CN101054702A - Method for manufacturing dimple on blood vessel metal support - Google Patents
Method for manufacturing dimple on blood vessel metal support Download PDFInfo
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- CN101054702A CN101054702A CNA2007100717264A CN200710071726A CN101054702A CN 101054702 A CN101054702 A CN 101054702A CN A2007100717264 A CNA2007100717264 A CN A2007100717264A CN 200710071726 A CN200710071726 A CN 200710071726A CN 101054702 A CN101054702 A CN 101054702A
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Abstract
The present invention discloses a process for fabricating micro-holes at blood vessel steel timber and belongs to a technology for preparing micro-holes at blood vessel steel timber. The process is used for resolving some following problems in the process for fabricating micro-holes at blood vessel steel timber in existence: the hatch diameters of the micro-hole and the well deepness are large, the sizes of the small wells are not identical, then the effect release step by step of medicaments are unfavorable; the arrangement of small well holes only surrounds the external surface of bracket and can be located at the bracket anchor jack as well as the profile plane and interior surface of the bridge muscle; and the cost of the existent processing method is high. Said process for fabricating micro-holes at blood vessel steel timber is realized through the following steps: (1) bracket pretreatment; (2) electric plating; (3) cleaning the bracket having metal plating layers; (4) removing the plating layers, wherein micro- holes overspread the steel timber after such processing. Micro- holes overspread the steel timber after such processing in accordance with the present invention, wherein the hatch dimension of the micro- holes is small and the longitudinal sections is circular or square figure , with a hatch diameter of 0.1-0.4 mu m and a depth of 0.1-0.4 mu m.
Description
Technical field
The invention belongs to the little hole of a kind of blood vessel through metal technology of preparing.
Background technology
The intravascular stent implantation is the interventional therapy heart trouble of fast development over nearly 10 years and the change technology of myocardial infarction.Small tubular bracket can strut those at once because the vascular embolization position that fat accumulation caused, reduced because open the damage and the risk of thoracic surgery bypass surgery, clinical disease such as myocardial ischemia and coronary heart disease can be eased after operation at once, saved life, can walking leave hospital behind the patient 24h, evident in efficacy.But in about 6 months after the naked through metal implantation, understand the vascular restenosis that produces about 25-30%, people have made the growth of medication coat or bracket for eluting medicament effort prevention scar tissue again, it carries medicine by the carrier that is coated on metal support surface, after implanting diseased region, medicine is released into painstaking effort tube wall tissue from carrier by type of elution and brings into play biological effect, tries hard to realize the controllability of drug release.Yet the clinical trail statistics shows that though bracket for eluting medicament can effectively reduce the vascular restenosis rate, it has thrombosed danger, and coating stent of medicine surface structure healing fraction of coverage is low.At present result of study shows: cause the coating stent of medicine surface structure cure that the low reason of fraction of coverage and drug carrier material cover the integral body of support and the degradable of drug carrier material be absorbed relevant.In order to reach the effect that performance carried stent Chinese traditional medicine suppresses restenosis, reduce the shared standoff surface-area of drug carrier material simultaneously, the tissue that improves rack surface is cured fraction of coverage and is become and reduce or avoid one of the measure of thrombus that happens suddenly late period.In order to achieve the above object, the someone considers to design carried stent; New trial has been done by some companies and research institution.The Van Humbeeck team of Belgian Univ Louvain in 2003 designs and has made pockmark type carried stent with laser; Reporting that according to another the U.S. The Business Week2005 Conor company develops a kind of The Small Well hole type drug stent recently on October 21, is to utilize computer to instruct laser fabrication technology to form hundreds of little wells on the support array to deposit medicine.But there is following problem in the blood vessel through metal that has little hole that above-mentioned two kinds of related laser processings of scheme go out: the excessive and longitudinal section of the opening size of (1) little well is the deep-well type, opening diameter is 8～25 μ m, well depth is 8～25 μ m, this is the support of 70-100 μ m for dagger width and bridge muscle width, well beyond the boundary of the admissible indicated range of support, this scope must not be greater than 5% of dagger width and the bridge muscle width and their degree of depth; (2) little well arranges to array, and the size of little well is evenly unified, this is formed on for drug release very easily, and the same time drug release in back finishes in the implanted body of support, and drug effect loses simultaneously, is unfavorable for the progressively release of medicine effect; (3) arranging of little well can only can't be positioned at the side and the internal surface of support dagger and bridge muscle round the outside surface of support, and the technology of utilizing laser to prepare little hole has improved the support processing cost.
Summary of the invention
The objective of the invention is to have in order to solve original method of on the blood vessel through metal, making little hole that little hole opening diameter is big, well depth dark, The Small Well hole size evenly unifiedly is unfavorable for progressively the discharging of medicine effect, arranging of little well can only be round the outside surface of support, can't be positioned at side and the internal surface and the high problem of original treatment process cost of support dagger and bridge muscle, and propose a kind of method of on the blood vessel through metal, making little hole.The method of making little hole on the blood vessel through metal realizes by following steps: (one) at ambient temperature, it is that 10～30% hydrochloric acid soln cleaned 5～10 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 5～10 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 10～30 minutes, takes out then to dry up; (2) with AlCl
3The quality percentage composition be 70～80%, the quality percentage composition of NaCl and KCl respectively is 10～15% AlCl
3-NaCl-KCl system or AlCl
3The quality percentage composition be 70～80% AlCl
3-NaCl system is put into electrolyzer and is heated to molten state, blood vessel through metal matrix is put into electrolyzer and at the AlCl of molten state
3-NaCl-KCl or AlCl
3Soaked among-the NaCl 10～15 minutes, and in electrolyzer, fed purity and be 99.99% argon gas, with the medical metal be then anode, blood vessel through metal matrix be negative electrode, electroplating temperature be 110～250 ℃, cathode current density be ± 5～± 50mA/cm
2Condition under electroplated 15～45 minutes; (3) the blood vessel through metal matrix that will have metal plating within 5～10 seconds after plating finishes is put into tap water and was cleaned 5～10 minutes, and the blood vessel through metal matrix that will have metal plating after tap water cleans and finishes is put into distilled water and carried out ultrasonic cleaning 10～30 minutes; (4) be that the sulphuric acid soln of 0.25～2.0mol/L or oxalic acid solution that volumetric molar concentration is 0.1～0.5mol/L are electrolytic solution with volumetric molar concentration, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, anodic oxidation voltage be 0.5～40V, current density be ± 10～± 60mA/cm
2, temperature is under 0～30 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 1～5 times of current density and kept this current density 10～100 seconds after 5～50 minutes, be about to be covered with little hole on the blood vessel through metal.Metal plating on the blood vessel through metal that the present invention handled comes off and be covered with little hole on the blood vessel through metal, little hole is that original position generates, little and the longitudinal section of the opening size in little hole is circular or square, the size in little hole is submicron order or nano level, opening diameter is 0.01～4 μ m, and the degree of depth is 0.01～4 μ m, and pitting is irregular arranges, and the size of little well is not evenly unified, is beneficial to the progressively release of medicine effect.
Description of drawings
Fig. 1 is that the blood vessel through metal after handling in the embodiment 12 amplifies 5000 times electronic scanning figure, and Fig. 2 is that the blood vessel through metal after handling in the embodiment 13 amplifies 5000 times electronic scanning figure.
Embodiment
Embodiment one: the method for making little hole in the present embodiment on the blood vessel through metal realizes by following steps: (one) at ambient temperature, it is that 10～30% hydrochloric acid soln cleaned 5～10 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 5～10 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 10～30 minutes, takes out then to dry up; (2) with AlCl
3The quality percentage composition be 70～80%, the quality percentage composition of NaCl and KCl respectively is 10～15% AlCl
3-NaCl-KCl system or AlCl
3The quality percentage composition be 70～80% AlCl
3-NaCl system is put into electrolyzer and is heated to molten state, blood vessel through metal matrix is put into electrolyzer and at the AlCl of molten state
3-NaCl-KCl or AlCl
3Soaked among-the NaCl 10～15 minutes, and in electrolyzer, fed purity and be 99.99% argon gas, with the medical metal be then anode, blood vessel through metal matrix be negative electrode, electroplating temperature be 110～250 ℃, cathode current density be ± 5～± 50mA/cm
2Condition under electroplated 15～45 minutes; (3) the blood vessel through metal matrix that will have metal plating within 5～10 seconds after plating finishes is put into tap water and was cleaned 5～10 minutes, and the blood vessel through metal matrix that will have metal plating after tap water cleans and finishes is put into distilled water and carried out ultrasonic cleaning 10～30 minutes; (4) be that the sulphuric acid soln of 0.25～2.0mol/L or oxalic acid solution that volumetric molar concentration is 0.1～0.5mol/L are electrolytic solution with volumetric molar concentration, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, anodic oxidation voltage be 0.5～40V, current density be ± 10～± 60mA/cm
2, temperature is under 0～30 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 1～5 times of current density and kept this current density 10～100 seconds after 5～50 minutes, be about to be covered with little hole on the blood vessel through metal.
Present embodiment is particularly useful for the processing to cardiovascular through metal matrix.
Embodiment two: the difference of present embodiment and embodiment one is in the step () at ambient temperature, it is that 15～25% hydrochloric acid soln cleaned 6～9 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 6～9 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 15～25 minutes, takes out then to dry up.Other step is identical with embodiment one.
Embodiment three: the difference of present embodiment and embodiment one is that step (in (one) at ambient temperature, it is that 20% hydrochloric acid soln cleaned 8 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 8 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 20 minutes, takes out then to dry up.Other step is identical with embodiment one.
Embodiment four: the difference of present embodiment and embodiment one is in the step () at ambient temperature, it is that 25% hydrochloric acid soln cleaned 6 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 8 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 18 minutes, takes out then to dry up.Other step is identical with embodiment one.
Embodiment five: the difference of present embodiment and embodiment one is in the step () at ambient temperature, it is that 30% hydrochloric acid soln cleaned 5 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 7 minutes, blood vessel through metal matrix after the washing processing is put into successively the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 16 minutes, takes out then to dry up.Other step is identical with embodiment one.
Embodiment six: the difference of present embodiment and embodiment one is in the step () at ambient temperature, it is that 28% hydrochloric acid soln cleaned 7 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 10 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 28 minutes, takes out then to dry up.Other step is identical with embodiment one.
Embodiment seven: the difference of present embodiment and embodiment one is that medical metal is medical stainless steel 316L, Medical C o-Cr alloy L605 or Nickel-titanium alloy for medical purpose NT508 in the step (two).Other step is identical with embodiment one.
Embodiment eight: the difference of present embodiment and embodiment one be in the step (two) electroplating temperature be 150～230 ℃, cathode current density be ± 15～± 40mA/cm
2Condition under electroplated 20～35 minutes.
Embodiment nine: the difference of present embodiment and embodiment one is in the step (two) that electroplating temperature is 130 ℃, cathode current density and is ± 38mA/cm
2Condition under electroplated 35 minutes.
Embodiment ten: the difference of present embodiment and embodiment one is in the step (two) blood vessel through metal matrix put into electrolyzer and at the AlCl of molten state
3-NaCl-KCl or AlCl
3Soaked among-the NaCl 12～14 minutes, and in electrolyzer, fed purity and be 99.99% argon gas, with the medical metal be then anode, blood vessel through metal matrix be negative electrode, electroplating temperature be 120～2400 ℃, cathode current density be ± 10～± 45mA/cm
2Condition under electroplated 18～40 minutes.Other step is identical with embodiment one.
Embodiment 11: the difference of present embodiment and embodiment one is in the step (two) blood vessel through metal matrix put into electrolyzer and at the AlCl of molten state
3-NaCl-KCl or AlCl
3Soaking among-the NaCl 15 minutes, and fed purity and be 99.99% argon gas in electrolyzer, is that anode, blood vessel through metal matrix are that to be 200 ℃, cathode current density be ± 35mA/cm for negative electrode, electroplating temperature then with the medical metal
2Condition under electroplated 30 minutes.Other step is identical with embodiment one.
Embodiment 12: the difference of present embodiment and embodiment one is in the step (two) blood vessel through metal matrix put into electrolyzer and at the AlCl of molten state
3-NaCl-KCl or AlCl
3Soaking among-the NaCl 13 minutes, and fed purity and be 99.99% argon gas in electrolyzer, is that anode, blood vessel through metal matrix are that to be 220 ℃, cathode current density be ± 30mA/cm for negative electrode, electroplating temperature with medical stainless steel 316L then
2Condition under electroplated 28 minutes.Other step is identical with embodiment one.
Be covered with little hole on the blood vessel through metal that present embodiment was handled, use electron microscope observation, amplify 5000 times electronic scanning figure as shown in Figure 1: the little and longitudinal section of the opening size of little well is circular, opening diameter is 0.01～4 μ m, the degree of depth is 0.01～4 μ m, pitting is irregular arranges, and the size of little well is not evenly unified, is beneficial to the progressively release of medicine effect.
Embodiment 13: the difference of present embodiment and embodiment one is in the step (two) AlCl
3The quality percentage composition be 70～80%, the quality percentage composition of NaCl and KCl respectively is 10～15% AlCl
3-NaCl-KCl system is put into electrolyzer and is heated to molten state, blood vessel through metal matrix is put into electrolyzer and at the AlCl of molten state
3Soaking among-the NaCl-KCl 10 minutes, and fed purity and be 99.99% argon gas in electrolyzer, is that anode, blood vessel through metal matrix are that to be 140 ℃, cathode current density be ± 6mA/cm for negative electrode, electroplating temperature with Medical C o-Cr alloy L605 then
2Condition under electroplated 40 minutes.Other step is identical with embodiment one.
Be covered with little hole on the blood vessel through metal that present embodiment was handled, use electron microscope observation, amplify 5000 times electronic scanning figure as shown in Figure 2: the little and longitudinal section of the opening size of little well is square, opening diameter is 0.1～4 μ m, the degree of depth is 0.1～4 μ m, pitting is irregular arranges, and the size of little well is not evenly unified, is beneficial to the progressively release of medicine effect.
Embodiment 14: the blood vessel through metal matrix that the difference of present embodiment and embodiment one is will to have within 6～9 seconds after plating finishes in the step (three) metal plating is put into tap water and was cleaned 6～9 minutes, and the blood vessel through metal matrix that will have metal plating after tap water cleans and finishes is put into distilled water and carried out ultrasonic cleaning 15～25 minutes.Other step is identical with embodiment one.
Embodiment 15: the blood vessel through metal matrix that the difference of present embodiment and embodiment one is will to have within 9 seconds after plating finishes in the step (three) metal plating is put into tap water and was cleaned 10 minutes, and the blood vessel through metal matrix that will have metal plating after tap water cleans and finishes is put into distilled water and carried out ultrasonic cleaning 25 minutes.Other step is identical with embodiment one.
Embodiment 16: it is that the sulphuric acid soln of 0.75～1.8mol/L or oxalic acid solution that volumetric molar concentration is 0.2～0.4mol/L are electrolytic solution that the difference of present embodiment and embodiment one is in the step (four) with volumetric molar concentration, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, anodic oxidation voltage be 1.5～35V, current density be ± 15～± 55mA/cm
2, temperature is under 5～25 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 2～4 times of current densities after 20～48 minutes and kept this current density 15～95 seconds.Other step is identical with embodiment one.
Embodiment 17: it is that the sulphuric acid soln of 1.0～1.5mol/L or oxalic acid solution that volumetric molar concentration is 0.25～0.35mol/L are electrolytic solution that the difference of present embodiment and embodiment one is in the step (four) with volumetric molar concentration, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, anodic oxidation voltage be 5～30V, current density be ± 20～± 45mA/cm
2, temperature is under 10～24 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 2～4 times of current densities after 25～45 minutes and kept this current density 20～90 seconds.Other step is identical with embodiment one.
Embodiment 18: the difference of present embodiment and embodiment one is in the step (four) with the volumetric molar concentration to be that the sulphuric acid soln of 1.4mol/L or oxalic acid solution that volumetric molar concentration is 0.3mol/L are electrolytic solution, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, is that 25V, current density are ± 40mA/cm at anodic oxidation voltage
2, temperature is under 20 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 3 times of current densities after 40 minutes and kept this current density 75 seconds.Other step is identical with embodiment one.
Embodiment 19: the difference of present embodiment and embodiment one is in the step (four) with the volumetric molar concentration to be that the sulphuric acid soln of 0.5mol/L is an electrolytic solution, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, is that 1V, current density are ± 50mA/cm at anodic oxidation voltage
2, temperature is under 20 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 3 times of current densities after 40 minutes and kept this current density 75 seconds.Other step is identical with embodiment one.
Embodiment 20: the difference of present embodiment and embodiment one is in the step (four) with the volumetric molar concentration to be that the oxalic acid solution of 0.2mol/L is an electrolytic solution, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, is that 5V, current density are ± 45mA/cm at anodic oxidation voltage
2, temperature is under 20 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 5 times of current densities after 40 minutes and kept this current density 20 seconds.Other step is identical with embodiment one.
Embodiment 21: the difference of present embodiment and embodiment one is in the step (four) with the volumetric molar concentration to be that the sulphuric acid soln of 1mol/L is an electrolytic solution, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, is that 10V, current density are ± 30mA/cm at anodic oxidation voltage
2, temperature is under 20 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 5 times of current densities after 40 minutes and kept this current density 20 seconds.Other step is identical with embodiment one.
Embodiment 22: the difference of present embodiment and embodiment one is in the step (four) with the volumetric molar concentration to be that the sulphuric acid soln of 1.5mol/L is an electrolytic solution, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, is that 40V, current density are ± 20mA/cm at anodic oxidation voltage
2, temperature is under 20 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 5 times of current densities after 40 minutes and kept this current density 15 seconds.Other step is identical with embodiment one.
Claims (10)
1, on the blood vessel through metal, make the method in little hole, it is characterized in that on the blood vessel through metal method of making little hole realizes by following steps: (one) at ambient temperature, it is that 10～30% hydrochloric acid soln cleaned 5～10 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 5～10 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 10～30 minutes, takes out then to dry up; (2) with AlCl
3The quality percentage composition be 70～80%, the quality percentage composition of NaCl and KCl respectively is 10～15% AlCl
3-NaCl-KCl system or AlCl
3The quality percentage composition be 70～80% AlCl
3-NaCl system is put into electrolyzer and is heated to molten state, blood vessel through metal matrix is put into electrolyzer and at the AlCl of molten state
3-NaCl-KCl or AlCl
3Soaked among-the NaCl 10～15 minutes, and in electrolyzer, fed purity and be 99.99% argon gas, with the medical metal be then anode, blood vessel through metal matrix be negative electrode, electroplating temperature be 110～250 ℃, cathode current density be ± 5～± 50mA/cm
2Condition under electroplated 15～45 minutes; (3) the blood vessel through metal matrix that will have metal plating within 5～10 seconds after plating finishes is put into tap water and was cleaned 5～10 minutes, and the blood vessel through metal matrix that will have metal plating after tap water cleans and finishes is put into distilled water and carried out ultrasonic cleaning 10～30 minutes; (4) be that the sulphuric acid soln of 0.25～2.0mol/L or oxalic acid solution that volumetric molar concentration is 0.1～0.5mol/L are electrolytic solution with volumetric molar concentration, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, anodic oxidation voltage be 0.5～40V, current density be ± 10～± 60mA/cm
2, temperature is under 0～30 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 1～5 times of current density and kept this current density 10～100 seconds after 5～50 minutes, be about to be covered with little hole on the blood vessel through metal.
2, the method of on the blood vessel through metal, making little hole according to claim 1, it is characterized in that in the step () at ambient temperature, it is that 15～25% hydrochloric acid soln cleaned 6～9 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 6～9 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 15～25 minutes, takes out then to dry up.
3, the method of on the blood vessel through metal, making little hole according to claim 1, it is characterized in that in the step () at ambient temperature, it is that 20% hydrochloric acid soln cleaned 8 minutes that blood vessel through metal matrix is put into mass concentration, after pickling finishes blood vessel through metal matrix is put into distilled water and carried out ultrasonic cleaning 8 minutes, blood vessel through metal matrix after the washing processing is put into successively again the acetone of analytical pure level, carry out ultrasonic cleaning in dehydrated alcohol and the secondary deionized water, acetone in the analytical pure level, dehydrated alcohol, the time of carrying out ultrasonic cleaning in the secondary deionized water is 20 minutes, takes out then to dry up.
4, the method for making little hole on the blood vessel through metal according to claim 1 is characterized in that medical metal is medical stainless steel 316L, Medical C o-Cr alloy L605 or Nickel-titanium alloy for medical purpose NT508 in the step (two).
5, the method for making little hole on the blood vessel through metal according to claim 1 is characterized in that in the step (two) blood vessel through metal matrix put into electrolyzer and at the AlCl of molten state
3-NaCl-KCl or AlCl
3Soaking among-the NaCl 12～14 minutes, is 99.99% argon gas feed purity in electrolyzer, with the medical metal be then anode, blood vessel through metal matrix be negative electrode, electroplating temperature be 120～240 ℃, cathode current density be ± 10～± 45mA/cm
2Condition under electroplated 18～40 minutes.
6, the method for on the blood vessel through metal, making little hole according to claim 1, it is characterized in that in the step (two) electroplating temperature be 150～230 ℃, cathode current density be ± 15～± 40mA/cm
2Condition under electroplated 20～35 minutes.
7, the method for making little hole on the blood vessel through metal according to claim 1 is characterized in that in the step (two) blood vessel through metal matrix put into electrolyzer and at the AlCl of molten state
3-NaCl-KCl or AlCl
3Soaking among-the NaCl 15 minutes, and fed purity and be 99.99% argon gas in electrolyzer, is that anode, blood vessel through metal matrix are that to be 200 ℃, cathode current density be ± 35mA/cm for negative electrode, electroplating temperature then with the medical metal
2Condition under electroplated 30 minutes.
8, the method for on the blood vessel through metal, making little hole according to claim 1, the blood vessel through metal matrix that it is characterized in that will having within 6～9 seconds after plating finishes in the step (three) metal plating is put into tap water and was cleaned 6～9 minutes, and the blood vessel through metal matrix that will have metal plating after tap water cleans and finishes is put into distilled water and carried out ultrasonic cleaning 15～25 minutes.
9, the method for on the blood vessel through metal, making little hole according to claim 1, it is characterized in that in the step (four) with volumetric molar concentration being that the sulphuric acid soln of 1.0～1.5mol/L or oxalic acid solution that volumetric molar concentration is 0.25～0.35mol/L are electrolytic solution, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, anodic oxidation voltage be 5～30V, current density be ± 20～± 45mA/cm
2, temperature is under 10～24 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 2～4 times of current densities after 25～45 minutes and kept this current density 20～90 seconds.
10, the method for on the blood vessel through metal, making little hole according to claim 1, it is characterized in that in the step (four) with the volumetric molar concentration being that the sulphuric acid soln of 1.4mol/L or oxalic acid solution that volumetric molar concentration is 0.3mol/L are electrolytic solution, the blood vessel through metal matrix that will have metal plating is put into electrolytic solution, is that 25V, current density are ± 40mA/cm at anodic oxidation voltage
2, temperature is under 20 ℃ the condition blood vessel through metal matrix that has metal plating to be carried out anodic oxidation to improve 3 times of current densities after 40 minutes and kept this current density 75 seconds.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012003803A1 (en) * | 2010-07-09 | 2012-01-12 | 微创医疗器械(上海)有限公司 | A drug carrying metal stent and manufacturing method therefor |
| CN102356184A (en) * | 2009-01-16 | 2012-02-15 | 雅培血管企业有限公司 | Method and solution for electropolishing stents made of high strength medical alloys |
| CN105030391A (en) * | 2015-07-07 | 2015-11-11 | 南昌大学 | Intravascular stent with surface textures |
| CN110961729A (en) * | 2019-12-21 | 2020-04-07 | 中北大学 | Ultrasonic micro-pit processing device based on cambered surface contact type force transmission structure |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19855421C2 (en) * | 1998-11-02 | 2001-09-20 | Alcove Surfaces Gmbh | Implant |
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2007
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102356184A (en) * | 2009-01-16 | 2012-02-15 | 雅培血管企业有限公司 | Method and solution for electropolishing stents made of high strength medical alloys |
| CN102356184B (en) * | 2009-01-16 | 2014-09-24 | 雅培血管企业有限公司 | Method and solution for electropolishing stents made of high strength medical alloys |
| WO2012003803A1 (en) * | 2010-07-09 | 2012-01-12 | 微创医疗器械(上海)有限公司 | A drug carrying metal stent and manufacturing method therefor |
| CN105030391A (en) * | 2015-07-07 | 2015-11-11 | 南昌大学 | Intravascular stent with surface textures |
| CN105030391B (en) * | 2015-07-07 | 2018-07-20 | 南昌大学 | A kind of intravascular stent with Surface Texture |
| CN110961729A (en) * | 2019-12-21 | 2020-04-07 | 中北大学 | Ultrasonic micro-pit processing device based on cambered surface contact type force transmission structure |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101054702B (en) | 2010-12-15 |
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