CN100559952C - Milk powder of a kind of reduction or maintenance blood sugar and preparation method thereof - Google Patents
Milk powder of a kind of reduction or maintenance blood sugar and preparation method thereof Download PDFInfo
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Abstract
The present invention is preferred materials such as methylpyridine chromium, glycine zine, biological calcium carbonate, CLA are prepared the milk powder that reduces or keep blood sugar with skimmed milk power.Skimmed milk power of the present invention can also be by the preparation of liquid milk spray-drying.After taking milk powder of the present invention, test-meal group crowd's Serum Leptin Levels and insulin level are all than descending before the experiment.
Description
Technical field
The present invention relates to a kind of reduction or keep milk powder of blood sugar and preparation method thereof, comprise CLA, mineral matter and vitamin in this milk powder.
Background technology
Contain a large amount of carbohydrate, fat, protein in the milk powder; it is outstanding composite nutrient food; but too much use usually can cause blood sugar to increase; but do not occur as yet at present supplying nutritional support; the milk powder that can not cause blood sugar to increase again; cause many people to be unwilling to eat milk powder, in the course of time, cause their nutrient imbalance again.
Diabetes (diabetes mellit μ s) are one group of clinical syndromes that is caused by the h and E factor interaction, absolute or relative deficiency and target tissue cell reduce insulin sensitivity because of insulin secretion, cause a series of metabolic disorders such as sugar, albumen, power and water Xie Zhi.Clinical is main common sign with the hyperglycaemia, and prolonged illness can cause the multisystem grievous injury and threat to life.Clinical IDD (IDDM, I type) and the adult-onset diabetes (NIDDM, II) type) of being divided into of diabetes.The target for the treatment of diabetes is the control hyperglycaemia, corrects metabolic disorder, prevents and delays complication.Main treatment means is for using insulin and oral hypoglycemic thing.
Modern study shows that diabetes are to cause chronic Nutrition and Metabolism imbalance because chronic energy is taken in greater than energy consumption, and the epidemiological study data shows that mineral matter, vitamin content are lower than normal population in diabetic's body.Zoopery has confirmed that fat mouse is suitably replenished mineral matter, vitamin can obviously improve metabolic disorder.
The energy that the diabetic took in can not be caused the disorder of carbohydrate, fat, energy and hormone metabolism by effective metabolism, thus secondary and diabetes, hypertension, hyperlipidemia and cancer occurred frequently.Therefore the diabetic has caused the concern of many countries to the harm of human health.China's recent two decades comes, and the incidence of diabetic and relevant disease thereof also is ascendant trend year by year, has accounted for dead first as angiocardiopathy.Therefore the diabetic has become one of nutritive disease that attracts most attention in the world wide.
Obviously, only contain nutrients such as a large amount of carbohydrate, fat, protein in the milk powder of producing at present, can only be used for nutritional support, and can not guarantee effective absorption metabolism of nutrition, and cause fertile diabetic or the high person of blood sugar to be unwilling to eat milk powder
Therefore, under the situation of taking in certain energy, keep the poised state of various metabolism, also should correspondingly increase supply essential minerals and vitamin in order to guarantee the high person of diabetic or blood sugar.
The purpose of this invention is to provide a kind of milk powder that reduces or keep blood sugar, contain specific minerals and vitamins in this milk powder, thus the supply of assurance diabetic or the high person's of blood sugar carbohydrate, fat, energy minerals and vitamins.Angle from the Nutrition and Metabolism regulation and control makes them under the prerequisite of nutrient balance, and blood fat reduces or be stable, obtains good quality of life.
CLA (Conj μ gated linoleic acid is hereinafter to be referred as CLA) is linoleic isomers, is the nutriment that is prevalent in the humans and animals body.Discover that CLA can effectively prevent the outbreak of diabetes (diabetes).Zoopery proof CLA has same even better effect with the medicine " thiazolidinediones " (being called for short TZDs) of the current a kind of new treatment diabetes of using.CLA can help to regulate and lower the level of glucose in the blood, prevents the generation of diabetes.
Three prices are one of essential trace elements of human body, as far back as 1969 just the someone find that 3 prices safeguard in the normal glucose metabolic process to have important effect as the confactor of insulin at body.Studies have shown that further the GTF of being made up of several amino acids and 3 prices has the glycometabolic function of the body of adjusting, can reach the effect of improving blood sugar concentration by increasing approach such as glucose oxidase, the generation of promotion glycogen.After clinical research was found 13 diabetes patient's meal supplement every day chromium 2-4 months, fasting blood-glucose had obtained tangible improvement.And a diabetic who accepts the treatment of 50 units of insulin every day can make the needs of exogenous insulin reduce to zero after mending chromium.Even to part diabetes patient in late period, behind the additional methyl chromium, its sugar tolerance and glycosylated hemoglobin situation also can take a turn for the better rapidly.32 routine type ii diabetes patients' benefit chromium effect observation is found that the hypoglycemic effect of chromium also is better than general antidiabetic drug.Chromium is except that having tangible blood sugar reducing function, and hypoglycemic experimenter also can correct its hypoglycemia symptom (knock and sleep, eye-blurred, tremble and excessively perspire) by mending chromium.Mend the various informative of chromium, Organic Chromium-methylpyridine chromium, stability is strong, is fat-soluble, can directly act on and histocyte by cell membrane smoothly, thereby be the Organic Chromium that the most easily is absorbed by the body at present.
Calcium is the abundantest inorganic elements of content in the human body, has physiological action widely.Bibliographical information, dietary calcium is by suppressing 1, and calcium trophic hormones such as the sharp thyroid hormone of 25-(OH) 2-D3 are regulated the endocellular liberation calcium ion concentration, alleviating hypertension, diabetes and fat risk.The high calcium meals can make cell reduce with calcium ion concentration, and studies show that intracellular calcium concentration is the primary signal that insulin discharges, so insulin secretion reduces, obviously improve hyperinsulinemia.Magnesium is second ion that enriches in the cell, is a critical confactor of many enzyme reactions.Relation between insulin and the magnesium is paid close attention in recent years widely.Studies show that magnesium is brought into play second messenger's effect in the activity of insulin.On the other hand, insulin itself is the important adjusting factor that magnesium is assembled in the cell.Low magnesium density may make replying of insulin and active impaired in the cell, continues the raising that Mg supplementation then is of value to type ii diabetes people beta Cell of islet respond and insulin active.Zinc and insulin exist close getting in touch.Insulin is unique hypoglycemic hormone in the body, and its molecular configuration has 4 metallic atom zinc, and it is zinc that 0.5% composition is arranged in the insulin of crystallization approximately.Zinc can improve the stability of insulin, and promotes that by activating the shuttle PEPB B proinsulin is converted into insulin.Therefore, zinc deficiency is relevant with insulin secretion minimizing and insulin resistance.Replenish zinc, glucose does not tolerate phenomenon and can be eased.Prompting zinc may have been brought into play important function in the activity of insulin.
Technical scheme
1 consumption of filling a prescription
CLA (CLA) 1000～2000mg
Methylpyridine chromium 620～830 μ g
Glycine zine 37.46～78.16mg
Magnesium sulfate .7H2O 300～800mg
Biological calcium carbonate 1280～2022mg
The skimmed milk power surplus
2 consumptions of filling a prescription
CLA (CLA) 1000mg
Methylpyridine chromium 620 μ g
Glycine zine 37.46mg
Magnesium sulfate .7H2O 300mg
Biological calcium carbonate 1280mg
The skimmed milk power surplus
3 consumptions of filling a prescription
CLA (CLA) 2000mg
Methylpyridine chromium 830 μ g
Glycine zine 78.16mg
Magnesium sulfate .7H2O 800mg
Biological calcium carbonate 2022mg
The skimmed milk power surplus
4 consumptions of filling a prescription
CLA (CLA) 1500mg
Methylpyridine chromium 724 μ g
Glycine zine 57.46mg
Magnesium sulfate .7H2O 500mg
Biological calcium carbonate 1884mg
The skimmed milk power surplus
With the above-mentioned substance weighing, being supplemented to gross weight with milk powder is 100g
People's recommended amounts: 50 restrain for each person every day, take at twice.
Wherein there is multiple class in the source of milk powder, wherein there is multiple class in the source of milk powder, can adopt conventional skimmed milk power, for example: new hundred benefit the nation New Zealand NZMP board skimmed milk power that border industry and trade Co., Ltd provides, Australia skimmed milk power and Ukraine's skimmed milk power that good prosperous middle Co., Ltd produces, German skimmed milk power and New Zealand's skimmed milk power that South Sea city dandelion dairy industry Co., Ltd produces, can also adopt liquid milk is the skimmed milk power that raw material is made
Milk powder adopts New Zealand NZMP board skimmed milk power (New Zealand NZMP company, No. 25, Wellington, NZL Te Lisi street), and its main component is as follows: lactose 54.1%, protein 33.4%, mineral matter 7.9%, moisture 3.8%, fat 0.8%.
Liquid milk is that the concrete grammar of raw material making skimmed milk power is:
Raw milk: free of contamination pure fresh milk 10kg is a raw material with health.
Clean breast: milk clarifier is removed foreign matters such as weeds.
Centrifugal: the butterfat centrifuge removes degrease.
Standardization:, make its content that dusts each main component of back be controlled at this scope: lactose 53.1～55.1%, protein 32.4～34.4%, mineral matter 7.5～8.3%, moisture 3.0～4.0%, fat 0.6～0.9% with the fresh cow milk standardization
Sterilization: adopt 83 ℃, 15 seconds high temperatures.
High-pressure homogeneous: the pressure homogeneous that adopts 18～22Mpa.
Vacuum concentrates: vacuum 600～700Pa, the content that makes dry in the liquid milk is 35～45%.
Spray-drying: EAT is controlled at 140～150 ℃, and leaving air temp is controlled between 75～85 ℃.
Cooling: adopt air-cooledly, milk powder is chilled to rapidly about 4 ℃.
Sieve: sieve and remove impurity and insoluble matter in the dry run, and CLA and milk powder are mixed.
Packing: adopt waterproof, lucifuge, free of contamination packaging material are packed.
Finished product: be stored in airtight, dry, 8～12 ℃ the environment.
Specific embodiment 1: functional components is directly joined in the skimmed milk power, and the concrete operations step is as follows:
Weighing: CLA 15g, magnesium sulfate .7H
2O 5g, glycine zine 574.6mg, methylpyridine chromium 7.24mg, biological calcium carbonate 18.84g material amounts to 39.4218g, so weighing milk powder (1000-34.4218)=960.5782g.The quantity of actual weighing milk powder is that standard is replenished with the quantity of the adding ingredient of actual weighing.
What of the amount of looking adopt the SS15-SVP series-V-type powder mixer of different model to make to add material and milk powder evenly mixes.
Packing, finished product: the milk powder after will mixing, be loaded in the sealing bag, be stored in the dry environment.
Specific embodiment 2: with the liquid milk is that raw material is made functional milk powder, and its technological process is as follows:
Raw milk: clean breast: fractionation of fatty: standardization: batching (adds magnesium sulfate .7H
2O, glycine zine, methylpyridine chromium, biological calcium carbonate): sterilization: high-pressure homogeneous: vacuum concentrates: spray-drying: cooling: add CLA: sieve: packing: finished product
The concrete operations step is as follows:
The weighing of functional materials: CLA 150g, magnesium sulfate .7H
2O 50g, glycine zine 5746mg, methylpyridine chromium 72.4mg, biological calcium carbonate 188.4g, the total amount of functional materials amounts to 394.2g,
In the 10kg liquid milk, its dry matter content is 11%, and moisture is 3% (moisture of the dry matter content of liquid milk and milk powder is different and different because of environmental unit etc. during production, replaces to get final product) in the milk powder.Therefore can get the milk powder amount and be (100kg*11%)/(1-3%)=1.134kg, the total amount that adds functional materials is 1.134kg*5.524%=62.6g.
Raw milk: free of contamination pure fresh milk 10kg is a raw material with health.
Clean breast: milk clarifier is removed foreign matters such as weeds.
Centrifugal: the butterfat centrifuge removes degrease.
Standardization:, make its content that dusts each main component of back be controlled at this scope: lactose 53.1～55.1%, protein 32.4～34.4%, mineral matter 7.5～8.3%, moisture 3.0～4.0%, fat 0.6～0.9% with the fresh cow milk standardization
Batching: 4 kinds of materials such as load weighted methylpyridine chromium are joined in the liquid milk after the standardization, stir.
Sterilization: adopt 83 ℃, 15 seconds high temperatures.
High-pressure homogeneous: the pressure homogeneous that adopts 20Mpa.
Vacuum concentrates: vacuum 650Pa, the content that makes dry in the liquid milk is 40%.
Spray-drying: EAT is controlled at 145 ℃, and leaving air temp is controlled between 78 ℃.
Cooling: adopt air-cooledly, make milk powder be chilled to 4 ℃ rapidly.Add CLA simultaneously.
Sieve: sieve and remove impurity and insoluble matter in the dry run, and CLA and milk powder are mixed.
Packing: adopt waterproof, lucifuge, free of contamination packaging material are packed.
Finished product: be stored in airtight, dry, 10 ℃ ℃ the environment.
Relevant zoopery result:
One, the zoopery of CLA
Select the healthy male Wister rat of body weight 80-100g, observe a week after, with the animal random packet, control group gives basal feed by body weight, all the other give high lipid food, ad lib.After three weeks, the animal that feeds high lipid food is the rat that standard screen is selected lipophilia with weight gain greater than the average of basic control animals weight gain.To have the rat of lipophilia to divide five groups at random by body weight, 20 every group, the high, medium and low dosage group of promptly basic control group, high fat group, CLA is weighed weekly once, and appetite and berley amount given in record.Respectively at the 6th week and etherization execution at the 12 weekend animal (12h is on an empty stomach before putting to death), the centrifugal 20min of blood sample room temperature 3000rpm, separation of serum is preserved insulin to be measured, blood sugar, blood fat for-80 ℃.Get testis week and the perirenal fat record of weighing.
1, the variation of rat body weight
The variation (g) of Table 1 rat body weight
Basis control group (Basic diet is mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat group (High fat is mass fraction): milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, normal diet 46.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The high dose group of CLA (3.00%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 3.00%CLA, normal diet 43.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Middle dosage group (1.50%CLA) milk powder 20% of CLA, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 1.5%CLA normal diet 44.8% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The low dose group of CLA (0.75%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 0.75%CLA, normal diet 45.55% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Last table as seen, body weight there was no significant difference (P＞0.05) before each treated animal experiment, As time goes on, each treated animal body weight increases gradually, from the 6th week, high fat diet group rat body weight is apparently higher than base set (P＜0.05), and since the 9th week, CLA height, middle dosage group rat body weight are starkly lower than high fat group rat (P＜0.05 respectively.
2, the variation of rat fat body ratio
By table 2, table 3 as seen, no matter the 6th week still was the 12 week, and the value of high fat group rat fat body ratio, all fat/body weight of testis, perirenal fat/body weight all is significantly higher than base set (P＜0.05).The value of each treated animal fat body ratio of CLA, all fat/body weight of testis, perirenal fat/body weight (except the 6th week) reduces gradually with the dosage increase, and be dose-response relationship, (P＜0.05, more than explanation CLA has the effect of tangible reduction body fat all to be starkly lower than high fat group.
The variation (6th week) of Table2 rat fat body ratio
Basis control group (Basic diet) (being mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat group (High fat) is mass fraction): milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, normal diet 47.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The high dose group of CLA (3.00%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 3.00%CLA, normal diet 43.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Middle dosage group (1.50%CLA) milk powder 20% of CLA, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 1.5%CLA normal diet 44.8% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The low dose group of CLA (0.75%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 0.75%CLA, normal diet 45.55% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The variation (12 th week) of Table 3 rat fat body ratios
Basis control group (Basic diet) (being mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat group (High fat) is mass fraction): milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, normal diet 47.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The high dose group of CLA (3.00%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 3.00%CLA, normal diet 43.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Middle dosage group (1.50%CLA) milk powder 20% of CLA, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 1.5%CLA normal diet 44.8% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The low dose group of CLA (0.75%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 0.75%CLA, normal diet 45.55% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
3, the variation of rat blood sugar level
The variation (mmol/l) of Table 4 rat blood sugar levels
Basis control group (Basic diet) (being mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat group (High fat) is mass fraction): milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, normal diet 47.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The high dose group of CLA (3.00%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 3.00%CLA, normal diet 43.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Middle dosage group (1.50%CLA) milk powder 20% of CLA, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 1.5%CLA normal diet 44.8% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The low dose group of CLA (0.75%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 0.75%CLA, normal diet 45.55% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
By table 4 as seen, the 6th week the time was respectively organized rat blood sugar does not have significant difference (p＞0.05).In the 12 week, high fat group rat blood sugar is significantly higher than base set (P＜0.05), and each dosage treated animal blood sugar of CLA significantly is lower than high fat group (P＜0.05), and along with the increase blood sugar level of dosage reduces gradually, illustrates that CLA has the obvious functions of blood sugar effect.
By table 5 as seen, As time goes on, each is organized insulin level and is increase trend.High fat group insulin level was higher than ground line (P＜0.05=, each dosage group insulin of CLA is compared with high fat group did not have significant difference the 6th when week.When the 12 week, (P＜0.05=compares with high fat group high fat group insulin level, and each dosage group insulin level of compositions such as CLA obviously reduces (P＜0.05=apparently higher than base set.
The variation of Table 5 rat serum insulin levels (μ IM/ml)
Basis control group (Basic diet) (being mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat group (High fat) is mass fraction): milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, normal diet 47.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The high dose group of CLA (3.00%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 3.00%CLA, normal diet 43.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Middle dosage group (1.50%CLA) milk powder 20% of CLA, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 1.5%CLA normal diet 44.8% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The low dose group of CLA (0.75%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 0.75%CLA, normal diet 45.55% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
4, rat insulin sensitiveness index variation
By table 6 as seen, As time goes on, each is organized rat insulin sensitiveness index and all is reduction trend.Respectively organize insulin sensitivity sex index there was no significant difference (p＞0.05) during the 6th week.During the 12 week, high fat group rat insulin sensitiveness index obviously reduces (P＜0.05) than base set, illustrates that insulin resistance has appearred in high fat group rat.The higher fat group of CLA experimental group rat insulin sensitiveness index courage shows increase, and (P＜0.05=illustrates that CLA can improve the insulin sensitivity of rat.
Table 6 rat insulin sensitiveness index variation
Annotate: insulin sensitivity sex index ISI=-log (FINS * FPG)
FINS is an empty stomach serum insulin (μ IM/ml), and FPG is fasting blood sugar (mmol/L)
Basic diet:(is mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat (being mass fraction): milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, normal diet 47.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The high dose group of CLA (3.00%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 3.00%CLA, normal diet 43.3% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Middle dosage group (1.50%CLA) milk powder 20% of CLA, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 1.5%CLA normal diet 44.8% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The low dose group of CLA (0.75%CLA) milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, 0.75%CLA, normal diet 45.55% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Two. the zoopery of dietary chromium
1, chromium is to the influence of rat body weight
Table 7 chromium are to the influence (g) of rat body weight
Basic diet: corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat diet: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, normal diet 46.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Fish oil: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, fish oil 5%, normal diet 41.29% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Fish: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, fish meal 10%, normal diet 37.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Oil﹠amp; Chromi μ m: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, 5% fish oil, methylpyridine chromium 0.75mg/kg, normal diet 41.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The Chromim:D group is the high chromium group of high fat (1% calcium): milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, methylpyridine chromium 0.75mg/kg, normal diet 46.3% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
By table 7 as seen, the 0th week, body weight there was no significant difference (P＜0.05) between each group, As time goes on, each organizes body weight increases gradually, and during the 3rd week, high fat control group and chromium treated animal body weight are apparently higher than basic control group.From the 4th week, four treated animals (high fat control group and three experiments) body weight of feeding high lipid food is apparently higher than basic control group (P＜0.05), and visible high lipid food can cause the increase of body weight.The body weight of three experimental group has the trend that is lower than high fat control group, but there was no significant difference (P＞0.05), may be because experiment periods be still short.
2, chromium is to the influence of rat fat body ratio
Table8 chromium is to the influence (%) of rat fat body ratio
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△
Basic diet: corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat diet: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, normal diet 46.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Fish oil: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, fish oil 5%, normal diet 41.29% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Fish: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, fish meal 10%, normal diet 37.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Oil﹠amp; Chromi μ m: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, 5% fish oil, methylpyridine chromium 0.75mg/kg, normal diet 41.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
By table 8 as seen, the fat body of high fat control group ratio, all fat/body weight of testis and perirenal fat/body weight are significantly higher than basic control group (P＜0.05), and the fat body ratio of three experimental group is significantly higher than basic control group, but significantly is lower than high fat control group (P, 0.05).Wherein all fat of the testis of three experimental group/body weight value and high fat control group do not have significant difference.The perirenal fat of fish oil group, fish oil+chromium group/body weight value significantly is lower than high fat control group (P＜0.05), and the perirenal fat of chromium group/body weight value and high fat control group do not have significant difference (P＜0.05).
3, chromium is to the influence of rat blood sugar
Table 9 chromium are to the influence (mmol/L) of rat blood sugar
Basic diet: corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat diet: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, normal diet 46.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Fish oil: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, fish oil 5%, normal diet 41.29% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Oil﹠amp; Chroumium: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, 5% fish oil, methylpyridine chromium 0.75mg/kg, normal diet 41.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
By table 9 as seen, the 1st, 2 whens week each group blood sugar do not have significant difference (P＜0.05).Passing in time, blood glucose value of each group all are increases trend, and the blood glucose value of high fat control group is higher than basic control group (P＜0.05) when the 4th, 5 weeks.And since three experimental group from just being starkly lower than high fat control group and basic control group (P＜0.05) the 3rd week, close with basic control group blood glucose value when the 4th, 5 weeks the trend that is lower than high fat control group was just arranged in first week.
4, chromium is to the influence of rat Langerhans islet.
Table 10 chromium are to the influence (μ IM/ml) of rat Langerhans islet
Basic diet: corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
High fat diet: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, normal diet 46.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Fishoil: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, fish oil 5%, normal diet 41.29% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
Oil﹠amp; Chroumium: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, 5% fish oil, methylpyridine chromium 0.75mg/kg, normal diet 41.22% adds suitable quantity of water and mixes thoroughly, repressed one-tenth graininess, oven dry.
The Chroumim:D group is the high chromium group of high fat (1% calcium): milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, methylpyridine chromium 0.75mg/kg, normal diet 46.3%, add suitable quantity of water and mix thoroughly, repressed one-tenth graininess, oven dry.
By table 10 as seen, each is organized the insulin value and passes in time all to be and increase trend, and since the insulin level of high fat control group be significantly higher than basic control group (P＜0.05) the 1st week.Except the insulin level of fish oil+chromium group from just being higher than basis contrast level the 1st week, since two experimental group also be significantly higher than basic control group (P＜0.05) in the 3rd week in addition.The insulin level of three experimental group significantly is lower than high fat control group (P＜0.05) since the 3rd week, and it is different with high fat control group that the insulin that three experimental group are described increases degree.
Three. dietary calcium
1, the various dose dietary calcium is to the influence of each group rat body weight and body fat content
Table 11 is respectively organized rat body weight and body fat content (X ± s)
Each group is compared with the C group, and significant difference is arranged
*P＜0.05;
A organizes basal feed group (being mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
The B group is the low calcium group (0.08% calcium) of high fat: milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, normal diet 47.22% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The C group is the normal calcium group of high energy (0.5% calcium): milk powder 20%, and glucose 33.7%, CALCIUM PYRUVIC 0.08%, normal diet 47.22% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The D group is high fat high calcium group (1% calcium): milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 46.3% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The E group is high fat high calcium group (1.5% calcium): milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 45.8% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The F group is high fat high calcium (1.5% calcium+600IU 1% vitamin D) group: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 44.8%, add suitable quantity of water and mix thoroughly, repressed one-tenth graininess, oven dry.
By table 11 as seen, body weight did not have marked difference before each organized rat experiment, pass in time, each organizes body weight increases gradually, when finishing, experiment compares with the C group, other is respectively organized rat body weight and all significantly reduces (P＜0.05), and the B group descends body weight owing to serious calcium deficiency causes long-term diarrhea, and body weight is organized a little less than A finally.D, the E of high fat high calcium meals, F group body fat content is compared remarkable reduction (P＜0.05) a little more than A group (P＜0.05) with the C group, and visible high calcium meals can obviously reduce body weight and body fat content.
2, various dose calcium is to the influence of experiment rat blood sugar in mid-term and blood fat
Rat blood sugar and blood lipid level (X ± s) is respectively organized in table 12 experiment mid-term
Each group is compared with the C group, and significant difference is arranged
*P＜0.05
A organizes basal feed group (being mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
The B group is the low calcium group (0.08% calcium) of high fat: milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, normal diet 47.22% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The C group is the normal calcium group of high energy (0.5% calcium): milk powder 20%, and glucose 33.7%, CALCIUM PYRUVIC 0.08%, normal diet 47.22% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The D group is high fat high calcium group (1% calcium): milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 46.3% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The E group is high fat high calcium group (1.5% calcium): milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 45.8% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The F group is high fat high calcium (1.5% calcium+600IU 1% vitamin D) group: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 44.8%, add suitable quantity of water and mix thoroughly, repressed one-tenth graininess, oven dry.
By table 12 as seen, compare with the C group, D, E, F group rat blood serum cholesterol and triglycerides all have a declining tendency.Cholesterol B group is compared remarkable reduction (P＜0.05) with the C group, and triglycerides A, B, D, F group are compared remarkable reduction (P＜0.05) with the C group.Blood sugar B group has been compared conspicuousness (P＜0.05) with the C group, and all the other each groups have downward trend, but there was no significant difference (P＜0.05).Each group there are no significant difference (P＞0.05) of HDL.Illustrate that the high calcium meals have obvious reduction effect to experiment rat blood serum triglycerides in mid-term, cholesterol and blood sugar are had the trend of reduction, but not statistically significant.Dietary calcium does not have obvious influence to serum high-density LP.
3, various dose calcium is to the influence of experiment rat fat in latter stage and blood sugar
Rat blood sugar and blood lipid level (X ± s) is respectively organized in table 13 experiment latter stage
A organizes basal feed group (being mass fraction): corn 37%, wheat bran 12%, flour 15%, dregs of beans 32%, vegetable oil 1.7%, stone flour 1%, calcium monohydrogen phosphate 0.8%, salt 0.2%, methionine 0.2%, lysine 0.1%
The B group is the low calcium group (0.08% calcium) of high fat: milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 0.08%, normal diet 47.22% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The C group is the normal calcium group of high energy (0.5% calcium): milk powder 20%, and glucose 33.7%, CALCIUM PYRUVIC 0.08%, normal diet 47.22% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The D group is high fat high calcium group (1% calcium): milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 46.3% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The E group is high fat high calcium group (1.5% calcium): milk powder 20%, and cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 45.8% adds suitable quantity of water to mix thoroughly, repressed one-tenth graininess, oven dry.
The F group is high fat high calcium (1.5% calcium+600IU 1% vitamin D) group: milk powder 20%, cholesterol 2.5%, cream 30%, cholic acid 1%, methylthiouracil 0.2%, CALCIUM PYRUVIC 1%, normal diet 44.8%, add suitable quantity of water and mix thoroughly, repressed one-tenth graininess, oven dry.
Each group is compared with the C group, and significant difference is arranged
*P＜0.05; The A group is the basal feed group, the B group is the low calcium group (0.08% calcium) of high energy, and the C group is the normal calcium group of high energy (0.5% calcium), and the D group is high fat high calcium group (1% calcium), the E group is high fat high calcium group (1.5% calcium), and the F group is high fat high calcium (1.5% calcium+600IM% vitamin D) group.
By table 13 as seen, each group there are no significant difference (P＞0.05) of blood sugar and HDL, each group of cholesterol and triglycerides are compared with the C group and are all significantly reduced (P＜0.05).Illustrate that the high calcium meals have significantly reduced serum triglyceride and cholesterol levels, have improved hyperlipidemia.
Formula milk crowd experimental result
Take of the present invention be the function milk powder of raw material preparation with NZMP board skimmed milk power after, user's blood pressure does not have the change effect, hematological system, urine, just also no abnormality seen of routine inspection, formula components does not have any detrimental effect to hepatic and renal function.Test-meal group crowd's Serum Leptin Levels and insulin level are all than descending before the experiment
With other conventional skimmed milk powers is the function milk powder of raw material preparation, has obtained same effect.
With the skimmed milk power that derives from liquid milk is the function milk powder of raw material preparation, has also obtained same effect,
List of references
1. Wang Mao rises.Chromium is to the influence of body health in the meals.Chinese food health magazine 1996,8 (3): 33-36
2. protect in week and learn Jiang Shu qin Zhou Ding.Chromium (III) supply dosage reaches the influence to physique and fat-reducing.Trace element and health research 1999,16 (3): 63-65
3. China Light Industry Press is write by " DRIs " Chinese Soclety of Nutrition
4. " Nutrition and Food Hygiene " the 5th edition
5.Fristsche，J.Rickert，R?and?Steinhart?H.(1999)Formation，contents，and?estimation?of?daily?intake?of?conjμgated?linoleic?acid?isomers?and?trans?fatty?acids?in?foods.In：Advances?in?Conj?μgated?Linoleic?AcidResearch(Yμrawecz，M.P.Mossobo，M.M.，Kramer，JKG，Pariza，M.W.and?Nelson，G.J.，eds.)，vol.L，pp.378-396.AOCS?Press，Champaign?6.Diabetes?Prevention?Program?Research?Groμp.(2002)Redμction?inthe?incidence?of?type?2diabetes?with?lifestyle?intervention?or?metformin.N.Engl.J.Med.346：393-404.
Claims (6)
1. milk powder that reduces or keep blood sugar, it is characterized in that: 100g milk powder is made up of following raw material:
CLA 1000～2000mg
Methylpyridine chromium 620～830 μ g
Glycine zine 37.46～78.16mg
Magnesium sulfate .7H2O 300～800mg
Biological calcium carbonate 1280～2022mg
The skimmed milk power surplus.
2. a kind of milk powder that reduces or keep blood sugar according to claim 1, it is characterized in that: 100g milk powder is made up of following raw material:
CLA 1000mg
Methylpyridine chromium 620 μ g
Glycine zine 37.46mg
Magnesium sulfate .7H2O 300mg
Biological calcium carbonate 1280mg
The skimmed milk power surplus.
3. a kind of milk powder that reduces or keep blood sugar according to claim 1, it is characterized in that: 100g milk powder is made up of following raw material:
CLA 2000mg
Methylpyridine chromium 830 μ g
Glycine zine 78.16mg
Magnesium sulfate .7H2O 800mg
Biological calcium carbonate 2022mg
The skimmed milk power surplus.
4. a kind of milk powder that reduces or keep blood sugar according to claim 1, it is characterized in that: 100g milk powder is made up of following raw material:
CLA 1500mg
Methylpyridine chromium 724 μ g
Glycine zine 57.46mg
Magnesium sulfate .7H2O 500mg
Biological calcium carbonate 1884mg
The skimmed milk power surplus.
5. according to any described a kind of preparation method who reduces or keep the milk powder of blood sugar among the claim 1-4, it is characterized in that: skimmed milk power mixes with each active material.
6. according to any described a kind of preparation method who reduces or keep the milk powder of blood sugar among the claim 1-4, it is characterized in that:
Raw milk: free of contamination pure fresh milk 10kg is a raw material with health,
Clean breast: milk clarifier is removed foreign matters such as weeds,
Centrifugal: the butterfat centrifuge removes degrease,
Standardization:, make the control range of its back component content that dusts with the fresh cow milk standardization: lactose 53.1～55.1%, protein 32.4～34.4%, mineral matter 7.5～8.3%, moisture 3.0～4.0%, fat 0.6～0.9%,
Batching: load weighted methylpyridine chromium, glycine zine, magnesium sulfate .7H2O, biological calcium carbonate are joined in the liquid milk after the standardization, stir,
Sterilization: adopt 83 ℃, 15 seconds high temperatures,
High-pressure homogeneous: adopt the pressure homogeneous of 18～22Mpa,
Vacuum concentrates: vacuum 600～700Pa, the content that makes dry in the liquid milk be 35～45%,
Spray-drying: EAT is controlled at 140～150 ℃, and leaving air temp is controlled between 75～85 ℃,
Cooling: adopt air-cooledly, make milk powder be chilled to 4 ℃ rapidly, add CLA simultaneously,
Sieve: sieve and remove impurity and insoluble matter in the dry run, and CLA and milk powder are mixed.
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| CN100448356C (en) * | 2006-07-05 | 2009-01-07 | 内蒙古蒙牛乳业（集团）股份有限公司 | A cow milk containing conjugated linoleic acid |
| CN1899051B (en) * | 2006-07-08 | 2010-09-08 | 南昌大学 | Method for preparing milk powder for regulating blood sugar |
| CN100496263C (en) * | 2006-08-31 | 2009-06-10 | 中国人民解放军第三军医大学第三附属医院 | Sour milk with function of lowering blood sugar |
| CN100409762C (en) * | 2006-09-28 | 2008-08-13 | 王增礼 | Konjaku flour suitable for diabetes |
| CN104814138A (en) * | 2014-08-20 | 2015-08-05 | 陕西九泰保健科技有限公司 | Blood sugar-reducing goat milk powder and preparation method therefor |
| CN112042753A (en) * | 2020-09-16 | 2020-12-08 | 甘肃华羚乳品股份有限公司 | Modified milk powder suitable for diabetes patients and preparation method thereof |
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