CN100560055C - Gel for eye use and preparation method thereof - Google Patents
Gel for eye use and preparation method thereof Download PDFInfo
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- CN100560055C CN100560055C CNB2006100023422A CN200610002342A CN100560055C CN 100560055 C CN100560055 C CN 100560055C CN B2006100023422 A CNB2006100023422 A CN B2006100023422A CN 200610002342 A CN200610002342 A CN 200610002342A CN 100560055 C CN100560055 C CN 100560055C
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Abstract
The present invention relates to gel for eye use, it is made up of substrate, active ingredient of Chinese herbs, adjuvant and water, and described substrate is hyaluronic acid and/or hyaluronate sodium, and described gel for eye use adopts following method preparation: water soluble adjuvant is added an amount of water, the heating make its dissolving, filter clear liquor; In above-mentioned clear liquor, add substrate, soak, leave standstill a few hours, stir afterwards; Add active ingredient of Chinese herbs in the mixture that above-mentioned steps obtains, supply water to specific content, stir evenly, packing gets finished product; Wherein, described substrate, active ingredient of Chinese herbs, adjuvant and glassware for drinking water have following mass ratio, substrate: active ingredient of Chinese herbs: adjuvant: water=0.05～10.0: 0.1～40.0: 1～14: 50～98; Described active ingredient of Chinese herbs is the wherein a kind of of following component: Fel Ursi or its extract, Margarita or its extract, Radix dactylicapni (Radix Dactylicapnotis) extract.This gel for eye use can improve medicine holdup time within the eye, reduces drug loss.
Description
Technical field
The present invention relates to a kind of with medicine and preparation method thereof, particularly a kind of Chinese medicine gel for eye use and preparation method thereof.
Background technology
Chinese medicine is China's quintessence of Chinese culture, and its toxic and side effects is little, and raw material variety is various, and the treatment by Chinese herbs ophthalmic also has very long history, and has many classical medicines.But Chinese medicine ophthalmic preparation seen on the present China market is of less types, and new varieties are phoenix feathers and unicorn horns especially.Comparing aspect the Western medicine research with foreign capitals, joint venture, domestic production producer all differs greatly on improving in research, extraction, the dosage form of middle pharmaceutically active ingredient.At present the dosage form of Chinese patent drugs for treatment eye part disease mainly contains eye drop, collyrium etc., and their major defect is that drug loss is big, has 70% to overflow from eye in use usually as eye drop, if then have nictation 9% to overflow from eye.Increasing the medicine viscosity can improve the drug loss situation and play the effect that increases curative effect.But a little less than the eyes of the human body tolerance outside stimulus degree, general adjuvant is difficult to reach the requirement of making tackifier as eye.
Summary of the invention
The technical problem to be solved in the present invention is intended to overcome the deficiency of above-mentioned prior art, and a kind of gel for eye use is provided, and this gel for eye use can increase the viscosity of active ingredient of Chinese herbs, increases curative effect of medication and reduces drug loss.
The technical solution used in the present invention is:
Gel for eye use, described gel for eye use is made up of substrate, active ingredient of Chinese herbs, adjuvant and water, described substrate is hyaluronic acid and/or hyaluronate sodium, described adjuvant is meant isoosmotic adjusting agent and cosolvent and/or antiseptic, and described gel for eye use is to adopt the method preparation that comprises the steps:
1) water soluble adjuvant is added an amount of water, the heating make its dissolving, filter clear liquor;
2) in above-mentioned clear liquor, add substrate, soak, leave standstill a few hours, stir afterwards;
3) add active ingredient of Chinese herbs in the mixture that above-mentioned steps obtains, supply water to specific content, stir evenly, packing gets finished product;
Wherein, described substrate, active ingredient of Chinese herbs, adjuvant and water have following mass ratio in described gel for eye use, substrate: active ingredient of Chinese herbs: adjuvant: water=0.05～10.0: 0.1～40.0: 1～14: 50～98; Described active ingredient of Chinese herbs is the wherein a kind of of following component: Fel Ursi or its extract, Margarita or its extract, Radix dactylicapni (Radix Dactylicapnotis) extract.
Further, also be included in step 2 in the preparation method of above-mentioned gel for eye use) afterwards, pure dissolubility adjuvant is dissolved in an amount of ethanol, be added to above-mentioned steps 2 after stirring slowly) mixture that obtains after the operation.
Hyaluronic acid (Haluronic acid, HA, have another name called glass acid) or its sodium salt, it is the good mucopolysaccharide of a kind of biochemical property, hyaluronic acid or its sodium salt are as the viscoelastic material of treatment of eye disorders, have excellent biological compatibility, superior chemical characteristic, water solublity, high-purity property, the transparency and the pH value that suits, as being the substrate of the gel for eye use of active component with Chinese medicine, hyaluronic acid and/or its sodium salt have extremely good performance.The present invention is the semisolid that the water-soluble back of hyaluronic acid and/or its sodium salt is formed, and this semisolid has certain viscosity, pharmaceutically active ingredient in can carrying, containing and prepare gel for eye use.
The selected Chinese medicine active medicine Fel Ursi powder (or its decocting in water precipitate with ethanol is handled the back material) of the present invention has heat-clearing and toxic substances removing, and the function that removing nebula makes eye bright can be used for acute and chronic catarrhal conjunctivitis, epidemic keratitis etc.Can take the direct and gel-type vehicle hybrid mode of Fel Ursi powder, also can take the handled thing of elder generation with Fel Ursi or Fel Ursi powder, promptly Fel Ursi or its powder material behind decocting in water, precipitate with ethanol, recovery ethanol joins the mode in the gel-type vehicle.No matter handle the back material as active substance with Fel Ursi powder or its decocting in water precipitate with ethanol, in gel for eye use, the ratio that is had is 0.5-20.0 weight % by the Fel Ursi powder active medicine, preferred 1.0-10.0 weight %.The Chinese medicine active medicine Margarita liquid that the present invention is selected and the mixture of Borneolum Syntheticum have clearing away heat-fire, and the function of nourishing the liver to improve visual acuity can be used for being used for the deficiency of the liver hyperactivity of fire and causes asthenopia disease and chronic conjunctivitis.With the mixture of Margarita liquid and Borneolum Syntheticum is that the ratio that Margarita liquid (contain total protein concentration and be no less than 1mg/ml) is had is 0.2-10.0 weight %, preferred 0.5-5.0 weight % in the gel for eye use made of active medicine; The ratio that Borneolum Syntheticum had is 0.001-1.0 weight %, preferred 0.01-0.5 weight %.
Further, in the gel for eye use of the present invention, preferably, described substrate, active ingredient of Chinese herbs, adjuvant and water have following mass ratio in described gel for eye use, substrate: active ingredient of Chinese herbs: adjuvant: water=0.2～2.0: 0.5～10.0: 2～5: 80～90.
Further, in the gel for eye use of the present invention, often add some adjuvants, this is included in medically operable isoosmotic adjusting agent, as sodium chloride, boric acid, Borax etc.; Dissolve in gel at operable promotion medicine medically, dispersive cosolvent, as promoting the dissolved ethanol of Borneolum Syntheticum, promote the dispersive poloxamer of medicine etc.Preferably, can also be added in medically operable antiseptic, as benzyl alcohol, ethylparaben, methyl parahydroxybenzoate etc.
Compared with the prior art gel for eye use of the present invention has following good effect: the viscosity that increases active ingredient of Chinese herbs, the raising medicine is the holdup time within the eye, reduce drug loss, have good biocompatibility, increase curative effect of medication, rapid-action with hyaluronic acid and/or hyaluronate sodium as the gel for eye use of substrate, bacteriostasis is strong, persistent period is of a specified duration, can its drug effect be strengthened effectively in conjunction with the effective ingredient of Chinese medicine preparation.
The specific embodiment
Below will be described in detail the specific embodiment of the present invention.
Embodiment 1
Table 1
| Composition | Fel Ursi powder | Hyaluronate sodium | Borax | Boric acid | Sodium chloride | Ethylparaben | Water | Total amount |
| Quality | 5g | 4g | 0.6g | 12g | 2.2g | 0.8g | 975.4g | 1000g |
As shown in table 1: get Fel Ursi powder, add 100g water for injection, heated and boiled made dissolving in 10 minutes, put coldly, added ethanol and made and contain alcohol amount and reach 75%, left standstill 24 hours, filtered filtrate recycling ethanol; Other gets Borax, boric acid, sodium chloride, ethylparaben, adds 800g water for injection, and heated and boiled makes dissolving, filters, and puts cold, add hyaluronate sodium, soak, leave standstill a few hours, stir evenly, mix with the medicinal liquid after reclaiming ethanol, after-teeming is penetrated water to ormal weight, stirs evenly packing.
Embodiment 2-4
Table 2
| Composition | Fel Ursi powder | Hyaluronate sodium | Sodium chloride | Ethylparaben | Water | Total amount |
| Embodiment 2 | 5g | 6g | 8g | 1g | 980.0g | 1000g |
| Embodiment 3 | 2g | 5g | 12g | 0.8g | 980.2g | 1000g |
| Embodiment 4 | 70 | 20 | 9.5 | 0.5g | 900g | 1000g |
As shown in table 2: get Fel Ursi powder, sodium chloride, ethylparaben adds 100g water for injection, and heated and boiled made dissolving in 10 minutes, puts coldly, adds ethanol and makes and contain alcohol amount and reach 75%, leaves standstill 24 hours, filters filtrate recycling ethanol; Other gets 800g water for injection, adds hyaluronate sodium, soaks, and leaves standstill a few hours, stirs evenly, and mixes with medicinal liquid after reclaiming ethanol, and after-teeming is penetrated water to ormal weight, stirs evenly packing.Said process carries out under aseptic condition.
Embodiment 5-7
Table 3
| Composition | Margarita liquid (contain total protein concentration and be no less than 1mg/ml) | Borneolum Syntheticum | Hyaluronate sodium | Sodium chloride | Benzyl alcohol | Ethanol | Water | Total amount |
| Embodiment 5 | 20ml | 1g | 5g | 12g | 2g | 2g | 957.98g | 1000g |
| Embodiment 6 | 200ml | 1.5g | 0.5 | 10g | 6g | 4g | 777.8g | 1000g |
| Embodiment 7 | 80ml | 2g | 2g | 8g | 2g | 6g | 899.92g | 1000g |
As shown in table 3: get sodium chloride, add about 80% amount water for injection, heated and boiled makes dissolving, filters, and puts coldly, adds hyaluronate sodium, soaks, and leaves standstill a few hours, stirs evenly.Borneolum Syntheticum, benzyl alcohol are dissolved in an amount of ethanol, slowly stir to join in the above-mentioned substrate, add Margarita liquid to this mixture, and after-teeming is penetrated water to ormal weight, stirs evenly packing.
Embodiment 8-10
Table 4
| Composition | Margarita layer powder | Natural Broneolum Syntheticum | Hyaluronic acid | Boric acid | Sodium borate | Sodium chloride | Ethylparaben | Ethanol | Water | Total amount |
| Embodiment 8 | 0.1 | 1.5g | 20g | 1g | 40g | 8g | 0.5g | 3.9g | 925g | 1000g |
| Embodiment 9 | 2.5g | 0.5g | 50g | 30g | 20g | 12g | 0.75g | 2.25g | 882g | 1000g |
| Embodiment 10 | 5g | 1g | 1g | 15g | 1g | 10g | 1g | 6g | 960g | 1000g |
As shown in table 4: sodium chloride, boric acid, Borax are added the water for injection of about 80% amount, and heated and boiled makes dissolving, filters, and puts coldly, adds hyaluronic acid, soaks, and leaves standstill a few hours, stirs.Borneolum Syntheticum, ethylparaben are dissolved in the adequate amount of ethanol, slowly stir to join in the above-mentioned substrate, add Margarita layer powder to this mixture, and after-teeming is penetrated water to ormal weight, stirs evenly packing.
Embodiment 11-13
Table 5
| Composition | Margarita layer powder | Natural Broneolum Syntheticum | Hyaluronate sodium | Sodium chloride | Benzyl alcohol | Ethanol | Water | Total amount |
| Implement | 0.5 | 1.3g | 25g | 9g | 20g | 4.2g | 940g | 1000g |
| Example 11 | ||||||||
| Embodiment 12 | 2g | 0.7g | 45g | 11g | 11g | 2.3g | 928g | 1000g |
| Embodiment 13 | 4.5g | 0.9g | 5g | 8.5g | 2g | 6.1g | 973g | 1000g |
As shown in table 5: sodium chloride is added the water for injection of about 80% amount, and heated and boiled makes dissolving, filters, and puts coldly, adds hyaluronate sodium, soaks, and leaves standstill a few hours, stirs.Borneolum Syntheticum, benzyl alcohol are dissolved in the adequate amount of ethanol, slowly stir to join in the above-mentioned substrate, add Margarita layer powder to this mixture, and after-teeming is penetrated water to ormal weight, stirs evenly packing.
Embodiment 14-16
Table 6
| Composition | The Radix dactylicapni (Radix Dactylicapnotis) coarse powder | Hyaluronate sodium | Hyaluronic acid | Boric acid | Borax | Ethylparaben | Water | Total amount |
| Embodiment 14 | 1000g | 50g | 50g | 15g | 1g | 0.5g | All the other are water | 1000 g |
| Embodiment 15 | 450g | 1g | 25g | 30g | 20g | 1g | All the other are water | 1000 g |
| Embodiment 16 | 100g | 25g | 1g | 1g | 40g | 0.75g | All the other are water | 1000 g |
As shown in table 6: the Radix dactylicapni (Radix Dactylicapnotis) coarse powder, according to the percolation (2005 editions appendix IO of Chinese Pharmacopoeia) under fluid extract and the extractum item, make solvent with ethanol, flood and carry out percolation after 24 hours, the liquid color is light to filtering.The liquid of filtering is concentrated into thick paste, with chloroform-ethanol refining total alkaloids.Boric acid, Borax, 0.8-1.2% are added the water for injection of about 80% amount, and heated and boiled makes dissolving, filters, and puts coldly, adds hyaluronate sodium, hyaluronic acid, soaks, and leaves standstill a few hours, stirs.Add total alkaloids to this mixture, after-teeming is penetrated water to ormal weight, stirs evenly packing.
Embodiment 17-19
Table 7
| Composition | The Radix dactylicapni (Radix Dactylicapnotis) coarse powder | Chlorobutanol | Hyaluronic acid | Boric acid | Borax | Sodium chloride | Water | Total amount |
| Embodiment 17 | 150g | 7g | 1g | 15g | 40g | 9.5g | All the other are water | 1000 g |
| Embodiment 18 | 600g | 2.5g | 50g | 1g | 20g | 12g | All the other are water | 1000 g |
| Implement | 900g | 5g | 25g | 30g | 1g | 7g | All the other | 1000 |
| Example 19 | Be water | g |
As shown in table 7: the Radix dactylicapni (Radix Dactylicapnotis) coarse powder, according to the percolation (2005 editions appendix IO of Chinese Pharmacopoeia) under fluid extract and the extractum item, make solvent with ethanol, flood and carry out percolation after 24 hours, the liquid color is light to filtering.The liquid of filtering is concentrated into thick paste, with chloroform-ethanol refining total alkaloids.Sodium chloride, boric acid, Borax, chlorobutanol are added the water for injection of about 80% amount, and heated and boiled makes dissolving, filters, and puts coldly, adds hyaluronate sodium, hyaluronic acid, soaks, and leaves standstill a few hours, stirs.Add total alkaloids to this mixture, after-teeming is penetrated water to ormal weight, stirs evenly packing.
The implementation result example
We take conventional pharmacological experimental method (Plating) to study with hyaluronic acid (or sodium salt) as the gel for eye use of substrate with not with the pharmacological action comparison of hyaluronic acid (or sodium salt) as the common gel for eye use of substrate.Result's (every milliliter contains 2.8 * 102 antibacterials) as shown in table 8.
Table 8
| Title | Onset time (min) | Kill the bacillus pyocyaneus time (min) | Kill the staphylococcus aureus time (min) | The continuous action time (h) |
| Embodiment 1 | 20 | 3 | 93 | 7.5 |
| Embodiment 2 | 21 | 3 | 92 | 7.8 |
| Embodiment 3 | 23 | 2.5 | 85 | 8.0 |
| Embodiment 4 | 24 | 2.5 | 86 | 8.1 |
| Embodiment 5 | 25 | 2 | 85 | 8.0 |
| It is an amount of that embodiment 1 does not add hyaluronate sodium adding carbomer 934 P | 29 | 5.5 | 123 | 6.0 |
| It is an amount of that embodiment 2 does not add hyaluronate sodium adding carbomer 934 P | 30 | 5 | 122 | 6.0 |
| It is an amount of that embodiment 3 does not add hyaluronate sodium adding carbomer 934 P | 36 | 5 | 110 | 6.2 |
| It is an amount of that embodiment 4 does not add hyaluronic acid adding carbomer 934 P | 34 | 5 | 109 | 6.1 |
| It is an amount of that embodiment 5 does not add hyaluronate sodium adding carbomer 934 P | 35 | 4.5 | 108 | 6.0 |
Can get by table 8: as the gel for eye use of substrate and not as the pharmacological action of the common gel for eye use of substrate not relatively with hyaluronic acid (or sodium salt) with hyaluronic acid (or sodium salt), rapid-action with hyaluronic acid (or sodium salt) as the gel for eye use of substrate, bacteriostasis is strong, persistent period is of a specified duration, can be effectively in conjunction with the effective ingredient of Chinese medicine preparation.Thereby as outstanding carrier (media), the bioavailability of pharmaceutically active ingredient in both can having increased can increase the viscosity of Chinese medicine ingredients again, reduces drug loss, increases curative effect of medication.
In sum, hyaluronic acid (or sodium salt) can be effectively in conjunction with the effective ingredient of Chinese medicine preparation.Thereby as outstanding carrier (media), the bioavailability of pharmaceutically active ingredient also can alleviate the stimulation to eye in both can having increased, and promoted the healing of eye wound, alleviated the ophthalmic uncomfortable symptom rapidly.Good water-solubility that hyaluronic acid has and viscosity make it can be used as gel-type vehicle.Medicine is dispersed in the hydrosol of hyaluronic acid (or sodium salt), makes gel for eye use, promptly can increase the viscosity of Chinese medicine ingredients, the raising medicine is the holdup time within the eye, reduces drug loss, can utilize hyaluronic good characteristic again, increases curative effect of medication.
Claims (3)
1, gel for eye use, it is characterized in that described gel for eye use is made up of substrate, active ingredient of Chinese herbs, adjuvant and water, described substrate is hyaluronic acid and/or hyaluronate sodium, described adjuvant is meant isoosmotic adjusting agent and cosolvent and/or antiseptic, and described gel for eye use is to adopt the method preparation that comprises the steps:
1) water soluble adjuvant is added an amount of water, the heating make its dissolving, filter clear liquor;
2) in above-mentioned clear liquor, add substrate, soak, leave standstill a few hours, stir afterwards;
3) add active ingredient of Chinese herbs in the mixture that above-mentioned steps obtains, supply water to specific content, stir evenly, packing gets finished product;
Wherein, described substrate, active ingredient of Chinese herbs, adjuvant and water have following mass ratio in described gel for eye use, substrate: active ingredient of Chinese herbs: adjuvant: water=0.05～10.0: 0.1～40.0: 1～14: 50～98; Described active ingredient of Chinese herbs is the wherein a kind of of following component: Fel Ursi or its extract, Margarita or its extract, Radix dactylicapni (Radix Dactylicapnotis) extract.
2, gel for eye use according to claim 1 is characterized in that further being included in step 2) afterwards, pure dissolubility adjuvant is dissolved in an amount of ethanol, be added to above-mentioned steps 2 after stirring slowly) mixture that obtains after the operation.
3, gel for eye use according to claim 2, it is characterized in that described substrate, active ingredient of Chinese herbs, adjuvant and water have following mass ratio, substrate: active ingredient of Chinese herbs: adjuvant in described gel for eye use: water=0.2～2.0: 0.5～10.0: 2～5: 80～90.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100023422A CN100560055C (en) | 2006-01-26 | 2006-01-26 | Gel for eye use and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100023422A CN100560055C (en) | 2006-01-26 | 2006-01-26 | Gel for eye use and preparation method thereof |
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| CN100560055C true CN100560055C (en) | 2009-11-18 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885767A (en) * | 2012-11-02 | 2013-01-23 | 江苏吉贝尔药业有限公司 | Novel olopatadine hydrochloride eye drop and preparation method thereof |
| CN103446365B (en) * | 2013-07-22 | 2015-04-08 | 徐璜明 | Ointment for treating myopia and preparation method thereof |
| CN107982281A (en) * | 2017-12-08 | 2018-05-04 | 河北金牛原大药业科技有限公司 | Ophthalmically acceptable semisolid preparation of Chinese medicine composition and preparation method thereof |
| CN112353923A (en) * | 2020-11-02 | 2021-02-12 | 李天生 | A topical Chinese medicinal eye drop |
-
2006
- 2006-01-26 CN CNB2006100023422A patent/CN100560055C/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 中华人民共和国卫生部药品标准中药成方制剂. 中华人民共和国卫生部药典委员会，143. 1998 * |
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