CN101052389A - Agent for recovery from cerebral fatigue - Google Patents
Agent for recovery from cerebral fatigue Download PDFInfo
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- CN101052389A CN101052389A CNA2005800378809A CN200580037880A CN101052389A CN 101052389 A CN101052389 A CN 101052389A CN A2005800378809 A CNA2005800378809 A CN A2005800378809A CN 200580037880 A CN200580037880 A CN 200580037880A CN 101052389 A CN101052389 A CN 101052389A
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- acid
- fatigue
- chlorogenic acid
- brain fag
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Abstract
The present invention relates to a recuperative agent for cerebral fatigue and a recuperative food for cerebral fatigue, each including as active ingredients one or more members selected from the group consisting of chlorogenic acids, caffeic acid, ferulic acid, and pharmaceutically acceptable salts thereof. According to the present invention, recuperation from the cerebral fatigue such as decreased calculating ability based on cerebral fatigue can be achieved.
Description
Technical field
The present invention relates to be used to make the fatigue that causes by the inherent ergasia of people (for example computing capability), i.e. the medicament and the food that are restored of brain fag.
Background technology
Fatigue is divided into substantially usually and is mental fatigue and human body fatigue.In modern society, be compared to human body fatigue, it is especially serious that the influence that mental fatigue causes becomes.As the fatigue recovery agent,, be actually with the human body nutritional supplementation when tired and be purpose though using supplementarys such as various vitamin and mineral.On the other hand, still be unknown about the fatigue recovery agent that mental fatigue is had effect usefulness.
About chlorogenic acid (chlorogenic acids), for example, its effect etc. that has antihypertensive function and improve vascular endothelial function of report is arranged, but the report (for example, with reference to patent documentation 1,2) of the effect that does not make when using a computer for a long time and be restored by the brain fag (decline of elaborative faculty) that continuous thinking causes.
Patent documentation 1: the spy opens the 2002-53464 communique
Patent documentation 2: the spy opens the 2003-261444 communique
Summary of the invention
The invention provides a kind of in chlorogenic acid, caffeic acid, ferulic acid and the pharmaceutically acceptable salt thereof is that people's brain fag restorative of effective ingredient or brain fag recover to use food to be selected from more than a kind.
In addition, the invention provides a kind of use in people's brain fag restorative is made more than a kind that is selected from chlorogenic acid, caffeic acid, ferulic acid and the pharmaceutically acceptable salt thereof.
The present invention also provides a kind of people's brain fag restoration methods, it is characterized in that, being selected from of effective dose carried out administration in chlorogenic acid, caffeic acid, ferulic acid and the pharmaceutically acceptable salt thereof more than a kind.
Description of drawings
Fig. 1 is the figure that the flicker value variable quantity behind the chlorogenic acid is taken in expression.
Fig. 2 is the figure of expression chlorogenic acid to the effect of asthenia.
Fig. 3 is the figure of expression chlorogenic acid to active happy effect.
Fig. 4 is the figure that the flicker value variable quantity behind the chlorogenic acid is taken in expression.
Fig. 5 is the figure of expression chlorogenic acid to the effect of asthenia.
Fig. 6 is the figure of expression chlorogenic acid to active happy effect.
Fig. 7 is the expression chlorogenic acid detects the effect of problem to alphanumeric figure.
Fig. 8 is the figure of expression chlorogenic acid to the effect of digital additive operation problem.
Fig. 9 is the figure of expression chlorogenic acid to the effect of impermanent memory problem.
The specific embodiment
The invention provides a kind of medicament that the fatigue that caused by the inherent ergasia of people (for example computing capability, continuously thinking etc.) is restored, i.e. agent for recovery from cerebral fatigue.
The present inventor's combination is estimated the flicker test of brain fag degree by visual fatigue and is made brain produce tired calculated load operation, explored and made the decline that causes computing capability etc. by continued operation, be the composition that brain fag is restored, find in being selected from chlorogenic acid, caffeic acid, ferulic acid and pharmaceutically acceptable salt thereof more than a kind in have the brain fag recovery effects.
Adopt the present invention, the ability drop that is caused by the mental fatigue (brain fag) that uses a computer for a long time afterwards, calculates and other thinking causes is restored.In addition, by before the ergasia operation of estimating the generation brain fag, taking, can alleviate brain fag.
The chlorogenic acid of Shi Yonging, caffeic acid, ferulic acid both can extract from the natural goods, the particularly plant that contain them in the present invention, also can the industrialness manufacturing by chemosynthesis.
Have stereoisomer in chlorogenic acid in the present invention, caffeic acid, the ferulic acid, in the present invention, can use pure stereoisomer or its mixture.In chlorogenic acid of the present invention, specifically, comprise 3-caffeoyl guinic acid (caffeoylquinc acid), 4-caffeoyl guinic acid, 5-caffeoyl guinic acid, 3,4-dicaffeoyl quinic acid, 3,5-dicaffeoyl quinic acid, 4,5-dicaffeoyl quinic acid, 3-feruloyl quinic acid (ferulylquinic acid), 4-feruloyl quinic acid, 5-feruloyl quinic acid and 3-Resina Ferulae acyl-(middle forests etc. such as 4-caffeoyl guinic acid, chemistry and technology that the coffee roasting is fried in shallow oil, great learning published Co., Ltd., p166-167).
By making chlorogenic acid, caffeic acid, ferulic acid salify improve water solublity, can increase physiological effectiveness.As its salt, so long as pharmaceutically acceptable salt gets final product.As forming so employed alkaline matter of salt, for example, can use alkali-metal hydroxide such as Lithium hydrate, sodium hydroxide, potassium hydroxide; The hydroxide of alkaline-earth metal such as magnesium hydroxide, calcium hydroxide; Basic amino acids such as inorganic bases such as ammonium hydroxide, arginine, lysine, histidine, ornithine; Organic bases such as monoethanolamine, diethanolamine, triethanolamine, but the hydroxide of special preferred as alkali or alkaline-earth metal.In the present invention, both can after its salt of preparation, make an addition in the compositions that is grouped into by other one-tenth, also can with chlorogenic acid etc. with become salt component to make an addition to respectively in the said composition, make it to form therein salt.
As containing chlorogenic acid, caffeinic natural goods extract, for example, preferably use the extract of plant extract such as Corchorus olitorius L., Caulis Sacchari sinensis, Folium Nandinae domesticae, blue berry, Semen Tritici aestivi from coffee, Brassica oleracea L.var.capitata L., Caulis et Folium Lactucae sativae, arithoke, Fructus Lycopersici esculenti, Fructus Solani melongenae, Rhizoma Solani tuber osi, Radix Dauci Sativae, Fructus Mali pumilae, pears, Fructus Pruni salicinae, peach, Fructus Pruni, Fructus Pruni pseudocerasi, Helianthi, dish.
For example, chlorogenic acid, be preferably from coffee and give birth to the extract that extracts the plant of bean, Folium Nandinae domesticae, immaturity Fructus Mali pumilae etc., more preferably acid aqueous solution of ascorbic acid, citric acid or the hot water with temperature extracts the extract that obtains from the seed of Rubiaceae coffee (Coffee arabica LINNE).
Specifically, as raw coffee bean extract, can enumerate long paddy CHUANXIANG material (strain) " FlavorFolder ", as Fructus Mali pumilae extract, can enumerate Nikka Wiskey (strain) " Applephenon ", as the sunflower seeds extract, can enumerate big Japanese Ink chemical industry (strain) " Heliant " etc.
As the natural goods extract, particularly plant extract that contain ferulic acid, for example, preferably coffee, Bulbus Allii Cepae, Radix Raphani, Fructus Citri Limoniae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Masson Pine, Rhizoma Coptidis, Resina Ferulae, Caulis Sacchari sinensis, corn, Fructus Hordei Vulgaris, Semen Tritici aestivi, rice etc., preferred especially rice.In the present invention, so-called rice refers to the life or the dry thing of the seed etc. of rice section Oryza sativa L. (Oryza sativa LINNE).
As the method for from plant, extracting ferulic acid, for example, can enumerate following method: the Testa oryzae oil that will be obtained by Testa oryzae is hydrolyzed to add the ferulic acid ester that the hot sulphuric acid depressed will obtain in the aquiferous ethanol part, refining and obtain after distributing with aquiferous ethanol under the alkalescence of room temperature and hexane.In addition, also can be with the culture fluid culture of bacteria (Pseudomonas) of the eugenol that contains the Oleum Caryophylli that obtains from alabastrum and the leaf of Myrtaceae Flos Caryophylli (Syzygium aromaticum MERRILL et PERRY) by vapor distillation or make from Allyl-4,3-guaiacol, with this culture fluid separate, refining and obtain.
In addition, ferulic acid also can be by chemosynthesis, for example, and by the condensation reaction manufacturing (Journal of American Chemical Society, 74,5346,1952) of vanillin and malonic acid.
So-called people's brain fag restorative of the present invention is brain fag medicament that is restored and the medicament that this brain fag is alleviated that makes based on people's ergasia.So-called people's ergasia refers to the intelligential ergasia of the ethics of following the people.As the particular content of people's ergasia, can enumerate thinking operation, calculating operation, computer operation etc.In addition, the brain fag of so-called ergasia based on above-mentioned people though individual variation is also arranged, for computation etc., refers to the state after 1～2 hour.
Based on the brain fag of ergasia, can implement flicker test and wait the mental fatigue of estimating by generations such as Cray Perrin test (Kraepelin test), ATMA, calculated load operations.
It originally is to be the continuous additive operation operation that purpose is used with the interview that Cray Perrin tests, specifically, be the laterally adjacent one-bit digital operation of addition successively arranged side by side, can be classified as the operation that brain fag takes place based on the operation of height ergasia.Here, Cray Perrin test can be used as the model system of computing capability, computer operation, continuous thinking etc. and is used for quantification.
ATMA, originally using as the moral function inspection technique, is the visual search problem of pressing down the target number of pointing out successively on contact screen, can write down the search response time of each target, can in each reaction, reconfigure target, perhaps append new target takes place.Therefore, also can measure ongoing working memory of problem and fatigue strength.
The calculated load operation is to give the operation that detects problem, digital addition computing problem, impermanent memory problem with alphanumeric to the testee.It is to click left mouse button when fixed numeral of prompting or letter that alphanumeric detects problem, if beyond it, the problem of the right button of clicking the mouse.Digital addition computing problem is the problem that the value after the 2 layer of 2 whole addition of bit digital that will be prompted is imported from keyboard.The impermanent memory problem, be that the left button of clicking the mouse is when inconsistent when being prompted on the right side with 4 corresponding to numerals of numeral that are prompted in the left side at first, the brain fag that the click the mouse problem of right button, 3 problems can be classified as based on the operation of ergasia produces operation.
So-called flicker test is the method for measuring with the vision response of the light source of arbitrary interval flicker, is the method for directly estimating cerebral cortex active state (fatigue state) by visual organ.
To measure brain fag degree recovery effects in order calculating, to implement flicker test, and then, in order to measure the reaction of spirit, preferably carry out finger tip plethysmographic pulsate wave and measure (chaos analysis).It is can be by the dynamic chaos of pulse and by finger tip with the digitized mensuration of general body state that finger tip plethysmographic pulsate wave is measured (chaos analysis).Chaos is characterised in that, by the generation implicative of each other of a plurality of chaos, forms 1 chaos in the part.Therefore, think, held the state of whole body since just can be only from the information of the part of health with numerical value if use the parsing of this theory.
In addition, in order to investigate subjective feeling of fatigue, preferably use many-sided emotion status scale, subjective symptoms investigation and about the questionnaire of fatigue.
As fatigue recovery effect of the present invention, the decline of flicker test value of expression mental fatigue (brain fag), the picked-up by chlorogenic acid etc. is restored and alleviates.
In addition, the brain fag that can be restored with people's brain fag restorative of the present invention mainly is based on the fatigue of desk work that the people carries out etc. when working and learning.
As chlorogenic acid of the effective ingredient of people's brain fag restorative of the present invention etc., though can directly take, but preferred salt pharmaceutically can allow, for example, can be with auxiliary element commonly used in medicine and field of food such as the form of hydrochlorate and excipient, carrier etc., for example lactose, sucrose, syrup, Mel, magnesium stearate, hydroxypropyl cellulose, various vitamins, citric acid, malic acid, spice, inorganic salt etc. are made capsule, tablet, powder, granule, potus, injection, some drop etc. together.
When being potus and food, as required, also can mix other physiology composition, mineral, vitamin, hormone, nutritional labeling, flavouring agent etc.In addition, as food, preferably be made for green tea and be beverage, oolong tea and be beverage, black tea and be beverage, coffee and be beverage, etc. to ooze be beverage.
People's brain fag restorative of the present invention and brain fag recover to use food, mainly the recovery that the brain function based on degradation under the computing capability of computer use etc. is descended is useful, its dose, be grown up every day, as chlorogenic acid, caffeic acid, ferulic acid or its pharmaceutically acceptable salt is 30～14000mg, 50～10000mg more preferably, more preferably 200～7600mg is preferably 250～3000mg especially.In order more effectively to manifest the brain fag recovery effects, think and preferably take continuously every day.In addition, people's brain fag of the present invention recovers use food, can be expressed as towards the person that feels the brain fag, be used for the recovery of brain function decline etc.
[embodiment]
8 of normal persons enter the certain room of temperature humidity, adapt to after 10 minutes, carry out the flicker test of rest state, then, carry out calculated load operation (alphanumeric detects problem 3 minutes, digital addition computing problem 5 minutes, impermanent memory problem 3 minutes), and then carry out flicker test.Behind the last flicker test, use subjective questionnaire (the brief version of many-sided emotion status scale), inquiry mental status feeling of fatigue at this moment.Have a rest after 5 minutes, carry out the test of flicker test, calculated load operation, flicker test once more successively.After this, drink with the chlorogenic acid beverage or the water (placebo) of the raw coffee bean extract combination that is main component, carry out flicker test once more.Simultaneously, before and after beverage, use subjective questionnaire inquiry mental status feeling of fatigue at this moment.Drinking with the chlorogenic acid is that the beverage of raw coffee bean extract combination (chlorogenic acid 300mg) of main component or water are after 30 minutes, after 60 minutes, after 90 minutes, after 120 minutes, similarly carry out flicker test, calculated load operation, flicker test, subjective questionnaire, estimate the flicker test after the calculated load operation of each time and the variation of subjective questionnaire score.Subjective questionnaire is the questionnaire that is used for measuring simultaneously the subjective state of multiple emotion, be to depressed uneasy (worry, uneasy, worried, there is not confidence, gloomy), asthenia is (boring, tired, lonely, lazy tired, despondent), active is happy (great-hearted, heartily, energetic, active, straightforward), inactive happy (low-pressure, comfortable, quiet, steady, relaxed), attentively (prudent, careful, sincere, deep thinking, careful) 5 projects, with 4 stages feeling which kind of degree (1. sensation not fully, 2. not too feel, 3. feel slightly, 4. the sensation clearly) questionnaire checked.
The result of flicker test is shown among Fig. 1.When taking placebo, when taking chlorogenic acid, the decline of flicker value is suppressed.Using the result of double factor variance analysis (Two factorfactorial ANOVA) research is to confirm the significant difference (p＜0.01=between sample (placebo and chlorogenic acid).In addition, as the one-factor analysis of variance (One factorANOVA), the multiple comparisons check of bit trial (epistasis test) down, use Fisher ' s PLSD result relatively to be, elapsed time after drinking sample is after 30 minutes, after 60 minutes, after 90 minutes, can confirm significant difference (p=0.02, p=0.04, p＜0.01).In addition, shown in Fig. 2,3, in the questionnaire of subjectivity, asthenia and active happy aspect, between sample (placebo and chlorogenic acid), can confirm significant difference (p=0.04, p=0.05).
8 of normal persons enter the certain room of temperature humidity, adapt to after 10 minutes, carry out the flicker test of rest state, then, carry out calculated load operation (alphanumeric detects problem 3 minutes, digital addition computing problem 3 minutes, impermanent memory problem 3 minutes, ATMT), and then carry out flicker test.Behind the last flicker test, use subjective questionnaire (the brief version of many-sided emotion status scale), inquiry mental status feeling of fatigue at this moment.Have a rest after 5 minutes, carry out the test of flicker test, calculated load operation, flicker test once more successively.Then, with 1.25g is raw coffee bean extract (the chlorogenic acid 600mg of main component with the chlorogenic acid, composition: chlorogenic acid 47.9%, caffeine 1.1%) powder or 644mg placebo (composition: chlorogenic acid 0.8%, caffeine 0%) are divided into and add up to 5 bag wafer packings, with 190mL diseases caused by retention of fluid usefulness, carry out flicker test once more.Simultaneously, drink the sample front and back, using subjective questionnaire inquiry mental status feeling of fatigue at this moment.Drinking with the chlorogenic acid is that the raw coffee bean extract of main component or placebo are after 15 minutes, after 30 minutes, after 60 minutes, after 90 minutes, after 120 minutes, similarly carry out the questionnaire of flicker test, calculated load operation, flicker test, subjectivity, the flicker test of evaluation after the calculated load operation of each time and the variation of the questionnaire score of subjectivity.Subjective questionnaire is the questionnaire that is used for measuring simultaneously the subjective state of multiple emotion, be to depressed uneasy (worry, uneasy, worried, there is not confidence, gloomy), asthenia is (boring, tired, lonely, lazy tired, despondent), active is happy (great-hearted, heartily, energetic, active, straightforward), inactive happy (low-pressure, comfortable, quiet, steady, relaxed), attentively (prudent, careful, sincere, deep thinking, careful) 5 projects, with 4 stages feeling which kind of degree (1. sensation not fully, 2. not too feel, 3. feel slightly, 4. the sensation clearly) questionnaire checked.
The result of flicker test is shown among Fig. 4.When taking placebo, when taking chlorogenic acid, the decline of flicker value is suppressed.Using the result of double factor variance analysis (Two factorfactorial ANOVA) research is to confirm the significant difference (p＜0.01) between sample (placebo and chlorogenic acid).In addition, shown in Fig. 5,6, in the questionnaire of subjectivity, asthenia and active happy aspect, between sample (placebo and chlorogenic acid), can confirm significant difference (p=0.05, p＜0.01).In addition,, use Fisher ' s PLSD result relatively to be as the down multiple comparisons check of bit trial, active happy aspect, the elapsed time after drinking sample can be confirmed significant difference (p=0.03) after being 15 minutes.And then the elapsed time after drinking sample is after 90 minutes, after 120 minutes, can confirm discrepant tendency (p=0.08, p=0.08).
In addition, the result of calculated load problem is illustrated among Fig. 7,8,9.As shown in FIG., detect in problem, the impermanent memory problem, between sample, can confirm significant difference (p=0.03, p＜0.01) at alphanumeric.Calculate in the problem at digital addition, between sample, can confirm discrepant tendency (p=0.08).
Claims (7)
1. people's brain fag restorative is characterized in that:
In chlorogenic acid, caffeic acid, ferulic acid and the pharmaceutically acceptable salt thereof is effective ingredient to be selected from more than a kind.
2. agent for recovery from cerebral fatigue as claimed in claim 1 is characterized in that:
It is the restorative that alleviates based on the brain fag of ergasia.
3. people's brain fag recovers to use food, it is characterized in that:
In chlorogenic acid, caffeic acid, ferulic acid and the pharmaceutically acceptable salt thereof is effective ingredient to be selected from more than a kind.
4. be selected from the use in people's brain fag restorative is made more than a kind in chlorogenic acid, caffeic acid, ferulic acid and the pharmaceutically acceptable salt thereof.
5. use as claimed in claim 4 is characterized in that:
Described agent for recovery from cerebral fatigue is the restorative that alleviates based on the brain fag of ergasia.
6. people's brain fag restoration methods is characterized in that:
With effective dose be selected from chlorogenic acid, caffeic acid, ferulic acid and pharmaceutically acceptable salt thereof carry out administration more than a kind.
7. method as claimed in claim 6 is characterized in that:
It is the method that alleviates based on the brain fag of ergasia.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004324516 | 2004-11-09 | ||
| JP324516/2004 | 2004-11-09 | ||
| JP048198/2005 | 2005-02-24 |
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| Publication Number | Publication Date |
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| CN101052389A true CN101052389A (en) | 2007-10-10 |
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| CNA2005800378809A Pending CN101052389A (en) | 2004-11-09 | 2005-11-08 | Agent for recovery from cerebral fatigue |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421456A (en) * | 2016-09-27 | 2017-02-22 | 青岛海澄知识产权事务有限公司 | Preparation method of mental fatigue relief composition |
| CN111758841A (en) * | 2020-08-19 | 2020-10-13 | 上海俏贝丽宠物用品有限公司 | Composition, additive and health product for promoting intelligence development of puppies and cats and preparation method thereof |
-
2005
- 2005-11-08 CN CNA2005800378809A patent/CN101052389A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421456A (en) * | 2016-09-27 | 2017-02-22 | 青岛海澄知识产权事务有限公司 | Preparation method of mental fatigue relief composition |
| CN111758841A (en) * | 2020-08-19 | 2020-10-13 | 上海俏贝丽宠物用品有限公司 | Composition, additive and health product for promoting intelligence development of puppies and cats and preparation method thereof |
| CN111758841B (en) * | 2020-08-19 | 2023-07-28 | 上海俏贝丽宠物用品有限公司 | Composition, additive and health product for promoting puppy and cat intelligence development and preparation method thereof |
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Open date: 20071010 |