CN101015510A - Macromolecular solid buccal mouth smell refreshing agent for eliminating peculiar smell of oral cavity - Google Patents
Macromolecular solid buccal mouth smell refreshing agent for eliminating peculiar smell of oral cavity Download PDFInfo
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- CN101015510A CN101015510A CN 200710086472 CN200710086472A CN101015510A CN 101015510 A CN101015510 A CN 101015510A CN 200710086472 CN200710086472 CN 200710086472 CN 200710086472 A CN200710086472 A CN 200710086472A CN 101015510 A CN101015510 A CN 101015510A
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Abstract
The invention relates to solid gel-type stabile chlorine dioxide slow releasing system with chitosan starch aqueous solution as tunica externa. The system can eliminate foreign flavor in mouth rapidly with easy residue clearing.
Description
It is that carrier is an adsorbed film with mouth soluble chitosan and starch that technical field the present invention relates to the polyvinyl alcohol gel, anhydrous crystal maltose is sugar-coat, with organic acid such as citric acids is the gel type solid stability chlorine dioxide slow-releasing system of activator, counteract oral malodour fast when sucking.
After the background technology stable ClO 2 solution is activated, have deodorization functions, U.S. Pat 4925656 has illustrated this solution concentration, using method, the scope of application and result of use.But the activation after the stability chlorine dioxide instability, easily decompose volatile, and United States Patent (USP) is a water quality, using needs container to deposit, and use extensively, and give the various chewing gum of counteract oral malodour function, need not stopping to chew to keep breath freshening, and the environmental pollution that its residue causes is difficult to thorough removing, a little one-tenth world-famous puzzles.
Summary of the invention the present invention proposes a kind of gel-type oral type compositions of counteract oral malodour fast.(used material umber and percent concentration are all by weight in the present invention).
With the 0.01%-0.1% stable ClO 2 solution is solvent, is alcoholysis degree 87%-89% structural formula:
Polyvinyl alcohol is configured to the poly-vinyl alcohol solution of 7%-20%, and accounting for this solution 1%-2%, molecular formula is C successively
6H
8O
7Citric acid and account for this solution 1%-5% powdered activated carbon and add this solution (active carbon can strengthen the intensity of gel), with well-known poly-vinyl alcohol solution freezing and crystallizing method this solution is made water-fast gel, meanwhile molecular weight 10,000 to 50,000, deacetylation 50%-90% structural formula is:
Chitosan be dissolved in the 0.2%-2% aqueous citric acid solution, make the chitosan aqueous solution of 1%-3% concentration, add and to account for this solution weight 1%, molecular formula is C
17H
35The stearic acid of COOH to reduce the breathability and the tensile strength of chitosan film, is (C with general molecular formula in addition
6H
10O
5)
nStarch joins the starch solution of making 2%-5% in the pure water, be heated to 90 ℃, treat after the starch solution gelatinizing two kinds of solution be chitosan solution and starch solution by 1: 1-2: 1 mixed (title mixed liquor), stir, temperature is reduced to 45 ℃, after preceding made polyvinyl alcohol gel being dipped this mixed solution or this mixed solution being sprayed to gel surface film forming to be dried, this process repeats 1-5 time, and dry back gel surface forms the transparent adsorbed film of being made up of chitosan and starch solution.For stoping moisture and the impurity in the chitosan film absorbed air, also need to wrap the 1-3 layer again by molecular formula: C at the chitosan film skin
12H
22O
11The sugar-coat made of anhydrous crystal maltose, anhydrous crystal maltose is dissolved in pure water, the syrup of 30%-50% concentration is made in heating, adding the citric acid that accounts for this syrup weight 0.2%-2% stirs, be cooled to 45 ℃, again the gel outer surface that is surrounded by chitosan film wrapped 1-3 layer sugar-coat again with the well-known sugar coating method of pharmaceutical field.Since on the chitosan molecule chain by numerous amino and hydroxyl, so chemisorbed type of having outstanding performance, the chlorine dioxide that the activation back discharges is adsorbed on the chitosan film, after citric acid when sucking in the sugar-coat and chitosan film mix, chitosan film is dissolved in the oral cavity, the chlorine dioxide that is adsorbed on the film is released in the oral cavity immediately, and halitosis can be disappeared from common people's olfactory sensation thereupon, and residue does not have adhesive and removes easily.
Acidic activator of the present invention also useful molecules formula is C
3H
6O
3L-lactic acid, molecular formula is C
4H
6O
6Tartaric acid, molecular formula is C
4H
6O
5Malic acid, molecular formula is C
4H
4O
4Fumaric acid substitute, consumption and using method and citric acid are same.
The specific embodiment
Embodiment 1
Get the chitosan of 2 weight portions and the stearic acid that has melted of 1 weight portion, join in the aqueous citric acid solution of 0.5%-1% concentration of 98 weight portions, be heated to the chitosan dissolving, the starch of getting two weight portions simultaneously joins and is heated to 90 ℃ in the pure water of 98 weight portions and treats after the starch gelatinization temperature to be reduced to 45 ℃, the mixed of two kinds of solution by 1: 1 stirred, meanwhile the anhydrous crystal maltose of 30 weight portions is joined in the pure water of 70 weight portions, the citric acid that adds 1 weight portion again, syrup is made in the heating that stirs, meanwhile 0.75 gram polyvinyl alcohol is dissolved in 6.75 grams, the 0.1% steady concentration ClO 2 solution, the citric acid that adds 75 milligrams, add 75 milligrams of powdered activated carbons again, stir, with freeze crystallization this solution is made water-fast gel, this gel is dipped behind preceding prepared chitosan and starch mixing fluid drying, gel surface forms hyaline membrane, after this process repeated 5 times, prepared anhydrous crystal maltose syrup sugar coating was 2 layers before the reuse.
Embodiment 2
0.5 gram polyvinyl alcohol is dissolved in 4.5 grams, the 0.1% steady concentration ClO 2 solution, add 50 milligrams of citric acids, the powdered activated carbon that adds 50 milligrams again stirs, produce process by embodiment 1 described gel this solution is made water-fast gel, produce chitosan and starch mixed liquor and anhydrous crystal maltose syrup by embodiment 1 described process again, polyvinyl alcohol gel is pressed embodiment 1 described process successively involucrum polysaccharide film and sugar-coat.When sucking, halitosis is disappeared thereupon from common people's olfactory sensation, its residue does not have adhesive and removes easily.
Claims (4)
1. deacetylation 50%-90%, molecular weight 10,000-50,000, structural formula is:
Molecular formula in 0.2%-2% is C
6H
8O
7Aqueous citric acid solution in, make the chitosan aqueous solution of 1%-3%, adding the molecular formula that accounts for this solution weight 1% is C
17H
35The stearic acid of COOH is (C with the 2%-5% general molecular formula again
6H
10O
5)
nAmidin through heating gelatinizing is by 1: 1-1: 2 mixed stirs, claim the chitosan amidin, and cool the temperature to 45 ℃ standby, be the stable ClO 2 solution by 0.01%-0.1% solvent simultaneously, the polyvinyl alcohol of alcoholysis degree 87%-89% is mixed with the poly-vinyl alcohol solution of 7%-20%, and adding successively accounts for the citric acid and the powdered activated carbon that accounts for this solution weight 1% of this solution weight 1%-2%, make water-fast through freezing and crystallizing, volume is at the polyvinyl alcohol gel of 5-10ml, after in the chitosan amidin, dipping drying and forming-film, this is dipped process and repeats 1-10 time, reuse concentration is the anhydrous crystal maltose syrup of 30%-50%, wherein include the citric acid that accounts for this syrup weight 0.2%-2%, sugar coating 1-3 layer.
2. the packing adventitia that can be used for the Pickering chlorine dioxide according to the described compositions chitosan of claim 1.
3. can be used as the adsorbing medium of chlorine dioxide according to the chitosan in the described compositions of claim 1.
4. but counteract oral malodour when sucking according to the described compositions of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100864723A CN101015510B (en) | 2007-03-13 | 2007-03-13 | Preparation method of macromolecular solid buccal mouth smell refreshing agent for eliminating peculiar smell of oral cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100864723A CN101015510B (en) | 2007-03-13 | 2007-03-13 | Preparation method of macromolecular solid buccal mouth smell refreshing agent for eliminating peculiar smell of oral cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101015510A true CN101015510A (en) | 2007-08-15 |
| CN101015510B CN101015510B (en) | 2010-11-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100864723A Expired - Fee Related CN101015510B (en) | 2007-03-13 | 2007-03-13 | Preparation method of macromolecular solid buccal mouth smell refreshing agent for eliminating peculiar smell of oral cavity |
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| CN (1) | CN101015510B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106476380A (en) * | 2016-09-30 | 2017-03-08 | 广西大学 | A kind of preparation technology of slow released ClO 2 antibacterial film |
| CN112043678A (en) * | 2020-09-18 | 2020-12-08 | 福州爱建生物科技有限公司 | Oral cavity peculiar smell self-receptor |
-
2007
- 2007-03-13 CN CN2007100864723A patent/CN101015510B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106476380A (en) * | 2016-09-30 | 2017-03-08 | 广西大学 | A kind of preparation technology of slow released ClO 2 antibacterial film |
| CN106476380B (en) * | 2016-09-30 | 2018-04-17 | 广西大学 | A kind of preparation process of slow released ClO 2 antibacterial film |
| CN112043678A (en) * | 2020-09-18 | 2020-12-08 | 福州爱建生物科技有限公司 | Oral cavity peculiar smell self-receptor |
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| Publication number | Publication date |
|---|---|
| CN101015510B (en) | 2010-11-10 |
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Granted publication date: 20101110 Termination date: 20140313 |