CN101032602A - Tianxiang capsule for releasing pressure - Google Patents

Abstract

The present invention is one kind of medicine capsule for preventing and treating hypertension, named as Tianxiang blood pressure lowering capsule. Tianxiang blood pressure lowering capsule of the present invention can eliminate mental stress and anxiety to avoid generation of angiotensins, raise the activity of ethanol dehydrogenase to reduce damage of alcohol on small artery, and degrade nicotine to avoid the stimulation of smoking on small artery, so as to prevent and treat hypertension.

Description

Tianxiang capsule for releasing pressure

Tianxiang capsule for releasing pressure belongs to the Chinese medicine sciemtifec and technical sphere.This medicine has higher using value in hypertensive prevention and treatment.

Essential hypertension is the modal cardiovascular disease of China, is more common in 40 years old later middle-aged and elderly people.Beginning of this disease is that arteriolosclerosis is the systemic disease of basic lesion, this course of disease is very long, symptom disappearing is indefinite, be difficult for adhering to treatment, be developed to late period, then cause the infringement on the heart, brain, kidney three big internal organs and optical fundus, and cause complicated clinical manifestation that severe patient can seriously be disabled deadly because of the heart and brain kidney is impaired.Yet at present the hypertension incidence rate of China is ascendant trend fast, and average prevalence is from 5.11% of nineteen fifty-nine, rise to 1991 12.8%.This disease is in geographical distribution, and northern area is higher than south, and the city is higher than the rural area.But along with the raising of people's living standard, this disease also obviously rises at the sickness rate in rural area, considerably beyond 5.11% of nineteen fifty-one.This shows that essential hypertension has become a great difficult problem that has a strong impact on compatriots and human life's health.Though essential hypertension can't be cured in fact, the application natural plants is done medicinal, and essential hypertension can prevent fully, and can cure.The research of Tianxiang capsule for releasing pressure is studied according to this reality is theoretical exactly, and is obtained very good result.

The research of Tianxiang capsule for releasing pressure at first is the screening study of spice.According to the cause of disease and the pathomechanism of essential hypertension, particularly relevant with this disease Chinese medicine theory is shot the arrow at the target, and brings high blood pressure down effectively, stops the generation and the development of essential hypertension.Therefore, in the years of researches practice, draft out the square medicine of existing Tianxiang capsule for releasing pressure, i.e. Rhizoma Gastrodiae, Folium Crossostephii Chinensis, Herba Apocyni veneti, Fructus Crataegi, Fructus Lycii, Herba Sonchi Oleracei, Cortex Periplocae.

Secondly, be the preparation method research of Tianxiang capsule for releasing pressure.According to the hypertension characteristics, for safe and effective, take medicine conveniently, drafted the following step of manufacturing:

1, adopt decoction and alcohol sedimentation technique, with the Rhizoma Gastrodiae in the side, Fructus Lycii, Fructus Crataegi, Herba Apocyni veneti, Cortex Periplocae, clean dry standby.

2, adopt decoction and alcohol sedimentation technique, insert in the Stainless Steel container, add the clear water of 8 times of amounts, decoct each 1 hour 3 times.Merge decoction liquor then, left standstill 24 hours, extract supernatant, concentrate this liquid and become rare paste.

3,75% the ethanol that the extract of rare paste is added 3 times of amounts, agitator treating precipitation 3 times, each 6 hours, extract supernatant, reclaim ethanol, till not having an alcohol flavor, and after being concentrated into rare paste, put in the Stainless Steel container standby.

4, the Folium Crossostephii Chinensis in the general side, Herba Sonchi Oleracei are cleaned and are dried, and put in the constant temperature pot of Stainless Steel to stir-fry, and temperature is no more than 65 ℃, loses effect in order to avoid destroy the active component in the medicine.

5, after the constant temperature parch, spice is pulverized with 60 mesh sieves.At this moment, mix with above-mentioned rare paste extract,, put 65 ℃ of calorstat inner dryings with the fritter that becomes the dough sample with this medicated powder.

6, with dried complete spice, cross 40 mesh sieves and pulverize, be sub-packed in afterwards in the capsule, every 0.5 gram, this is a Tianxiang capsule for releasing pressure.

The 3rd is the functional study of Tianxiang capsule for releasing pressure.According to the pharmacological function of Tianxiang capsule for releasing pressure,, Tianxiang capsule for releasing pressure is carried out basis and clinical efficacy and the Its Mechanisms and the observation of pharmacodynamics just with the basis with clinically set up contrast.The result shows, Tianxiang capsule for releasing pressure, but suppressing the hyperactive liver to relieve the wind syndrome, causing resuscitation with aromatic drugs, blood circulation promoting regulates qi, Qi-benefiting and heart-nourishing, logical hundred arteries and veins of temperature, transfer smooth meridians, the liver and the kidney tonifying.So all excessive rising of liver-YANG, dizzy, the soreness of the waist and knees of headache, tinnitus are forgetful, insomnia and dreamful sleep, dysphoria with feverish sensation in the chest palms and soles, numb hand and foot, breast sun are not opened up, the nervous cards such as sexual impotence, clear urine in large amounts of breathing hard, pass out semen, that all can dredge looses it.And with regard to modern medical theory, the buck functionality of Tianxiang capsule for releasing pressure is as follows with mechanism.

1, spirit psychological long-term hypertonicity, anxiety, fidgety etc., can make the functional disorder of corticocerebral high-level center, the adjusting function of subcortical center weakens, when wherein vasomotor centre thereby produce when being punctured into main impulsion, orthosympathetic postganglionic fibers is then secreted a large amount of norepinephrine and catecholamine etc., act on the α receptor on the tiny arterial smooth muscle cell, cause that the contractility of tiny tremulous pulse is strengthened, make hypertension.Tianxiang capsule for releasing pressure can suppress orthosympathetic irritability, and stoping vaso-excitor material is the release of feritin, Endothelin, catecholamine, avoids the excess shrinkage and the spasm of tiny tremulous pulse, thereby makes the rising of blood pressure controlled.Moreover Tianxiang capsule for releasing pressure has the merit of tranquilizing the mind, calm relieving restlessness, thus can eliminate spiritual psychological hypertonicity and anxiety, thus the fluctuation of stabilizing blood pressure or rising effectively.

2, the small artery that causes of sympathetic activation shrinks, and can directly cause the kidney ischemia, and the kidney ischemia stimulates the ε emiocytosis feritin of the other device of ball of renal glomerulus again.Feritin with the liquid of bleeding after, make proangiotensin change hypertensin 1 into, when the latter passes through organizing of lung and kidney with blood flow, the angiotensin activating enzymes by the there change into hypertensin 2, hypertensin 2 can directly cause the strong contraction of tiny tremulous pulse, makes hypertension form hypertension.Tianxiang capsule for releasing pressure, by basis and clinical research repeatedly, the result shows, can suppress the activity of angiotensin activating enzymes effectively, stops the generation of hypertensin 2, not only reduces blood effectively, and stops hypertensive formation and development.

When 3, plasma cholesterol increases, the change of vascular endothelial cell recurring structure can be stimulated, after the endotheliocyte of this moment is impaired, excessive Endothelin can be secreted.Endothelin is the strongest vaso-excitor material of effect known to so far, and its vasoactive smooth cell causes that vasoconstriction makes hypertension.Simultaneously, cause endotheli ocytosis and smooth muscle cell proliferation, cause vessel wall thickening, sclerosis, impel hypertensive generation and development.Tianxiang capsule for releasing pressure can suppress the generation of Endothelin effectively, stops hypertensive formation and development.

4, smoking can directly stimulate the little blood vessel of tremulous pulse in vascular endothelial cell and the vascular smooth muscle cell, particularly brain, causes their convulsive contractions.Its mechanism of action is contained nicotine and a cigarette alkali in the cigarette, and not only the toxicity to the various cells of blood vessel is bigger, and in acting on brain during tiny arteries, very easily stimulates the memory cell in the brain and makes the smoker become latent.Tianxiang capsule for releasing pressure, can degrade effectively cigarette alkali and nicotine stop its damaging action to all kinds of vascular endothelial cells and smooth muscle cell, thus the formation of prophylaxis of hypertension and development significantly.

5, ethanol is early widely utilized as a kind of beverage and flavoring agent.Drink and particularly drink for a long time, the ethanol in the wine can directly stimulate blood vessel wall, particularly brain small artery, promotes these arteriolar spasm and the contraction of tetanic property.Simultaneously, reverse again act on all kinds of venules, peripheral blood is refluxed reduce, cause that the rhythm of the heart accelerates, cause blood pressure to increase.Tianxiang capsule for releasing pressure, effective ingredient wherein is a puerarin, this composition can improve the activity of ethanol dehydrogenase and aldehyde degassing enzyme effectively, make the ethanol in the blood be transformed into benzaldehyde apace, again through the catalysis of aldehydic acid dehydrogenase, generate benzoic acid and excrete, thereby stop the infringement of ethanol, stoped hypertensive generation and development all kinds of blood vessels by kidney.

In sum, Tianxiang capsule for releasing pressure is the hypertensive effective plant amedica of treatment.Tianxiang capsule for releasing pressure not only has clear and definite chemical constituent, and content standard is controlled.Moreover, it is fast that these product still have produce effects, and taking convenience is without any side effects again, and Tianxiang capsule for releasing pressure can bring high blood pressure down quickly and effectively, and can stop hypertensive generation and development up hill and dale.

Claims (8)

1, Tianxiang capsule for releasing pressure belongs to the modern Chinese medicine sciemtifec and technical sphere.This medicine is a raw material with natural plant Rhizoma Gastrodiae, Folium Crossostephii Chinensis flower, Herba Apocyni veneti, Fructus Crataegi, Fructus Lycii, Cortex Periplocae, Herba Sonchi Oleracei, Radix Puerariae, adopt decoction and alcohol sedimentation technique, extract the effective ingredient of relevant plant amedica, institute's effective ingredient of carrying is to be Tianxiang capsule for releasing pressure after excipient is allocated with parch complete Herba Sonchi Oleracei and Folium Crossostephii Chinensis flower.This medicine is carried out efficacy study, the result shows, can stop the generation of Endothelin, angiotensin, still can effectively improve the activity of ethanol dehydrogenase, aldehydic acid dehydrogenase, have simultaneously the function of degraded cigarette alkali and nicotine again, thereby prevent hypertensive formation and development effectively.Therefore be that Tianxiang capsule for releasing pressure is prevention and treats hypertensive effective new drug.

2, the decoction and alcohol sedimentation technique according to claims 1, it specifically is characterized as, and adopts decoction and alcohol sedimentation technique, insert in the Stainless Steel container handling clean Rhizoma Gastrodiae, Fructus Crataegi, Herba Apocyni veneti, Fructus Lycii, Cortex Periplocae, Radix Puerariae, add the clear water of 8 times of amounts, decoct each 1 hour 3 times.Merge decoction liquor then, left standstill 24 hours, extract supernatant, concentrate this liquid and become rare paste.75% the ethanol that again extract of rare paste is added 3 times of amounts, agitator treating precipitation 3 times, each 6 hours, extract supernatant, reclaim ethanol, till not having an alcohol flavor, and after being concentrated into rare paste, put in the Stainless Steel container standby.

3, the excipient according to claims 1, its concrete feature be, the Folium Crossostephii Chinensis in the side, Herba Sonchi Oleracei are cleaned and dried, and puts in the constant temperature pot of Stainless Steel to stir-fry, and temperature is no more than 65 ℃, loses effect in order to avoid destroy the active component in the tea.After the constant temperature parch, spice is pulverized with 60 mesh sieves.At this moment, mix with above-mentioned rare paste extract,, put 65 ℃ of calorstat inner dryings with the fritter that becomes the dough sample with medicated powder.With dried extract, cross 40 mesh sieves and pulverize, be sub-packed in afterwards in the hard capsule, every 0.5 gram, this is a Tianxiang capsule for releasing pressure.

4, according to the generation of the described inhibition angiotensin of claims 1, its concrete feature is, spirit psychological long-term hypertonicity, anxiety, fidgety etc., can make the functional disorder of corticocerebral high-level center, the adjusting function of subcortical center weakens, when wherein vasomotor centre thereby produce when being punctured into main impulsion, orthosympathetic postganglionic fibers is then secreted a large amount of norepinephrine and catecholamine etc., act on the α receptor on the tiny arterial smooth muscle cell, the contractility that causes tiny tremulous pulse is strengthened, and makes hypertension.Tianxiang capsule for releasing pressure can suppress orthosympathetic irritability, and stoping vaso-excitor material is the release of feritin, catecholamine, avoids the excess shrinkage and the spasm of tiny tremulous pulse, thereby makes the rising of blood pressure controlled.Moreover Tianxiang capsule for releasing pressure has the merit of tranquilizing the mind, calm relieving restlessness, thus can eliminate spiritual psychological hypertonicity and anxiety, thus the fluctuation of stabilizing blood pressure or rising effectively.

5, according to the generation of the described inhibition Endothelin of claims 1, its concrete special sheet is, when plasma cholesterol increases, can stimulate the change of vascular endothelial cell recurring structure, after the endotheliocyte of this moment is impaired, can secrete excessive Endothelin.Endothelin is the strongest vaso-excitor material of effect known to so far, and its vasoactive smooth cell causes that vasoconstriction makes hypertension.Simultaneously, cause endotheli ocytosis and smooth muscle cell proliferation, cause vessel wall thickening, sclerosis, impel hypertensive generation and development.Tianxiang capsule for releasing pressure can suppress the generation of Endothelin effectively, stops hypertensive formation and development.

6, degraded cigarette alkali and the nicotine according to claims 1, its concrete feature is that smoking can directly stimulate the little blood vessel of tremulous pulse in vascular endothelial cell and the vascular smooth muscle cell, particularly brain, causes their convulsive contractions.Its mechanism of action is contained nicotine and a cigarette alkali in the cigarette, and not only the toxicity to the various cells of blood vessel is bigger, and in acting on brain during tiny arteries, very easily stimulates the memory cell in the brain and makes the smoker become latent.Tianxiang capsule for releasing pressure, can degrade effectively cigarette alkali and nicotine stop its damaging action to all kinds of vascular endothelial cells and smooth muscle cell, thus the formation of prophylaxis of hypertension and development significantly.

7, according to the described raising ethanol dehydrogenase of claims 1 and the activity of aldehydic acid dehydrogenase, its concrete feature is that ethanol is early widely utilized as a kind of beverage and flavoring agent.Drink and particularly drink for a long time, the ethanol in the wine can directly stimulate blood vessel wall, particularly brain small artery, promotes these arteriolar spasm and the contraction of tetanic property.Simultaneously, reverse again act on all kinds of venules, peripheral blood is refluxed reduce, cause that the rhythm of the heart accelerates, cause blood pressure to increase.Tianxiang capsule for releasing pressure, effective ingredient wherein is a puerarin, this composition can improve the activity of ethanol dehydrogenase and aldehyde degassing enzyme effectively, make the ethanol in the blood be transformed into benzaldehyde apace, again through the catalysis of aldehydic acid dehydrogenase, generate benzoic acid and excrete, thereby stop the infringement of ethanol, stoped hypertensive generation and development all kinds of blood vessels by kidney.

8, according to product on the described tea-drinking culture of claims 1, its concrete feature is that Tianxiang capsule for releasing pressure is prevention and treats hypertensive effective new drug.Have clear and definite chemical constituent, content standard is controlled.Moreover, it is fast that these product still have produce effects, and taking convenience is without any side effects.Therefore, Tianxiang capsule for releasing pressure is the hypertensive effective new drug of prophylactic treatment.