CN101080201A - System and method for predicting physical properties of an aneurysm from a three-dimensional model thereof - Google Patents

System and method for predicting physical properties of an aneurysm from a three-dimensional model thereof Download PDF

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Publication number
CN101080201A
CN101080201A CNA2005800433242A CN200580043324A CN101080201A CN 101080201 A CN101080201 A CN 101080201A CN A2005800433242 A CNA2005800433242 A CN A2005800433242A CN 200580043324 A CN200580043324 A CN 200580043324A CN 101080201 A CN101080201 A CN 101080201A
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aneurysm
representation
simulation
simulated
data
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CN100581465C (en
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P·M·J·龙根
R·苏尔蒙德
R·P·J·赫曼斯
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Koninklijke Philips NV
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Koninklijke Philips Electronics NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/504—Clinical applications involving diagnosis of blood vessels, e.g. by angiography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A61B5/02014—Determining aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A61B5/1076—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions inside body cavities, e.g. using catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/46—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment with special arrangements for interfacing with the operator or the patient
    • A61B6/461—Displaying means of special interest
    • A61B6/466—Displaying means of special interest adapted to display 3D data
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders

Abstract

A three-dimensional rotational angiography (3DRA) system, in which a finite element method (FEM) package is incorporated which can read in suface meshes (20b) of a reconstructed 3DRA image of an aneurysm to generate FEM meshes (20a) which are closely approximated to the observed aneurysm (20b) in an iterative process by changing the material properties of the aneurysm used in generating the simulated representations (20a) thereof. Thus, the material properties of the closely approximated simulated representation (20a) can be used in subsequent analysis of the physical properties of the aneurysm under consideration.

Description

Predict the system and method for aneurysmal physical characteristic from aneurysmal threedimensional model
Technical field
Present invention relates in general to predict the system and method for aneurysmal physical characteristic from aneurysmal threedimensional model.
Background technology
Cerebral aneurysm is the pathology expansion that often appears near the arteriae cerebri of circle of Willis (Willis Circle) medium-sized artery bifurcated, and is caused by the blood vessel wall that weakens usually.The most serious result is that particularly as if patient's hypertension, aneurysm rupture causes the intracranial hemorrhage and may cause death.At present aneurysmal origin, growth and disruptive mechanism also there is not deep understanding.
Three-dimensional rotational angiography art (3DRA) is the relative newer technology that is used for the imaging of human body medium vessels.The 3D high-resolution picture of the reconstruction that produces from rotation DSA data takes into account potential noticeable quantitative study.Digital subtracting visualization (DSA) is aneurysmal description and aneurysmal size, neck and the standard definite with the relation of vascular tree that is used for head.Three-dimensional rotational angiography art (3DRA) produces the projection (MIP) of maximum intensity and the surface of deepening gradually shows (SSD) image, and these images provide the three-dimensional visual data that produces from rotational DSA.The image of these high-resolution cerebral aneurysm can and can be estimated aneurysmal volume at least in theory from any desirable angle observation.
During (brain) vascular interventions, in order to select the correct treatment to the patient, it is topmost assessing aneurysmal size and characteristic.But, the reconstruction of aneurysmal 3DRA only provides relevant this pathological geometry information usually.In order to obtain more information, the model of setting up the behavior that is used to describe aneurysmal machinery and material is necessary.In " the auxiliary prediction of computer simulation cerebral aneurysm " (http://www.fluent.com/solutions/articles/ja071.pdf) literary composition that Hector V.Ortega is shown, discussed the blood flow of accurately simulating in the aneurysm and helped research worker to predict aneurysmal growth pattern and risk of rupture.This article illustrates that any aneurysmal behavior depends on its geometry and hemodynamics, and consider aneurysmal self-characteristic, for example geometry, blood flowing characteristic, haemoconcentration, viscosity and speed advise computer modeling technique is used for aneurysmal research.But, this technology relates to the simulation of the blood flow in the given aneurysm, and this aneurysm has given geometry and uses the physiological parameter of having measured.
Summary of the invention
The object of the present invention is to provide a kind of system and method that is used to predict the physical characteristic of aneurysm wall, i.e. the physiological parameter of Wei Zhi aneurysm wall is to provide the relevant distinctive out of Memory of pathological patient, to help to formulate treatment plan Xiang the doctor.
According to the present invention, a kind of system that is used to analyze the aneurysm characteristic is provided, this system comprises:
Image device, this imaging device are used to produce this aneurysmal three-dimensional representation;
Analog, this analog is used for producing simulation aneurysm shape and this simulation aneurysm shape approximation is arrived this aneurysmal three-dimensional representation, to produce this aneurysmal simulated representation, this simulated representation has relative data, and these data limit one or more substance characteristics relevant with simulated representation and distribute; And
Data output device, these data representations are derived from aneurysmal one or more substance characteristics of simulated representation.
According to the present invention, the method for analyzing aneurysmal characteristic is provided, this method comprises:
Produce this aneurysmal three-dimensional representation;
Produce simulation aneurysm shape and this simulation aneurysm shape approximation is arrived this aneurysmal three-dimensional representation, to produce this aneurysmal simulated representation, this simulated representation has relative data, and these data limit one or more substance characteristics relevant with simulated representation and distribute; And
The output expression is derived from the data of aneurysmal one or more substance characteristics of simulated representation.
Like this, just can then the physiological parameter of synthetic simulated representation be distributed to aneurysm itself and predict aneurysmal unknown physiological parameter by making simulated representation (cover estimation or the predict physiologic parameter relevant with this simulated representation arranged) be suitable for aneurysmal three-dimensional representation.Aneurysmal these physiological parameters or substance characteristics can comprise elastic constant, anisotropy data and the growth parameter(s) etc. of geometric constant, elasticity of blood vessels protein part, the thickness of geometric constant such as wall, the elastic constant of elasticity of blood vessels protein part such as Young's modulus or Poisson's ratio, anisotropy data such as collagen fiber direction and corresponding hardness (for every layer of blood vessel), growth parameter(s) such as collagen thicken and extend time constant.Those of skill in the art will appreciate that these parameters depend on that selection is used for the particular type of the material model of aneurysm wall.
Advantageously, image device comprises three-dimensional rotational angiography art (3DRA) device.In a preferred embodiment, analog comprises Finite Element Method (FEM) simulation package, and this simulation package advantageously adopts the non-linear component model of the behavior of describing aneurysm wall.In a preferred embodiment, by simulated representation and three-dimensional representation being carried out iteration relatively (iteratively comparing) and utilize synthetic difference measurement (resultant different measure) to estimate that new substance characteristics is approximate to three-dimensional representation with simulated representation, repeat simulation process then to produce new simulated representation.
The data of three-dimensional representation and corresponding aneurysmal one or more substance characteristics of expression can be shown simultaneously.Can be provided with device and carry out one or more dimensional measurements relevant, these geometrical measurements can be combined in the simulation process, to produce simulated representation with three-dimensional representation.
Will understand these and other aspect of the present invention from the embodiment that describes below, and by with reference to the embodiment that describes below these and other aspect of the present invention being described.
Description of drawings
Now only the mode by example is described embodiments of the invention, and with reference to the accompanying drawings, in these accompanying drawings:
Fig. 1 shows the aneurysmal exemplary table veil by the FEM technical modelling;
Fig. 2 a and 2b show before the aneurysmal formation respectively and the sketch map of the part of blood vessel afterwards, and aneurysm forms in the point of weakness of blood vessel wall, and blood vessel wall has stood certain blood pressure;
Fig. 3 is the sketch map of the non-linear component model of aneurysm wall;
Fig. 4 a, 4b and 4c schematically show and make aneurysmal simulated representation be suitable for the involved step of being studied of aneurysmal observed diagram; And
Fig. 5 shows the schematic flow diagram according to the principle steps of the method for one exemplary embodiment of the present invention.
The specific embodiment
The reduction that the present invention relates to blood vessel wall basically is the situation of the neoplastic main cause of tremulous pulse.Usually the system layout among the present invention is become and be configured to obtain the physical model line number value simulation of going forward side by side, purpose is to predict machinery and the geometric sense related as the formation of brain saccular aneurysm that these numerical simulations are based on the advanced feature theory.
In first kind of situation, determined that by utilizing finite element software bag such as Mart/Mentat 2000 to carry out the neoplastic numerical simulation of tremulous pulse the physical dimension that is similar to neck of saccular aneurysm can make an explanation by the distribution that utilizes mechanical property, so that this physical dimension heart elasticity reduction therein, but it is also the same basically hard with parent blood vessel at its boundary vicinity, as can be as seen from Figure 1, the figure shows by the mimic aneurysm of Finite Element Method (FEM), this Finite Element Method (FEM) has illustrated total maximum tension, and aneurysm stands this tension force in different positions.As can be seen, maximum tension appears at dome 10, stably reduce around 12 in the bottom then, and also the same hard basically at neck 14 with parent blood vessel 16.Determined that by the distribute distortion of the weakened curved border circular areas 18 that is used for simulated blood vessel 16 of mechanical property that the front is mentioned typical aneurysm shape begins to form gradually.
Those of skill in the art can understand that aneurysm wall shows the nonlinear elasticity sexual behaviour, and this part ground is because when becoming too big as tension force, the collagen activation will occur, the elastic characteristic of collagen activation change aneurysm wall.Therefore, non-linear behavior and mechanical instability can occur during aneurysmal formation gradually, and this mechanical instability can be used for predicting possible breaking.Like this, in simulation process, be necessary to use actual non-linear configurations model, as be shown in the simplified model among Fig. 3, incorporating collagen activation when this model becomes too big at tension force.Fig. 3 shows displacement and tension force in the blood vessel wall very simply and becomes how (very) occur during tension force sclerosis (or softening) when big, and this figure only is the example of this behavior.There is shown when becoming greater than certain value as if the power in the spring on the left side, another spring works and has different elastic constants, thereby causes the harder or softer behavior of population structure.Those of skill in the art can understand other non-linear configurations model of this model and aneurysm wall.
Therefore, referring to Fig. 2 a and 2b, simulation is from the blood vessel wall of initial health, and the growth of simulation aneurysm 20 when the influence that is used in certain blood pressure P changes down the vessel wall properties of point of weakness 18 of blood vessel wall, so that for any certain simulation aneurysm, the data relevant with aneurysmal vessel wall properties that estimate or prediction can be associated with this simulation, by changing the substance characteristics in the simulation, correspondingly to change the aneurysmal shape of simulation.
Therefore, the present invention relates to the research of alleged " indirect problem ", and adopt the combination of three-dimensional image data such as three-dimensional rotational angiography art (3DRA) and analog result.Generally speaking, " indirect problem " substance characteristics of relating to by changing in the simulated representation makes simulated representation be suitable for the three-dimensional representation of " indirect problem " to reach desired variation.So, referring to Fig. 4 a, initial simulated representation 20a even not similar with the aneurysmal 3DRA diagram 20b strictness of studying, therefore, the change of substance characteristics in the simulation is illustrated the strict similarly simulated representation 20a of 20b to provide more strictly with 3DRA, shown in Fig. 4 b.If be necessary, substance characteristics can be changed repeatedly, so that simulated representation 20a is as far as possible strictly approximate with 3DRA diagram 20b, shown in Fig. 4 c.
Since the distribution of substance characteristics determine should with the viewed 3DRA physical dimension that obtains by the scanning of the three-dimensional rotational angiography art similar shape of simulated representation as far as possible strictly, so this distribution of substance characteristics can provide the distinctive estimation of patient of the aneurysmal substance characteristics of studying, and the aneurysmal relevant clinically machinery of studying and the actual estimation of geometrical property.
Referring to Fig. 5, the principle steps of technology that flow chart shows " indirect problem " described above.At first carry out the blood vessel order, the doctor obtains the rotation vascularity by this blood vessel order in step 202, then this rotation vascularity is sent to the 3DRA station to rebuild in step 204, so that observed aneurysm diagram 206 to be provided.Next step, the Finite Element Method that utilization moves on identical work station (FEM) simulation 210 also adopts non-linear configurations model 212 as non-linear configurations model shown in Figure 3 to calculate simulated representation 208, comprises the physical dimension and the stress and strain that are associated.
Simulated representation 208 and observed diagram 206 are compared, and difference 214 is used for estimating to be used for mimic new physics and substance characteristics, and in step 216 novel substance parameter more automatically correspondingly.Repeat this step and be similar to viewed diagram up to simulated representation strictness sufficiently.The result of this process is aneurysmal physical data collection 218, and except how much 3DRA data, physical data collection 218 also can show in step 220, and may be after normal 3DRA view.Also can provide other information, these information can provide support Xiang the doctor when working out treatment plan.For example, can (with the similar mode of mode that the stenosis relevant with angiogram is provided) calculate and show the aneurysm order of severity.Can obtain other IVUS measured value from 3DRA diagram, and these IVUS measured values can be attached in the simulation package, for example, can carry out like this being included among the FEM simulation with thickness information with blood vessel and aneurysm wall.IVUS represents intravascular ultrasound, in this intravascular ultrasound, the sound wave changer is introduced in the blood vessel, can obtain the internal characteristics of more detailed blood vessel wall structure and blood vessel wall by this sound wave changer, for example, and blood, thrombosis, soft speckle and different vascular laminas.This information is additional and (3D) inner chamber only is shown usually outside the 3DRA image.
Therefore, embodiments of the invention described above comprise that the adaptation that 3DRA uses changes, Finite Element Method (FEM) inclusion is combined in this adaptation variation, this Finite Element Method (FEM) bag can read in the surface mesh of the 3DRA volume rebuild, producing the FEM net, these FEM nets can strictly be similar to viewed aneurysm and can be used for the analysis to the aneurysmal physical characteristic studied of back.
The present invention can be used for being furnished with the X-ray system of 3DRA work station, but also can be used for imaging system, as MR and CT.
It should be noted that the present invention will be described rather than limit for the mentioned embodiment in front, and those of skill in the art can multiple alternate embodiment, and do not deviate from the scope of the present invention that limits by appending claims.In claims, be placed on any reference marks in the bracket and should not be construed as claims are limited.Word " comprise " and similarly word do not get rid of element or element the step or step in listing in any claim on the whole.The singular references of element is not got rid of the plural connotation of this element, and vice versa.Hardware that can be by comprising some different elements and can implement the present invention by the computer of suitable programming.In listing the device claim of several equipment, some in these equipment can embody with identical project by one in the hardware.Only in different mutually dependent claims, quote some tolerance and do not show that these metric combinations can not be used for producing good effect.

Claims (8)

1. system that is used to analyze aneurysm (20) characteristic, described system comprises:
Image device (202,204), described imaging device (202,204) is used to produce the three-dimensional representation (206) of described aneurysm (20);
Analog (210), described analog (210) is used for producing simulation aneurysm shape (208) and this simulation aneurysm shape approximation is arrived described aneurysmal described three-dimensional representation, to produce described aneurysmal simulated representation, described simulated representation has relative data, and described these data limit one or more substance characteristics relevant with described simulated representation and distribute; And
Data output device (220), described these data representations are derived from one or more substance characteristics of the described aneurysm (20) of described simulated representation.
2. the system as claimed in claim 1 is characterized in that: described imaging device (202,204) comprises three-dimensional rotational angiography art (3DRA) device.
3. the system as claimed in claim 1, it is characterized in that: described analog (210) comprises Finite Element Method (FEM) simulation package.
4. system as claimed in claim 3 is characterized in that: described simulation package adopts the non-linear component model (212) of the behavior of describing aneurysm wall.
5. the system as claimed in claim 1, it is characterized in that:, repeat described simulation process then to produce new simulated representation by described simulated representation and described three-dimensional representation being carried out iteration relatively and utilize synthetic difference measurement to estimate that new substance characteristics is approximate to described three-dimensional representation with described simulated representation.
6. the system as claimed in claim 1 is characterized in that: can and represent that the data of one or more substance characteristics of corresponding aneurysm (20) show simultaneously with described three-dimensional representation.
7. the system as claimed in claim 1 is characterized in that: comprise the device that carries out one or more dimensional measurements relevant with described three-dimensional representation, described these geometrical measurements can be combined in the described simulation process, to produce simulated representation.
8. method of analyzing the characteristic of aneurysm (20), described method comprises:
Produce the three-dimensional representation (206) of (202,204) described aneurysms (20);
Produce (210) simulation aneurysm shape (208) and described simulation aneurysm shape (208) approximate (214,216) is arrived described aneurysmal described three-dimensional representation (206), to produce the simulated representation of described aneurysm (20), described simulated representation has relative data (218), and described these data (218) limit one or more substance characteristics relevant with described simulated representation and distribute; And
Output (220) expression is derived from the data of one or more substance characteristics of the aneurysm (20) of described simulated representation.
CN200580043324A 2004-12-17 2005-12-14 System and method for predicting physical properties of an aneurysm from a three-dimensional model thereof Expired - Fee Related CN100581465C (en)

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CN103957807B (en) * 2012-11-15 2016-06-29 株式会社东芝 Guiding system and the system of evaluation
CN109472823A (en) * 2018-10-26 2019-03-15 强联智创（北京）科技有限公司 A kind of measurement method and system of the Morphologic Parameters of intracranial aneurysm image
CN109493348A (en) * 2018-10-26 2019-03-19 强联智创（北京）科技有限公司 A kind of measurement method and system of the Morphologic Parameters of intracranial aneurysm image

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CN104392051A (en) * 2014-11-28 2015-03-04 段少银 Solid wall and fluid finite element model of arterial aneurysm of internal carotid
CN109472823A (en) * 2018-10-26 2019-03-15 强联智创（北京）科技有限公司 A kind of measurement method and system of the Morphologic Parameters of intracranial aneurysm image
CN109493348A (en) * 2018-10-26 2019-03-19 强联智创（北京）科技有限公司 A kind of measurement method and system of the Morphologic Parameters of intracranial aneurysm image

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JP5175552B2 (en) 2013-04-03
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WO2006064479A1 (en) 2006-06-22
ATE415864T1 (en) 2008-12-15
EP1827236B1 (en) 2008-12-03
JP2008523877A (en) 2008-07-10
CN100581465C (en) 2010-01-20
US20090238420A1 (en) 2009-09-24
US7865001B2 (en) 2011-01-04

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