CN101050192A - Method for synthesizing semicarbazide c,p - aldehyde group benzoic acid of derivative of semicarbazide - Google Patents
Method for synthesizing semicarbazide c,p - aldehyde group benzoic acid of derivative of semicarbazide Download PDFInfo
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- CN101050192A CN101050192A CN 200710022542 CN200710022542A CN101050192A CN 101050192 A CN101050192 A CN 101050192A CN 200710022542 CN200710022542 CN 200710022542 CN 200710022542 A CN200710022542 A CN 200710022542A CN 101050192 A CN101050192 A CN 101050192A
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- amino
- urea
- terephthalaldehydic acid
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- semicarbazide
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Claims (2)
- A Urea,amino-the contract synthetic method of terephthalaldehydic acid of derivative Urea,amino-, it is characterized in that with Urea,amino-be raw material, under agitation with the terephthalaldehydic acid reaction, with silicon thin-layer chromatography monitoring reaction terminal point, the synthesizing amino urea terephthalaldehydic acid that contracts, step is:(1) synthetic: Urea,amino-is to wait a mole charging capacity with terephthalaldehydic acid, earlier Urea,amino-is used dissolved in distilled water, in addition terephthalaldehydic acid is dripped N, dinethylformamide makes dissolving, under agitation Urea,amino-solution is added in the terephthalaldehydic acid solution, temperature of reaction is controlled at 20~30 ℃, reacts 2 hours;(2) reaction end monitoring: the silicon thin-layer chromatography monitoring, 1cm place, silica gel thin sheet lower end makes a sea line, draws reaction solution 1 μ l point in line place, point sample finishes, and dries up, and thin plate is put into the chromatography fluid cylinder, chromatographic solution is methyl alcohol-chloroform mixed solvent, methyl alcohol/chloroform volume ratio 1: 19 is launched chromatography to 5~6cm place, gets plate, dry up solvent, thin plate is placed uv analyzer, observe at the 254nm wavelength, at R F=0.3~0.32 observes corresponding point, as reaction end;(3) purify: reacting liquid filtering is obtained white solid, filter then, repeats 2~3 times, filter and expect to put into 30 ℃ of dryings of vacuum drying oven, obtain the derivative Urea,amino-terephthalaldehydic acid that contracts with distilled water wash.
- 2. synthetic method according to claim 1, it is characterized in that the making of used silica gel thin layer plate: get silica gel 12g, be dissolved in the sodium cellulose glycolate solution of 40ml 0.5% mass concentration, fully stir into pasty state with glass stick, ultra-sonic oscillation 1 minute are uniformly coated on 3cm * 8cm sheet glass, after the In Shade seasoning, the baking oven of putting into 105 ℃ activates 1 hour, and it is standby to put into loft drier then.
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CNB2007100225429A CN100526292C (en) | 2007-05-11 | 2007-05-11 | Method for synthesizing semicarbazide c,p - aldehyde group benzoic acid of derivative of semicarbazide |
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CNB2007100225429A CN100526292C (en) | 2007-05-11 | 2007-05-11 | Method for synthesizing semicarbazide c,p - aldehyde group benzoic acid of derivative of semicarbazide |
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CN101050192A true CN101050192A (en) | 2007-10-10 |
CN100526292C CN100526292C (en) | 2009-08-12 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103880711A (en) * | 2014-03-06 | 2014-06-25 | 陕西科技大学 | Method for preparing aldehyde semicarbazone Schiff base |
CN106093379A (en) * | 2016-06-08 | 2016-11-09 | 中国科学院广州生物医药与健康研究院 | A kind of semicarbazides derivatization reagent and rapid detection card thereof |
CN106905715A (en) * | 2017-03-01 | 2017-06-30 | 山西大学 | Faded pigment of one organic molecular species modification and preparation method thereof |
-
2007
- 2007-05-11 CN CNB2007100225429A patent/CN100526292C/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103880711A (en) * | 2014-03-06 | 2014-06-25 | 陕西科技大学 | Method for preparing aldehyde semicarbazone Schiff base |
CN106093379A (en) * | 2016-06-08 | 2016-11-09 | 中国科学院广州生物医药与健康研究院 | A kind of semicarbazides derivatization reagent and rapid detection card thereof |
CN106905715A (en) * | 2017-03-01 | 2017-06-30 | 山西大学 | Faded pigment of one organic molecular species modification and preparation method thereof |
CN106905715B (en) * | 2017-03-01 | 2018-07-24 | 山西大学 | The pigment and preparation method thereof that fades of one organic molecular species modification |
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CN100526292C (en) | 2009-08-12 |
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