CN100999541A - Synthesizing process of fluorine propionate ticasone - Google Patents
Synthesizing process of fluorine propionate ticasone Download PDFInfo
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Abstract
The present invention relates to new technological process of converting carboxylic acid into thiocarboxylic acid, and is especially synthesis process of fluticasone acetate. The present invention prepares fluticasone acetate with medicinal level flumethasone as initial material and through one of six technological paths, and has the advantages of short reaction path, high yield, simple reaction condition, high product purity, low cost, etc.
Description
Technical field
The invention discloses the operational path of preparing fluticasone propionate from the fluorine compound of cheapness, relate to a kind of novel process that carboxylic acid is changed into thiocarboxylic acid.
Background technology
Fluticasone propionate is used for the treatment of gently, moderate and severe chronic asthma, can prevent and treat seasonal allergic rhinitis (comprising spring fever) and catarrhus perennialis, is the choice drug of treatment chronic asthma.Existing product relies on import, and to making quality product, price limited, production cost is high.
Summary of the invention
It is the synthetic method that opens the fluticasone propionate of beginning raw material that the object of the invention is to invent with fluorine compound.
The present invention program has six kinds:
One may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under 30～40 ℃ of conditions, generates 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid with sodium periodate or Periodic acid solution reaction;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the acetone, under the nitrogen protection condition, at 30～40 ℃, add N successively under stirring, the N-dimethyl sulphide is for urea chloride, diisopropyl ethyl amine and potassiumiodide, stir, generate 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid adds in the methylene dichloride, nitrogen protection and stirring are down, reaction solution is cooled to 5 ℃ ± 1 ℃, add triethylamine, drip the mixed solution of propionyl chloride and methylene dichloride, continue to stir after 3 hours and add diethylamine, after continuing to be stirred to reaction and finishing, adding methylene dichloride makes reactant molten entirely, tell organic phase, use sodium carbonate solution respectively, the hydrochloric acid soln washing is washed with water to pH7 ± 1 again, dry, decompression gets little yellow solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid;
4) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid is dissolved in the ethyl acetate, stirs and is cooled to 0 ℃ ± 1 ℃, under the salt of wormwood katalysis, reacts with Bromofluoromethane; After reaction finishes, add sodium carbonate solution, ethyl acetate, standing demix is told organic phase; The water ethyl acetate extraction merges organic liquor, and drying makes the fluticasone propionate crude product;
5) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
It two may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under 30～40 ℃ of conditions, generates 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid with sodium periodate or Periodic acid solution reaction;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the dimethyl formamide, in the nitrogen protection condition,, stir adding carbonylic imidazole down at 30～40 ℃, stirring reaction, reaction solution is cooled to 0 ℃ ± 2 ℃, feeds hydrogen sulfide, continues to stir, after question response finishes, elimination insolubles, filtrate are poured in the frozen water of hydrochloric acid soln, generate white depositions, after filtration, be washed with water to pH7 ± 1, drying under reduced pressure makes 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid adds in the methylene dichloride, nitrogen protection and stirring are down, reaction solution is cooled to 5 ℃ ± 1 ℃, add triethylamine, drip the mixed solution of propionyl chloride and methylene dichloride, continue to stir after 3 hours and add diethylamine, after continuing to be stirred to reaction and finishing, adding methylene dichloride makes reactant molten entirely, tell organic phase, use sodium carbonate solution respectively, the hydrochloric acid soln washing is washed with water to pH7 ± 1 again, dry, decompression gets little yellow solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid;
4) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid is dissolved in the ethyl acetate, stirs and is cooled to 0 ℃ ± 1 ℃, under the salt of wormwood katalysis, reacts with Bromofluoromethane; After reaction finishes, add sodium carbonate solution, ethyl acetate, standing demix is told organic phase; The water ethyl acetate extraction merges organic liquor, and drying makes the fluticasone propionate crude product;
5) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
It three comprises following steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under the effect of catalyzer alkali, uncovered being exposed in the air, 30～40 ℃ were stirred 3～4 days, and made 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the acetone, under the nitrogen protection condition, at 30～40 ℃, add N successively under stirring, the N-dimethyl sulphide is for urea chloride, diisopropyl ethyl amine and potassiumiodide, stir, generate 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid adds in the methylene dichloride, nitrogen protection and stirring are down, reaction solution is cooled to 5 ℃ ± 1 ℃, add triethylamine, drip the mixed solution of propionyl chloride and methylene dichloride, continue to stir after 3 hours and add diethylamine, after continuing to be stirred to reaction and finishing, adding methylene dichloride makes reactant molten entirely, tell organic phase, use sodium carbonate solution respectively, the hydrochloric acid soln washing is washed with water to pH7 ± 1 again, dry, decompression gets little yellow solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid;
4) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid is dissolved in the ethyl acetate, stirs and is cooled to 0 ℃ ± 1 ℃, under the salt of wormwood katalysis, reacts with Bromofluoromethane; After reaction finishes, add sodium carbonate solution, ethyl acetate, standing demix is told organic phase; The water ethyl acetate extraction merges organic liquor, and drying makes little fluticasone propionate crude product;
5) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
It four may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under the effect of catalyzer alkali, uncovered being exposed in the air, 30～40 ℃ were stirred 3～4 days, and made 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the dimethyl formamide, in the nitrogen protection condition,, stir adding carbonyl dimidazoles down at 30～40 ℃, stirring reaction, reaction solution is cooled to 0 ℃ ± 2 ℃, feeds hydrogen sulfide, continues to stir, after question response finishes, elimination insolubles, filtrate are poured in the frozen water of hydrochloric acid soln, generate white depositions, after filtration, be washed with water to pH7 ± 1, drying under reduced pressure makes 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid adds in the methylene dichloride, nitrogen protection and stirring are down, reaction solution is cooled to 5 ℃ ± 1 ℃, add triethylamine, drip the mixed solution of propionyl chloride and methylene dichloride, continue to stir after 3 hours and add diethylamine, after continuing to be stirred to reaction and finishing, adding methylene dichloride makes reactant molten entirely, tell organic phase, use sodium carbonate solution respectively, the hydrochloric acid soln washing is washed with water to pH7 ± 1 again, dry, decompression gets little yellow solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid;
4) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid is dissolved in the ethyl acetate, stirs and is cooled to 0 ℃ ± 1 ℃, under the salt of wormwood katalysis, reacts with Bromofluoromethane; After reaction finishes, add sodium carbonate solution, ethyl acetate, standing demix is told organic phase; The water ethyl acetate extraction merges organic liquor, and drying makes the fluticasone propionate crude product;
5) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
It five may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under 30～40 ℃ of conditions, generates 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid with sodium periodate or Periodic acid solution reaction;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the methylene dichloride, nitrogen protection and stirring are cooled to 5 ℃ ± 1 ℃ with reaction solution, in triethylamine and diethylamine katalysis down, drip the mixed solution of propionyl chloride and methylene dichloride, be stirred to reaction and finish; Adding methylene dichloride makes reactant molten entirely, tell organic phase, respectively with sodium carbonate solution, hydrochloric acid soln washing, be washed with water to pH7 ± 1 again, drying makes white solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid is dissolved in the ethyl acetate, stirring is cooled to-25 ℃ ± 2 ℃, under the katalysis of 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide salt hydrochloric acid or carbonyl dimidazoles, react to finishing with the fluoro thiomethyl alcohol; Add sodium hydrogen carbonate solution and ethyl acetate, standing demix is told organic phase, and the water ethyl acetate extraction with organic liquor drying, decompression, makes the fluticasone propionate crude product;
4) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
It six may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under the effect of catalyzer alkali, uncovered being exposed in the air, 30～40 ℃ were stirred 3～4 days, and made 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the methylene dichloride, nitrogen protection and stirring are cooled to 5 ℃ ± 1 ℃ with reaction solution, in triethylamine and diethylamine katalysis down, drip the mixed solution of propionyl chloride and methylene dichloride, be stirred to reaction and finish; Adding methylene dichloride makes reactant molten entirely, tell organic phase, respectively with sodium carbonate solution, hydrochloric acid soln washing, be washed with water to pH7 ± 1 again, drying makes white solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid is dissolved in the ethyl acetate, stirring is cooled to-25 ℃ ± 2 ℃, under the katalysis of 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide salt hydrochloric acid or carbonyl dimidazoles, react to finishing with the fluoro thiomethyl alcohol; Add sodium hydrogen carbonate solution and ethyl acetate, standing demix is told organic phase, and the water ethyl acetate extraction with organic liquor drying, decompression, makes the fluticasone propionate crude product;
4) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
It is starting raw material that the present invention adopts the pharmaceutical grade fluorine compound, and by six kinds of operational paths, the preparation fluticasone propionate has the reaction scheme weak point, the yield height, and reaction conditions is easy, advantages such as cost, product yield height, purity height.
Embodiment
Embodiment one production step:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
At 30～40 ℃, in reaction flask, with fluorine compound (6 α, 9 alpha-difluoro-11 betas, 17 α-21-trihydroxy--16 Alpha-Methyls-3-pregnant steroid-1,4-diene-3,20-diketone) 4.590g (11mmol) is dissolved in tetrahydrofuran (THF) (50ml) and methyl alcohol (50ml) mixed solvent, stir and add sodium periodate solution (9.58g, 44.8mol are dissolved in the 40ml water) down.In 30～40 ℃ of stirrings 6 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, the reclaim under reduced pressure organic solvent, the reaction solution cooled and filtered gets white crystals shape solid, washes drying under reduced pressure with water.Obtain 4.39g white crystals shape solid, i.e. 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid, yield 99%.[α]
D 20+64.0°(c＝0.01DMF)。
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid (code name: Compound I I):
Compound (I) 5.18g (13.1mmol) is dissolved in (75ml) in the acetone; nitrogen protection; at 30～40 ℃; stir and add N down successively; the N-dimethyl sulphide is for urea chloride 4.06g (32.8mmol), and diisopropyl ethyl amine 2.52g (19.7mmol) reaches potassiumiodide 1.30g (7.8mmol); continue to stir 5 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, use dimethyl formamide (55ml) successively, and water (350ml) is handled, be cooled to about 0 ℃, continue to stir 1 hour, filter, leach thing and wash with water, drying under reduced pressure, get the 5024g white crystal, promptly prepare 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid, yield 97%.Crude product is directly used in the next step.[α]
D 20+93.0°(c＝0.01DMF)
3, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid (code name: compound III):
Compound (II) 4.53g (11mmol) is added in the 60ml methylene dichloride; nitrogen protection and stirring are down; reaction solution is cooled to 5 ℃ of right sides; add triethylamine 2.75g (27.5mmol); drip the mixed solution of propionyl chloride 2.53g (27.5mmol) and methylene dichloride; continue to stir adding diethylamine 2.86g (38.5mmol) after 3 hours, continue to stir 2 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, add methylene dichloride and make reactant molten entirely, tell organic phase, use the 2.0N sodium carbonate solution respectively, 2.0N the hydrochloric acid soln washing is washed with water to about pH7 drying again, the reclaim under reduced pressure methylene dichloride, the little yellow solid of 4.74g, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid, yield 92%.[[α]
D 20-30.0°(c＝0.005CH
2Cl
2)。
4, preparation androstane-1,4-diene-17-thiocarboxylic acid, 6,9-two fluoro-11-hydroxyls-16-methyl-3-oxo-17-(1-propionyloxy)-(6 α, 11 β, 16 α, 17 α)-, S-(methyl fluoride) ester, that is, and the fluticasone propionate crude product:
Compound (III) 4.23g (9mmol) is dissolved in the 80ml ethyl acetate, stirring is cooled to about 0 ℃, behind the adding salt of wormwood 2.52g (18mmol), adds Bromofluoromethane 3.04g (27mmol), continue stirring reaction about 6 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, add 5% sodium carbonate solution 100ml, continue to stir adding 150ml ethyl acetate after 2 hours, standing demix, tell organic phase, water extracts for three times with the 50ml ethyl acetate, merges organic liquor, drying, the reclaim under reduced pressure ethyl acetate gets micro white crude product fluticasone propionate.
5, make the fluticasone propionate elaboration:
Use acetone recrystallization.Drying under reduced pressure, the 3.42g white crystal, i.e. fluticasone propionate finished product, total recovery 76%.Measure purity 〉=99% with HPLC.[[α]
D 20+32.0°(c＝0.01CH
2Cl
2)。
Embodiment two production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
At 30～40 ℃, in reaction flask, with fluorine compound (6 α, 9 alpha-difluoro-11 betas, 17 α-21-trihydroxy--16 Alpha-Methyls-3-pregnant steroid-1,4-diene-3,20-diketone) 3.53g (8.6mmol) is dissolved in tetrahydrofuran (THF) (50ml) and methyl alcohol (50ml) mixed solvent, stir and add Periodic acid solution (6.60g, 34.4mmol are dissolved in the 60ml water) down.In 30～40 ℃ of stirrings 6 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, the reclaim under reduced pressure organic solvent, the reaction solution cooled and filtered gets white crystals shape solid, washes drying under reduced pressure with water.Obtain 3.34g white crystals shape solid, i.e. 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid.Yield 98%.[α]
D 20+64.0°(c＝0.01DMF)，
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid (code name: Compound I I):
With step 2 (summary) in the example one
3, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid (code name: compound III):
With step 3 (summary) in the example one
4, fluticasone propionate crude product:
With step 4 (summary) in the example one
5, make the fluticasone propionate elaboration:
With step 5 (summary) in the example one
Embodiment three production steps:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
At 30～40 ℃, in reaction flask, with fluorine compound (6 α, 9 alpha-difluoro-11 betas, 17 α-21-trihydroxy--16 Alpha-Methyls-3-pregnant steroid-1,4-diene-3, the 20-diketone) 3.98g (9.7mmol) is dissolved in tetrahydrofuran (THF) (50ml) and methyl alcohol (50ml) mixed solvent, adds catalyzer alkali, uncovered being exposed in the air, 30～40 ℃ were stirred 3～4 days, followed the tracks of reaction with thin-layer chromatography and finished.After reaction finishes, the reclaim under reduced pressure organic solvent, the reaction solution cooled and filtered gets white crystals shape solid, washes drying under reduced pressure with water.Obtain 3.78g white crystals shape solid, i.e. 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid.Yield 98.6%.[[α]
D 20+64.0°(c＝0.01DMF)。
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid (code name: Compound I I):
With step 2 (summary) in the example one
3, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid (code name: compound III):
With step 3 (summary) in the example one
4, fluticasone propionate crude product:
With step 4 (summary) in the example one
5, make the fluticasone propionate elaboration:
With step 5 (summary) in the example one
Embodiment four production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
With step 1 (summary) in the example one
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid (code name: Compound I I):
Compound (I) 15.8g (0.04mol) is dissolved in (150ml) in the dimethyl formamide; nitrogen protection; at 30～40 ℃; stir and add carbonyl dimidazoles (CDI) 13.0g down; continue to stir 5 hours, reaction solution is cooled to about 0 ℃, feeds hydrogen sulfide after 1 hour; continue to stir 5 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, elimination insolubles, filtrate are poured in the frozen water of 2.0N hydrochloric acid soln (350ml), and the adularescent throw out generates, filter, be washed with water to about pH7, drying under reduced pressure gets the 3.95g white crystal, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid, yield 96%.Crude product is directly used in the next step.[α]
D 20+92.0°(c＝0.01DMF)
3, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid (code name: compound III):
With step 3 (summary) in the example one
4, fluticasone propionate crude product:
With step 4 (summary) in the example one
5, make the fluticasone propionate elaboration:
With step 5 (summary) in the example one
Embodiment five production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
With step 1 (summary) in the example two
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid (code name: Compound I I):
With step 2 (summary) in the example four
3, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid (code name: compound III):
With step 3 (summary) in the example one
4, fluticasone propionate crude product:
With step 4 (summary) in the example one
5, make the fluticasone propionate elaboration:
With step 5 (summary) in the example one
Embodiment six production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
With step 1 (summary) in the example three
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid (code name: Compound I I):
With step 2 (summary) in the example four
3, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid (code name: compound III):
With step 3 (summary) in the example one
4, fluticasone propionate crude product:
With step 4 (summary) in the example one
5, make the fluticasone propionate elaboration:
With step 5 (summary) in the example one
Embodiment seven production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
Slightly (with step 1) in the example one
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid (code name: compound V)
Compound (I) 7.92g (20mmol) is added in the 50ml methylene dichloride; nitrogen protection and stirring are down; reaction solution is cooled to 5 ℃ of right sides; add triethylamine 5.10g (50mmol); drip the mixed solution of propionyl chloride 4.63g (50mmol) and methylene dichloride; continue to stir adding diethylamine 7.1g (70mmol) after 3 hours, continue to stir 2 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, add methylene dichloride and make reactant molten entirely, tell organic phase, use the 2.0N sodium carbonate solution respectively, 2.0N the hydrochloric acid soln washing is washed with water to about pH7 drying again, the reclaim under reduced pressure methylene dichloride, the 8.59g white solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid, yield 95%.[α]
D 20+13.0°(c＝0.01DMF)
3, preparation crude product fluticasone propionate:
Compound (V) 3.84g (8.5mmol) is dissolved in the 60ml ethyl acetate, stirring is cooled to about-25 ℃, after adding 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide salt hydrochloric acid (EDC) 4.88g (25.5mol), add fluoro thiomethyl alcohol 1.88g (25.85mmol), continue stirring reaction about 6 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, add 5% sodium hydrogen carbonate solution 100ml, continue to stir adding 150ml ethyl acetate after 2 hours, standing demix, tell organic phase, water extracts for three times with the 50ml ethyl acetate, merges organic liquor, drying, the reclaim under reduced pressure ethyl acetate gets micro white crude product fluticasone propionate.
4, make the fluticasone propionate elaboration:
Use acetone recrystallization.Drying under reduced pressure gets 3.23g leukoplast fluticasone propionate elaboration, yield 76%.Measure purity 〉=99% with HPLC.
[α]
D 20+34.5.0°(c＝0.01CH
2Cl
2)
Embodiment eight production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
With step 1 (summary) in the example two
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid (code name: compound V)
With step 2 (summary) in the example seven.
3, preparation crude product fluticasone propionate:
With step 3 (summary) in the example seven.
4, make the fluticasone propionate elaboration:
With step 4 (summary) in the example seven.
Embodiment nine production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
With step 1 (summary) in the example three
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid (code name: compound V)
With step 2 (summary) in the example seven.
3, preparation crude product fluticasone propionate:
With step 3 (summary) in the example seven.
4, make the fluticasone propionate elaboration:
With step 4 (summary) in the example seven.
Embodiment ten production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
Slightly (with step 1) in the example one
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid (code name: compound V)
With step 2 (summary) in the example seven.
3, preparation crude product fluticasone propionate:
Compound (V) 4.52g (10mmol) is dissolved in the 60ml ethyl acetate, stirring is cooled to about-25 ℃, behind adding carbonyl dimidazoles (CDI) 5.68g (35mmol), adds fluoro thiomethyl alcohol 1.98g (30mmol), continue stirring reaction about 8 hours, follow the tracks of reaction with thin-layer chromatography and finish.After reaction finishes, add 5% sodium hydrogen carbonate solution 100ml, continue to stir adding 150ml ethyl acetate after 2 hours, standing demix, tell organic phase, water extracts for three times with the 50ml ethyl acetate, merges organic liquor, drying, the reclaim under reduced pressure ethyl acetate gets micro white crude product fluticasone propionate.
4, make the fluticasone propionate elaboration:
Use acetone recrystallization.Drying under reduced pressure gets 3.70g leukoplast fluticasone propionate elaboration, yield 74%.Measure purity 〉=99% with HPLC.
[[α]
D 20+34.5.0°(c＝0.01CH
2Cl
2)。
Embodiment 11 production steps:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
With step 1 (summary) in the example two
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid (code name: compound V)
With step 2 (summary) in the example seven.
3, preparation crude product fluticasone propionate:
With step 3 (summary) in the example ten.
4, make the fluticasone propionate elaboration:
With step 4 (summary) in the example ten.
Embodiment 12 production stages:
1, preparation 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid (code name: Compound I):
Slightly (with step 1) in the example three
2, preparation 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid (code name: compound V)
With step 2 (summary) in the example seven.
3, preparation crude product fluticasone propionate:
With step 3 (summary) in the example ten.
4, make the fluticasone propionate elaboration:
With step 4 (summary) in the example ten.
Sum up, can make the fluticasone propionate elaboration respectively by above 12 kinds of methods, total recovery is 74%～76%, measures with high performance liquid chromatography (HPLC), and purity all reaches more than 99%.
Claims (6)
1, the synthetic method of fluticasone propionate is characterized in that may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under 30～40 ℃ of conditions, generates 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid with sodium periodate or Periodic acid solution reaction;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the acetone, under the nitrogen protection condition, at 30～40 ℃, add N successively under stirring, the N-dimethyl sulphide is for urea chloride, diisopropyl ethyl amine and potassiumiodide, stir, generate 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid adds in the methylene dichloride, nitrogen protection and stirring are down, reaction solution is cooled to 5 ℃ ± 1 ℃, add triethylamine, drip the mixed solution of propionyl chloride and methylene dichloride, continue to stir after 3 hours and add diethylamine, after continuing to be stirred to reaction and finishing, adding methylene dichloride makes reactant molten entirely, tell organic phase, use sodium carbonate solution respectively, the hydrochloric acid soln washing is washed with water to pH7 ± 1 again, dry, decompression gets little yellow solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid;
4) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid is dissolved in the ethyl acetate, stirs and is cooled to 0 ℃ ± 1 ℃, under the salt of wormwood katalysis, reacts with Bromofluoromethane; After reaction finishes, add sodium carbonate solution, ethyl acetate, standing demix is told organic phase; The water ethyl acetate extraction merges organic liquor, and drying makes the fluticasone propionate crude product;
5) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
2, the synthetic method of fluticasone propionate is characterized in that may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under 30～40 ℃ of conditions, generates 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid with sodium periodate or Periodic acid solution reaction;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the dimethyl formamide, in the nitrogen protection condition,, stir adding carbonylic imidazole down at 30～40 ℃, stirring reaction, reaction solution is cooled to 0 ℃ ± 2 ℃, feeds hydrogen sulfide, continues to stir, after question response finishes, elimination insolubles, filtrate are poured in the frozen water of hydrochloric acid soln, generate white depositions, after filtration, be washed with water to pH7 ± 1, drying under reduced pressure makes 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid adds in the methylene dichloride, nitrogen protection and stirring are down, reaction solution is cooled to 5 ℃ ± 1 ℃, add triethylamine, drip the mixed solution of propionyl chloride and methylene dichloride, continue to stir after 3 hours and add diethylamine, after continuing to be stirred to reaction and finishing, adding methylene dichloride makes reactant molten entirely, tell organic phase, use sodium carbonate solution respectively, the hydrochloric acid soln washing is washed with water to pH7 ± 1 again, dry, decompression gets little yellow solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid;
4) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid is dissolved in the ethyl acetate, stirs and is cooled to 0 ℃ ± 1 ℃, under the salt of wormwood katalysis, reacts with Bromofluoromethane; After reaction finishes, add sodium carbonate solution, ethyl acetate, standing demix is told organic phase; The water ethyl acetate extraction merges organic liquor, and drying makes the fluticasone propionate crude product;
5) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
3, the synthetic method of fluticasone propionate is characterized in that may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under the effect of catalyzer alkali, uncovered being exposed in the air, 30～40 ℃ were stirred 3～4 days, and made 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the acetone, under the nitrogen protection condition, at 30～40 ℃, add N successively under stirring, the N-dimethyl sulphide is for urea chloride, diisopropyl ethyl amine and potassiumiodide, stir, generate 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid adds in the methylene dichloride, nitrogen protection and stirring are down, reaction solution is cooled to 5 ℃ ± 1 ℃, add triethylamine, drip the mixed solution of propionyl chloride and methylene dichloride, continue to stir after 3 hours and add diethylamine, after continuing to be stirred to reaction and finishing, adding methylene dichloride makes reactant molten entirely, tell organic phase, use sodium carbonate solution respectively, the hydrochloric acid soln washing is washed with water to pH7 ± 1 again, dry, decompression gets little yellow solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid;
4) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid is dissolved in the ethyl acetate, stirs and is cooled to 0 ℃ ± 1 ℃, under the salt of wormwood katalysis, reacts with Bromofluoromethane; After reaction finishes, add sodium carbonate solution, ethyl acetate, standing demix is told organic phase; The water ethyl acetate extraction merges organic liquor, and drying makes little fluticasone propionate crude product;
5) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
4, the synthetic method of fluticasone propionate is characterized in that may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under the effect of catalyzer alkali, uncovered being exposed in the air, 30～40 ℃ were stirred 3～4 days, and made 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the dimethyl formamide, in the nitrogen protection condition,, stir adding carbonyl dimidazoles down at 30～40 ℃, stirring reaction, reaction solution is cooled to 0 ℃ ± 2 ℃, feeds hydrogen sulfide, continues to stir, after question response finishes, elimination insolubles, filtrate are poured in the frozen water of hydrochloric acid soln, generate white depositions, after filtration, be washed with water to pH7 ± 1, drying under reduced pressure makes 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-androstane-1,4-diene-17 β-thiocarboxylic acid adds in the methylene dichloride, nitrogen protection and stirring are down, reaction solution is cooled to 5 ℃ ± 1 ℃, add triethylamine, drip the mixed solution of propionyl chloride and methylene dichloride, continue to stir after 3 hours and add diethylamine, after continuing to be stirred to reaction and finishing, adding methylene dichloride makes reactant molten entirely, tell organic phase, use sodium carbonate solution respectively, the hydrochloric acid soln washing is washed with water to pH7 ± 1 again, dry, decompression gets little yellow solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid;
4) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-thiocarboxylic acid is dissolved in the ethyl acetate, stirs and is cooled to 0 ℃ ± 1 ℃, under the salt of wormwood katalysis, reacts with Bromofluoromethane; After reaction finishes, add sodium carbonate solution, ethyl acetate, standing demix is told organic phase; The water ethyl acetate extraction merges organic liquor, and drying makes the fluticasone propionate crude product;
5) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
5, the synthetic method of fluticasone propionate is characterized in that may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under 30～40 ℃ of conditions, generates 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid with sodium periodate or Periodic acid solution reaction;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the methylene dichloride, nitrogen protection and stirring are cooled to 5 ℃ ± 1 ℃ with reaction solution, in triethylamine and diethylamine katalysis down, drip the mixed solution of propionyl chloride and methylene dichloride, be stirred to reaction and finish; Adding methylene dichloride makes reactant molten entirely, tell organic phase, respectively with sodium carbonate solution, hydrochloric acid soln washing, be washed with water to pH7 ± 1 again, drying makes white solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid is dissolved in the ethyl acetate, stirring is cooled to-25 ℃ ± 2 ℃, under the katalysis of 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide salt hydrochloric acid or carbonyl dimidazoles, react to finishing with the fluoro thiomethyl alcohol; Add sodium hydrogen carbonate solution and ethyl acetate, standing demix is told organic phase, and the water ethyl acetate extraction with organic liquor drying, decompression, makes the fluticasone propionate crude product;
4) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
6, the synthetic method of fluticasone propionate is characterized in that may further comprise the steps:
1) fluorine compound is dissolved in tetrahydrofuran (THF) and the methyl alcohol solvent, under the effect of catalyzer alkali, worn-out mouthful is exposed in the air, 30～40 ℃ were stirred 3～4 days, and made 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid;
2) with 6 α, 9 alpha-difluoro-11 betas, 17 alpha-dihydroxy-s-16 Alpha-Methyls-3-oxygen androstane-1,4-diene-17 β-carboxylic acid is dissolved in the methylene dichloride, nitrogen protection and stirring are cooled to 5 ℃ ± 1 ℃ with reaction solution, in triethylamine and diethylamine katalysis down, drip the mixed solution of propionyl chloride and methylene dichloride, be stirred to reaction and finish; Adding methylene dichloride makes reactant molten entirely, tell organic phase, respectively with sodium carbonate solution, hydrochloric acid soln washing, be washed with water to pH7 ± 1 again, drying makes white solid, i.e. 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid;
3) with 6 α, 9 alpha-difluoro-11 betas-hydroxy-16 alpha--methyl-3-oxygen-17 α-propionyloxy androstane-1,4-diene-17 β-carboxylic acid is dissolved in the ethyl acetate, stirring is cooled to-25 ℃ ± 2 ℃, under the katalysis of 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide salt hydrochloric acid or carbonyl dimidazoles, react to finishing with the fluoro thiomethyl alcohol; Add sodium hydrogen carbonate solution and ethyl acetate, standing demix is told organic phase, and the water ethyl acetate extraction with organic liquor drying, decompression, makes the fluticasone propionate crude product;
4) with fluticasone propionate crude product acetone recrystallization, drying under reduced pressure makes fluticasone propionate.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102558273A (en) * | 2010-12-14 | 2012-07-11 | 浙江省天台县奥锐特药业有限公司 | Method for preparing fluticasone furoate |
| CN104350063A (en) * | 2012-05-08 | 2015-02-11 | 埃塞克斯治疗公司 | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| CN110698530A (en) * | 2019-10-30 | 2020-01-17 | 山东赛托生物科技股份有限公司 | Synthesis method of fluticasone propionate |
| CN111303229A (en) * | 2020-03-06 | 2020-06-19 | 中山大学·深圳 | Preparation method of fluticasone propionate intermediate |
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2006
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102558273A (en) * | 2010-12-14 | 2012-07-11 | 浙江省天台县奥锐特药业有限公司 | Method for preparing fluticasone furoate |
| CN102558273B (en) * | 2010-12-14 | 2014-07-02 | 浙江省天台县奥锐特药业有限公司 | Method for preparing fluticasone furoate |
| CN104350063A (en) * | 2012-05-08 | 2015-02-11 | 埃塞克斯治疗公司 | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| CN110698530A (en) * | 2019-10-30 | 2020-01-17 | 山东赛托生物科技股份有限公司 | Synthesis method of fluticasone propionate |
| CN111303229A (en) * | 2020-03-06 | 2020-06-19 | 中山大学·深圳 | Preparation method of fluticasone propionate intermediate |
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