CN100581496C - Cryosurgical device and method for cooling surfaces - Google Patents

Abstract

A cryosurgery device for dispensing a liquid refrigerant from a container having a valve stem extending outwardly therefrom. The device includes an actuator adapted to seat on the valve stem of the container in order to depress the valve stem to release the refrigerant from the container. The actuator includes an inner passageway having opposed ends disposed therein, one of the ends of the passageway being in fluid communication with the valve stem. An applicator tube is mounted to the actuator at the other end of the inner passageway. A cap is disposed on the top of the container. The actuator is movably positioned on the cap and a shield is attached to the cap to completely receiving the applicator tube. Liquid refrigerant can only be dispensed when the actuator is positioned properly and the applicator tube is disposed within the shield means.

Description

The method of cryosurgery device and cooling surface

Related application

The application is incorporated by reference herein in 60/610,534 the priority that 35 U.S.C. § require that the U.S. Provisional Application the 60/672nd, 506 submitted on April 19th, 2005 and JIUYUE in 2004 submitted on the 17th for 119 times.

Background of invention

1. Technical field

The present invention relates to the cryosurgery device and by method by the shaping applicator dispense liquid refrigerant cools surface of porous material; and more particularly; relate to a kind of device with distribution system, this distribution system has the protectiveness sheath makes cold-producing medium only could discharge when the correct assembling of device.

2. The explanation of correlation technique

A part local freezing so that the dermatosis such as wart is removed of human body or animal is provided as everyone knows.The surgeon has used liquid nitrogen to apply pathological changes has been removed from skin.This Therapeutic Method is effective, but stands such shortcoming: need professional equipment to come condensation nitrogen, need the storage device of specialty, and the inherent peril of carrying and distribute the material of about-196 ℃ of fluidizing point.In processing procedure, need a certain amount of technology, so that too much tissue injury does not take place.

Recently, developed by employing and be contained in the whole bag of tricks that liquid refrigerant in the pressure vessel is cryogenically treated dermatosis.In these methods, be fed in the hollow supply pipe from the low temperature agent of the effective dose of pressure vessel, this hollow supply pipe have the top that is positioned at pipe cotton, fiber or plastic foam applicator, make cryogenic substance accumulate in the applicator.The skin surface of pathological changes contacts the temperature that sufficiently long a period of time is reduced to the temperature of dermatosis tissue with the agent of permission low temperature freezing skin with the applicator that gathers the low temperature agent then, break low temperature agent evaporation simultaneously with the permanent irrecoverable property of cell membrane that the dermatosis cell takes place.A period of time (general about 20 to about 60 seconds, according to the degree of depth of boiling point He the freezing tissue of wanting of cold-producing medium) afterwards removes from skin surface with applicator soon, allows the frigorifico skin tissue of dermatosis slowly to thaw then.In several weeks next, refrigerated tissue is removed from surrounding skin.

U.S. Patent No. 4,865,028 (Swart); U.S. Patent No. 5,516,505 (McDow); U.S. Patent No. 5,200,170 (McDow); U.S. Patent No. 5,330,745 (McDow); U.S. Patent No. 5,738,682 (Jensma); U.S. Patent No. 6,296,410 (Ruizendaal); U.S. Patent No. 6,092,527 (Jensma); U.S. Patent No. 6,296,410 (Ruizendaal); U.S. Patent No. 6,387,090 (Jensma); With the example that has disclosed among U.S. publication application No.2005/0043723 people such as () Howlett dermatosis coating low temperature agent device.The content of these patents and application is incorporated by reference herein.U.S. Patent No. 4,865,028 has disclosed a kind of method and apparatus that is used to provide therapeutic effect, and it provides cold-producing medium to realize by the applicator by the Cotton Gossypii applicator head that comprises surrounding tube subexit outlet side, and pipe directly be placed on the position that will treat or near.U.S. Patent No. 6,092,527,6,387,090 and 5,738,682 the local refrigerated method and apparatus that is used to provide to wart or other growth-gen has been provided.The patent of Jensma has disclosed by opening shaping applicator tip that the chamber foam forms and especially by preferably being used for of the present inventionly driving the applicator that the chamber foam is formed on the Cotton Gossypii tip.

The mode of cryogenic system performance characteristic is that wherein the low temperature agent moves on to applicator from container.Should almost not have the loss of cryogenic substance in transmission, therefore, cryogenic substance should be walked effective and the shortest path so that the maximum effectiveness of treatment dermatosis to be provided.

Summary of the invention

The invention provides a kind of be used for the dermatosis place or near the cryosurgery device of coating low-temperature refrigerant, the accurate and controlled supply of low-temperature refrigerant can be provided.

The invention still further relates to a kind of distribution system, wherein keep excessive cryogen in the bin to avoid the supersaturation of applicator tip.Excessive bin accommodates excessive cryogen, and can demonstrate applicator and when be full of fully and can keep cryogen when applicator does not exist.

Cryosurgery device of the present invention also be used for low-temperature refrigerant be coated in the dermatosis place or near, wherein cryogenic substance is walked effective and short path and is arrived applicator tip.

The present invention also provides low-temperature refrigerant is coated in dermatosis place or near cryosurgery device, and it is made economical and is easy to be used by consumer.

According to the present invention, a kind of cryosurgery device is provided, be used for from having container allocation liquid refrigerant from its outward extending valve lever.This device comprises actuator, is suitable for being placed on the valve lever of container, discharges cold-producing medium to push down valve lever from container.This actuator comprises having the internal path that wherein is provided with the opposite end, and a wherein end of path is communicated with the valve lever fluid.Applicator is installed on the actuator at the other end of internal path.The guard apparatus that is communicated with actuator is admitted applicator fully.With the device of actuator and guard apparatus interlocking, make liquid refrigerant only when described actuator engages with described guard apparatus, just can be assigned to applicator.

The present invention also provides a kind of method from cryosurgery device dispense liquid cold-producing medium, may further comprise the steps: the container of liquid refrigerant is provided, has from its outward extending valve lever.Actuator mechanism is attached to container, and actuator mechanism comprises the internal path that is communicated with valve lever and applicator fluid.Applicator is arranged in the guard apparatus.With actuator and guard apparatus interlocking, make that cold-producing medium passes actuator and enters applicator from described valve lever when actuator mechanism is activated; When power that actuator is applied so that cold-producing medium is assigned to applicator.

These and other feature of the present invention, aspect and advantage will be from about better displaying the following detailed description of the preferred embodiment of accompanying drawing, wherein:

Description of drawings

Fig. 1 is the axonometric chart of apparatus of the present invention first embodiment.

Fig. 2 is the cutaway view that the line I-I along Fig. 1 obtains.

Fig. 3 A and 3B are the medicated cap of device of Fig. 1 embodiment and the axonometric chart of sheath, and Fig. 3 C is a cutaway view of obtaining medicated cap and sheath along the line II-II of Fig. 3 B, and Fig. 3 D is the medicated cap of Fig. 3 C and the side view of sheath, and Fig. 3 E is the cutaway view of the medicated cap obtained of the line III-III along Fig. 3 D.

Fig. 4 A-4D is the axonometric chart of unassembled state actuator housing and insert.

Fig. 5 A is assembled into the housing of actuator and the axonometric chart of insert, and Fig. 5 B is the upward view of the actuator of Fig. 5 A, and Fig. 5 C is the cutaway view of the actuator obtained of the line IV-IV along Fig. 5 A.

Fig. 6 is the cutaway view of the actuator casing obtained of the line V-V along Fig. 4 C.

Fig. 7 is the cutaway view of the actuator insert obtained of the line VI-VI along Fig. 4 D.

Fig. 8 is the partial sectional view of another embodiment of apparatus of the present invention.

Fig. 9 is the partial sectional view with device of the Fig. 8 that changes the outlet design.

Figure 10 is the axonometric chart of medicated cap of the device of Fig. 8.

Figure 11 is the cutaway view of the distribution system obtained of the line VII-VII along Fig. 8.

Figure 12 is the actuator of Figure 11 and the amplification view of cap assembly.

Figure 13 and 14 is the cutaway view of second embodiment of the invention, shows actuator to be placed on the medicated cap improperly.

Figure 15 is the amplification view of the pointed part of Figure 14.

Figure 16 is the axonometric chart of another embodiment of apparatus of the present invention.

Figure 17 is the axonometric chart of the device of knocked-down Figure 16.

Figure 18 is the axonometric chart according to the another embodiment of apparatus of the present invention.

Figure 19 is the axonometric chart of the device of knocked-down Figure 18.

Figure 20 is the axonometric chart of another embodiment again according to the present invention.

Figure 21 is the axonometric chart of the unassembled device of Figure 20.

Figure 22 is the axonometric chart according to another embodiment of apparatus of the present invention.

Figure 23 is the axonometric chart of the device of knocked-down Figure 22.

Figure 24 A and 24B are the axonometric charts of another embodiment of the present invention.

Figure 25 A and 25B are the axonometric charts of further embodiment of this invention.

The specific embodiment

The present invention relates to the cryosurgery device and by method by the shaping applicator dispense liquid refrigerant cools surface of porous material.This device has distribution system, and this distribution system has the protectiveness sheath makes cold-producing medium only could discharge when the correct assembling of device.Under the possible situation, represent similar parts with identical label.

Referring to Fig. 1 and 2, cryogenic system 10 of the present invention comprises the container 12 that holds the fluid under pressure cryogen.Medicated cap 14 is arranged on the top of container 12.Medicated cap 14 comprises the protectiveness sheath 20 that is used to cover applicator 18.Actuator 16 is received in the medicated cap 14.Medicated cap 14 and container 12 combine with actuator 16, applicator 18 and protectiveness sheath 20 and form distribution system of the present invention.

This device is suitable for comprising wart (wart), horn, achrocordon, molluscum contagiosum, senile plaque, dermatofibroma, keloid, granuloma annulare, porokeratosisplantaris, hemangioma, malignant lentigo, keratoeanthoma, basal cell, bowen's disease, lentigodiscreta, chondrodermatitis, epidermis hemorrhoid, leukoplasia, purulent granuloma and Kaposi in order to remove various dermatosiss.But, for the purpose of brief, following description will be only with reference to the treatment of wart; The treatment of other situation is similarly, and just time of contacting with diseased region of the size of applicator tip and liquid coolant can be different.

As shown in Figure 2, applicator tube 18 is fixed on the actuator 16, and this assembly provides actuating so that cold-producing medium is fed to applicator tube.Should be appreciated that applicator tube 18 can be to be attached to actuator 16 removedly or for good and all.Applicator tube 18 extends down into sheath 20.

Applicator 18 is hollow pipes and comprises the tip 28 of being made by the porous material that is arranged on and is fixed on the one end.Most advanced and sophisticated 28 can be made by any suitable porous material, such as, but not limited to Cotton Gossypii, open chamber foam, sintering thermoplastic materials, sintering metal, glass or ceramic frit or polyolefin or polyester non-woven fabric.U.S. Patent No. 4,865,028 (Swart); U.S. Patent No. 5,516,505 (McDow); U.S. Patent No. 5,200,170 (McDow); U.S. Patent No. 5,330,745 (McDow); U.S. Patent No. 5,738,682 (Jensma); U.S. Patent No. 6,296,410 (Ruizendaal); U.S. Patent No. 6,092,527 (Jensma); U.S. Patent No. 6,296,410 (Ruizendaal); U.S. Patent No. 6,387,090 (Jensma); With disclosed multiple applicator and the tip materials that can be used as applicator tip of the present invention among the U.S. publication application No.2005/0043723 (people such as Howlett).The content of these patents is incorporated by reference herein.Preferably, applicator and tip are such as U.S. Patent No. 5,738,682 (Jensma); U.S. Patent No. 6,092,527 (Jensma); U.S. Patent No. 6,387, the foam on the Cotton Gossypii tip that discloses among 090 (Jensma).Preferably, most advanced and sophisticated 28 for example be fixed to applicator tube 18 by hot weld known in the art, ultrasonic bond, binding agent etc.

When the valve open of container 12, liquid refrigerant is full of applicator tube 18 and soaks into most advanced and sophisticated 28.Most advanced and sophisticated then 28 compress the wart or the pathological changes that will remove from skin momently.Along with cold-producing medium evaporates from the tip, can at least a portion of treatment time, replenish by the liquid that is retained in the pipe.Preferably, because health, applicator tube 18 and most advanced and sophisticated 28 is only used once, abandons then.

Shown in Fig. 1-3E,, protectiveness sheath 20 is set in order during cryogen being assigned to soaking into of applicator 18 most advanced and sophisticated 28, to keep cold-producing medium.Sheath 20 comprises that opening 22 overflows in sheath to allow superfluous gas.Should be appreciated that opening can be arranged on the hole on the jacket wall or the design of some other equivalences.In addition, this opening can be positioned at the arbitrfary point along sheath.

Sheath 20 be connected to medicated cap 14 and can by transparent such as polyethylene or opaque moulding material make.Applicator tube 18 extends into protectiveness sheath 20 and is received in wherein fully when the device assembling.Be to be understood that diameter, length or variable-widthization the applicator tip and the length of tube of sheath 20 to adapt to different sizes and/or type.Applicator tube 18 can be for good and all or removedly to be attached to actuator 16.Sheath 20 drips on one's body the user as protectiveness guard shield cryogen when preventing to distribute, and distributes to stop as the interlocking part, unless sheath is in place.As shown in the figure, sheath 20 surrounds applicator 18 fully, makes user can not contact with liquid refrigerant after the neutralization of initial allocation process has just applied.Sheath 20 comprises protrusion 24, and protrusion 24 extends to the inner passage 26 of admitting applicator tube 18 from medicated cap 14.

Waste storage device 50 is positioned at the bottom of sheath 20.Bin 50 is used to hold the cryogen of any surplus in the porous material that does not remain on tip 28.The shape that bin 50 preferably has is vision to indicate whether to have distributed enough cryogens.Because limited the fill area of bin 50, can reduce the cryogen waste so have the Inner footpath 52 that forms by the end.Sheath 20 can comprise that indicating mechanism is used for determining that porous material has been full of cryogen.Bin 50 also can comprise the absorber material that can charge into superfluous cryogen.It is also understood that the present invention has also considered dissimilar bins.For example, bin can not have the Inner bar maybe can have along its length increases or swedged shape.

In the embodiment of Fig. 1-17, sheath and medicated cap are shown as one single piece and can be made up of the combination of the molded plastics resin such as polypropylene, metal or other suitable material or material.Actuator 16 can be made by similar material.Should be appreciated that the present invention has considered other material.Equally, shown in other embodiments of the invention, sheath and lid can be independent removable and not need permanent attachment.

Referring to Fig. 2, when medicated cap 14 was attached to container 12, outlet of container bar 34 extended upward by medicated cap 14 again.Also shown in Fig. 3 E, medicated cap 14 comprises the protuberance 36 of bar 34 by its extension.The opening 32 (Fig. 3 A) that bar 34 extends up through medicated cap 14 enters protuberance 36.Protuberance 36 is surrounded by circumferential rib 38 and makes the top of protuberance 36 not extend to rib 38 tops.After this will further describe rib 38.

Aerosol container 12 holds cold-producing medium and comprises annular sidewall 42 and the roof 44 of closed ring sidewall 42 upper ends.The cervical region 46 of reduced is arranged on roof 44 centers and extends upward from it.Cervical region 46 has central opening 48, is contained in liquid refrigerant there with transmission with the internal fluid communication of container 12.As the normal conditions in present technique field, aerosol container 12 is made by electroplating steel plate, aluminum and other material; The selection of material is not strict especially, and contact with content can be anticorrosive with the ability that can stand the internal pressure that produces be prior Consideration.

Liquid refrigerant can be any suitable liquid refrigerant, as long as can drop to the temperature of freezing skin with the temperature with the wart tissue as the low temperature agent, with when the low temperature agent is evaporated, makes permanent irreversible the breaking of cell membrane of generation dermatosis cell.If the temperature of wart was reduced to approximately below-20 ℃ at least about 20 seconds, the wart tissue will damage.Many low boiling point refrigerant/aerosol propellant are applicable to this purpose, comprise halogenated hydrocarbons, ether and Hydrocarbon.Because environment reason, previous very general Chlorofluorocarbons (CFCs) cold-producing medium has been forbidden most of uses, is generally replaced by the fluorohydrocarbon complex; For example, boiling point is-26.5 ℃ commercial refrigeration agent 1,1,1, and the 2-tetrafluoroethene can be used for the present invention.Container internal pressure reaches desired boiling point or because of other reason, this material can be the mixture of some cold-producing medium chemical compounds in order to reduce.Those skilled in the art know many available cold-producing medium chemical compounds and mixture.

The example of usable mixtures has: the propane of the propane of the dimethyl ether of 82 weight % and 18 weight % and the dimethyl ether of 95 weight %, 2 weight % and the iso-butane of 3 weight %.For the purposes of the present invention, most suitable liquid refrigerant be the mixture of 75 weight % dimethyl ether and 25 weight % propane, can produce the temperature below-20 ℃ approximately on the human body skin surface in when coating.

Conventional spring on-load pressure aerosol valve (not shown) is arranged on the cervical region 46 of container 12.The CONSTRUCTED SPECIFICATION of valve is known and the concrete structure of valve does not form part of the present invention.The example of this valve can find by patent documentation, for example in U.S. Patent No. 6,039,306 and No.6, in 318,603 and many other patents and at A.R.Gennaro, Ed, The Science and Practice ofPharmacy the 20th phase Lippincott, Williams ﹠amp; Wilkins, Baltimore, Md., 2000 971-972 pages or leaves, full content are incorporated by reference herein.

The roof 44 of medicated cap 14 engages the ring edge 47 of container 12 so that medicated cap is fixed to the upper.Soak pipe 30 and be connected with valve and extend into container 12, export bar 34 and extend container 12.Be to be understood that to make and soak pipe and 30 extend into the only a bit of distance in container 12 inside, perhaps even can cancel it, even make that container 12 upsets still can the fluid transfer cold-producing medium.Well-known as the present technique field, when outlet bar 34 pressurizeds, valve open, and cold-producing medium turns back to its normal position (usually owing to the spring applied pressure that is arranged in the valve) and valve closing by soaking pipe 32, valve and outlet bar 34 flow containers 12 until outlet bar 34.

Referring to Fig. 3 A-3E, medicated cap 14 comprises sidewall 13,15.As shown in Figure 1, when assembling parts to carry out the branch timing, actuator 16 is between the sidewall 13,15 of medicated cap 14.Interval between the sidewall 13 and 15 should be minimum, for example less than 1/2 inch.

Illustrate in greater detail as Fig. 4 A-5C, actuator 16 is formed by actuator casing 60 and actuator insert 62.Actuator casing 60 has top 64, and top 64 comprises the prompting part 58 that groove is arranged of user finger usefulness.Actuator insert 62 is received in the housing 60 fully and comprises 68 tops 66 of extending from the bottom.Referring to Fig. 4 B, 5C, 6 and 7, the top 66 of insert 62 comprises slit 72.When insert is positioned at housing, the passage (Fig. 5 C) that slit 72 forms between top 64 and the top 66.

As shown in Figure 7, insert 62 also has two inner passages 74,76, is communicated with passage/slit 72 to form path 70, is depicted as the u shape path that extends through when housing and insert assembling here.Path 70 has opposite end 78 and 80.One end 78 is admitted applicator tube 18 (Fig. 2).The other end 80 of path 70 is admitted outlet bars 34, makes the coaxial and fluid of outlet bar 34 and path 70 be communicated with.End 80 has shoulder 82, around the opening of path 70.Actuator 16 is positioned at medicated cap 14, makes outlet bar 34 80 be received within the path in the end, makes the top edge of outlet bar 34 against inner annular shoulder 82.

Optional prompting part 58 guiding user are placed finger tip to carry out maximum actuation.Owing to the pressure that is applied at prompting part 58 places on actuator 16 upper surfaces, actuator 16 pivots around protrusion 24, and the inner annular shoulder 82 of insert 62 force the outlet bar 34 inwardly towards container 12 to open valve and to discharge cold-producing medium, then cold-producing medium from the outlet bar 34 advance by path 70.

If actuator 16 correctly is not arranged on the medicated cap 14, the protuberance 36 of medicated cap 14 will stop the distribution of cryogen.In addition, as shown in Figure 2, outlet bar 34 is owing to the reason of size can not be placed in the end 78 of path 70.

Not only user can not be arranged on actuator 16 on the medicated cap 14 by this way, and the end of applicator tube 18 can not be fixed in the end 80 of path 70.As Fig. 5 C is shown specifically, 78 places in the end, the external diameter of applicator tube 18 is less than the Inner footpath of the end 80 of path 70.Therefore, too pine and applicator tube 18 can drop out in this cooperation meeting.In addition because the narrow-pitch between the sidewall 13,15 of medicated cap 14, and since the top depression of protuberance 36 in protrusion 38, user can not enter outlet bar 34 and activate valve.

Fig. 8-15 shows according to another embodiment of the present invention.Device 100 comprises the applicator tube 18 (having aforesaid porous tip) that is fixed to actuator 116, and it provides actuating so that cold-producing medium is fed to applicator tube.Should be appreciated that applicator tube 18 can be removedly or for good and all be attached to actuator 116.Applicator tube 18 extends down into sheath 120.Protectiveness sheath 120 comprises the outlet 22 that is positioned on its wall.Fig. 9 shows the another location of outlet.In this embodiment, outlet 22 is positioned at the side of sheath.

Referring to Figure 10, medicated cap 114 comprises sidewall 113,115.As shown in Figure 8, when assembling each parts to carry out the branch timing, actuator 116 is between the sidewall 113,115 of medicated cap 114.Spacing between the sidewall 113,115 should be minimum, for example is less than 1/2 inch.When medicated cap 114 was attached to container 12, outlet of container bar 34 extended up through medicated cap 114.Along what export the bar setting is safety block protuberance 126, will further specify it at this.Sheath 120 forms one with medicated cap 114, and comprises slope 128, extends to the inner passage 122 of admitting applicator tube 18 from medicated cap 114.Medicated cap 114 also comprises the pivot protrusion 124 that is used for actuator 16, also will further specify it at this.

As Figure 11 and 12 illustrated in greater detail, actuator 116 comprised the u shape path 140 that extends through it.Path 140 has the opposite end; One end 142 is admitted applicator tube 18.The other end 144 of path 140 is admitted outlet bars 34, makes the coaxial and fluid of outlet bar 34 and path 140 be communicated with.End 144 has shoulder 146, around the opening of path 140.Actuator 116 is positioned at medicated cap 14, exports bar 34 like this and is received within the path, makes the top edge that exports bar 34 against inner annular shoulder 146.

The top of actuator can comprise that prompting part 58 is to guide user placement finger tip to carry out maximum actuation.Owing to the pressure that is applied at prompting part 58 places on actuator 116 upper surfaces, actuator 116 pivots around protrusion 124, and inner annular shoulder 146 force the outlet bar 34 inwardly towards container 12 to open valve and to discharge cold-producing medium, then cold-producing medium from the outlet bar 34 advance by path 140.

Referring to Figure 13-15, if actuator 116 correctly is not arranged on the medicated cap 114, the protuberance 126 of medicated cap 114 will prevent the distribution of cryogen.As shown in figure 13, protuberance 126 prevents that actuator 116 from placing backward, and promptly the end 142 of path 140 is not communicated with the passage 122 of sheath 120.In addition, as shown in figure 14, owing to the interference between the rib of size reason and protuberance 126 and actuator 116, outlet bar 34 can not be placed in the end 142 of path 140.Not only user can not be arranged on actuator 116 on the medicated cap 114 by this way, and the end of applicator tube 18 can not be fixed in the end 144 of path 140.As Figure 15 is shown specifically, 144 places in the end, the external diameter of applicator tube 18 is less than the Inner footpath of path 140.Therefore, too pine and bar can drop out in this cooperation meeting.

Referring to Figure 16 and 17, in another embodiment of the present invention, wherein use the label identical to represent similar parts with previous embodiment, sheath 120 can comprise transparent bottom part 132.Actuator 116 can comprise hinged end 136.

Referring to Figure 18 and 19, in another embodiment of the present invention, medicated cap 150 and sheath 160 are formed by the two interlocking parts that separate.Medicated cap 150 comprises the hole 152 that is used to admit actuator 156.Actuator 156 comprise top section 158 and as described above among the embodiment like that with applicator 16 with export the internal path that bar 34 is communicated with.Sheath 160 also comprises bin 162 and is used to indicate cryogen to be transferred to most advanced and sophisticated 48 labelling.Sheath 160 is included in the arm 164 that extends on the every side of actuator so that sheath is interlocked on actuator and the medicated cap.Applicator head 48 can have short length, bottom for example from the applicator head top to pipe, and the length of applicator head can be about 40-80mm.

In the embodiment shown in Figure 20 and 21, medicated cap 166 and sheath 170 form single single piece.Medicated cap 166 comprises the slit 168 that is used to admit actuator 172.As other embodiment of the present invention, actuator 172 comprises the internal path that is communicated with outlet bar 34 and applicator 18.Applicator 18 can be positioned at the pipe 174 of actuator 172.Unless medicated cap 166/ sheath 170 is contained on the container 12 with actuator 172, and the distribution of cryogen can not take place.

Referring to the embodiment shown in Figure 22 and 23, medicated cap 176 and sheath 180 can form single single piece.Medicated cap 176 comprises elongated slot 178, and applicator 18 and actuator 182 are by its setting.During assembling, outlet bar 34 extends through slit 178 to be communicated with actuator 182 and its path.Sheath 180 also comprises the bin 184 that is used to hold useless cryogen.

In the embodiment of Figure 24 A and 24B, applicator 18 is arranged in the actuator 188 in the mode identical with previous embodiment.Medicated cap 192 is installed on the container 12.Actuator 188 is positioned at medicated cap 192 to engage with outlet bar (not shown).Be attached on the medicated cap 192 is the bin 194 that is used to seal applicator.A pair of cold guard shield 198 is attached on the medicated cap 192 and extends along the either side of bin.

Shown in Figure 25 A and 25B, lid 200 comprises from its upwardly extending bin 202.Bin 202 extends around the outlet bar, and applicator 18 is communicated with the outlet bar of container 12.Lid 200 is included in a plurality of holes 204 of its spaced around.Rotation wedging type actuator 206 is positioned near each hole 204, and we are designed to be rotated with the valve of pushing down the outlet bar cryogen is assigned to applicator tube 18.Guard shield 210 is inhaled above container and lid.Guard shield 210 comprises a plurality of ears 212 that engage with rotation wedge actuator by hole 204.When guard shield 210 was rotated, actuator was rotated to distribute cryogen.Unless device is assembling as shown in the figure, guard shield 210 stops the distribution of cryogen.

In a word, each embodiment all comprises and must correctly assemble so that install two or more parts of proper handling.Parts can be container tank, are equipped with the suitable fixture of the triggering part interlocking that is designed to and installs.These parts also can be dispensing head or the triggering parts that is attached to the outlet of container tank.It maybe can be the monomeric unit that comprises applicator that dispensing head can have the cooperation that allows applicator to insert.

During operation, medicated cap, guard shield and the actuator that has an applicator are preferably assembled in advance with pressurization-gas cascade 12.As mentioned above, the tip preferably is permanently attached on the applicator tube.Then, actuator is pressed down to open valve and to enter applicator tube from the container allocation cryogen by the path in the actuator.After the distribution, actuator and applicator tube can remove and applicator do not removed from actuator from container; The tip that cold-producing medium is contained in wherein is coated to wart the preceding paragraph time immediately, and for example 20 seconds, so that wart is freezing.

Although the present invention is described its special embodiment, other variation and modification and other use also are conspicuous for those skilled in the art.Therefore, preferably, the present invention is not subjected to the restriction of particular content here, but only is subjected to the restriction of appended claims.

Claims (24)

1. a cryosurgery device is used for being outward extended with valve lever by the container allocation liquid refrigerant from described container, and described device comprises:

Actuator, be suitable for being placed on the described valve lever of described container, discharge liquid refrigerant in order to push described valve lever from described container, described actuator comprises the internal path that wherein is provided with the opposite end, and an end of described path is communicated with described valve lever fluid;

Applicator is installed on described actuator at the other end of described internal path;

Guard apparatus is communicated with described actuator, is used for admitting fully described applicator; And

Be used for device, make described liquid refrigerant only when described actuator engages with described guard apparatus, just can be dispensed into applicator described actuator and described guard apparatus interlocking.

2. device as claimed in claim 1, it is characterized in that described guard apparatus comprises the medicated cap that is installed on the described container, described actuator is arranged on the described medicated cap movably, described guard apparatus also comprises the sheath that is attached on the described medicated cap, is used to admit described applicator.

3. device as claimed in claim 2 is characterized in that, described sheath and medicated cap are an integral body.

4. device as claimed in claim 2 is characterized in that described sheath is attached on the described medicated cap removedly.

5. device as claimed in claim 2 is characterized in that, described actuator comprises actuator casing and is arranged on the interior actuator insert of described actuator casing.

6. device as claimed in claim 5 is characterized in that, described internal path extends through described actuator insert.

7. device as claimed in claim 2 is characterized in that described medicated cap comprises the sidewall at a pair of interval, and described actuator is between described sidewall.

8. device as claimed in claim 7 is characterized in that, described medicated cap is included in upwardly extending protuberance between described sidewall, the valve lever of described container by described protuberance around.

9. device as claimed in claim 8, it is characterized in that, described interlock comprises the shoulder that is positioned at described actuator internal path end, and described shoulder and the engagement of described valve lever are only to distribute described liquid refrigerant when described actuator is positioned on the described medicated cap.

10. device as claimed in claim 2 is characterized in that, described sheath comprises the bin that is arranged on its bottom.

11. device as claimed in claim 2 is characterized in that, described sheath comprises at least one opening that is used for discharging from it excess gas.

12. device as claimed in claim 5 is characterized in that, described medicated cap comprises the sidewall at a pair of interval, and described actuator is arranged between the described sidewall.

13. device as claimed in claim 9 is characterized in that, described medicated cap is included in upwardly extending protuberance between described sidewall, the valve lever of described container by described protuberance around.

14. device as claimed in claim 10, it is characterized in that, described interlock comprises the shoulder of the internal path that is positioned at described actuator insert, and the engagement of described shoulder and described valve lever is only to distribute described liquid refrigerant when described actuator insert and housing are positioned on the described medicated cap.

15. the method from cryosurgery device dispense liquid cold-producing medium may further comprise the steps:

The container of liquid refrigerant is provided, and this container has from its outward extending valve lever;

Actuator mechanism is attached to described container, and described actuator mechanism comprises the internal path that is communicated with described valve lever and applicator fluid;

Described applicator is arranged in the guard apparatus;

With described actuator mechanism and described guard apparatus interlocking, make that cold-producing medium passes described actuator mechanism and enters described applicator from described valve lever when activating described actuator mechanism; And

Described actuator mechanism is applied power so that described cold-producing medium is assigned to described applicator.

16. method as claimed in claim 15 is characterized in that, also comprises such step: provide medicated cap on described container, described valve lever extends upward into described medicated cap.

17. method as claimed in claim 16 is characterized in that, the step of attached described actuator mechanism comprises described actuator mechanism is arranged between the spaced-apart sidewalls of described medicated cap.

18. method as claimed in claim 16, it is characterized in that, described guard apparatus and hat are integral, and the described step that described applicator is placed in the described guard apparatus comprises: an end of described applicator is placed in first end of described actuator mechanism internal path and with described actuator mechanism and is placed in the described medicated cap, and the other end of described applicator is placed in the sheath of described guard apparatus.

19. method as claimed in claim 18, it is characterized in that, described step with described actuator mechanism and described guard apparatus interlocking comprises that the described valve lever with described container is placed in second end of described internal path, described second end comprises a shoulder, and described shoulder engages with described valve lever only to distribute described liquid refrigerant when described actuator mechanism is positioned on the described medicated cap.

20. method as claimed in claim 18 is characterized in that, before being set to described actuator mechanism on the described medicated cap, described applicator is fixed in first end of the inner passage of described actuator mechanism.

21. method as claimed in claim 15, it is characterized in that the described step that described actuator mechanism is attached to described container comprises: the actuator insert is placed in the described actuator casing and with described actuator casing and described actuator insert be arranged on the described medicated cap.

22. a cryosurgery device is used for being outward extended with valve lever by the container allocation liquid refrigerant from described container, described device comprises:

Actuator, be used for engaging with the described valve lever of described container, discharge cold-producing medium in order to push described valve lever from described container, described actuator comprises the internal path that wherein is provided with the first and second relative ends, and first end of described path is communicated with described valve lever fluid;

Applicator tube is attached to described second end of described internal path;

Guard shield mechanism is communicated with described actuator, is used for admitting fully described applicator tube; And

Be used for device, make described liquid refrigerant only when described actuator engages with described guard shield mechanism, just can be dispensed into applicator described actuator and the interlocking of guard shield mechanism.

23. device as claimed in claim 22 is characterized in that, described guard shield mechanism comprise the medicated cap that is arranged on the described container and with described hat all-in-one-piece, be used to admit the sheath of applicator tube.

24. device as claimed in claim 23, it is characterized in that, described interlock comprises the shoulder of internal path first end that is positioned at described actuator, wherein only is positioned on the described medicated cap and described applicator tube is positioned at and could distributes described liquid refrigerant when described sheath and described shoulder mesh with described valve lever at described actuator.

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