CN101023981A - Use of total flavone of lamiophlomis rotata leaf-stem in preparing medicine for promoting healing of bone fracture - Google Patents
Use of total flavone of lamiophlomis rotata leaf-stem in preparing medicine for promoting healing of bone fracture Download PDFInfo
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- CN101023981A CN101023981A CN 200610020340 CN200610020340A CN101023981A CN 101023981 A CN101023981 A CN 101023981A CN 200610020340 CN200610020340 CN 200610020340 CN 200610020340 A CN200610020340 A CN 200610020340A CN 101023981 A CN101023981 A CN 101023981A
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Abstract
The present invention relates to an application of lamiophlomis rotata flavone in preparation of medicine for promoting union of fracture. Said lamiophlomis rotata total flavone is obtained by extracting Chinese medicinal material lamiophlomis rotata, and the medicine containing lamiophlomis rotata total flavone not only has the actions of promoting blood circulation, stopping pain and resisting inflammation, but also has the action of promoting union of fracture.
Description
Technical field
The present invention relates to medical technical field, particularly the new purposes of flavones ingredient in the Radix Lamiophlomidis Rotatae.
Background technology
Radix Lamiophlomidis Rotatae mainly is distributed in China southwest and northwestward Hengduan mountain range middle part, east and periphery mountain region, and the mesophorbium, coryphile, meadow filling that is common in 2700-4500 rice is from, river shoal and alpine talus vegetation.The Radix Lamiophlomidis Rotatae distribution area maximum in mesophorbium, coryphile wherein is in alpine talus vegetation area occupied minimum.
184 pages of regulation Radix Lamiophlomidis Rotataes of Chinese Pharmacopoeia version in 2005 are the dry herb of labiate Radix Lamiophlomidis Rotatae Lamiophlomis rotata (Benth.) Kudo..Medicinal part is a herb, promptly comprises root, stem, leaf.
The patent of existing relevant Radix Lamiophlomidis Rotatae mainly relates to the pharmaceutical dosage form of Radix Lamiophlomidis Rotatae, the preparation technology who all relates to the Radix Lamiophlomidis Rotatae dispersible tablet as CN02134169.9, CN200410023011.8, CN03117413.2 relates to the particulate preparation method of Radix Lamiophlomidis Rotatae, and CN200410021816.9, CN200410155090.8, CN200410038265.7 all relate to the preparation method of Duyiwei soft capsule; CN200410021152.6 relates to novel form of Radix Lamiophlomidis Rotatae extract and preparation method thereof, CN200410022734.6, CN200410051660.9 all relate to a kind of Radix Lamiophlomidis Rotatae extract and its preparation technology and application thereof, and what above patent was mentioned mainly is the preparation method of common lamiophlomis root preparation.
According to present Research to Radix Lamiophlomidis Rotatae, the main effect of Radix Lamiophlomidis Rotatae, Radix Lamiophlomidis Rotatae extract and Duyiwei total flavone for invigorate blood circulation, effect such as pain relieving, antiinflammatory, generally be used for the wound pain behind the surgical operation, hemorrhage, rheumatic arthralgia and metrorrhagia, dysmenorrhea, gingival swelling and pain, hemorrhage etc., its application aspect orthopedics department at present only limits to as pain relieving, and it has the effect that promotes union of fracture without any bibliographical information.
Summary of the invention
Purpose of the present invention just provides the new purposes of Duyiwei total flavone in the medicine of preparation promotion union of fracture.
The technical solution adopted for the present invention to solve the technical problems is: the application of Duyiwei total flavone in the medicine of preparation promotion union of fracture.Duyiwei total flavone be from the Chinese medicine Radix Lamiophlomidis Rotatae, extract and flavones ingredient, it can be used for preparing and has the medicine that promotes the union of fracture effect.
Wherein, above-mentioned Duyiwei total flavone comprises flavone aglycone and/or flavonoid glycoside etc.And flavone aglycone comprises one or more and other flavone aglycone of not identifying structure as yet fully that extracts in luteolin, Quercetin and the isorhamnetin from Radix Lamiophlomidis Rotatae.
The medicine of above-mentioned promotion union of fracture can be made any suitable oral administration or the medicine of topical administration or drug administration by injection, as injection, transfusion, powder pin, little pin, pill, suspensoid, mixture, oral liquid, obedient agent, drop pill, tablet, slow releasing tablet, capsule, soft capsule, granule etc.
Above-mentioned Duyiwei total flavone can extract from the Radix Lamiophlomidis Rotatae medical material by multiple common method and make, and for example, can prepare by the method that includes but not limited to following steps:
(1), preparation Radix Lamiophlomidis Rotatae crude extract: get the raw medicinal material Radix Lamiophlomidis Rotatae or pulverize after Radix Lamiophlomidis Rotatae, extract with water extraction or decoction and alcohol sedimentation technique or ethanol extraction method or ethanol extract from water precipitation, get extracting solution, this extracting solution is condensed into rare extractum, promptly get the Radix Lamiophlomidis Rotatae crude extract;
(2), refining: will (1) go on foot the Radix Lamiophlomidis Rotatae crude extract that makes and cross macroporous adsorptive resins, the low-concentration ethanol eluting of first water or 1%-30%, the eluent of this water or low-concentration ethanol is discarded need not; The higher concentration ethanol elution of reuse 40%-95% is collected this higher concentration ethanol elution, and is behind the recovery ethanol that remainder is concentrated, dry, must contain the Radix Lamiophlomidis Rotatae extract of flavones ingredient, i.e. Duyiwei total flavone.
Low polar macroporous adsorbent resin during wherein the macroporous adsorbent resin described in (2) one-step refining can be selected for use is as D101, D201, D301, AB-8, X-5 and HPD series etc.Used drying means can be methods such as oven dry or drying under reduced pressure or spray drying or lyophilization.
As required, through the Duyiwei total flavone of above-mentioned (2) one-step refining gained, also available n-butyl alcohol or ethyl acetate or polyamide etc. are further purified processing, to obtain the higher Duyiwei total flavone of active constituent content.
The Radix Lamiophlomidis Rotatae medical material that the present invention is used is meant herb (comprising root, stem and leaf) or the aerial parts (being mainly stem and leaf) of labiate Radix Lamiophlomidis Rotatae Lamiophlomis rotate (Benth.) Kudo..
Compared with prior art, the invention has the beneficial effects as follows: the present invention is used to Duyiwei total flavone to prepare the medicine with promotion union of fracture effect, this is the new application of Radix Lamiophlomidis Rotatae medical material at field of medicaments, not only widened the clinical application range of Radix Lamiophlomidis Rotatae, also selected simultaneously for fracture patient provides new treatment.
The specific embodiment
The present invention is described in further detail below in conjunction with the specific embodiment.
Embodiment one Duyiwei total flavone promotes the pharmacodynamics test of union of fracture
Animal: the SD rat, male, body weight 180～220g.
Medicine: Duyiwei total flavone, inventor oneself preparation is by 0.1, two dosed administrations of 0.05g/Kg.Positive control drug: bone setting tablet, the Dalian pharmaceutical factory of traditional Chinese medicine produces.
Test method: get 80 of the male adult rats of SD, pentobarbital sodium anesthesia, the right lower limb of iodine tincture and alcohol disinfecting rat, laterally sawing, operation causes lower limb tibiofibula stage casing 3mm complete collyriculum, and art finishes sews up the incision, and will not cover wrapping, ip penicillin infection, 3d causes the rat fracture model continuously.Rat model is divided into 4 groups at random, according to the form below dosage gastric infusion, everyone 1 time, continuous 30d.Respectively at behind the medicine 15,30d, every group get 10 rat anesthesias at random after, adopt 47kV, 100mA, 0.6s, take the X-ray sheet under the 90cm condition, press X-ray sheet evaluation criterion and grade.
Influence to the rat fracture
| Group | Dosage (g/kg) | Mus number (only) | 15d | 30d | ||||||
| + | ++ | +++ | ++++ | + | ++ | +++ | ++++ | |||
| Model group | The equal-volume distilled water | 10 | 8 | 2 | 0 | 0 | 7 | 3 | 0 | 0 |
| The bone setting tablet group | 1.5 | 10 | 4 | 6 | 0 | 0 | 4 | 5 | 1 | 0 |
| Duyiwei total flavone | 0.1 | 10 | 2 | 6 | 1 | 1 | 0 | 1 | 3 | 6 |
| Duyiwei total flavone | 0.05 | 10 | 3 | 7 | 0 | 0 | 1 | 2 | 5 | 2 |
Annotate :+many more, the healing degree is good more.
The result shows that the X-ray sheet of two the dosage groups of back 15 days Duyiwei total flavones of fracturing has more obviously change, and the rat fracture end is fuzzy, the silly formation of bone is arranged, slight periosteal reaction is arranged, obvious with the effect of heavy dose group, matched group bone setting tablet group also has same purpose, but than a little less than the Duyiwei total flavone; And that model group only shows as fracture end is fuzzy, and slight periosteal reaction is arranged, and indivedual bones are silly as seen; Fracture back 30d, the damaged place of Duyiwei total flavone group have than boniness is silly and form, and heal in heavy dose of group (take a sample 10) rat damaged place of fracturing, and model group is compared with 15d and do not had obviously improvement.
Embodiment two promotes the Duyiwei total flavone soft capsule of union of fracture
Get described Duyiwei total flavone 3kg, other gets vegetable oil 7kg, and mixing is made capsule casing material with gelatin, is pressed into soft capsule, promptly makes the medicine of the soft capsule dosage form that contains 30% Radix Lamiophlomidis Rotatae stem and leaf extract.
Embodiment three promotes the Duyiwei total flavone injectable powder of union of fracture
Get described Duyiwei total flavone 300g, be dissolved in the 10000ml water for injection, adopt existing injectable powder lyophilizing preparation technology, promptly make the medicine of the injectable powder type that contains the Radix Lamiophlomidis Rotatae stem and leaf extract.
Embodiment four promotes the Duyiwei total flavone capsule of union of fracture
Get described Duyiwei total flavone 400g, other gets starch 600g, and mix homogeneously adopts existing capsules preparation technique, promptly makes the medicine of the capsule formulation that contains 40% Radix Lamiophlomidis Rotatae stem and leaf extract.
Embodiment five promotes the Duyiwei total flavone drop pill of union of fracture
Get described Duyiwei total flavone 300g, other gets the 500g Macrogol 4000, adopts existing drop pill preparation technology, promptly makes the medicine of the drops that contains 37.5% Radix Lamiophlomidis Rotatae stem and leaf extract.
Embodiment six promotes the Duyiwei total flavone granule and the tablet of union of fracture
Get described Radix Lamiophlomidis Rotatae stem and leaf extract total flavones 300g, other gets sucrose 700g, starch 200g, and mix homogeneously adopts existing tablet producing technology, granulates, and sieves, and drying promptly makes the medicine of the granule dosage form that contains 25% Radix Lamiophlomidis Rotatae stem and leaf extract; Also can be with the granule that makes through further tabletting, drying promptly makes the medicine of the Tabules that contains 25% Radix Lamiophlomidis Rotatae stem and leaf extract.
Embodiment seven promotes the Duyiwei total flavone slow releasing tablet of union of fracture
Get described Duyiwei total flavone 300g, other gets polyethylene 60g and preparation slow releasing tablet other pharmaceutic adjuvant commonly used, mix homogeneously, adopt existing slow releasing tablet preparation technology, granulate tabletting, drying promptly makes the medicine of the slow releasing tablet dosage form that contains the Radix Lamiophlomidis Rotatae stem and leaf extract.
Embodiment eight promotes the Duyiwei total flavone injection of union of fracture
Get described Duyiwei total flavone 50g, be dissolved in the 10000ml water for injection, adopt existing process for preparation of injection, promptly make the injection (containing transfusion) of 5mg/ml.
Claims (6)
1, the application of Duyiwei total flavone in the medicine of preparation promotion union of fracture.
2, the application of Duyiwei total flavone according to claim 1 in the medicine of preparation promotion union of fracture, it is characterized in that: described Duyiwei total flavone comprises flavone aglycone and/or flavonoid glycoside.
3, the application of Duyiwei total flavone according to claim 2 in the medicine of preparation promotion union of fracture, it is characterized in that: described flavone aglycone comprises one or more in luteolin, Quercetin and the isorhamnetin.
4, the application of Duyiwei total flavone according to claim 1 in the medicine of preparation promotion union of fracture, it is characterized in that: described medicine is the medicine of oral administration.
5, the application of Duyiwei total flavone according to claim 1 in the medicine of preparation promotion union of fracture, it is characterized in that: described medicine is the medicine of drug administration by injection.
6, the application of Duyiwei total flavone according to claim 1 in the medicine of preparation promotion union of fracture, it is characterized in that: described medicine is the medicine of topical administration.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610020340 CN101023981A (en) | 2006-02-23 | 2006-02-23 | Use of total flavone of lamiophlomis rotata leaf-stem in preparing medicine for promoting healing of bone fracture |
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| CN 200610020340 CN101023981A (en) | 2006-02-23 | 2006-02-23 | Use of total flavone of lamiophlomis rotata leaf-stem in preparing medicine for promoting healing of bone fracture |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105132172A (en) * | 2015-08-28 | 2015-12-09 | 安徽中烟工业有限责任公司 | Method for preparing orris root flavonoid matter for tobaccos from orris roots |
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2006
- 2006-02-23 CN CN 200610020340 patent/CN101023981A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105132172A (en) * | 2015-08-28 | 2015-12-09 | 安徽中烟工业有限责任公司 | Method for preparing orris root flavonoid matter for tobaccos from orris roots |
| CN105132172B (en) * | 2015-08-28 | 2019-06-18 | 安徽中烟工业有限责任公司 | A method of preparing tobacco orrisroot Flavonoid substances from orrisroot |
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