CN101048385A - Process for production of 4-aminopyrimidines - Google Patents
Process for production of 4-aminopyrimidines Download PDFInfo
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- CN101048385A CN101048385A CN 200580036805 CN200580036805A CN101048385A CN 101048385 A CN101048385 A CN 101048385A CN 200580036805 CN200580036805 CN 200580036805 CN 200580036805 A CN200580036805 A CN 200580036805A CN 101048385 A CN101048385 A CN 101048385A
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Abstract
A process for the production of 4-aminopyrimidines represented by the general formula (3) [wherein R<SUP>1</SUP> and R<SUP>2</SUP> are each hydrogen or an optionally substituted inert group, or R<SUP>1</SUP> and R<SUP>2</SUP> may be united to form a ring; and R<SUP>4</SUP> is hydrogen or a hydrocarbon group], characterized by conducting a reaction among ammonia, a 3-substituted or -unsubstituted acrylonitrile compound represented by the general formula (1): CR<SUP>1</SUP>(CN)=CR<SUP>2</SUP>Y [wherein R<SUP>1</SUP> and R<SUP>2</SUP> are each as defined above; and Y is amino or OR (wherein R is hydrogen or a hydrocarbon group)], and an organic acid compound represented by the general formula (2): (R<SUP>3</SUP>O)<SUB>3</SUB>CR<SUP>4</SUP> [wherein R<SUP>3</SUP> is a hydrocarbon group; and R<SUP>4</SUP> is as defined above].
Description
Technical field
The present invention relates to make the method for 4-aminopyrimidine compounds by 3-replacement or non-substituted acrylonitrile compound.The 4-aminopyrimidine compounds is the useful compound of raw material, synthetic intermediate as medical agricultural chemicals etc.
Background technology
At present, the method as making the 4-aminopyrimidine compounds for example records: in the presence of phosphoryl chloride, make the reaction of methane amide and amide compound, the manufacturing yield is 6～32% various 4-aminopyrimidine compounds (for example with reference to patent documentation 1).But, in this method, must use methane amide and the high phosphoryl chloride of toxicity, and have the extremely low problem of yield with teratogenecity, be disadvantageous as the industrial making method of 4-aminopyrimidine compounds.
Patent documentation 1: Japanese Patent Publication 46-22157 communique
Summary of the invention
The problem that invention will solve
Problem of the present invention is to address the above problem, and a kind of manufacture method that can make the industrial suitable 4-aminopyrimidine compounds of 4-aminopyrimidine compounds under the condition of gentleness by easy method is provided.
The method that is used to deal with problems
The present invention relates to the manufacture method of the 4-aminopyrimidine compounds shown in a kind of general formula (3), it is characterized in that,
Make ammonia,
3-shown in the general formula (1) replace or non-substituted acrylonitrile compound and
Organic acid compound shown in the general formula (2) reacts,
CR
1(CN)＝CR
2Y (1)
In the formula, R
1And R
2The expression hydrogen atom maybe can have the substituent group that reacts of not participating in, in addition, and R
1And R
2Bonding and form ring, and Y is mutually represented amino or OR, and wherein, R represents hydrogen atom or alkyl,
(R
3O)
3CR
4 (2)
In the formula, R
3The expression alkyl, R
4Expression hydrogen atom or alkyl,
In the formula, R
1, R
2And R
4Identical with aforementioned definitions.
The invention effect
According to the present invention, can provide the manufacture method that under the condition of gentleness, to make the industrial suitable 4-aminopyrimidine compounds of 4-aminopyrimidine compounds by easy method.
Embodiment
The 3-that uses in the reaction of the present invention replaces or non-substituted acrylonitrile compound exist following general formula (1a) or (1b) shown in steric isomer, the preferred mixture that uses arbitrary isomer and their arbitrary proportion among the present invention.
In its general formula (1), when its 3-oxygen base acrylonitrile compound of representing with OR for Y, R is hydrogen atom or alkyl, as alkyl, specifically, for example can enumerate alkyl such as methyl, ethyl, propyl group, butyl, amyl group, hexyl, heptyl, octyl group, nonyl, decyl; Cycloalkyl such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, suberyl, ring octyl group; Aralkyl such as benzyl, styroyl, hydrocinnamyl; Aryl such as phenyl, p-methylphenyl, naphthyl, anthryl.In addition, these groups comprise various isomer.
In the 3-replacement of using in the reaction of the present invention or non-substituted acrylonitrile compound, when Y is amino, be 3-aminoacrylonitrile compound.In its general formula (1), R
1And R
2For hydrogen atom maybe can have the substituent group that reacts of not participating in, specifically, for example be alkyl, cycloalkyl, aralkyl, aryl, halogen atom, hydroxyl, alkoxyl group, alkylthio, nitro, cyano group, carbonyl, amino or carboxyl.In addition, R
1And R
2Bonding forms ring mutually.
As aforesaid alkyl, for example can enumerate methyl, ethyl, propyl group, butyl, amyl group, hexyl, heptyl, octyl group, nonyl, decyl etc.In addition, these groups comprise various isomer.
As aforementioned cycloalkyl, for example can enumerate cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, suberyl, ring octyl group etc.
As aforementioned aralkyl, for example can enumerate benzyl, styroyl, hydrocinnamyl etc.In addition, these groups comprise various isomer.
As aforementioned aryl, for example can enumerate phenyl, p-methylphenyl, naphthyl, anthryl etc.In addition, these groups comprise various isomer.
As aforementioned halogen atom, for example can enumerate fluorine atom, chlorine atom, bromine atoms, iodine atom.
As aforementioned alkoxyl group, for example can enumerate methoxyl group, oxyethyl group, propoxy-etc.In addition, these groups comprise various isomer.
As aforementioned alkylthio, for example can enumerate methylthio group, ethylmercapto group, rosickyite base etc.In addition, these groups comprise various isomer.
Aforesaid alkyl, cycloalkyl, aralkyl, aryl, alkoxyl group and alkylthio can have substituting group.As this substituting group, the substituting group that can enumerate the substituting group that connects by carbon atom, connect by Sauerstoffatom, the substituting group that connects by nitrogen-atoms, the substituting group that connects by sulphur atom, halogen atom etc.
As the aforementioned substituting group that connects by carbon atom, for example can enumerate alkyl such as methyl, ethyl, propyl group, butyl, amyl group, hexyl; Cycloalkyl such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclobutyl; Thiazolinyls such as vinyl, allyl group, propenyl, cyclopropenyl radical, cyclobutene base, cyclopentenyl; Heterocyclic radicals such as quinolyl, pyridyl, pyrrolidyl, pyrryl, furyl, thienyl; Aryl such as phenyl, tolyl, fluorophenyl, xylyl, xenyl, naphthyl, anthryl, phenanthryl; Acyl groups such as ethanoyl, propionyl, acryl, valeryl, hexamethylene carbonyl, benzoyl, naphthoyl base, toluyl (also can by acetalation); Carboxyl; Carbalkoxy such as methoxycarbonyl, ethoxycarbonyl; Aryloxy carbonyls such as carbobenzoxy; Haloalkyls such as trifluoromethyl; Cyano group.In addition, these groups comprise various isomer.
As the aforementioned substituting group that connects by Sauerstoffatom, for example can enumerate hydroxyl; Methoxyl group, oxyethyl group, propoxy-, butoxy, pentyloxy, hexyloxy, heptan alkoxyl group such as oxygen base, benzyloxy; Aryloxy such as phenoxy group, toluene acyloxy, naphthyloxy.In addition, these groups comprise various isomer.
As the aforementioned substituting group that connects by nitrogen-atoms, for example can enumerate primary aminos such as methylamino-, ethylamino, fourth amino, hexamethylene amino, phenylamino, naphthylamino; Dimethylamino, diethylin, dibutylamino, first and second amino, first fourth amino, diphenylamino, N-methyl-secondary amino groups such as N-sulfonyl methane amino; Heterocyclic amino group such as morpholinyl, piperidyl, piperazinyl, pyrazolidyl, pyrrolidyl, indyl; Imino-.In addition, these groups comprise various isomer.
As the aforementioned substituting group that connects by sulphur atom, for example can enumerate sulfydryl; Thio alkoxies such as sulfo-methoxyl group, thio ethoxy, sulfo-propoxy-; Thio-aryloxies such as sulfo-phenoxy group, sulfo-toluene acyloxy, sulfo-naphthyloxy etc.In addition, these groups comprise various isomer.
As aforementioned halogen atom, can enumerate fluorine atom, chlorine atom, bromine atoms, iodine atom.
The organic acid compound that uses in the reaction of the present invention is as described above shown in the general formula (2).In this general formula (2), R
3Be alkyl, specifically, alkyl such as methyl, ethyl, propyl group, butyl, amyl group, hexyl, heptyl, octyl group, nonyl, decyl for example; Cycloalkyl such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, suberyl, ring octyl group; Aralkyl such as benzyl, styroyl, hydrocinnamyl; Aryl such as phenyl, p-methylphenyl, naphthyl, anthryl are preferably alkyl, more preferably methyl, ethyl.In addition, these groups comprise various isomer.
In addition, R
4For hydrogen atom or with aforementioned R
3Shown alkyl definition is identical.As such organic acid compound, for example can enumerate original acid A ester, ethyl orthoformate, ortho-acetic acid methyl esters, ethyl orthoacetate, former methyl propionate, former ethyl propionate, former methyl-butyrate, former ethyl butyrate, former M-nitro benzoic acid methyl esters and former ethyl benzoate etc., can suitably use at least a kind that is selected from by in these groups of forming.
The relative 1 mole of 3-of the usage quantity of aforementioned organic acid compound replaces or non-substituted acrylonitrile compound is preferably 1.0～15 moles, more preferably 1.1～5.0 moles.
The existence that is reflected at solvent of the present invention is carried out down or under not existing.As employed solvent,, for example can enumerate alcohols such as methyl alcohol, ethanol, Virahol, propyl carbinol, the trimethyl carbinol, Pentyl alcohol as long as do not hinder reaction just to have no particular limits; N, amidess such as dinethylformamide, N-Methyl pyrrolidone; N, N '-urea classes such as dimethyl-imidazolinone; Sulfoxide classes such as dimethyl sulfoxide (DMSO); Arene such as benzene,toluene,xylene, mesitylene; Ethers such as diethyl ether, tetrahydrofuran (THF), diox are preferably alcohols, amides, more preferably use methyl alcohol, ethanol, N, N '-dimethyl-imidazolinone.In addition, these solvents can use or mix two or more uses separately.
Wait the usage quantity of suitably regulating aforementioned solvents according to the homogeneity of reaction solution, stirring property, preferred 1g 3-relatively replaces or non-substituted acrylonitrile compound is 0～50g, and more preferably 0～20g is preferably 0～5g especially.
The amount of the ammonia that uses in the reaction of the present invention replaces with respect to 1 mole of 3-or non-substituted acrylonitrile compound is preferably 1.0～100 moles, and more preferably 1.1～40 moles, be preferably 2.0～40 moles especially, most preferably be 2.1～40 moles.In addition, the form of employed ammonia has no particular limits, and can be the form arbitrarily of gas, liquid, and in addition, the solution that can also make organic solvent (for example, alcohols) uses.In addition, the ammonia of these forms and ammonia solution can use separately or be use mixing two or more.
Reaction of the present invention for example can be by replacing in the presence of ammonia, with 3-or methods such as non-substituted acrylonitrile compound, organic carboxyl acid compound and solvent and stirring are carried out.The temperature of reaction of this moment is preferably 40～250 ℃, and more preferably 50～200 ℃, reaction pressure has no particular limits.
In addition, the 4-aminopyrimidine compounds that obtains by reaction of the present invention, after reaction finishes, by for example neutralize, extract, filter, concentrate, general methods such as distillation, recrystallization, crystallization, column chromatography carry out separation and purification.
Embodiment
Below, enumerate embodiment and come the present invention is specifically described, but scope of the present invention is not limited thereto.
Embodiment 1 (synthesizing of 4-aminopyrimidine)
In the internal volume with whipping appts, reflux cooler and thermometer is in the stainless steel pressure vessel of 1000ml, add ammonia-aqueous isopropanol of 83.0g (1.0mol) 3-methoxy acrylonitrile, 212g (2.0mol) original acid A ester and 355g (2.5mol) 12 weight %, reacted 12 hours down at 145 ℃ while stirring.After reaction finished, by the part (about 5ml) (absolute quantitation method) of gas chromatographic analysis gained reaction solution, the result had generated 67.3g 4-aminopyrimidine (reaction yield: 70.8%).Then, under reduced pressure concentration of reaction solution adds 54.8g gac and 747ml Virahol, stirs 1 hour down at 90 ℃.After stirring end, filter also concentrated filtrate under reduced pressure.Repeat 2 this activated carbon treatment operations.After stirring end, filter also concentrated filtrate under reduced pressure.In enriched material, add 125ml Virahol and 665ml toluene, it is warming up to 90 ℃ and obtain uniform solution, be cooled to 0 ℃ then, separate out crystal.Filter and the crystal of dry gained, obtain the 4-aminopyrimidine (separation yield: 46.5%) of the white crystal shape of 4.22g purity 99.9% (the area percentage of trying to achieve by gas-chromatography).
The physics value of 4-aminopyrimidine is as follows.
1H-NMR(CDCl
3，δ(ppm))：6.46(1H，d，J＝6.0Hz)、6.81(2H，brs)、8.03(1H，d，J＝6.0Hz)、8.33(1H，d，J＝0.7Hz)
CI-MS(m/e)：96(M+1)
Embodiment 2 (synthesizing of 4-aminopyrimidine)
In the internal volume with whipping appts, reflux cooler and thermometer is in the stainless steel pressure vessel of 1000ml, add ammonia-methanol solution of 90.0g (1.1mol) 3-methoxy acrylonitrile, 230g (2.2mol) original acid A ester and 351g (4.3mol) 21 weight %, reacted 6.5 hours down at 145 ℃ while stirring.Reaction is analyzed reaction solution by gas-chromatography after finishing, and the result has generated 72.7g 4-aminopyrimidine (reaction yield: 70.6%).
Embodiment 3 (synthesizing of 4-aminopyrimidine)
In the internal volume with whipping appts, reflux cooler and thermometer is in the stainless steel pressure vessel of 300ml, add ammonia-aqueous isopropanol of 14.4g (173mmol) 3-methoxy acrylonitrile, 38.5g (260mmol) ethyl orthoformate and 74.9g (519mmol) 11.8 weight %, reacted 9 hours down at 150 ℃ while stirring.Reaction is analyzed reaction solution by gas-chromatography after finishing, and the result has generated 12.0g 4-aminopyrimidine (reaction yield: 72.7%).
Embodiment 4 (synthesizing of 2-methyl-4-aminopyrimidine)
In internal volume is in the stainless steel pressure vessel of 10ml, adds ammonia-methanol solution of 1.0g (12mmol) 3-methoxy acrylonitrile, 3.9g (32mmol) ortho-acetic acid methyl esters and 4.0g (56mmol) 24 weight %, reacts 8 hours down at 130 ℃ while stirring.After reaction finishes, in reaction solution, add the 20ml hexane, stir after-filtration, obtain the 2-methyl-4-aminopyrimidine (separation yield: 72%) of 0.94g yellow crystals shape.
The physics value of 2-methyl-4 aminopyrimidine is as follows.
1H-NMR(DMSO-d
6，δ(ppm))：2.29(3H，s)、6.22(1H，dd，J＝5.9，0.5Hz)、6.69(2H，brs)、7.94(1H，d，J＝5.9Hz)
CI-MS(m/e)：109(M+1)
Embodiment 5 (synthesizing of 6-methyl-4-aminopyrimidine)
In internal volume is in the stainless steel pressure vessel of 10ml, add ammonia-methanol solution of the amino propenyl cyanide of 3-, 2.48g (23.4mmol) original acid A ester and 1.42g (17.5mmol) the 21 weight % of 1.0g (11.7mmol) purity 96%, reacted 15 hours down at 130 ℃ while stirring.After reaction finished, under reduced pressure concentration of reaction solution added 10ml Virahol and 660mg gac in enriched material, stirred 1 hour after-filtration down at 90 ℃.In the filtrate of gained, add the 660mg gac, stirred 1 hour down at 90 ℃ once more.Filter the back concentrated filtrate, add 1.8ml Virahol and 3ml toluene in enriched material, be heated to 90 ℃, slowly cooling was then stirred 1 hour down at-5 ℃.Filter the solid separated out, the drying under reduced pressure solid obtains the 6-methyl-4-aminopyrimidine (separation yield: 26%) of the white crystal shape of 326mg purity 99.5% (the area percentage of trying to achieve by gas-chromatography).
6-methyl-4-aminopyrimidine physics value as follows.
1H-NMR(DMSO-d
6，δ(ppm))：2.17(3H，s)、6.25(1H，s)、6.65(2H，brs)、8.21(1H，s)
CI-MS(m/e)：110(M+1)
Industrial utilizability
It is phonetic to the present invention relates to make 4-amino by 3-replacement or non-substituted acrylonitrile compound The method of acridine compound. The 4-aminopyrimidine compounds is former as medical agricultural chemicals etc. Material, the useful compound of synthetic intermediate can be used for for example passing through TOHKEMY The method that 2003-64056 puts down in writing is made the acid amides derivative as pharmaceuticals.
Claims (11)
1. the manufacture method of the 4-aminopyrimidine compounds shown in the general formula (3) is characterized in that,
Make ammonia,
3-shown in the general formula (1) replace or non-substituted acrylonitrile compound and
Organic acid compound shown in the general formula (2) reacts,
CR
1(CN)＝CR
2Y (1)
In the formula, R
1And R
2The expression hydrogen atom maybe can have the substituent group that reacts of not participating in, in addition, and R
1And R
2Bonding and form ring, and Y is mutually represented amino or OR, and wherein, R represents hydrogen atom or alkyl,
(R
3O)
3CR
4 (2)
In the formula, R
3The expression alkyl, R
4Expression hydrogen atom or alkyl,
In the formula, R
1, R
2And R
4Identical with aforementioned definitions.
2. manufacture method according to claim 1, wherein, relative 1 mole of 3-replaces or non-substituted acrylonitrile compound, uses the ammonia of 1.0～100 molar weights.
3. manufacture method according to claim 1, wherein, relative 1 mole of 3-replaces or non-substituted acrylonitrile compound, uses the ammonia of 1.1～40 molar weights.
4. according to each described manufacture method of claim 1～3, wherein, relative 1 mole of 3-replaces or non-substituted acrylonitrile compound, uses the organic acid compound of 1.0～15 molar weights.
5. according to each described manufacture method of claim 1～3, wherein, relative 1 mole of 3-replaces or non-substituted acrylonitrile compound, uses the organic acid compound of 1.1～5.0 molar weights.
6. according to each described manufacture method of claim 1～5, wherein, be reflected under 40～250 ℃ and carry out.
7. according to each described manufacture method of claim 1～5, wherein, be reflected under 50～200 ℃ and carry out.
8. according to each described manufacture method of claim 1～7, wherein, 3-replaces or non-substituted acrylonitrile compound is 3-oxygen base acrylonitrile compound or 3-aminoacrylonitrile compound.
9. manufacture method according to claim 8, wherein, 3-oxygen base acrylonitrile compound is at least a kind that is selected from the group that 3-methoxy acrylonitrile, 3-ethoxy propylene nitrile, 3-propoxy-vinyl cyanide and 3-butoxy vinyl cyanide formed.
10. according to each described manufacture method of claim 1～9, wherein, organic acid compound is at least a kind that is selected from the group that original acid A ester, ethyl orthoformate, ortho-acetic acid methyl esters, ethyl orthoacetate, former methyl propionate, former ethyl propionate, former methyl-butyrate, former ethyl butyrate, former M-nitro benzoic acid methyl esters and former ethyl benzoate form.
11. according to each described manufacture method of claim 1～9, wherein, organic acid compound is original acid A ester or ethyl orthoformate.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004313290 | 2004-10-28 | ||
| JP313290/2004 | 2004-10-28 | ||
| JP313291/2004 | 2004-10-28 | ||
| JP162335/2005 | 2005-06-02 |
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| Publication Number | Publication Date |
|---|---|
| CN101048385A true CN101048385A (en) | 2007-10-03 |
Family
ID=38772201
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200580036805 Pending CN101048385A (en) | 2004-10-28 | 2005-10-28 | Process for production of 4-aminopyrimidines |
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|---|---|
| CN (1) | CN101048385A (en) |
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2005
- 2005-10-28 CN CN 200580036805 patent/CN101048385A/en active Pending
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