CN105030391A - Intravascular stent with surface textures - Google Patents
Intravascular stent with surface textures Download PDFInfo
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- CN105030391A CN105030391A CN201510392744.7A CN201510392744A CN105030391A CN 105030391 A CN105030391 A CN 105030391A CN 201510392744 A CN201510392744 A CN 201510392744A CN 105030391 A CN105030391 A CN 105030391A
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- intravascular stent
- surface texture
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- texture
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Abstract
The invention provides an intravascular stent with surface textures. The intravascular stent is characterized by being composed of a plurality of supporting ribs (1) and a plurality of connecting ribs (3) which are distributed in the axial direction. All the supporting ribs (1) are connected through the connecting ribs (3). The surface of the intravascular stent is of a texture form (2). The surface of the intravascular stent is of the texture form with anti-adhesion performance and can reduce adhesion and aggregation of blood platelets, the anti-coagulation function is improved, and the occurrence rate of in-stent restenosis is reduced. Compared with other technologies, the intravascular stent can reach the hemadostenosis position more smoothly under the traction effect of a guide wire, and has better flexibility; the radial rebounding rate and the axial retraction rate after the intravascular stent is swelled and expanded are small, and the intravascular stent has a better expansion characteristic.
Description
Technical field
The invention belongs to technical field of medical instruments, relate to intravascular stent.
Background technology
Cardiovascular disease is one of Etiological of harm healthy elder.Intravascular stent implantation is owing to having that wound is small, success rate is high and one of the advantage important means becoming Cardiovarscular such as handling safety, but in-stent restenosis is the key issue affecting clinical efficacy.Support is inserted in process and is easily caused vascular endothelial cell to come off to the mechanical damage of blood vessel wall, and insert protein adsorption and platelet adhesion and gathering in rear easy initiation blood, cause new thrombosis, inflammatory reaction and neointimal tissue proliferation, cause the generation of in-stent restenosis.
For solving the problem of in-stent restenosis, at present, research staff has carried out linguistic term to intravascular stent, and as have developed bracket for eluting medicament, on support, contained medicine effectively can suppress the propagation of vascular smooth muscle cell, reduces the incidence rate of in-stent restenosis.But because distortion and the reason such as medicine and support adhesion deficiency easily cause medicine layer to be peeled off and come off when bracket for eluting medicament is inserted, cause rack surface medicine to cover the problems such as imperfect, affect therapeutic effect.
Surface texture utilizes physics, chemistry or micro-processing method to process the geometry micro structure by certain regular distribution, as micro-hole or microflute etc., to change the physical property of material surface at material surface artificially.Scientific worker is by scientific experimentation, numerical computations, binding analysis and demonstration, prove that compound texture that the array in the nick hole, very low power etc. of certain parameter and multiple yardstick and various types of surface texture combine has anti-ly to stick, control frictional resistance, reduce friction loss, improve surface bearing capacity and improve the effects such as lubricating status, had successful Application case in mechanical industry field.
Summary of the invention
The object of this invention is to provide a kind of intravascular stent with surface texture, overcome the deficiency that existing technology Chinese medicine FirebirdTM exists.Intravascular stent surface of the present invention adopts micro-processing method to process the surface texture with anti-adhesion, decrease hematoblastic sticking and gathering, improve anticoagulant functions, thus reach the effect suppressing in-stent restenosis, there is better compliance and expansion characteristics.
The present invention is achieved through the following technical solutions.
A kind of intravascular stent with surface texture of the present invention is TRS, by axial distribution many groups brace rod (1) and organize dowel (3) more and form, wherein, connected by dowel (3) between each brace rod (1), the surface of intravascular stent is texture form (2).
Wherein, the cross sectional shape of brace rod (1) and dowel (3) is all the geometries such as triangle, rectangle or circle, and brace rod (1) and dowel (3) have identical sectional dimension.
Dowel (3) form of intravascular stent of the present invention is S shape, V-arrangement, W shape, linear or { shape isoline or SPL type of attachment.
The intravascular stent with surface texture of the present invention, when its surface texture shape is circular surface texture, preferred diameter is 0.02 ~ 0.06mm, preferred aspect ratio (degree of depth of surface texture and the ratio of the radial dimension of support muscle cross section) is 5 ~ 30:100, and preferred spacing is 0.2 ~ 0.5mm.
The intravascular stent with surface texture of the present invention, when the shape of its surface texture is square face texture, the preferred length of side is 0.02 ~ 0.06mm, and preferred aspect ratio is 10 ~ 60%, and preferred spacing is 0.2 ~ 0.5mm.
The circle that the shape of surface texture of the present invention (2) exemplifies except above-mentioned, square except, in fact can be with the different various geometries of limit number, as: triangle, tetragon ... polygon is until circle, and limit can equal or geometry not etc. to centre distance.
The processing method of surface texture of the present invention (2) can adopt micro-processing method, as lithography or laser processing technology etc.
The material of intravascular stent of the present invention is the material for the manufacture of intravascular stent such as rustless steel, Nitinol, platinum, gold, degradable biomaterial or multilayer materials.
Beneficial effect of the present invention is that invented intravascular stent surface is for having the texture form of anti-Adhesion property, and this surface energy reduces hematoblastic sticking and gathering, improves anticoagulant functions, reduces the incidence rate of in-stent restenosis.Compared with other technologies, intravascular stent of the present invention can arrive angiostenosis position more smoothly under seal wire draw, has better compliance; Radial rebound rate after described intravascular stent expanse and axial retraction rate less, there is better expansion characteristics.
Accompanying drawing explanation
Fig. 1 is structural plan of the present invention expanded view.In figure: 1 is brace rod, 2 is surface texture, and 3 is dowel.
Fig. 2 is ductwork type structural representation of the present invention.
Fig. 3 is square face texture schematic diagram of the present invention.In figure: 4 is square face texture.
Fig. 4 is the circular surface texture of embodiment 1 and untextured intravascular stent compliance correlation curve.
Fig. 5 is the circular surface texture of embodiment 1 and untextured intravascular stent expanded radially deformation curve when inserting.
Fig. 6 is the circular surface texture of embodiment 1 and untextured intravascular stent axial expansion deformation curve when inserting.
Fig. 7 is the square face texture of embodiment 2 and untextured intravascular stent compliance correlation curve.
Fig. 8 is the square face texture of embodiment 2 and untextured intravascular stent expanded radially deformation curve when inserting.
Fig. 9 is the square face texture of embodiment 2 and untextured intravascular stent axial expansion deformation curve when inserting.
Detailed description of the invention
Below in conjunction with drawings and Examples explanation clearly technical scheme of the present invention.
As shown in Figure 1, 2, the intravascular stent with surface texture of the present invention, be made up of 6 groups of brace rods 1 and 5 groups of S shape dowels 3, connected by dowel 3 between each brace rod 1, the brace rod 1 of intravascular stent and the cross section of dowel 3 are square-section, and the depth of section of described brace rod 1 and dowel 3 is identical.The brace rod surface of intravascular stent is equally distributed texture 2.
Embodiment 1.
The intravascular stent with surface texture described in the present embodiment, surface texture shape is circular surface texture 2, and diameter is 0.05mm, aspect ratio is 25%, and spacing is 0.5mm, and this surface has anti-Adhesion property, reduce hematoblastic sticking and gathering, improve anticoagulant functions.As shown in Figure 4, adopt the compliance of finite element numerical simulation to support to analyze, result shows that the circular surface texture of the present embodiment maintains the compliance of conventional stent, and makes moderate progress; As shown in Figure 5 and Figure 6, the radial rebound rate of intravascular stent in expansion process of the circular surface texture of the present embodiment is 1.17%, axial stretching rate is 1.42%, the radial rebound rate of untextured conventional stent and axial stretching rate are respectively 2.75% and 1.45%, radial rebound rate and the axial stretching rate of the intravascular stent of the circular surface texture of the present embodiment are less than untextured intravascular stent, show that the deformation quantity that circular texture support produces after expansive force unloading is less, expansion characteristics is better.
Embodiment 2.
The intravascular stent with surface texture described in the present embodiment, the shape of surface texture is square face texture.The length of side of two kinds of square face texture described in this implementation column is respectively 0.05mm, 0.05mm, aspect ratio is respectively 25%, 25%, spacing is respectively 0.27mm, 0.5mm, square face texture in these two kinds of preferable range all can improve the anti-adhesion of rack surface, effective suppression is hematoblastic sticks and gathering, improves anticoagulant functions.As shown in Figure 7, the elastic deformation of the intravascular stent of two kinds of square face texture of the present embodiment is comparatively large, has compliance more better than untextured conventional stent; As shown in Figure 8 and Figure 9, the radial rebound rate of the intravascular stent of two kinds of square face texture of the present embodiment is respectively 2.73%, 2.75%, axial stretching rate is respectively 1.72%, 1.3%, be less than radial rebound rate and the axial stretching rate of untextured conventional stent in embodiment 1, show, than untextured conventional stent, there is better expansion characteristics.
In practical application, the anti-Adhesion property on adjusting pole surface and the mechanical property of support can be come, by increasing or reduce support brace rod and dowel unit to adapt to the pathological changes narrow blood vessel of different length by changing the shape of surface texture, aspect ratio and distribution form.Technical scheme provided by the present invention, object is anti-adhesion in order to strengthen rack surface and anticoagulant functions, and support has better compliance and expansion characteristics inserting in process, reduces the incidence rate of stent restenosis.
The above is only the preferred embodiments of the invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvement and distortion, these improve and distortion also should be considered as protection scope of the present invention.
Claims (6)
1. have an intravascular stent for surface texture, it is characterized in that by many groups brace rod (1) of axial distribution and organize dowel (3) more and form, wherein, connected by dowel (3) between each brace rod (1), the surface of intravascular stent is texture form (2).
2. the intravascular stent with surface texture according to claim 1, it is characterized in that the cross sectional shape of described brace rod (1) and dowel (3) is all the geometries such as triangle, rectangle or circle, brace rod (1) and dowel (3) have identical sectional dimension.
3. the intravascular stent with surface texture according to claim 1, is characterized in that dowel (3) form of described intravascular stent is S shape, V-arrangement, W shape, linear or { shape.
4. the intravascular stent with surface texture according to claim 1 and 2, is characterized in that described intravascular stent, and when its surface texture shape is circular surface texture, diameter is 0.02 ~ 0.06mm, and aspect ratio is 5 ~ 30:100, and spacing is 0.2 ~ 0.5mm.
5. the intravascular stent with surface texture according to claim 1 and 2, is characterized in that described intravascular stent, and when the shape of its surface texture is square face texture, the length of side is 0.02 ~ 0.06mm, and aspect ratio is 10 ~ 60%, and spacing is 0.2 ~ 0.5mm.
6. the intravascular stent with surface texture according to claim 1, is characterized in that the material of described intravascular stent is rustless steel, Nitinol, platinum, gold, degradable biomaterial or multilayer materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510392744.7A CN105030391B (en) | 2015-07-07 | 2015-07-07 | A kind of intravascular stent with Surface Texture |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510392744.7A CN105030391B (en) | 2015-07-07 | 2015-07-07 | A kind of intravascular stent with Surface Texture |
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| CN105030391A true CN105030391A (en) | 2015-11-11 |
| CN105030391B CN105030391B (en) | 2018-07-20 |
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| CN201510392744.7A Active CN105030391B (en) | 2015-07-07 | 2015-07-07 | A kind of intravascular stent with Surface Texture |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110633490A (en) * | 2019-07-23 | 2019-12-31 | 北京航空航天大学 | Axiomatic design-based plant intervention medical instrument key parameter extraction and evaluation method |
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| US20050211680A1 (en) * | 2003-05-23 | 2005-09-29 | Mingwei Li | Systems and methods for laser texturing of surfaces of a substrate |
| CN102885664A (en) * | 2006-10-20 | 2013-01-23 | 生物传感器国际集团有限公司 | Drug-delivery endovascular stent and method of use |
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| CN101054702A (en) * | 2007-02-02 | 2007-10-17 | 哈尔滨工业大学 | Method for manufacturing dimple on blood vessel metal support |
| US20080300668A1 (en) * | 2007-05-30 | 2008-12-04 | Craig Bonsignore | Stent/fiber structural combinations |
| CN101732114A (en) * | 2008-11-04 | 2010-06-16 | 微创医疗器械(上海)有限公司 | Coronary artery stent with medicine carrying grooves |
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| CN110633490A (en) * | 2019-07-23 | 2019-12-31 | 北京航空航天大学 | Axiomatic design-based plant intervention medical instrument key parameter extraction and evaluation method |
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