CN100574763C - 局部稳定的前列腺素e化合物剂型 - Google Patents

局部稳定的前列腺素e化合物剂型 Download PDF

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Publication number
CN100574763C
CN100574763C CN200380110112A CN200380110112A CN100574763C CN 100574763 C CN100574763 C CN 100574763C CN 200380110112 A CN200380110112 A CN 200380110112A CN 200380110112 A CN200380110112 A CN 200380110112A CN 100574763 C CN100574763 C CN 100574763C
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CN
China
Prior art keywords
compartment
pge
weight portion
weight
prostaglandin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200380110112A
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English (en)
Chinese (zh)
Other versions
CN1756532A (zh
Inventor
Y·J·莫
D·W·弗兰克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring International Center (switzerland) S A
Original Assignee
Nexmed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nexmed Inc filed Critical Nexmed Inc
Publication of CN1756532A publication Critical patent/CN1756532A/zh
Application granted granted Critical
Publication of CN100574763C publication Critical patent/CN100574763C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN200380110112A 2003-01-03 2003-12-31 局部稳定的前列腺素e化合物剂型 Expired - Fee Related CN100574763C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/336,481 US6841574B2 (en) 2003-01-03 2003-01-03 Topical stabilized prostaglandin E compound dosage forms
US10/336,481 2003-01-03

Publications (2)

Publication Number Publication Date
CN1756532A CN1756532A (zh) 2006-04-05
CN100574763C true CN100574763C (zh) 2009-12-30

Family

ID=32681022

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200380110112A Expired - Fee Related CN100574763C (zh) 2003-01-03 2003-12-31 局部稳定的前列腺素e化合物剂型

Country Status (16)

Country Link
US (1) US6841574B2 (enExample)
EP (1) EP1585483B1 (enExample)
JP (2) JP2006514068A (enExample)
KR (2) KR101174788B1 (enExample)
CN (1) CN100574763C (enExample)
AT (1) ATE468098T1 (enExample)
AU (1) AU2003300113B2 (enExample)
BR (1) BR0317924A (enExample)
CA (1) CA2512015C (enExample)
DE (1) DE60332656D1 (enExample)
DK (1) DK1585483T3 (enExample)
ES (1) ES2343246T3 (enExample)
IL (1) IL169425A (enExample)
PT (1) PT1585483E (enExample)
WO (1) WO2004062632A1 (enExample)
ZA (1) ZA200505321B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004226A1 (en) * 1998-12-10 2005-01-06 Nexmed (Holdings), Inc. Compositions and methods for amelioration of human female sexual dysfunction
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US20050181030A1 (en) * 2003-01-03 2005-08-18 Mo Y. J. Topical stabilized prostaglandin E compound dosage forms
BRPI0408454A (pt) 2003-03-21 2006-04-04 Nexmed Holdings Inc composição tópica, método de tratar a ejaculação precoce, e, uso da composição
WO2005051960A2 (en) * 2003-11-22 2005-06-09 Midwest Research Laboratories, Llc Hydrocarbyl aminohydrocarbonoates and aminohydrocarbonol hydrocarbonoates as antimicrobial and antiviral agents
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
US20060286172A1 (en) * 2005-06-03 2006-12-21 Anu Mahashabde Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
ITMI20051417A1 (it) * 2005-07-22 2007-01-23 Mipharm S P A Formulazione topica in forma di gel contenente come ingredienti attivi ciclovit e lidocaina
CN101321511A (zh) * 2005-12-06 2008-12-10 莫诺索尔克斯有限公司 递送活性剂的局部用薄膜组合物
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
US7560489B2 (en) * 2006-10-11 2009-07-14 Nexmed Holdings, Inc. Stabilized prostaglandin E composition
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
ES2921527T3 (es) 2009-06-03 2022-08-29 Forsight Vision5 Inc Administración de fármaco en segmento anterior
EP2693877A4 (en) 2011-04-07 2014-11-19 Nexmed Holdings Inc METHOD AND COMPOSITION FOR TREATING RAYNAUD SYNDROME
CN106073986B (zh) 2011-09-14 2019-01-11 弗赛特影像5股份有限公司 治疗患者的眼睛的装置
PT2911623T (pt) 2012-10-26 2019-11-21 Forsight Vision5 Inc Sistema oftálmico para libertação prolongada de fármaco no olho
US8900625B2 (en) 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
WO2019142015A1 (es) * 2018-01-18 2019-07-25 Caicedo Pinto, David Felipe Composicion farmaceutica para la disfuncion erectil de administracion transdermica via uretral en gotas

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818517A (en) * 1986-01-24 1989-04-04 Akzo N.V. Pharmaceutical preparation for obtaining a highly viscose hydrogel or suspension
CN1267191A (zh) * 1998-06-15 2000-09-20 马克罗化学有限公司 治疗阴茎勃起障碍的组合物和方法
CN1284862A (zh) * 1997-11-05 2001-02-21 尼克斯梅德控股公司 输送前列腺素e1的表皮给药组合物

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3883576A (en) * 1971-02-02 1975-05-13 Upjohn Co Prostaglandin E{HD 3 {B analogs
US3826823A (en) * 1972-09-25 1974-07-30 Syntex Inc Stabilized prostaglandin preparations
US3875300A (en) * 1972-12-18 1975-04-01 Ortho Pharma Corp Composition for sustained release of a medicament and method of using same
US4136162A (en) * 1974-07-05 1979-01-23 Schering Aktiengesellschaft Medicament carriers in the form of film having active substance incorporated therein
US5017382A (en) * 1979-03-21 1991-05-21 National Research Development Corporation Controlled release compositions (II)
JPS5770816A (en) * 1980-10-17 1982-05-01 Ono Pharmaceut Co Ltd Multilayered film preparation of prostagladin of prolonged action
JPS58134019A (ja) * 1982-02-05 1983-08-10 Ono Pharmaceut Co Ltd プロスタグランジン含有持続放出型三層状フイルム製剤及びその製造方法
JPS5948409A (ja) * 1982-09-10 1984-03-19 Teikoku Seiyaku Kk 矯正的歯牙移動促進剤
JPS6185315A (ja) * 1984-10-04 1986-04-30 Teikoku Seiyaku Kk シ−ト状製剤
US5219885A (en) * 1987-02-16 1993-06-15 Froelich Juergen Prostaglandin E1 derivatives as pharmaceutically active agents, and pharmaceutical compositions containing these compounds, especially for transcutaneous administration
BR9203277A (pt) * 1992-08-21 1994-03-01 Cesar Roberto Dias Nahoum Utilizaccao de drogas eretogenicas e respectivas metodologias de aplicacao
US5380760A (en) * 1993-11-19 1995-01-10 Minnesota Mining And Manufacturing Company Transdermal prostaglandin composition
SE9501670L (sv) * 1995-05-05 1996-06-10 Perstorp Ab Omläggningsset
US20020004529A1 (en) * 1997-10-20 2002-01-10 Gary W. Neal Methods, compositions, and kits for enhancing female sexual desire and responsiveness
US6593369B2 (en) * 1997-10-20 2003-07-15 Vivus, Inc. Methods, compositions, and kits for enhancing female sexual desire and responsiveness
US6414028B1 (en) * 1997-11-05 2002-07-02 Nexmed Holdings, Inc. Topical compositions containing prostaglandin E1
WO1999066870A1 (en) * 1998-06-25 1999-12-29 Lavipharm Laboratories, Inc. A device and method for the treatment of erectile dysfunction
US6323241B1 (en) * 2000-01-10 2001-11-27 Nexmed (Holdings) Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction
KR100402334B1 (ko) * 2000-06-23 2003-10-22 환인제약 주식회사 알프로스타딜 외용제

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4818517A (en) * 1986-01-24 1989-04-04 Akzo N.V. Pharmaceutical preparation for obtaining a highly viscose hydrogel or suspension
CN1284862A (zh) * 1997-11-05 2001-02-21 尼克斯梅德控股公司 输送前列腺素e1的表皮给药组合物
CN1267191A (zh) * 1998-06-15 2000-09-20 马克罗化学有限公司 治疗阴茎勃起障碍的组合物和方法

Also Published As

Publication number Publication date
KR101174788B1 (ko) 2012-08-20
CN1756532A (zh) 2006-04-05
CA2512015A1 (en) 2004-07-29
KR20050098853A (ko) 2005-10-12
EP1585483A1 (en) 2005-10-19
AU2003300113B2 (en) 2010-03-11
IL169425A (en) 2010-11-30
EP1585483B1 (en) 2010-05-19
BR0317924A (pt) 2005-11-29
WO2004062632A1 (en) 2004-07-29
PT1585483E (pt) 2010-06-17
DK1585483T3 (da) 2010-07-19
US20040131664A1 (en) 2004-07-08
DE60332656D1 (de) 2010-07-01
JP2012036196A (ja) 2012-02-23
CA2512015C (en) 2011-11-08
ATE468098T1 (de) 2010-06-15
US6841574B2 (en) 2005-01-11
ES2343246T3 (es) 2010-07-27
JP5395138B2 (ja) 2014-01-22
EP1585483A4 (en) 2006-04-19
AU2003300113A1 (en) 2004-08-10
HK1090293A1 (zh) 2006-12-22
ZA200505321B (en) 2006-04-26
KR20110042138A (ko) 2011-04-22
JP2006514068A (ja) 2006-04-27

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Effective date of registration: 20170714

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Patentee after: Ferring International Center (Switzerland) S. A.

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Patentee before: Nexmed Inc.

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