CN100553647C - The preparation method of Echinacea extract - Google Patents
The preparation method of Echinacea extract Download PDFInfo
- Publication number
- CN100553647C CN100553647C CNB2006100318452A CN200610031845A CN100553647C CN 100553647 C CN100553647 C CN 100553647C CN B2006100318452 A CNB2006100318452 A CN B2006100318452A CN 200610031845 A CN200610031845 A CN 200610031845A CN 100553647 C CN100553647 C CN 100553647C
- Authority
- CN
- China
- Prior art keywords
- echinacea
- extract
- preparation
- echinacea extract
- raw material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
What the preparation method of Echinacea extract, raw material adopted is the Echinacea herb of fresh state, through extracting, concentrate Echinacea extract.The present invention has realized extracting total caffeic acid derivant to greatest extent from Echinacea, has simplified the Technology flow process of extracting purification, has saved production cost, and the deep development for the Echinacea product provides infrastructural support simultaneously.
Description
Technical field
The present invention relates to a kind of plant extract, refer in particular to the preparation method of Echinacea extract.
Background technology
Echinacea (Echinacea purpurea.L., Echinacea angustifolia) is a Compositae genus echinacea herbaceos perennial, has another name called SONGGUOJU, originates in the central and west regions in North America, and China part provinces and cities are existing to introduce a fine variety.Recent research result shows: contain materials such as a large amount of caffeic acid derivants and alkylamide in its flower and wounded in the battle branch and leaf and the root; an oxygen species and free radical that caffeic acid derivant in the Echinacea extract has antiinflammatory action and can have reactivity by removing, thus the protection skin collagen is not subjected to the infringement of free radical.The caffeic acid derivant comprises chicoric acid, chlorogenic acid, echinacosid, coffee tartaric acid and cinarine etc.Many-sided research data proves: Echinacea can promote cellular immune function, promotes the generation of T lymphocyte and bone-marrow-derived lymphocyte and strengthens its activity; Strengthen the phagocytic function of macrophage; Activate splenocyte and improve its rate of increase.Echinacea external suppress virus duplicate, have data to show: so long as the disease of infected by microbes, Echinacea can both be brought into play its good physiological effect, with the antibiotic coupling, also can quicken the recovery from illness; The viral infection that general antibiotic is not dealt with, Echinacea can tackle calmly by activating immune system.Compare with antibiotic, Echinacea in use can not produce drug resistance, does not have recurrence.Infectious effect to upper respiratory tract is obvious.
On American-European natural drug market, the Echinacea preparation has become a kind of outstanding health care and adjuvant drug, is one of best-selling plant class preparation. and the health food that with the Echinacea extract is main component is in Europe and U.S.'s fast sale.
Domestic research to Echinacea at present is few, has technical bottleneck especially on the commercial production of high-quality mark extraction Echinacea caffeic acid derivant, is unfavorable for the deep development of Echinacea product.Using raw material in the general technology of report all is to thank to the period Echinacea and gather in drying in the sun dry product afterwards transferring from blooming spend.But the caffeic acid derivant quality mark of the Echinacea raw material after the inventor finds to shine, dry in the shade is not high, and owing to the dry and storage through segment length's time, the destructiveness of its effective ingredient is also very big.In addition, technology does not require the specific period and the position of raw material.How to satisfy the chicoric acid mass fraction and make relevant report in the low-cost acquisition of the Echinacea extract of 1%-9% prescription also nobody.
Summary of the invention
Purpose of the present invention aims to provide and a kind ofly can make full use of caffeic acid derivant high-quality percentage ratio in the Echinacea raw material growth course, helps the abundant extraction of effective ingredient, improves yield, the preparation method of the Echinacea extract that reduces cost.
The objective of the invention is to realize by following manner:
What raw material adopted is the Echinacea herb of fresh state, through extracting, concentrate Echinacea extract.
The inventor discover the present invention adopt the Echinacea of fresh bud stage blade, alabastrum and wounded in the battle side shoot extract best in quality, yield is best.
Above raw material is through alcohol extraction, and alcoholic solvent reclaims, and obtains Echinacea extract behind the extracting solution concentrate drying.
Fresh state is in the Echinacea aerial parts of bud stage, or is in the blade of the bud stage Echinacea of fresh state, includes alabastrum and wounded in the battle side shoot, gets squeezeding juice and raw material slag through cold pressing, and squeezeding juice concentrates, and drying is Echinacea extract.
The raw material slag is through alcohol extraction, and alcoholic solvent reclaims, and extracting solution concentrates, and drying obtains the extract of Echinacea.
Raw material slag after described the squeezing the juice was with the reflux, extract, of 70%-95% ethanol or methanol 2 times, each 1～4 hour.The extracting solution concentrating under reduced pressure, is Echinacea extract after drying at solvent recovery.
Described cold pressing is to mix with fresh Echinacea with the water of weight ratio 1～2: 1.
Described squeezeding juice after macroporous resin adsorption with the Different concentrations of alcohol eluting, get eluent, eluent reclaims, concentrates, and is Echinacea extract after the drying, and is refining that total caffeic acid derivant quality percentage ratio is the Echinacea extract of 10%-60% through ethyl acetate again.
The root of the Echinacea of fresh state through water or alcohol extraction, obtains Echinacea extract behind the extracting solution concentrate drying.
The root of the Echinacea of fresh state through squeeze the juice squeezeding juice and slag, after squeezeding juice drying or the lyophilizing Echinacea root juice powder, squeeze the juice slag behind alcohol or water extraction, reclaim, concentrate, dry Echinacea root extract.
The present invention has realized extracting total caffeic acid derivant to greatest extent from Echinacea, has simplified the Technology flow process of extracting purification, has saved production cost, and the deep development for the Echinacea product provides infrastructural support simultaneously.
In the raw material of Echinacea was investigated, the inventor had crucial discovery, and promptly the mass fraction of the chicoric acid of caffeic acid derivant exceeds 2.5～5.5 times than the plant after drying in the fresh plant.Concrete data see the following form.
| Seedling | Flower in earlier stage | Alabastrum | Just spend | Contain flower | Wither | |
| Bright product (meter of giving money as a gift) | 3.4 | 2.7 | 4.6 | 4.1 | 3.5 | 2.2 |
| Dry product (meter of giving money as a gift) | 0.8 | 0.6 | 1.7 | 1.35 | 1.27 | 0.4 |
No matter which growth period the Echinacea plant is in as can be seen from the above table, and the content of its bright product all is higher than the content of dry product.
Technology of the present invention is simple, and effective ingredient can farthest be kept.The present invention has adopted the Echinacea of fresh state as extracting raw material; In the general used former plant of drying in the sun, the chicoric acid content of caffeic acid derivant (meter of giving money as a gift) is in 0.01%～1.5% scope, and the inventor discovers that by experiment the chicoric acid content (meter of giving money as a gift) of genus coffea acid derivative in the fresh former plant can reach 1%～4.5%, as seen both gaps are fairly obvious, because original raw material causes the forfeiture of the effective ingredient of Echinacea in daily dry run.The inventor discovers that also the bud stage that is accumulated in of Echinacea secondary metabolite caffeic acid derivant is a top level in addition, especially in blade and alabastrum.Thereby the inventor adopts fresh Echinacea to extract, especially the blade of bud stage, alabastrum and to contain colored side shoot be optimum feed stock.The present invention can save material and manufacturing cost greatly owing to the content of the extract effective ingredient caffeic acid derivant that has adopted fresh Echinacea raw material to make is much higher than the extract of being made by dry product, helps the purification of subsequent handling.Its correlational study of the present invention yet there are no relevant report.
The inventor is by following experimentation, and having determined to be in the bud stage Echinacea is that the best of wanting required for the present invention is collected the stage.
We pass through the investigation to the whole growth cycle of fresh medical material, find effective biological total amount the highest period, to reach the reduction industrial production cost, increase the purpose of product profit, the fresh medical material that found that the Echinacea of bud stage is the optimum feed stock condition mode.(seeing accompanying drawing)
Description of drawings
Accompanying drawing: the biological total amount of the unit are of Echinacea is with the changing trend diagram of trophophase.
Accompanying drawing is described is the caffeic acid derivative total amount (mainly referring to Cichoric acid, chlorogenic acid, echinacosid and coffee tartaric acid) that contains in the Echinacea plant of unit are region and the curve map of Echinacea growth cycle correlation, and main five points of curve form: seedling during the phase unit are region Echinacea caffeic acid derivative total amount be 6.75 kilograms; The caffeic acid derivative total amount of flower unit are region Echinacea during early stage is 19.25 kilograms; Unit are region Echinacea caffeic acid derivative total amount is 26.5 kilograms during bud stage; Unit are region Echinacea caffeic acid derivative total amount is 25.85 kilograms during the florescence; Unit are region Echinacea caffeic acid derivative total amount is 10.75 kilograms when withering the phase. Can find out that from whole curve map the Echinacea that is in bud stage is biological total amount the highest period in the unit are. Biological total caffeic acid derivative=biological total amount * Echinacea caffeic acid derivative content (meter of giving money as a gift), biological total amount refers to the Echinacea output (meter of giving money as a gift) of unit are.
The specific embodiment
Embodiment 1
Choose fresh, do not have the yellow aerial parts that withers, do not have addling, is in the Echinacea plant of bud stage, after the chopping, with 95% ethanol of 2 times of bright medical material weight reflux, extract, together 2 times, each 2 hours.Merge extractive liquid, reclaims solvent, concentrates, dry chicoric acid mass fraction is 6% Echinacea extract.
Embodiment 2
Choose fresh, do not have the yellow aerial parts that withers, do not have addling, is in the Echinacea plant of bud stage, after the chopping, with the methanol of 2 times of bright medical material weight reflux, extract, together 2 times, each 2 hours.Merge extractive liquid, concentrates, dry chicoric acid mass fraction is 5% Echinacea extract.
Embodiment 3
The Echinacea extract of total chicoric acid mass fraction 6% that embodiment 1 is obtained is through ethyl acetate extraction 3 times, and it is 17% Echinacea extract that concentrate drying promptly gets total chicoric acid mass fraction.
Embodiment 4
Choose fresh, do not have the yellow aerial parts that withers, do not have addling, is in the Echinacea plant of seedling phase, after the chopping, with 90% ethanol of 2 times of bright medical material weight reflux, extract, together 2 times, each 2 hours.Merge extractive liquid, reclaims, concentrates, cooling, standing separation get precipitate, and it is 5% Echinacea extract that drying precipitate is got total chicoric acid mass fraction.
Choose fresh, do not have the yellow aerial parts that withers, do not have addling, is in the Echinacea plant of full-bloom stage, after the chopping, with 90% ethanol of 2 times of bright medical material weight reflux, extract, together 2 times, each 2 hours.Merge extractive liquid, reclaims, concentrates, cooling, standing separation get precipitate, and it is 4% Echinacea extract that drying precipitate is got the chicoric acid mass fraction.
Embodiment 6
Choose fresh, do not have the yellow aerial parts that withers, do not have addling, is in the Echinacea plant of blossom fall phase, after the chopping, with 90% ethanol of 2 times of bright medical material weight reflux, extract, together 2 times, each 2 hours.Merge extractive liquid, reclaims, concentrates, cooling, standing separation get precipitate, and it is 4% Echinacea extract that drying precipitate is got the chicoric acid mass fraction.
Embodiment 7
Choose fresh, as not have the Echinacea plant that yellowly withers, do not have addling, is in bud stage leaf and alabastrum, alabastrum side shoot part, after the chopping, with 90% ethanol of 2 times of bright medical material weight reflux, extract, together 2 times, each 2 hours.Merge extractive liquid, reclaims, concentrates, cooling, standing separation get precipitate, and it is 9% Echinacea extract that drying precipitate is got the chicoric acid mass fraction.
Embodiment 8
Choose fresh, do not have a yellow aerial parts that withers, do not have addling, is in the Echinacea plant of bud stage.With weight ratio is the water and the fresh plant input juice extractor of 2 times of amounts.The back filter pressing separation of squeezing the juice obtains squeezeding juice and raw material slag.Squeezeding juice concentrates, obtain the chicoric acid mass fraction after the drying is 3% Echinacea extract.
Embodiment 9
The raw material slag part that embodiment 8 is obtained is with methanol, reflux, extract, 2 times, each 2 hours.The extracting solution concentrating under reduced pressure is recovered to does not have alcohol flavor substantially, concentrates, promptly gets the extract that contains total caffeic acid derivant 7% after the drying.Be 20% Echinacea extract with this Echinacea extract with the refining chicoric acid mass fraction that obtains of ethyl acetate backflow again.
After squeezeding juice is crossed macroporous resin adsorption,, reclaim, concentrate, promptly get total chicoric acid mass fraction after the drying and be 30% Echinacea extract again with 3 times of column volumes of ethanol elution of 80%, and with eluent earlier with 3 times of column volumes of ethanol elution (putting in addition) of 10%.This extract with ethyl acetate backflow twice, is obtained the chicoric acid mass fraction and is 45% Echinacea extract.
The raw material slag part that embodiment 9 is obtained is with 95% ethanol, reflux, extract, 2 times, each 2 hours.The extracting solution concentrating under reduced pressure is recovered to does not have alcohol flavor substantially, obtains the chicoric acid mass fraction after the drying and be 7% Echinacea extract.
Embodiment 11
Choose fresh, do not have yellow leaf and the wounded in the battle side shoot part of withering, not having addling, be in the Echinacea plant of blossom fall phase, be the water and the fresh plant input juice extractor of 2 times of amounts with weight ratio.Obtain squeezeding juice and raw material slag with the separation of cylinder filter press technique after squeezing the juice.
With raw material slag part with 90% ethanol, reflux, extract, 2 times, each 2 hours.The extracting solution concentrating under reduced pressure is recovered to does not have alcohol flavor substantially, obtains containing the chicoric acid mass fraction after the drying and be 9% Echinacea extract.
After squeezeding juice is crossed macroporous resin,, reclaim, concentrate, promptly get total chicoric acid mass fraction after the drying and be 6% Echinacea extract again with 3 times of column volumes of ethanol elution of 90%, and with eluent earlier with 3 times of column volumes of ethanol elution (putting in addition) of 10%.
Embodiment 12
Choose fresh, do not have a yellow aerial parts that withers, do not have addling, is in the Echinacea plant of seedling phase.With weight ratio is the water and the fresh plant input juice extractor of 1 times of amount.The back filter pressing of squeezing the juice obtains squeezeding juice and raw material slag.
With raw material slag part with 90% ethanol, reflux, extract, 2 times, each 2 hours.The extracting solution concentrating under reduced pressure is recovered to does not have alcohol flavor substantially, after the drying the chicoric acid mass fraction be 5% Echinacea extract.
After squeezeding juice is crossed macroporous resin,, reclaim, concentrate, promptly get total chicoric acid mass fraction after the drying and be 20% Echinacea extract again with 3 times of column volumes of ethanol elution of 90%, and with eluent earlier with 3 times of column volumes of ethanol elution (putting in addition) of 10%.
Embodiment 13
Choose fresh, do not have a yellow aerial parts that withers, do not have addling, is in the Echinacea plant of anthesis.With weight ratio is the water and the fresh plant input juice extractor of 2 times of amounts.The filter pressing of squeezing the juice obtains squeezeding juice and raw material slag.
With raw material slag part with 90% ethanol, reflux, extract, 2 times, each 2 hours.The extracting solution concentrating under reduced pressure is recovered to does not have alcohol flavor substantially, obtains containing the chicoric acid mass fraction after the drying and be 4% Echinacea extract.
After squeezeding juice is crossed macroporous resin,, reclaim, concentrate, promptly get total chicoric acid mass fraction after the drying and be 18% Echinacea extract again with 3 times of column volumes of ethanol elution of 90%, and with eluent earlier with 3 times of column volumes of ethanol elution (putting in addition) of 10%.
Embodiment 14
Choose fresh, do not have a yellow aerial parts that withers, do not have addling, is in the Echinacea plant of blossom fall phase.With weight ratio is the water and the fresh plant input juice extractor of 2 times of amounts.Obtain squeezeding juice and raw material slag with the separation of cylinder filter press technique after squeezing the juice.
With raw material slag part with 90% ethanol, reflux, extract, 2 times, each 2 hours.The extracting solution concentrating under reduced pressure is recovered to does not have alcohol flavor substantially, obtains containing the chicoric acid mass fraction after the drying and be 2% Echinacea extract.
After squeezeding juice is crossed macroporous resin,, reclaim, concentrate, promptly get total chicoric acid mass fraction after the drying and be 12% Echinacea extract again with 3 times of column volumes of ethanol elution of 90%, and with eluent earlier with 3 times of column volumes of ethanol elution (putting in addition) of 10%.
Choose the root of fresh Echinacea, the ethanol with 95%, reflux, extract, 2 times, each 2 hours.The extracting solution concentrating under reduced pressure is recovered to does not have alcohol flavor substantially, and drying obtains total chicoric acid mass fraction and be 4% Echinacea extract.
Embodiment 16
Choose the root of fresh Echinacea, water is squeezed the juice.With the squeezeding juice concentrating under reduced pressure, a part is dry, obtains total chicoric acid mass fraction and be 2% Echinacea root juice powder, and it is 3% Echinacea extract that another part lyophilizing gets the chicoric acid mass fraction.
Embodiment 17
After the squeezeding juice of embodiment 16 crossed macroporous resin,, reclaim, concentrate, promptly get the Echinacea root extract after the drying again with 3 times of column volumes of ethanol elution of 80%, and with eluent earlier with 3 times of column volumes of ethanol elution of 10%.This extract with ethyl acetate backflow twice, is obtained total chicoric acid mass fraction and is 15% Echinacea root extract.
Claims (7)
- What 1, the preparation method of Echinacea extract, raw material adopted is fresh state, is in the aerial parts of bud stage Echinacea, through extracting, concentrate Echinacea extract.
- 2, the preparation method of Echinacea extract according to claim 1, what raw material adopted is fresh state, is in blade, alabastrum and the wounded in the battle side shoot part of the Echinacea of bud stage.
- 3, the preparation method of each Echinacea extract according to claim 1 and 2, fresh feed are through alcohol extraction, and alcoholic solvent reclaims, and obtains Echinacea extract behind the extracting solution concentrate drying.
- 4, the preparation method of Echinacea extract according to claim 1 and 2: the aerial parts of the Echinacea of fresh state, get squeezeding juice and raw material slag through cold pressing, squeezeding juice concentrates, and drying is Echinacea extract.
- 5, the preparation method of Echinacea extract according to claim 4, raw material slag are through alcohol extraction, and alcoholic solvent reclaims, and extracting solution concentrates, and drying obtains the extract of Echinacea.
- 6, the preparation method of Echinacea extract according to claim 4, described cold pressing are to mix with fresh Echinacea with the water of weight ratio 1～2: 1.
- 7, the preparation method of Echinacea extract according to claim 4, described squeezeding juice after macroporous resin adsorption with the Different concentrations of alcohol eluting, get eluent, eluent reclaims, concentrates, be Echinacea extract after the drying, refining that total caffeic acid derivant quality percentage ratio is the Echinacea extract of 10%-60% through ethyl acetate again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100318452A CN100553647C (en) | 2006-06-16 | 2006-06-16 | The preparation method of Echinacea extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100318452A CN100553647C (en) | 2006-06-16 | 2006-06-16 | The preparation method of Echinacea extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1957961A CN1957961A (en) | 2007-05-09 |
| CN100553647C true CN100553647C (en) | 2009-10-28 |
Family
ID=38069914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100318452A Active CN100553647C (en) | 2006-06-16 | 2006-06-16 | The preparation method of Echinacea extract |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100553647C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106387581A (en) * | 2016-09-20 | 2017-02-15 | 合肥工业大学 | Preparation technology of chicoric acid enriched fresh echinacea purpurea squeezed juice |
| CN107981354A (en) * | 2017-11-20 | 2018-05-04 | 合肥工业大学 | A kind of preparation method and application of fresh Echinacea oral liquid |
| CN114053210B (en) * | 2021-10-26 | 2023-09-29 | 海南全星制药有限公司 | Mopirocin ointment and preparation method thereof |
-
2006
- 2006-06-16 CN CNB2006100318452A patent/CN100553647C/en active Active
Non-Patent Citations (12)
| Title |
|---|
| commission E 植物药专论（2）. 德国.国外医药，植物药分册，第19卷第4期. 2004 |
| commission E 植物药专论(2). 德国.国外医药，植物药分册，第19卷第4期. 2004 * |
| david d kitts retention of caffeic acid derivatives in dride cehinaceapurpruea. hyum ock kim ,timothy d durance christine h scaman.J.agric food chem,Vol.48 . 2000 |
| david d kitts retention of caffeic acid derivatives in dride cehinaceapurpruea. hyum ock kim,timothy d durance christine h scaman.J.agric food chem,Vol.48. 2000 * |
| richard scalzo pattems of variation in alkamides and cichoric acid in rootsand a boveground parts of echinacea purpuea. luping qu ,ying chen ,xiping wang.Hortscience,Vol.40 No.5. 2005 |
| richard scalzo pattems of variation in alkamides and cichoric acid in rootsand a boveground parts of echinacea purpuea. luping qu,ying chen,xiping wang.Hortscience,Vol.40 No.5. 2005 * |
| 国际流行的免疫调节剂--紫锥菊及其制剂. 肖培根.中草药，第27卷第1期. 1996 |
| 应用大孔吸附树脂吸附分离技术制备菊苣酸的研究. 吴启林，袁其明，陈营文.北京化工大学学报自然科学版，第31卷第5期. 2004 |
| 引种紫锥菊有效成分菊苣酸含量研究. 窦德明，崔树玉，曹永智，严亚娟，帅绯.中草药，第32卷第11期. 2001 |
| 松果菊中有效成分菊苣酸的含量研究. 王弘，刘文芝，鲁晓蕾，陈世忠，艾铁民.中国中药杂志，第27卷第6期. 2002 |
| 神奇的免疫植物 紫锥菊. 陈洪亮，禚宝山，陈嘉琪，吴连勇，李德发，常碧影.饲料研究，第10卷. 2005 |
| 药材新宠紫锥菊. 李鹏.大自然，第5卷. 2004 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1957961A (en) | 2007-05-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102451235B (en) | Preparation method of olive leaf extract | |
| CN101773593B (en) | Method for preparing antioxidative active extractive of sweet potato leaves | |
| CN102106931B (en) | Method for producing diverse extracts of berry tea | |
| CN101260131A (en) | Method for extracting iridoid active site and monomer from eucommia bark | |
| CN101912480A (en) | Method for preparing procyanidin extract of lycium ruthenicum murr | |
| CN101781279B (en) | Preparation method of grape seed procyanidin | |
| CN1981799B (en) | Preparing method for extracts of red clover | |
| CN100553647C (en) | The preparation method of Echinacea extract | |
| CN101926452B (en) | Wild jujube leaf total flavonoids extract and preparation method thereof | |
| CN101829284A (en) | Process for extracting and refining flavone in highland barley seedlings by enzymolysis-membrane ultrafiltration | |
| CN1899382B (en) | Method for preparing forsythia fruit effective part | |
| CN108640956A (en) | A method of preparing flavonoid glycoside from tea seed | |
| CN101554394A (en) | Process for extracting total flavonoid from canola plant bee pollen | |
| CN104211754A (en) | Method for preparing polysaccharides and glycoproteins from Medicago sativa L. stems | |
| CN101696381B (en) | Novel process for preparing highland barley flavone extract and application thereof in health wine | |
| CN1850140A (en) | Method for preparing chrysanthemum formula granules | |
| CN103232515A (en) | Cyclocarya paliurus glucoside I preparation method | |
| CN102648965A (en) | Industrialization preparation method of lophatherum gracile general flavone | |
| CN104224867A (en) | Sugarless herba lysimachiae granules and preparation method thereof | |
| CN104706688A (en) | Method for preparing effective parts of nutmeg total lignanoids | |
| CN108126000A (en) | Arasaponin extracts preparation method in fresh Radix Notoginseng | |
| CN108420848A (en) | A kind of method that microwave radiation technology prepares flavone compound in lightyellow sophora flower | |
| CN101991628B (en) | Process for preparing non-toxic extractive from asarum heterotropoides | |
| CN105708882A (en) | Extraction process of sweet potato fol. flavone | |
| CN104719559B (en) | A kind of preparation method of glutinous rehmannia bud seedling tea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: HUNAN BRILLIANCE+ ABUNDANCE SCIENTIFIC CHINESE HER Free format text: FORMER NAME: HUNAN BRILLIANCE+ ABUNDANCE SCIENTIFIC CHINESE HERBAL MEDICINE CO.,LTD |
|
| CP01 | Change in the name or title of a patent holder |
Address after: 410329 Liuyang biomedical industry park, Liuyang, Hunan Patentee after: Hunan Chunguang Jiuhui Modern Chinese Traditional Medicine Co., Ltd. Address before: 410329 Liuyang biomedical industry park, Liuyang, Hunan Patentee before: PhytoWay Inc. |
|
| CP02 | Change in the address of a patent holder |
Address after: 410331 No. 10, Kangping Road, Liuyang economic and Technological Development Zone, Hunan Patentee after: Hunan Chunguang Jiuhui Modern Chinese Traditional Medicine Co., Ltd. Address before: 410329 Liuyang biomedical industry park, Liuyang, Hunan Patentee before: Hunan Chunguang Jiuhui Modern Chinese Traditional Medicine Co., Ltd. |
|
| CP02 | Change in the address of a patent holder |