrometer (IMS) drift tube and method of generation of being used for. use the present invention ion migration ratio spectrometer (IMS) drift tube can be produced the drift field required voltage and be reduced to tens volts even a few volt, can utilize common IC circuit to produce drift field with comparalive ease, this is integrated to ion migration ratio spectrometer (IMS) circuit, and miniature drift tube of ion migration ratio spectrometer (IMS) and circuit is integrated, has great importance.
For achieving the above object, technical solution of the present invention provides a kind of transient state drift field method that is used for the ion migration ratio spectrometer drift tube, it uses transient electric field as the drift field in the ion migration ratio spectrometer drift tube, promptly constantly between (T+m Δ T) to (T+ (m+1) Δ T), ionic group all floats to the zone between m+1, m+2, the m+3 drift electrode, distinguishes making alive V on drift tube m+1, m+2 and m+3 drift electrode
(m+1) (m+1), V
(m+1) (m+2)And V
(m+1) (m+3), V
(m+1) (m+1), V
(m+1) (m+2)And V
(m+1) (m+3)Satisfy V
(m+1) (m+1)-V
(m+1) (m+2)=V
(m+1) (m+2)-V
(m+1) (m+3)=EL is the transient electric field of E at drift tube m+1, m+2 and m+3 zone formation intensity of drifting about between the electrode.
Described transient state drift field method the steps include:
S1, be under the drift field effect of E in intensity, the ion that need to detect is that regional required time is Δ T=L/EK between the adjacent drift electrode of L by spacing, wherein K is the mobility of ion, then arrive between (T+ Δ T) difference making alive V on first, second, third drift of drift tube electrode at moment T
11, V
12And V
13, V
11, V
12And V
13Satisfy V
11-V
12=V
12-V
13=EL, it is the transient electric field of E that zone between first, second, third drift of drift tube electrode constitutes intensity, in the zone of the ionic group that needs during this period of time to detect between first, second, third of drift tube drift electrode and be subjected to this transient electric field effect, described T is the moment that ionic group all enters the ion drift district;
S2, constantly between (T+ Δ T) to (T+2 Δ T), ionic group float to second, third, the zone between the 4th drift electrode, making alive V respectively on drift tube second, third and the 4th drift electrode
22, V
23And V
24, V
22, V
23And V
24Satisfy V
22-V
23=V
23-V
24=EL, drift tube second, third, to constitute intensity be the transient electric field of E in the 4th zone of drift between the electrode;
S3, constantly between (T+2 Δ T) to (T+3 Δ T), ionic group floats to the the 3rd, the 4th, the 5th zone between the drift electrode, making alive V respectively on drift tube the 3rd, the 4th and the 5th drift electrode
33, V
34And V
35, V
33, V
34And V
35Satisfy V
33-V
34=V
34-V
35=EL, it is the transient electric field of E that the zone between the the 3rd, the 4th, the 5th drift of drift tube electrode constitutes intensity;
S4, repeat above S1, S2, S3 step, the voltage of controlling adjacent three drift electrodes is the transient electric field of E with formation intensity of the zone between it, every time through Δ T, in check drift electrode just backward order pass 1, making the area of space that needs the ionic group place detected that intensity always be arranged is that the transient electric field of E exists;
S5, the ionic group that needs are detected all float to faraday's dish.
Described transient state drift field method, its described voltage that is added on the different drift electrodes, its waveform is square wave, triangular wave, sawtooth wave, sine wave, or the stack of above-mentioned various waveforms, or irregular waveform.
The present invention uses low-voltage to produce the stable state drift field that the transient electric field mobile with measured matter ion drift replaces using in the conventional ion mobility spectrometer (IMS) the high voltage generation.The present invention adds that at the different drift of drift tube electrode transient voltage produces required drift field, its described voltage that is added on the drift region drift electrode, its frequency is by the mobility of measured object and the size decision of drift region, its size is by the spacing decision of the drift field intensity of required generation and drift electrode, and the phase relation that it is described to be added in voltage on the waveform of the voltage on the drift region drift electrode and the different drift electrode can be adjusted according to theoretical analysis and experimental data.
The thought of transient state drift field proposed by the invention and method reduce ion migration ratio spectrometer (IMS) greatly and set up the drift field required voltage, help the integrated of ion migration ratio spectrometer (IMS) circuit.
Description of drawings
Fig. 1 is ion migration ratio spectrometer (IMS) structural representation;
Fig. 2 is institute's making alive synoptic diagram on conventional ion mobility spectrometer (IMS) the drift electrode;
Fig. 3 is a kind of ion migration ratio spectrometer (IMS) drift tube that the inventive method transient state drift field ultimate principle is described electrode institute making alive synoptic diagram that respectively drifts about;
Ion migration ratio spectrometer (IMS) drift tube that Fig. 4 realizes the transient state drift field for the inventive method the is a kind of electrode institute making alive synoptic diagram that respectively drifts about;
Another realizes ion migration ratio spectrometer (IMS) drift tube of the transient state drift field electrode institute making alive synoptic diagram that respectively drifts about to Fig. 5 for the inventive method;
Fig. 6 is ion migration ratio spectrometer (IMS) drift tube of a kind of improved realization transient state drift field of the inventive method electrode institute making alive synoptic diagram that respectively drifts about.
Embodiment
The transient state drift field method principle that the present invention is used for the ion migration ratio spectrometer drift tube is:
When charged ion quickened to travel forward under the drift field effect, meeting and neutral drift gas molecule bumped and slow down, and ion continues to be quickened by electric field then, and slow down in the collision back again, moves so repeatedly.Motion on this ion microcosmic shows as ion and obtains an average drift velocity v on macroscopic view
d, under the weak electric field situation, it and electric field strength E are directly proportional: v
d=KE, the proportionality constant K in the formula is the mobility of ion, it is and the relevant physical quantitys of factor such as quality, size, collision cross-section and dipole moment of ion and drift gas molecule that it also is subjected to the influence of extraneous factors such as temperature, air pressure.Ion mobility K is the characteristic of compound (perhaps functional group, ion), it is relevant with migration gas, under low electric field intensity, the mobility of specific ion can be according to Mason-Schamp equation [E A Mason, Ion mobility:Its role in plasma chromartograhpy, TW Carr, Ed., New York:Plenum Press, 1984,43] scheduling theory and experimental data are determined.
The motion conditions of ion in drift field be by the decision of the stressing conditions of ion, and ion at suffered electric field force of moment only with it this electric field of region is relevant constantly.Promptly theoretically, if in the drift process, can guarantee each constantly the electric field intensity of ion region always be E, then the motion conditions of ion is the same with motion conditions in the steady uniform electric field that is E an intensity.According to this principle, need in the overall process of drift, not keep the electric field in whole ion drift district, and only need keep the drift field of ion region to get final product.The macro manifestations that ion moves in the ion drift district is known by people, be engraved in the position in ion drift district in the time of ion can being known according to the mobility K of ion drift district electric field intensity and specific ion, only set up the drift that required drift field can guarantee ion, can significantly reduce like this and set up the required voltage of drift field in this zone.
Discuss for convenience, referring to Fig. 1, suppose that total N drift electrode 6 is evenly distributed in ion migration ratio spectrometer shown in Figure 1 (IMS) drift tube, distance each other is L.The mobility of certain specific ion that we need detect is K.Be under the drift field effect of E in intensity then, ion is by regional required time Δ T=L/KE between the adjacent electrode 6.
Consider the motion conditions of specific ion in drift field that a mobility is K.
In traditional ion migration ratio spectrometer (IMS), by on n electrode 6, adding constant voltage (V
0-nEL) (n=1 in the formula, 2,3 ... N, V
0Be a constant) obtain the drift field that intensity is E, need working voltage to be at least the power supply of ((N-1) EL).And in the method for the invention, between (T+ Δ T), ion is in the zone between first, second electrode 6 at moment T, distinguishes making alive V on first, second electrode 6 during this period of time
11, V
12, V
11And V
12Satisfy V
11-V
12=EL; Between the moment (T+ Δ T) to (T+2 Δ T), ion has moved to the zone between second, third electrode 6, distinguishes making alive V on second, third electrode 6 during this period of time
22, V
23, V
22And V
23Satisfy V
22-V
23=EL; Constantly between (T+ (n-1) Δ T) to (T+n Δ T), ion motion is to the zone between n, (n+1) individual drift electrode 6, at the time in the moment (T+ (n-1) Δ T) to (T+n Δ T) difference making alive V on n, (n+1) individual drift electrode 6
Nn, V
N (n+1), V
NnAnd V
N (n+1)Satisfy V
Nn-V
N (n+1)=EL (n=1 in the formula, 2,3 ... N), the supply voltage of required like this use only need be higher than (EL), only is the 1/N-1 of institute's working voltage in the classic method.
More than discussing is ultimate principle of the present invention, actual in ionic group is distributed in the certain space, and the switching of voltage needs certain hour on the drift electrode 6, so only between two adjacent drift electrodes 6, set up ion migration ratio spectrometer (IMS) poor performance of drift field, can only make the only a few ion in the ionic group finish the drift process.Consider from aspects such as ionic group distribution, voltage switching and drift field homogeneitys, should between at least three adjacent drift electrodes, set up drift field.The present invention is used for the transient state drift field method of ion migration ratio spectrometer drift tube, and the step of setting up drift field between three adjacent drift electrodes is:
S1, because of being under the drift field effect of E in intensity, the ion that need to detect is that regional required time is Δ T=L/KE between the adjacent drift electrode of L by spacing, wherein K is the mobility of ion, then arrive between (T+ Δ T) difference making alive V on first, second, third drift of drift tube electrode 6 at moment T
11, V
12And V
13, V
11, V
12And V
13Satisfy V
11-V
12=V
12-V
13=EL, it is the transient electric field of E that zone between first, second, third of drift tube drift electrode 6 constitutes intensity, in the zone of the ionic group that needs during this period of time to detect between first, second, third drift of drift tube electrode 6 and be subjected to this transient electric field effect.On drift tube other drift electrode 6 except that first, second, third drift electrode 6, can add free voltage or be in suspended state.Described T is the moment that ionic group all enters the ion drift district.
S2, constantly between (T+ Δ T) to (T+2 Δ T), ionic group float to second, third, the zone between the 4th drift electrode 6, making alive V respectively on drift tube second, third and the 4th drift electrode 6
22, V
23And V
24, V
22, V
23And V
24Satisfy V
22-V
23=V
23-V
24=EL, drift tube second, third, to constitute intensity be the transient electric field of E in the 4th zone of drift between the electrode 6.Can add free voltage or be in suspended state except that second, third, on the 4th drift other electrode 6 that drifts about the electrode 6 at drift tube.
S3, constantly between (T+2 Δ T) to (T+3 Δ T), ionic group floats to the the 3rd, the 4th, the 5th zone between the drift electrode 6, making alive V respectively on drift tube the 3rd, the 4th and the 5th drift electrode 6
33, V
34And V
35, V
33, V
34And V
35Satisfy V
33-V
34=V
34-V
35=EL, it is the transient electric field of E that the zone between the the 3rd, the 4th, the 5th drift of drift tube electrode 6 constitutes intensity.On drift tube other drift electrode 6 except that the the 3rd, the 4th, the 5th drift electrode 6, can add free voltage or be in suspended state.
S4, repeat above step, the voltage of controlling adjacent three drift electrodes is the transient electric field of E with formation intensity of the zone between it, every time through Δ T, in check drift electrode just backward order pass 1, making the area of space that needs the ionic group place detected that intensity always be arranged is that the transient electric field of E exists.
Promptly constantly between (T+m Δ T) to (T+ (m+1) Δ T), ionic group float to m+1, m+2, a m+3 drift electrode the zone, difference making alive V on drift tube m+1, m+2 and m+3 electrode 6 that drifts about
(m+1) (m+1), V
(m+1) (m+2)And V
(m+1) (m+3), V
(m+1) (m+1), V
(m+1) (m+2)And V
(m+1) (m+3)Satisfy V
(m+1) (m+1)-V
(m+1) (m+2)=V
(m+1) (m+2)-V
(m+1) (m+3)=EL, it is the transient electric field of E that the zone between drift tube m+1, m+2, a m+3 drift electrode 6 constitutes intensity.On drift tube other drift electrode 6 except that m+1, m+2, a m+3 drift electrode 6, can add free voltage or be in suspended state.
S5, the ionic group that needs are detected all float to faraday and coil 7.
If the distribution length of the ionic group that detects on drift direction is l, if l and L satisfy l＜L, then at moment T, ionic group is all in first, second zone between the electrode of respectively drifting about, under the effect of above-mentioned transient state drift field, whole ions of ionic group can float to faraday and coil 7 (do not consider the collision loss and the diffusion of ion and suppose that the transient state drift field is a uniform electric field).
If l and L can not satisfy l＜L, then can't make the ionic group that need to detect constantly at (T+m Δ T), all float to m+1, m+2 the drift electrode the zone, constitute in the Δ T time period before promptly should be constantly between latter two drift electrode in three adjacent drift electrodes of transient electric field, can't make whole ions of ionic group under the effect of described transient state drift field, float to faraday like this and coil 7.
Suppose l＜hL, wherein h is the integer greater than 1.Coil 7 to improve the sensitivity of ion migration ratio spectrometer (IMS) for the whole ions that make ionic group can float to faraday, then should set up the transient state drift field between h+1 adjacent drift electrode at least.Its method and to set up the method for transient state drift field between three adjacent drift electrodes similar: it is the transient electric field of E that the voltage of controlling adjacent h+1 drift electrode constitutes intensity with the zone between it, every time through Δ T, in check drift electrode just backward order pass 1, making the area of space that needs the ionic group place detected that intensity always be arranged is that the transient electric field of E exists.
Below in conjunction with description of drawings specific implementation method of the present invention:
Figure 1 shows that ion migration ratio spectrometer (IMS) principle and structural representation.Among the figure, injection port 1, ionization source 2, ionization chamber 3, ion control gate 4, ion drift district 5, drift electrode 6, faraday coils 7, drift gas inlet 8, drift gas outlet 9, peripheral circuit 10 etc., concrete structure is a known technology, does not give unnecessary details at this.
Sample enters ionization chamber 3 by injection port 1, after ionization chamber 3 is by ionization, enter ion drift district 5 by ion control gate 4, under electric field action by ion drift district 5, coil 7 by faraday and detect gas current, can obtain sample for information about by analyzing the drift collection of illustrative plates.A plurality of drift electrodes 6 are arranged in the ion drift district 5, the ion migration ratio spectrometer of traditional structure (IMS) instrument is to add constant voltage at each drift electrode 6, required drift field (as 200V/cm) is set up in 5 whole space in the drift region, need to use the high voltage of going up kilovolt, be difficult to realize with integrated circuit.
Fig. 2 is 6 the making alive synoptic diagram of electrode that respectively drift about in the conventional ion mobility spectrometer (IMS).Among the figure, each 6 making alive of electrode that drift about is a steady voltage, and it is EL that spacing is powered up pressure reduction by the adjacent drift electrode 6 of L, and forming intensity in whole drift region 5 like this is the steady drift field of E.Need working voltage to be at least the power supply of (N-1) EL for forming this drift field, wherein N is the number of drift electrode 6.
Fig. 3 is a kind of ion migration ratio spectrometer (IMS) drift tube that the inventive method transient state drift field ultimate principle is described 6 making alive synoptic diagram of electrode that respectively drift about.Respectively drifting about among the figure, institute's making alive has only two states on the electrode 6, be respectively V and V+EL, control is respectively drifted about 6 making alive waveforms of electrode as shown in Figure 3, then arrive (the T+ Δ T) time period at T, because spacing is that institute's making alive is respectively V+EL and V on the adjacent drift electrode 11 of L and the electrode 12 that drifts about, it is the drift field of E that the space between drift electrode 11 and drift electrode 12 forms intensity; Same principle, arrive (the T+2 Δ T) time period at (T+ Δ T), it is the drift field of E that space between drift electrode 12 and the drift electrode 13 forms intensity ... arrive (the T+n Δ T) time period at (T+ (n-1) Δ T), it is the drift field of E that space between drift electrode (n+10) and the drift electrode (n+11) forms intensity, n=1 wherein, 2 ... N-1, N is the number of drift electrode.So just can form one in whole ion drift district in time and the transient state drift field that moves, regulating time parameter Δ T can make the translational speed of electric field identical with the drift velocity that will detect ion, the motion conditions of this ion be that motion conditions in the steady drift field of E is identical in intensity, and the supply voltage that adopts the required use of the inventive method only need be higher than EL and gets final product, and only is the 1/N-1 of institute's working voltage in the classic method.
Fig. 4, Fig. 5 are respectively other two kinds of ion migration ratio spectrometer (IMS) drift tubes of realizing the transient state drift fields of the inventive method 6 the making alive synoptic diagram of electrode that respectively drift about. and the voltage that is added on the drift electrode 6 is respectively sawtooth wave and triangular wave, can guarantee at T that to (the T+ Δ T) time period spacing is that in the adjacent drift electrode 11 of L and the space between the drift electrode 12 intensity to be arranged be the drift field of E; To (the T+2 Δ T) time period, spacing is that in the adjacent drift electrode 12 of L and the space between the drift electrode 13 intensity to be arranged be the drift field of E at (T+ Δ T) ..., can form one in whole ion drift district in time and the transient state drift field that moves.
The transient state drift field that the inventive method proposed, ion migration ratio spectrometer (IMS) drift tube that can be used for various ways, the content of the inventive method comprise but are not limited only to be used for the transient state drift field of structure ion migration ratio spectrometer shown in Figure 1 (IMS) drift tube.
The transient state drift field that the present invention proposes can have various ways, and Fig. 4, Fig. 5 are two examples wherein.According to the substance classes of required detection, the professional is easy to select from thought of the present invention the transient state drift field of a lot of other forms, and content of the present invention comprises but is not limited only to the transient state drift field implementation method shown in Fig. 3,4,5.Being added in drift tube and drifting about respectively that the waveform of voltage can be square wave, triangular wave, sawtooth wave, sine wave etc. on the electrode 6, also can be the stack of above-mentioned various waveforms, can also be various irregular waveforms.
It may be noted that Fig. 3, Fig. 4, Fig. 5 just are the synoptic diagram of explanation the inventive method, do not consider that ionic group has certain space distribution under the truth, the electrode voltage switching needs factors such as time and drift field homogeneity.After considering above-mentioned factor, have only the ion of ratio seldom can pass through Fig. 3, Fig. 4, transient state drift field shown in Figure 5 in the ionic group.In order to improve the performance of transient state drift field, need between three adjacent drift electrodes, to set up drift field at least simultaneously.
Fig. 6 is 6 the making alive synoptic diagram of electrode that respectively drift about of setting up drift field a kind of while of the inventive method between three adjacent drift electrodes 6.Respectively drifting about among the figure, institute's making alive has only three kinds of states on the electrode 6, be respectively V, V+EL, V+2EL, control is respectively drifted about 6 making alive waveforms of electrode as shown in Figure 6, then arrive (the T+ Δ T) time period at T, because spacing is that institute's making alive is respectively V+2EL, V+EL and V on the adjacent drift electrode 11,12,13 of L, it is the drift field of E that the space between drift electrode 11,12,13 forms intensity; Same principle, arrive (the T+2 Δ T) time period at (T+ Δ T), it is the drift field of E that space between the drift electrode 12,13,14 forms intensity ... arrive (the T+n Δ T) time period at (T+ (n-1) Δ T), it is the drift field of E that space between drift electrode (n+10), (n+11), (n+12) forms intensity, n=1 wherein, 2 ... N-2, wherein N is the number of drift electrode.So just can be 5 form one in time and the transient state drift field that moves in whole ion drift district, regulating time parameter Δ T can make the translational speed of electric field identical with the drift velocity that will detect ionic group, promptly at (T+ (n-1) Δ T) to (the T+n Δ T) time period, ionic group from be positioned at drift electrode (n+10) and (n+11) between spatial movement to drift about electrode (n+11) and (n+12) the space.Can guarantee ionic group region electric field intensity so always for E, the motion conditions of ionic group be that motion conditions in the steady drift field of E is identical in intensity, and the supply voltage of the required use of employing the inventive method only need be higher than 2EL and gets final product.Same principle adds the voltage signal of other waveforms such as triangular wave, sine wave on three adjacent drift electrodes 6 also can realize transient state drift field same as shown in Figure 6.
In the method for the present invention, the voltage signal frequency that is added on the drift electrode 6 is determined by the mobility of measured object and the size of drift region.The general drift velocity of ion in the weak electric field of 200V/cm be about 5～10m/s, if the spacing L of drift electrode 6 is in millimeter or centimetre magnitude, then ion by regional required time Δ T between the adjacent drift electrode 6 10
-4Second or 10
-3Second-time is added in the voltage signal frequency of drift on the electrode 6 on 10KHz or lower magnitude.Along with dwindling and the increase of electrode 6 numbers that drift about of drift region size, the voltage signal frequency will raise, but also in the attainable scope of integrated circuit.
Claims (3)
1. production method that is used for the transient state drift field of ion migration ratio spectrometer drift tube, it is characterized in that: use transient electric field as the drift field in the ion migration ratio spectrometer drift tube, promptly constantly between (T+m Δ T) to (T+ (m+1) Δ T), ionic group all floats to the zone between m+1, m+2, the m+3 drift electrode, distinguishes making alive V on drift tube m+1, m+2 and m+3 drift electrode
(m+1) (m+1), V
(m+1) (m+2)And V
(m+1) (m+3), V
(m+1) (m+1), V
(m+1) (m+2)And V
(m+1) (m+3)Satisfy V
(m+1) (m+1)-V
(m+1) (m+2)=V
(m+1) (m+2)-V
(m+1) (m+3)=EL is the transient electric field of E at drift tube m+1, m+2 and m+3 zone formation intensity of drifting about between the electrode.
2. the production method of transient state drift field as claimed in claim 1 is characterized in that: step is:
S1, be under the drift field effect of E in intensity, the ion that need to detect is that regional required time is Δ T=L/KE between the adjacent drift electrode of L by spacing, wherein K is the mobility of ion, then arrive between (T+ Δ T) difference making alive V on first, second, third drift of drift tube electrode at moment T
11, V
12And V
13, V
11, V
12And V
13Satisfy V
11-V
12=V
12-V
13=EL, it is the transient electric field of E that zone between first, second, third drift of drift tube electrode constitutes intensity, in the zone of the ionic group that needs during this period of time to detect between first, second, third of drift tube drift electrode and be subjected to this transient electric field effect, described T is the moment that ionic group all enters the ion drift district;
S2, constantly between (T+ Δ T) to (T+2 Δ T), ionic group float to second, third, the zone between the 4th drift electrode, making alive V respectively on drift tube second, third and the 4th drift electrode
22, V
23And V
24, V
22, V
23And V
24Satisfy V
22-V
23=V
23-V
24=EL, drift tube second, third, to constitute intensity be the transient electric field of E in the 4th zone of drift between the electrode;
S3, constantly between (T+2 Δ T) to (T+3 Δ T), ionic group floats to the the 3rd, the 4th, the 5th zone between the drift electrode, making alive V respectively on drift tube the 3rd, the 4th and the 5th drift electrode
33, V
34And V
35, V
33, V
34And V
35Satisfy V
33-V
34=V
34-V
35=EL, it is the transient electric field of E that the zone between the the 3rd, the 4th, the 5th drift of drift tube electrode constitutes intensity;
S4, repeat above S1, S2, S3 step, the voltage of controlling adjacent three drift electrodes is the transient electric field of E with formation intensity of the zone between it, every time through Δ T, in check drift electrode just backward order pass 1, making the area of space that needs the ionic group place detected that intensity always be arranged is that the transient electric field of E exists;
S5, the ionic group that needs are detected all float to faraday's dish.
3. the production method of transient state drift field as claimed in claim 1 or 2, it is characterized in that: the described voltage that is added on the different drift electrodes, its waveform is square wave, triangular wave, sawtooth wave, sine wave, or the stack of above-mentioned various waveforms, or irregular waveform.
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| CN200610089347A CN101093211B (en) | 2006-06-21 | 2006-06-21 | Transient drift field method in use for drift tube of ionic mobility spectrometer |
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| CN200610089347A CN101093211B (en) | 2006-06-21 | 2006-06-21 | Transient drift field method in use for drift tube of ionic mobility spectrometer |
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| CN101788529B (en) * | 2010-01-27 | 2013-09-11 | 徐伟 | Chemical warfare agent detector and method for detecting chemical warfare agent by using same |
| CN103871820B (en) * | 2012-12-10 | 2017-05-17 | 株式会社岛津制作所 | Ion mobility analyzer and combination unit thereof and ion mobility analysis method |
| US9147565B1 (en) * | 2014-12-30 | 2015-09-29 | Morpho Detection, Llc | Ion mobility spectrometer and method of using the same |
| GB2562690B (en) | 2016-09-27 | 2022-11-02 | Micromass Ltd | Post-separation mobility analyser |
| WO2018215622A1 (en) * | 2017-05-24 | 2018-11-29 | B. Braun Melsungen Ag | Electrode arrangement for a drift tube |
| CN110958914A (en) | 2017-08-10 | 2020-04-03 | 拉皮斯坎系统股份有限公司 | System and method for substance detection using a thermally stable collection device |
| DE102018113331B4 (en) * | 2018-06-05 | 2023-06-15 | Gottfried Wilhelm Leibniz Universität Hannover | Ion-mobility spectrometer |
| US11609214B2 (en) | 2019-07-31 | 2023-03-21 | Rapiscan Systems, Inc. | Systems and methods for improving detection accuracy in electronic trace detectors |
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