CN101065155A - Hydrogen peroxide vapor sterilizer and sterilizing methods using the same - Google Patents
Hydrogen peroxide vapor sterilizer and sterilizing methods using the same Download PDFInfo
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- CN101065155A CN101065155A CNA200580040368XA CN200580040368A CN101065155A CN 101065155 A CN101065155 A CN 101065155A CN A200580040368X A CNA200580040368X A CN A200580040368XA CN 200580040368 A CN200580040368 A CN 200580040368A CN 101065155 A CN101065155 A CN 101065155A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/208—Hydrogen peroxide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/12—Apparatus for isolating biocidal substances from the environment
- A61L2202/122—Chambers for sterilisation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
Abstract
Disclosed is a method for sterilizing an article with hydrogen peroxide in a reaction vessel, comprising: maintaining an inner space of the reaction vessel at a vacuum pressure lower than an equilibrium vapor pressure of hydrogen peroxide; heating the inner space of the reaction vessel to a temperature from 30 to 60 0C; injecting a hydrogen peroxide solution into the inner space of the reaction vessel; thermally vaporizing the hydrogen peroxide solution within the reaction vessel; sealing the inner space of the reaction vessel and maintaining the article in a hydrogen peroxide vapor atmosphere; and introducing external gas into the inner space of the reaction vessel to increase the pressure of the inner space to a predetermined value not more than the atmospheric pressure. The method allows the effective sterilization of an article having a narrow, long lumen.
Description
Technical field
The present invention relates to a kind of by using the hydrogen peroxide killing microorganisms to come the method and apparatus that article are sterilized.More particularly, the present invention relates to a kind of by making under vacuum state the steam that heating forms to hydrogenperoxide steam generator contact the method and the bactericidal unit of sterilizing with article.
Background technology
For the article (hereinafter referred to as " article ") that must sterilize to being used for specific purpose are sterilized, as various medical instruments and equipment (comprising disposable), hydrogenperoxide steam generator is widely used in kills the microorganism of surviving on these article.This problem has been proposed a lot of technology, some representative technology wherein below will be described.
The Korean patent No. 0132233 that is entitled as " hydrogen peroxide plasma disinfection system (Hydrogen Peroxide PlasmaSterilization System) " discloses a kind of technology, wherein, after article being carried out pretreatment by article are contacted with hydrogenperoxide steam generator, microorganism is killed by the active component that is generated by hydrogen peroxide plasma, and the hydrogen peroxide that remains in the article dissociates into nonpoisonous chemicla.
The Korean patent No. 10-0351014 that is entitled as " method for steam sterilization and equipment and the anhydrous hydrogen peroxide complex (Vapor Sterilization Method Using Non-Aqueous Hydrogen PeroxideSource; Apparatus therefor and Non-Aqueous Hydrogen Peroxide Complex) that use the anhydrous hydrogen peroxide source " discloses a kind of container, article contact with the hydrogen peroxide steam that is provided by the source in this container, and described source mainly comprises the anhydrous hydrogen peroxide complex.In addition, this container also is furnished with heater, is used for this complex is heated, to produce steam from this complex.
Because government regulation forbids the article working concentration is higher than 60% hydrogen peroxide, therefore the common working concentration of above-mentioned disinfection system is the hydrogen peroxide of 50-58%.Yet the sterilization effect that uses low concentration hydrogen peroxide like this to reach can not be satisfactory.As the replacement scheme of avoiding this problem, developed a kind of method for steam sterilization, the feature of this method is to use the complex that obtains by aqueous hydrogen peroxide solution being concentrated (for example, removing the moisture in the aqueous hydrogen peroxide solution).
Usually, traditional steam sterilizing system is configured to inside reactor or outside the generation and the diffusion hydrogen peroxide steam, and generates plasma, and this plasma contacts with article then.In this system, sterilization process carries out in reactor with low-pressure state.Therefore, in this state, the hydrogen peroxide steam plasma of playing the part of pivotal player in sterilization process is difficult to be penetrated in the instrument with long and narrow tube chamber (for example having long 50cm, diameter and be the endoscope of 1mm or littler pipe).That is to say, use traditional hydrogen peroxide vapor sterilization equipment thoroughly not sterilize instrument with long and narrow cavity.
The halfway reason of sterilizing is, because the molecular weight of water is generally little than hydrogen peroxide, thereby steaming pressure ratio hydrogen peroxide height, therefore when sterilization, water has more preferably occupied long and narrow cavity, for example tube chamber than hydrogen peroxide steam.
In addition,, directly contact the change that can cause medical apparatus and instruments color to occur, or cause the performance (as being provided with) of medical apparatus and instruments to change with the hydrogen peroxide steam plasma according to traditional plasma sterilization method.When article occupy reactor volume 70% or when above, after sterilizing in traditional disinfection system, the part of article is not sterilized probably yet.
And owing to plasma must generate in the inner space of reactor equably, thereby the size of the reactor of legacy system is very limited.In addition, when generating plasma cathode self bias may take place, near the article this may cause are not sterilized yet.
Traditional system is configured to basically by hydrogen peroxide steam being provided in reactor or coming the article of reactor are sterilized with the active component that generation is used for killing microorganisms by generating hydrogen peroxide plasma, thereby, if the volume of article is bigger, traditional system can't thoroughly sterilize.In addition, hydrogen peroxide may just discharge under the situation that is not decomposed into oxygen, hydrogen G﹠W fully, thereby causes air pollution, and this may cause user or patient respiratory disease to occur.
Most of traditional disinfection systems all are equipped with negative electrode and anode, are used for generating plasma at reactor.As U.S. Patent number 6,365,102 is disclosed, and before article were put into reactor, system need remain on the temperature of reactor 30 ℃ or higher, to obtain best sterilization effect.This patent has proposed a kind of method, this method comprises the chamber evacuation, generate plasma in chamber, chamber is vented to be about atmospheric pressure or be lower than atmospheric pressure and with evacuation, generate plasma and ventilate and repeat at least twice.
In addition, above-mentioned patent proposes, because the fully radiation of energy of plasma under vacuum state, so that can't improve the temperature of reactor at short notice, therefore the air that imports in the reactor plays the effect of the effective media that transmits energy of plasma, thereby has improved the temperature of reactor.
Though above-mentioned United States Patent (USP) is characterised in that the temperature of stage reactors remains on 30 ℃ in early days, thereby aqueous hydrogen peroxide solution is evaporated easily, do not make the hydrogen peroxide steam condensation, but above-mentioned United States Patent (USP) is sterilized in the mode identical with traditional technology still.
The desired low-pressure state of the sterilizing methods of United States Patent (USP) can not guarantee the article with long and narrow tube chamber (for example long 50cm of being, diameter are 1mm or littler soft endoscope) are sterilized, and this is because the main hydrogen peroxide steam plasma of being responsible for killing microorganisms can not be penetrated in the tube chamber well.
Summary of the invention
Therefore, consider the problems referred to above of the prior art and propose the present invention, the purpose of this invention is to provide a kind of equipment and method of using hydrogen peroxide steam the article with diffusion limited zone to be carried out effective sterilizing.In order to achieve the above object, the invention provides a kind of method of using hydrogen peroxide that article are sterilized in reactor, this method comprises: the vacuum pressure condition that reactor inner space is remained below the hydrogen peroxide equilibrium vapor pressure; The temperature of the inner space of reactor is heated to 30-60 ℃; In the inner space with the hydrogenperoxide steam generator injecting reactor; With the hydrogenperoxide steam generator thermal evaporation in the reactor; The inner space of sealed reactor also remains on article in the hydrogen peroxide steam environment; With extraneous gas is imported in the inner space of reactor, be increased to pressure and be not more than atmospheric predetermined value the inner space.
In the method, preferably extraneous gas is directed into the pressure of 100 to 600 holders.And, in the preferred case, before importing step, earlier extraneous gas is heated.
In the method for the invention, heating steps preferably includes the use radiant heating device, and the inner space of reactor is heated.In the preferred case, this radiant heating device is infrared lamp or Halogen light.In addition, this radiant heating device can be with mode radiant heat energy intermittently.
In the method for the invention, repeatedly import step, progressively to increase the pressure of inner space.
According to modification of the present invention, this method may further include: the pressure of inner space is reduced to the predetermined vacuum pressure that keeps step or lower; With after importing step, the pressure with the inner space is increased to atmospheric pressure or lower once more.In this revised, this method may further include: after increasing step once more, with blood pressure lowering and once more pressurization repeat at least once.
In the method for the invention, described extraneous gas can be an air.
In order to achieve the above object, the invention provides a kind of hydrogen peroxide vapor sterilization device, this device comprises: reactor is used to hold article; Vacuum pump is used for reactor is remained on vacuum pressure condition; The hydrogen peroxide liquid reservoir, this hydrogen peroxide liquid reservoir is installed in the outside of reactor, is used for providing aqueous hydrogen peroxide solution to reactor; Vaporizer, this vaporizer is installed in the inside of reactor, is used for by heater the aqueous hydrogen peroxide solution that is provided by liquid reservoir being evaporated, and described heater is associated with vaporizer; And heater, this heater is installed in the inwall or outer wall of reactor, is used for the inner space of reactor is remained at predetermined temperature.
In the hydrogen peroxide vapor sterilization device, described reactor may further include: radiant heating device, this radiant heating device is exposed in the inner space of reactor, is used to heat this inner space.Relevant therewith, this radiant heating device can comprise Halogen light or infrared lamp.In addition, this radiant heating device can comprise heating lamp and window, and this window is used for the inner space of heating lamp and reactor is separated.
According to modification of the present invention, described hydrogen peroxide vapor sterilization device may further include the pressure relief device that is used for gas is imported reactor, and described pressure relief device comprises the filter that is used for filtering gas and is used to control the pressure relief valve that gas flows into.In this revised, this pressure relief device comprised the hot-air blower fan, is used for before gas is imported filter gas being heated.
In addition, described hydrogen peroxide vapor sterilization device may further include plasma processing unit, and this plasma processing unit is arranged on the discharge tube between reactor and the vacuum pump, is used for the gas of reactor inner space is decomposed into innocuous substance.Relevant therewith, described hydrogen peroxide vapor sterilization device may further include the plasma generator that is arranged on the reactor outside, and the plasma guiding device is installed between plasma generator and reactor.
Description of drawings
Be elaborated below in conjunction with accompanying drawing, more to be expressly understood above-mentioned and other purposes, feature and other advantages of the present invention, wherein:
Fig. 1 is the structural representation of expression according to hydrogen peroxide vapor sterilization device of the present invention;
Fig. 2 is the tonogram of reactor, and hydrogen peroxide vapor sterilization process of the present invention is described;
Fig. 3 to Fig. 6 is the tonogram of expression according to the hydrogen peroxide vapor sterilization process of embodiment of the present invention; With
Fig. 7 is the sketch map of expression structure of the hydrogen peroxide vapor sterilization device of another embodiment according to the present invention.
The specific embodiment
Now should be with reference to the accompanying drawings, identical Reference numeral is used to indicate same or analogous assembly in all different accompanying drawings.
Fig. 1 is the structural representation of the expression use hydrogen peroxide plasma according to the present invention hydrogen peroxide vapor sterilization device of sterilizing.
As shown in this figure, hydrogen peroxide vapor sterilization device of the present invention comprises reactor 10, and this reactor 10 comprises chamber, and dish 13 is arranged in the chamber, is used for holding articles 11, for example medical apparatus or operation tool.Usually, article 11 are placed on the dish 13, are wrapped up by packaging material simultaneously.Reactor 10 carries out evacuation by vacuum pump 14, and described vacuum pump 14 is connected to the lower position of reactor 10 by discharge tube 15.One side of reactor 10 is provided with door 16.
The plasma generator 20 that is arranged on reactor 10 outsides comprises: plasma chamber 21, two electrodes toward each other are installed in this plasma chamber 21, and between described two electrodes, generate optimum plasma; With power supply 22, be electrically connected with plasma chamber, be used to electrode that high voltage is provided.
On discharge tube 15, be provided with plasma processing unit 30, so that the hydrogen peroxide steam of reactor 10 inside is through plasma.The structure of these plasma processing unit 30 structures and plasma generator 20 much at one, just the plasma chamber 31 of plasma processing unit 30 is installed on the discharge tube 15, power supply 32 is electrically connected with plasma chamber 31 simultaneously, so that chamber 31 generates optimum plasma.Therefore, omitted its detailed description.On the discharge tube 15 between reactor 10 and the plasma chamber 31, be provided with automatic pressure control valve 34.
In order to make plasma generator 20 and plasma processing unit 30 generate plasma, can adopt various technology, as in the electric field that uses high-voltage direct current or alternating current, adopting arc discharge, radio-frequency discharge etc.
In addition, the zigzag inner bottom part of reactor 10 is provided with vaporizer 40, and reactor is provided with heater 41 under 10 bottoms.Be provided with outside hydrogen peroxide liquid reservoir 42 and be connected, be used for providing aqueous hydrogen peroxide solution to vaporizer 40 with vaporizer 40.Because hydrogen peroxide offers vaporizer 40 by hydrogen peroxide liquid reservoir 42 after reactor 10 is evacuated, so the hydrogen peroxide liquid reservoir can adopt any structure that can utilize pressure differential when hydrogen peroxide is provided.Flow control valve 43 is arranged between vaporizer 40 and the hydrogen peroxide liquid reservoir 42, uses this flow control valve 43 can control hydrogen peroxide flow to vaporizer from liquid reservoir flow velocity.
Shown tonogram among Fig. 2, used the sterilization process of hydrogen peroxide with explanation according to reactor of the present invention.To describe sterilization process of the present invention in detail with reference to this tonogram.
At first, to being installed in vaporizer 40 and reactor 10 external heated devices 41 and 18 power supplies respectively, so that the temperature of vaporizer 40 and reactor is elevated to 10 to 30 ℃ or higher.In the present invention, may before other steps, reactor and vaporizer not heated, but as mentioned below, can heat at reasonable time.For example, after hydrogen peroxide is provided or before vaporizer is heated.
Then, will be placed on the dish, close subsequently and call 16 with the article (as medical apparatus or operation tool) that packing sheet is wrapped in.At this moment, control valve 43,45 and automatic pressure control valve 34 all are in closed condition, described control valve 43 and 45 is separately positioned between reactor 10 and the hydrogen peroxide liquid reservoir 42 and between reactor 10 and the filter 46, and described automatic pressure control valve 34 is installed on the discharge tube 15 between reactor 10 and the plasma processing unit 30.Can use any packing sheet that can allow air penetration to pass through, as fabric.
With after being installed in automatic pressure control valve 34 on the discharge tube 15 and opening, the running of vacuum pump 14 is extracted air out from reactor 10 and plasma chamber 21, to reach predetermined pressure (300 * 10
～3Holder or littler).At this moment, the electrode and the plasma processing unit 30 that is installed on the discharge tube 15 of article on plasma body generator 20 do not apply electric field to power supply 22.When forming predetermined pressure by vacuum pump 14 in reactor 10 inside, the automatic pressure control valve 34 on the discharge tube 15 is closed.
Subsequently, turn-on flow rate control valve 43 is to offer the aqueous hydrogen peroxide solution in the hydrogen peroxide liquid reservoir 42 in the vaporizer 40 in the reactor 10.Owing to the pressure differential of evacuation reactor hydrogen peroxide is imported in the reactor automatically.In a single day aqueous hydrogen peroxide solution is injected in the reactor and just is evaporated, and this is because the temperature of the vaporizer 40 that is heated by heater 41 is enough to evaporate this solution.Along with the diffusion of hydrogen peroxide steam, this steam begins to contact with article 11 and it is sterilized.At this moment, reactor 10 is in vacuum state, and vaporizer 40 has been heated.Because aqueous hydrogen peroxide solution evaporates, so the hydrogen peroxide vapor of reactor 10 pressure is increased to equilibrium vapor pressure gradually.
After the aqueous hydrogen peroxide solution evaporation, according to the temperature of chamber interior, the gross pressure of reactor 10 remains on 1 to 100 holder.Because the temperature by external heater 18 reactors 10 remains on 30-60 ℃, so hydrogen peroxide steam can condensation, but keep its original state, play a part biocide continuously.
According to the present invention, the distance that hydrogen peroxide steam is penetrated into article 11 has been shortened in the evaporation of biocide in the chamber.In addition, owing to keeping the condition of high temperature in the chamber, so keep higher hydrogen peroxide vapor to press in the chamber, and prevent its condensation.Thereby the present invention can render a service the article 11 that are applied to the hydrogen peroxide steam diffusion limited with potential sterilization.According to the concentration of hydrogen peroxide, finishing sterilization generally needs about 5 minutes or shorter time.Yet though can sterilize to article in 5 minutes, suggestion keeps disinfecting action preset time (about 30 minutes).
The hydrogen peroxide vapor of control in the reactor 10 state of (being reaction pressure) of pressing is kept preset time, and this time is enough to article are sterilized, and opens pressure relief valve 45 subsequently, importing in the chamber through the extraneous air that filter 46 purifies.In case the internal pressure of reactor 10 reaches 100 to 600 holders in the ventilation process, the pressure relief valve just closes.The upper limit of overpressure scope if import too much extraneous air just then the temperature of chamber descends, thereby causes the condensation of hydrogen peroxide steam and steam.Therefore, preferably, the amount that imports extraneous air is controlled in the pressure limit of above setting.
Increasing suddenly of reactor 10 internal pressures has the diffusion limited zone external and internal pressure difference of article 11 of (for example tube chamber) increases making, thereby makes hydrogen peroxide steam easily be diffused in the diffusion limited zone of article 11.
Behind the internal pressure maintenance preset time with chamber, vacuum pump 14 work, and the automatic pressure control valve 34 on the discharge tube 15 is opened, thereby gas (hydrogen peroxide steam) is taken away from reactor 10 and plasma chamber 21, to required pressure (1 holder or still less).Then, in the same manner as described above the pressure in the reactor 10 is increased to once more 100 holders or higher, and keeps preset time.
During vacuum pump 14 work, automatic pressure control valve 34 on the discharge tube 15 is in opening after first sterilization, hydrogen peroxide steam residual in the reactor 10 is discharged in the plasma chamber 31 of plasma processing unit 30 by discharge tube 15, is discharged in the air then.
When reducing owing to the discharging of reactor 10 along with the pressure of plasma chamber 21 and 31, by power supply 22 and 32 respectively the high voltage that applies of article on plasma body cavity 21 and 31 electrode make and produce plasma between the electrode.When generating plasma in the plasma chamber 21 of plasma generator 20, formed active component spreads in whole reactor 10, to keep plasma environment.Before being discharged into plasma processing unit 30 from reactor, hydrogen peroxide steam is mainly decomposed by the active component that is filled in the reactor 10 at hydrogen peroxide steam.
Simultaneously, also generate plasma in the plasma chamber 31 on discharge tube 15, to form plasma environment.Thereby the plasma steam that remains in reactor 10 inside when passing through the plasma chamber 31 of plasma processing unit 30 then, is decomposed into nontoxic component by energy of plasma, i.e. water, oxygen molecule and hydrogen by discharge tube 15.The gas of discharging neither can be polluted environment by these nontoxic molecular compositions, also can not damage health.
Though as mentioned above, the catabolic process of hydrogen peroxide carries out after preliminary sterilization is finished, and also can carry out in advance, is promptly carrying out during when gas bleeding after the pressure increase of reactor.
Because residual hydrogen dioxide steam decomposes and discharging in the reactor 10, so the pressure in the reactor 10 is reduced to 100 * 10
-3Holder or lower.When vacuum pump 14 was provided with predetermined pressure in the reactor 10, the automatic pressure control valve 34 on the discharge tube 15 was a closed condition, and ended power supply 22,32 article on plasma body generators 20 and plasma processing unit 30 applies high voltage.
Afterwards, as mentioned above, repeat once following process at least: in the vaporizer 40 with aqueous hydrogen peroxide solution injecting reactor 10, article are sterilized, increased the pressure of reactor 10 and keep the low-pressure state of reactor 10.Alternately keep high pressure and low-pressure state in chamber, this can improve the sterilization effect to the diffusion limited zone of article significantly.
Owing to formed low pressure in reactor 10 when sterilization is finished, therefore along with open gradually pressure relief valve 45, the air that purifies through filter 10 imports in the reactor 10, to reach atmospheric pressure.Then, door 16 is opened, and takes out the sterilized article that are wrapped in 11.
During with the residual hydrogen peroxide steam of discharging from reactor 10, the description of the attended operation of plasma generator 20 and plasma processing unit 30 is opposite, pass through in the process of plasma chamber 31 along discharge tube 15 at residual hydrogen peroxide steam, if necessary, have only plasma processing unit 30 work, thereby hydrogen peroxide steam is decomposed into the nontoxic component that law allows discharging.
Referring to Fig. 3 to Fig. 6, the various embodiments of the sterilizing methods that uses hydrogen peroxide are described.Fig. 3 is the tonogram of bactericidal unit, acquisition in the following manner: inject and evaporate aqueous hydrogen peroxide solution, diffusion hydrogen peroxide steam, predetermined hydrogen peroxide vapor pressure is kept preset time, at least repeat once following process afterwards, be about to air and import in the chamber to predetermined pressure, discharge the gas (hydrogen peroxide steam) of reactor 10 to predetermined vacuum pressure immediately.Fig. 4 and Fig. 3 are similar, and its difference is: repeat once following process, promptly import air to predetermined pressure, this pressure is kept scheduled time, discharges gas (hydrogen peroxide steam) in the reactor 10 to predetermined vacuum pressure then.Fig. 5 is the tonogram of bactericidal unit, acquisition in the following manner: inject and evaporate aqueous hydrogen peroxide solution, diffusion hydrogen peroxide steam, predetermined hydrogen peroxide vapor pressure is kept preset time, progressively carry out following process afterwards, promptly import air to predetermined pressure, with this pressure maintenance preset time.
Referring to Fig. 6, air is imported in the reactor 10 to reach predetermined pressure, discharge gas (hydrogen peroxide steam) in the reactor 10 then to predetermined vacuum pressure, such process repeats once (line a and b) at least.Dotted line among Fig. 6 has been described following process: the gas (hydrogen peroxide steam) that injects and evaporate aqueous hydrogen peroxide solution, diffusion hydrogen peroxide and discharging reactor 10, repeat following process afterwards, be about to the gas (line c) in air injecting reactor 10 and the discharging reactor 10.
In Fig. 3 to Fig. 6, T1 and T2 scope separately is 0 to 30 minute, can control this scope according to the attribute of article 11.
Sterilizing methods according to above-mentioned embodiment is characterised in that evaporation and diffusion hydrogen peroxide and injection and discharged air, and described sterilizing methods can be strengthened the infiltration of biocide in the diffusion limited zone of article, has therefore improved sterilization effect significantly.
Embodiment 1
Relatively the sterilization effect of traditional method and method of the present invention in traditional method, only carry out the hydrogen peroxide diffusion, and in the method for the invention, the hydrogen peroxide diffusion combines with supercharging (ventilation) process, and the result is shown in hereinafter table 1.
In sterile test, use BI (Biological Indicator, biological indicator) by company's production of the U.S.." bacstearothermophilus (Bacillus Stearothermophilus) " [the several 2.04 * 10n of spore, n=6] is as the test microorganism.To after sterilizing by the tube chamber of various sizes manufacturing, BI is applied to each tube chamber according to each method.The BI sample that will take off from tube chamber was cultivated 48-72 hour in identical incubator, then the change color of measuring samples.To every kind of situation, test all repeats 10 times, and the number of times of qualified sterilization (no growth of microorganism) is counted.
Table 1
(unit: mm)
| Sterilization process (injects H 2O 2) | Φ2×1000 | Φ2×2000 | Φ1×1000 | Φ1×2000 |
| Tradition- | 10/10 | 6/10 | 0/10 | 0/10 |
| Invention-diffusion rear venting | 10/10 | 10/10 | 10/10 | 10/10 |
*Permeate successful number of times/test total degree
*Permeate successfully: the reaction that is negative of BI sample
*The infiltration failure: the BI sample is positive
As shown in table 1, for the article that are of a size of Φ 2 * 1000, two kinds of methods have all obtained good sterilization result, but when the size stenosis of article is narrow (Φ 1), traditional method and sterilization effect of the present invention have significant difference.Can believe that this species diversity is due to the fact that and causes: the importing of air increased pressure differential, and pressure differential is the key factor of hydrogen peroxide steam infiltration, thereby makes hydrogen peroxide steam be easy to be penetrated in the tube chamber that is of a size of Φ 1.
Spread hydrogen peroxide steam, import air and, further strengthened sterilization effect by air importing increase pressure to after the chamber evacuation.What can also believe is, a lot of pressure differentials can provide more strong driving force, helps in the zone that hydrogen peroxide steam is penetrated into diffusion limited, as tube chamber.
Fig. 7 is the structural representation of expression hydrogen peroxide vapor sterilization device of another embodiment according to the present invention.
As shown in Figure 7, the structure of this bactericidal unit and the bactericidal unit among Fig. 1 are similar.Same components by with Fig. 1 in identical Reference numeral indicate, do not further specify at this.
Different with the bactericidal unit of Fig. 1, be equipped with hot-air blower fan 47 and pharoid 50 according to the bactericidal unit of this embodiment.
Hot-air blower fan 47 is positioned at the front end of filter 46, is used to heat extraneous air, and the air of heating is offered reactor.Hot-air blower 47 can be specially thermoconverter, and this thermoconverter comprises electric heater, as nichrome wire.The operation of hot-air blower fan 47 can prevent the probability that following situation takes place: after the discharging hydrogen peroxide steam, when in pressurization stages, when importing in the chamber without the air of heating, extraneous air makes hydrogen peroxide and water vapor condensation.If because the importing of extraneous air causes water vapor condensation, the moisture of condensation can stop up the diffusion limited zone of tube chamber, be penetrated in the tube chamber thereby hinder hydrogen peroxide steam.Yet, be used to provide the hot-air blower fan of hot-air can not allow condensation, thereby improved sterilizing efficiency.
According to this embodiment, be provided with radiant heating device 50 and be used for head it off.In evacuation and sterilization process, the inner space of reactor 10 remains on low-pressure state.Under this state, the conduction by heater 18 can't reach the thermal balance in effectively heat passage and the chamber interior space.For example, when by heater 18 chamber wall being heated to about 60 ℃, the chamber indoor environment temperature only reaches 20-40 ℃, and the temperature that article keep is then lower.
The radiant heating device 50 of Fig. 7 can be increased to the temperature of chamber interior the level identical with inwall.Therefore, radiant heating device 50 will heat by hydrogen peroxide steam, steam and the article of radiation to chamber interior, thereby eliminate the probability of steam condensation fully.Especially, the benefit of radiation heating is: if article are transparent, then no matter the quantity of article or volume how, can both heat all article equably.
In addition, if the inwall of reactor 10 is made of metal or is coated with metal, it can reflect heat energy or caloradiance, thus the inside of reactor heating equably.Infrared lamp or Halogen light can be used as radiant heating device 50.Certainly, can use any heater that heats in radiating mode.
In this embodiment of the present invention, radiant heating device 50 comprises lamp 52 and window 54 (for example quartzy), and described window 54 is used for the lamp 52 and the inner space of reactor are separated.In addition, preferably be provided with reflecting mirror 56, thereby assemble the light of emission backward at the back side of lamp 52.According to present embodiment, the radiant heating device 50 of right quantity can be installed on the inwall of reactor.
Alternatively, radiant heating device 50 is ON/OFF off and on, thereby prevents the article superheated.
Be equipped with the bactericidal unit of the present invention of above-mentioned heater, can prevent clogging, the reason that produces this clogging is the inlet condensation of steam at diffusion limited zone (as tube chamber), causes hydrogen peroxide steam can't be penetrated in this zone.
Industrial usability
As mentioned above, according to the present invention, the vaporizer that is installed in chamber interior has reduced the amount of the required aqueous hydrogen peroxide solution of sterilizing.In addition, built-in vaporizer has shortened the distance between vapour source and the article, thereby has improved sterilizing efficiency.
In addition, in the process of using hydrogen peroxide steam to carry out disinfection, extraneous air imported help making biocide to be penetrated into the diffusion limited zone in the chamber, tube chamber for example, thus improved sterilizing efficiency.
And then, before importing extraneous air, use heater that it is heated earlier, can prevent to reduce the temperature of inside reactor like this because of the importing cool exterior air, and the water vapor condensation phenomenon that is caused thus, thereby hydrogen peroxide steam is easy to be penetrated in the diffusion limited zone.
In addition, the radiant heating device that is installed in inside reactor directly heats hydrogen peroxide steam, steam and article, thereby prevents the condensation of steam, has improved the sterilization of hydrogen peroxide steam and has renderd a service.
Though disclose preferred implementation of the present invention for illustrative purposes, but for a person skilled in the art, under the situation that does not break away from the scope and spirit of the present invention described in claim, obviously can implement various modifications, interpolation and replacement.
Claims (18)
1. method of in reactor, using hydrogen peroxide that article are sterilized, this method comprises:
Reactor inner space is remained below the vacuum pressure condition of hydrogen peroxide equilibrium vapor pressure;
The temperature of the inner space of reactor is heated to 30 ℃-60 ℃;
Inner space with the hydrogenperoxide steam generator injecting reactor;
With the hydrogenperoxide steam generator thermal evaporation in the reactor;
The inner space of sealed reactor, and article are remained in the hydrogen peroxide steam environment; With
Extraneous gas is imported in the inner space of reactor, be increased to pressure and be not more than atmospheric predetermined value the inner space.
2. method according to claim 1, wherein, the pressure that extraneous gas reached of importing is 100 to 600 holders.
3. method according to claim 1 before importing step, also comprises the heating extraneous gas.
4. method according to claim 1, wherein, described heating steps comprises that the use radiant heating device heats the inner space of reactor.
5. method according to claim 4, wherein, described radiant heating device is infrared lamp or Halogen light.
6. method according to claim 4, wherein, described radiant heating device is with mode radiant heat energy intermittently.
7. method according to claim 1 wherein, repeatedly imports step, progressively to increase the pressure of inner space.
8. according to each described method in the claim 1 to 7, also comprise:
The pressure of inner space is reduced to the predetermined vacuum pressure that keeps step or lower; With
After importing step, the pressure with the inner space is increased to atmospheric pressure or lower once more.
9. method according to claim 8 also comprises: after increasing step once more, repeat a blood pressure lowering and supercharging once more at least.
10. according to each described method in the claim 1 to 9, wherein, described extraneous gas is an air.
11. a hydrogen peroxide vapor sterilization device, this device comprises:
Reactor is used to hold article;
Vacuum pump is used for reactor is remained on vacuum pressure condition;
The hydrogen peroxide liquid reservoir, this hydrogen peroxide liquid reservoir is installed in the outside of reactor, is used to reactor that aqueous hydrogen peroxide solution is provided;
Vaporizer, this vaporizer is installed in the inside of reactor, is used for by heater the aqueous hydrogen peroxide solution that is provided by the hydrogen peroxide liquid reservoir being evaporated, and described heater is associated with vaporizer; With
Heater, this heater are installed in the inwall or the outer wall of reactor, are used for the inner space of reactor is remained at predetermined temperature.
12. hydrogen peroxide vapor sterilization device according to claim 11, wherein, described reactor also comprises: radiant heating device, this radiant heating device is exposed to the inner space of reactor, is used to heat this inner space.
13. hydrogen peroxide vapor sterilization device according to claim 12, wherein, described radiant heating device comprises Halogen light or infrared lamp.
14. hydrogen peroxide vapor sterilization device according to claim 12, wherein, described radiant heating device comprises heating lamp and window, and this window is used to separate the inner space of heating lamp and reactor.
15. hydrogen peroxide vapor sterilization device according to claim 11 also comprises the pressure relief device that is used for gas is imported reactor, described pressure relief device comprises the filter that is used for filtering gas and is used to control the pressure relief valve that gas flows into.
16. hydrogen peroxide vapor sterilization device according to claim 15, wherein, described pressure relief device comprises the hot-air blower fan, is used for before gas is imported filter gas being heated.
17. hydrogen peroxide vapor sterilization device according to claim 11, also comprise plasma processing unit, this plasma processing unit is arranged on the discharge tube between reactor and the vacuum pump, is used for the gas of reactor inner space is decomposed into innocuous substance.
18. hydrogen peroxide vapor sterilization device according to claim 11 also comprises plasma generator, this plasma generator is arranged on the outside of reactor, and the plasma guiding device is installed between plasma generator and reactor.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20040098050 | 2004-11-26 | ||
| KR1020040098050 | 2004-11-26 | ||
| KR1020040105319 | 2004-12-14 |
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| CN101065155A true CN101065155A (en) | 2007-10-31 |
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| CNA200580040368XA Pending CN101065155A (en) | 2004-11-26 | 2005-11-25 | Hydrogen peroxide vapor sterilizer and sterilizing methods using the same |
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| CN102284071A (en) * | 2011-09-08 | 2011-12-21 | 杭州泰林生物技术设备有限公司 | Transferring cabin with peroxide biological decontamination function |
| CN102350003A (en) * | 2011-10-28 | 2012-02-15 | 成都老肯科技股份有限公司 | Hydrogen peroxide low-temperature sterilizing equipment and use method thereof |
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| CN111671941A (en) * | 2016-07-11 | 2020-09-18 | 株式会社普拉斯 | Sterilizing apparatus and sterilizing method |
| CN111671941B (en) * | 2016-07-11 | 2022-08-23 | 株式会社普拉斯 | Sterilizing apparatus and sterilizing method |
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