CN101000689A - Contour projection method of tumour 3D anatomy structure in radiotherapy plan system - Google Patents
Contour projection method of tumour 3D anatomy structure in radiotherapy plan system Download PDFInfo
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- CN101000689A CN101000689A CN 200610022710 CN200610022710A CN101000689A CN 101000689 A CN101000689 A CN 101000689A CN 200610022710 CN200610022710 CN 200610022710 CN 200610022710 A CN200610022710 A CN 200610022710A CN 101000689 A CN101000689 A CN 101000689A
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Abstract
A method for obtaining projected outline of tumour3-D dissection structure in radiotherapy system includes projecting tumour3-D dissection structure onto projection plane to set up label image, mapping projection line section obtained from projection plane on said label image to obtain binary label image by drawing lines on label image, carrying out scan-search on pixel point of binary label image according to specified direction to confirm initial outline then tracking each outline point to obtain projection outline of tumour 3-D dissection structure.
Description
Technical field
The present invention relates to a kind of graphic processing method, particularly a kind of contour projection method that in radiotherapy treatment planning system, obtains tumour 3 D anatomy structure.
Background technology
At present, utilize radioactive ray to kill or suppress one of basic means that malignant tumour is the treatment cancer patient, the expert estimates that nearly 70% tumour patient need accept radiation therapy.Radiocurable target is ray to be focused on to kill tumour cell in the diseased region to greatest extent, and makes normal surrounding tissue and organ be subjected to maximum protection.3 dimensional conformal radiation therapy is by adopting stereotaxic technique, the irregular wild irradiation of the non-coplanes of technology implementation such as the lead of additional special shape or multi-diaphragm collimator on therapy apparatus, it is consistent with target region shape that the shape of each irradiation field is observed on the BEV at bundle, makes the isodose surface target area of linking closely on three-dimensional spatial distribution.Target region shape is the contour projection of target area on BEV.
The checking of traditional launched field design is to carry out on analog machine Simulator, and by the film that obtains on the analog machine, whether the check launched field is feasible.The defective that this simulation process exists is: whole simulation process, comprise frame, the placement of the sick bed anglec of rotation, and operation such as film production is very consuming time; Itself there is the blind area in the x actinoscopy X, as liver, spleen etc., adds that many tumours are positioned at human body than the depths, makes target area and vitals be difficult to accurate location on film, thereby influences the acquisition of optimum radiotherapy planning.Because the gray scale of CT image is directly corresponding with tissue density, utilize the CT image sequence data, projection algorithm by complexity, can obtain the X film image that the traditional X-ray ray machine produces on computers, finish the proof procedure of analog machine, this is called as empty simulation, and English is Virtual Simulator.Its output image is exactly DRR, and English is Digitally Reconstructed Radiograph.Empty simulation can realize interactively launched field design and checking.Usually need to show simultaneously the corresponding projection of vitals, tumour target area on the DRR image, this also needs to calculate its contour projection.
Be being the body surface that unit constitutes in radiotherapy treatment planning system, express 3 D anatomy structure by triangular plate.With 3 D anatomy structure projection on projection plane, its contour projection is for surrounding the maximum outline of view field.
The human organ complex structure, the triangular plate quantity that constitutes organ surface is very big usually, and projection plane, projecting direction all have very big arbitrariness, therefore adopts the graphics method to calculate contour projection and has suitable complicacy.
Summary of the invention
The objective of the invention is: provide a kind of contour projection method that in radiotherapy treatment planning system, obtains tumour 3 D anatomy structure, to realize the suitable shape design and the checking of irradiation field.
Obtain the contour projection method of tumour 3 D anatomy structure in the radiotherapy treatment planning system, may further comprise the steps:
A) tumour 3 D anatomy structure that will represent with the triangular plate structure projects to and sets up marking image on the projection plane;
B) with the projection line segment on each every limit of triangular plate of obtaining on the projection plane, be mapped to setting-out on the marking image, the pixel zone that obtains having mark forms the two-value marking image;
C) on the two-value marking image, pixel direction is in accordance with regulations carried out scanning search, determine initial profile point after, carry out each point and follow the tracks of, to obtain the contour projection of tumour 3 D anatomy structure.
Advantage of the present invention is: with setting-out and contour tracing method replaced in the prior art to projection line intersegmental ask complex calculation such as friendship, ordering, choice, thereby a large amount of computing times have been saved, have very high applicability, be the clinical practice of the radiotherapy treatment planning system condition of providing convenience.
Description of drawings
Fig. 1 is to be the tumour 3 D anatomy structure that unit constitutes with the triangular plate
Fig. 2 is projected coordinate system and marking image;
Fig. 3 is the process flow diagram of picture projection line segment;
Fig. 4 is the marking image after the setting-out;
Fig. 5 is a direction chain code synoptic diagram;
Fig. 6 is that profile is followed the tracks of synoptic diagram;
Fig. 7 is a contour projection.
Embodiment
Below in conjunction with accompanying drawing, be described in detail in the radiotherapy treatment planning system, obtain the contour projection method of tumour 3 D anatomy structure:
Step 1: the tumour 3 D anatomy structure that will represent with the triangular plate structure projects to and sets up marking image on the projection plane;
Fig. 1 is to be the tumour 3 D anatomy structure that unit makes up with the triangular plate, and Fig. 2 is projected coordinate system and marking image.In Fig. 2, be XOY plane with the projection plane, be that the central shaft of launched field is the Z axle with projecting direction, set up projected coordinate system.The bounding box (described bounding box promptly is the minimum rectangular parallelepiped that surrounds tumour 3 D anatomy structure) of tumour 3 D anatomy structure 1 is projected to the XOY plane of projected coordinate system, obtain a maximum rectangular area 2 that surrounds, set up the marking image that adapts with this rectangular area 2 sizes, this image origin (coordinate is the pixel of [0,0]) is in the upper left corner 3 of rectangular area.
Step 2: with the projection line segment on each every the limit of triangular plate on the projection plane, be mapped to the pixel zone that setting-out on the marking image obtains having mark, form the two-value marking image;
Fig. 3 is the process flow diagram of picture projection line segment.Among the figure, draw the flow process of projection line segment, two summits of triangular plate are projected to XOY plane, just can obtain two end points of projection line segment according to this.Then these two end points are mapped on the marking image, and setting-out on marking image, the pixel of its process is done mark, obtain having the pixel zone of mark, form the two-value marking image;
Concrete grammar is:
First step ST1: calculate the coordinate of summit under projected coordinate system of all triangular plates, pending triangular plate sequence number n is placed reference position 0;
The second step ST2: begin to handle the triangular plate that sequence number is n, m places article one limit 0 with its three arms of angle sequence number;
The 3rd step ST3: the m bar limit that begins to handle current triangular plate;
The 4th step ST4: the mapping point and the setting-out of calculating this limit end points of projection line section on marking image;
The 5th step ST5: judge that this triangular plate has not setting-out of limit or not? if have, m points to next bar limit (m adds 1), and returns for the 3rd step ST3 step; If no, promptly m=3 enters next step;
The 6th step ST6: judge that having triangular plate or not is untreated? if have, n points to next triangular plate (n adds 1), and returns for the second step ST2 step; If no, promptly all triangular plates are all handled, draw the projection line segment and finish.
Fig. 4 is the marking image after the setting-out, and it is that the pixel value of the pixel crossed of a width of cloth mark is 1, and the pixel value of other pixel is 0 bianry image.
Step 3: on the two-value marking image, pixel direction is in accordance with regulations carried out scanning search, determine to carry out each point tracking behind the initial profile point, to obtain the contour projection of tumour 3 D anatomy structure.
On how much, has topological consistance owing to constitute the triangular plate of 3 D anatomy structure, on through the marking image after the setting-out operation, scribble the zone that pixel constituted that mark is crossed, corresponding to the view field of tumour 3 D anatomy structure, its outermost edge is exactly a contour projection.
In embodiments of the present invention, provided a profile track algorithm that can be adapted to arbitrary shaped region.This algorithm is based on the thought of direction chain code, and Fig. 5 has provided the synoptic diagram of direction chain code.As can be seen from the figure: for any pixel P, 8 pixels that it is contiguous can be represented with eight basic orientation 0,1,2,3,4,5,6,7 of direction chain code.
If R is join domain in the bianry image, and the gray scale of each pixel is that pixel value is 1 on the zone, the frontier point of R is defined as pixel such among the R, has at least a point to be the pixel in R not in its 8 neighborhoods, and all set of these frontier points promptly constitute the outline line of region R.
Definition: direction is the current direction in the search procedure.Its span is 0,1,2,3,4,5,6,7, corresponds respectively to 8 directions of the direction chain code of Fig. 5 pixel P.
Fig. 6 is that profile is followed the tracks of synoptic diagram.Tracking is as follows:
The first step: search initial profile point; The two-value marking image is scanned each pixel from top to bottom, from left to right, is point up to finding a pixel, with this initial point as the profile tracing process, and the direction of regulation scanning search;
Second step: scan current profile neighborhood of a point point; With direction is the direction of scanning, by counterclockwise testing the neighborhood territory pixel point of current point one by one, it is that 0 neighborhood territory pixel point is not next point that all scanning obtains pixel value, having only scanning to obtain pixel value is that 1 neighborhood territory pixel point is only the point that finds, and repeats this can find a series of pixels with the process of combining point P
nRegulation is by counterclockwise direction of travel search, the direction of subsequent direction of scanning direction capture vegetarian refreshments contiguous chain code 5 1. in this example;
The 3rd step: the point of this target area of obtaining of test whether be initial profile point 1., if this profile tracing process finishes, follow the tracks of all point formation outline lines that obtain; If this point be not initial profile point 1., then with this point as the search next point starting point, repeat second the step.
With Fig. 6 is that the concrete practice of example is as follows:
1) Fig. 6 is scanned each pixel from top to bottom, from left to right, up to finding a pixel 1. to be point, with this starting point as the profile tracing process;
2) shown in Figure 5 by the direction chain code, 1. be initial according to pixel among Fig. 6, the direction direction of its scanning search gets the direction of this pixel contiguous chain code value 5 1., scanned the corresponding pixel points among Fig. 6 2., because of its pixel value is 0 (unmarked mistake), 2. pixel is not point, is skipped;
3) then direction by counterclockwise according to the direction of this pixel contiguous chain code value 6 1., the corresponding pixel points in the scintigram 6 3., its pixel value is 1 (mark is crossed), so be the target area point, is accepted as point;
4) again with pixel 3. as new profile trace point, initial direction of scanning direction gets the direction of this pixel contiguous chain code value 5 3., the scanning neighboring pixel 4., because of its pixel value is 0 (unmarked mistake), so 4. this pixel is not point;
5) then 5. direction scans next pixel by the direction of getting this pixel contiguous chain code value 6 3. counterclockwise, and its pixel value is 0, and 5. pixel is not point;
6) 6. direction by the direction of getting this pixel contiguous chain code value 7 3. counterclockwise, scans next pixel again, and its pixel value is 1, and 6. this pixel is point;
7) 7. direction by the direction of getting this pixel contiguous chain code value 5 6. counterclockwise, scans next pixel again, and its pixel value is 0, and 7. this pixel is not point;
8) 8. direction by the direction of getting this pixel contiguous chain code value 6 6. counterclockwise, scans next pixel again, and its pixel value is 0, and 8. this pixel is not point;
9) 9. direction by the direction of getting this pixel contiguous chain code value 7 6. counterclockwise, scans next pixel again, and its pixel value is 0, and 9. this pixel is not point;
10) 10. direction by the direction of counterclockwise capture vegetarian refreshments contiguous chain code value 0 6., scans next pixel again, and its pixel value is 1, and 10. this pixel is point;
11) direction by the direction of counterclockwise capture vegetarian refreshments contiguous chain code value 7 10., scans next pixel again, and its pixel value is 0, and this pixel is not a point;
12) direction by the direction of counterclockwise capture vegetarian refreshments contiguous chain code value 0 10., scans next pixel again, and its pixel value is 0, and this pixel is not a point;
13) direction by the direction of counterclockwise capture vegetarian refreshments contiguous chain code value 1 10., scans next pixel again, and its pixel value is 1, and pixel is a point;
14) direction presses the direction of the contiguous chain code value 7 of counterclockwise capture vegetarian refreshments again, scans next pixel , and its pixel value is 0, and this pixel is not a point;
15) direction presses the direction of the contiguous chain code value 0 of counterclockwise capture vegetarian refreshments again, scans next pixel , and its pixel value is 0, and this pixel is not a point;
16) direction presses the direction of the contiguous chain code value 1 of counterclockwise capture vegetarian refreshments again, scans next pixel , and its pixel value is 0, and this pixel is not a point;
17) direction presses the direction of the contiguous chain code value 2 of counterclockwise capture vegetarian refreshments again, scans next pixel
Its pixel value is 0, this pixel
It or not point;
18) direction presses the direction of the contiguous chain code value 3 of counterclockwise capture vegetarian refreshments again, scans next pixel
Its pixel value is 1, this pixel
It is point;
19) direction is again by counterclockwise capture vegetarian refreshments
The direction of contiguous chain code value 1, scan next pixel
Its pixel value is 0, this pixel
It or not point;
20) direction is again by counterclockwise capture vegetarian refreshments
The direction of contiguous chain code value 2, scan next pixel
Its pixel value is 0, this pixel
It or not point;
21) direction is again by counterclockwise capture vegetarian refreshments
The direction of contiguous chain code value 3, scan next pixel
Its pixel value is 0, this pixel
It or not point;
22) direction is again by counterclockwise capture vegetarian refreshments
The direction of contiguous chain code value 4, scan next pixel
Its pixel value is 1, this pixel
It is point;
23) direction is again by counterclockwise capture vegetarian refreshments
The direction of contiguous chain code value 3, scan next pixel
Its pixel value is 0, this pixel
It or not point;
24) direction is again by counterclockwise capture vegetarian refreshments
The direction of contiguous chain code value 4, scan next pixel
Its pixel value is 1, this pixel
It is point; Because pixel
1. overlapping with pixel is a pixel, therefore by pixel 1., pixel 3., pixel 6., pixel 10., pixel , pixel
Pixel
Each point has been formed the tumor structure outline line on the marking image.
From last example as can be seen: on marking image pixel being carried out profile spotting scaming method, promptly is the pixel P that searches for some
n, when determining that it is current point, track-while-scan work down promptly is the direction of search in accordance with regulations, scans this pixel P
nAround contiguous 8 pixels, it is that 0 pixel is not next point that all scanning obtains pixel value, having only the scanning element value is that 1 pixel is only next point, subsequent profile spotting scaming process, be to be sweep starting point with new point, 8 contiguous around it pixels are tested one by one as sweep object, pixel value by its test is determined next point, repeat this process, coincide and obtain outline line up to last point that searches out and initial profile point.Fig. 7 is the contour projection that obtains after following the tracks of, and this contour projection is the contour projection of target area.
Claims (1)
1, obtain the method for 3 D anatomy structure contour projection in the radiotherapy treatment planning system, may further comprise the steps:
Step 1, the tumour 3 D anatomy structure that will represent with the triangular plate structure projects to and sets up marking image on the projection plane;
Step 2 with the projection line segment on each every the limit of triangular plate on the projection plane, is mapped to the pixel zone that setting-out on the marking image obtains having mark, forms the two-value marking image;
Step 3 is carried out scanning search to pixel direction in accordance with regulations on the two-value marking image, determine to carry out each point tracking behind the initial profile point, to obtain the contour projection of tumour 3 D anatomy structure; Wherein the concrete practice of step 1 is:
At first, making with the triangular plate is the tumour 3 D anatomy structure that unit constitutes;
Then, on projection plane, be that the central shaft of launched field is the Z axle with projecting direction, set up projected coordinate system;
Then, the bounding box of tumour 3 D anatomy structure is projected on the XOY plane of projected coordinate system, obtain a maximum rectangular area that surrounds, thereby set up the marking image that adapts with this rectangular area size;
The concrete practice of step 2 is:
First step ST1: calculate the coordinate of summit under projected coordinate system of all triangular plates, the triangular plate number n is placed 0;
The second step ST2: choose n triangular plate, m is counted on the bar limit place 0;
The 3rd step ST3: the m bar limit of choosing current triangular plate;
The 4th step ST4: the mapping point and the setting-out of calculating this limit projection line section end points on marking image;
The 5th step ST5: judge that this triangular plate has not setting-out of limit or not? if there is m to add 1, and returned for the 3rd step ST3 step; If no, promptly m=3 entered for the 6th step;
The 5th step ST6: judge to have not setting-out of triangular plate or not? if there is n to add 1, and returned for the second step ST2 step; If no, promptly n equals the number of all triangular plates, draws the projection line segment and finishes.
The concrete practice of step 3 is:
The first step, search initial profile point; The two-value marking image is scanned each pixel from top to bottom, from left to right, is point up to finding a pixel, with this initial profile point as the profile tracing process, and the direction of regulation scanning search;
In second step, scan current profile neighborhood of a point point; With direction is the direction of scanning, by counterclockwise testing the neighborhood territory pixel point of current point one by one, it is that 0 neighborhood territory pixel point is not next point that all scanning obtains pixel value, having only the scanning element value is that 1 neighborhood territory pixel point is only the point that finds, and repeats this can find a series of pixels with the process of combining point P
n
The 3rd step: the point P of this target area that test obtains
nWhether be the initial profile point,, follow the tracks of all point that obtain and constitute outline line if this profile tracing process finishes; If this point P
nNot the initial profile point, then with this point P
nAs the starting point of the next point of search, repeated for second step.
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