CN100544790C - The sound wave inserting needle system of microneedle array paster - Google Patents
The sound wave inserting needle system of microneedle array paster Download PDFInfo
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- CN100544790C CN100544790C CNB2006100408764A CN200610040876A CN100544790C CN 100544790 C CN100544790 C CN 100544790C CN B2006100408764 A CNB2006100408764 A CN B2006100408764A CN 200610040876 A CN200610040876 A CN 200610040876A CN 100544790 C CN100544790 C CN 100544790C
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- microneedle array
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Abstract
The invention discloses a kind of sound wave inserting needle system of microneedle array paster, it is characterized in that: comprise ring for fixing, acoustic vibration generator, the inner edge bottom of described ring for fixing is provided with the fixed ring piece of inside stretching, extension, the acoustic vibration generator stretches in the ring for fixing, the lower end is through pad and fixed ring piece location, the pad bottom surface is pasted with site, constitutes microneedle array paster installation position; Wherein, the operating frequency of described acoustic vibration generator is 10H
Z～100KH
Z, output is less than 60W, and the position that is provided with of described fixed ring piece makes the adhesion paster to the distance of the ring for fixing bottom surface height greater than corresponding microneedle array paster.The present invention can reduce near the sense of discomfort patient's pain spot, and the degree of depth that penetrates on the skin of various character is consistent, the difference of avoiding the skin difference to bring.
Description
Technical field
The present invention relates to a kind of device relevant with the percutaneous dosing technology, especially a kind of making strengthens the device that the infiltrative micro-needle array chip repeatability of percutaneous dosing penetrates keratodermatitis.
Background technology
Most drug is with form oral administrations such as tablet, capsules at present.Yet because the degraded of medicine in gastrointestinal and the first pass effect of liver, many oral drugs are most of or all inefficacies before reaching site of action.Another common administering mode is to make medicine penetrate the drug administration by injection of biological barrier (as skin, mucosa, blood vessel barrier), comprises the input of subcutaneous injection and vein.Though this method is effective, have an injection and can bring extra pain to the patient, cause local skin damage, hemorrhage easily at injection point, because wound is an infection point, can increase the danger of disease propagation simultaneously.Injection also requires by trained people's operation, needing therefore to be not suitable for patient long-term and the control successive administration.
The novel medication of one class is a transdermal administration, can avoid above-mentioned shortcoming.Transdermal administration is meant in the skin surface administration, makes medicine to pass through each layer of skin near constant speed, absorbs through blood capillary to enter body circulation generation whole body or local therapeutic effects, and such preparation is commonly referred to transdermal patch.Transdermal administration and subcutaneous injection or vein input administration is with a kind of medication administration method on principle.Transdermal administration is applied to treat local skin or general disease, has safer, stable and the good advantage of patient compliance than other dosage forms.Wherein passive transdermal administration technology is to be that driving force makes drug diffusion see through skin to enter blood flow and produce drug effect with simple Concentraton gradient, and diffusion rate depends on the size and the hydrophilic of drug molecule and passes cuticular Concentraton gradient.It is the horny layer of skin that medicine sees through the topmost barrier of skin, because skin is very low to the permeability of most drug, the medicine that can pass skin performance drug effect effectively by passive diffusion seldom.Therefore seek and promote that drug transdermal absorption way is one of key issue of exploitation transdermal drug delivery system technology.
For promoting the drug transdermal permeability, people begin to adopt mechanical means to make keratodermatitis produce micropore and break.This mechanical means is to act on skin by a kind of device that has many micro-protuberances, little nail or micropin to cause the wound of skin minimum degree and medicine is entered in the body.These micropin one classes are hollow, and another kind of is solid, normally arrange the microneedle array that forms by a plurality of micro-protuberances.
These microneedle array devices can significantly improve percutaneous penetration of drugs, and its method that penetrates skin has two kinds usually, and a kind of is that hands is pricked, and a kind of is automatic inserting needle device, the automatic blood sampler that uses when being similar to the finger tip blood sampling.The disadvantage that micropin is penetrated skin with hands is everyone dynamics difference when using, and the degree of depth that causes penetrating has significant difference, even same individual also can cause the depth of needle difference because each dynamics of pricking is variant.Use automatic inserting needle device because be in certain dynamics following moment microneedle array to be penetrated skin, have following shortcoming: (1) because the skin properties difference, the degree of depth difference that penetrates; (2) want to allow the darker of pinprick, need bigger elastic force, sense of discomfort is arranged near wound.Can rest on the skin after making microneedle array penetrate skin, U.S. Alza company discloses a kind of micropin holder in United States Patent (USP) 6855131B2, has a style of one's own with automatic inserting needle device.This inserting needle device can improve the repeatability of inserting needle, but can not solve because of the different differences of bringing of skin.But be that hands is pricked or automatic inserting needle device all needs certain dynamics just can make microneedle array penetrate skin, because the common flexible of microneedle array of macromolecular material and some metal materials but hardness deficiency are difficult to penetrate skin or are easy to generate bending.
Summary of the invention
The object of the invention provides a kind ofly utilizes sound wave vibrations to make the microneedle array paster penetrate the system of skin, utilize sound wave vibrations efficient and amplitude that microneedle array is penetrated in the skin, easy to use and reduce patient's sense of discomfort, simultaneously within a certain period of time, can keep the degree of depth unanimity of having an acupuncture treatment, improve the acupuncture treatment precision.
For achieving the above object, the technical solution used in the present invention is: a kind of sound wave inserting needle system of microneedle array paster, comprise ring for fixing, acoustic vibration generator, the inner edge bottom of described ring for fixing is provided with the fixed ring piece of inside stretching, extension, the acoustic vibration generator stretches in the ring for fixing, the lower end is through gel pad and fixed ring piece location, and gel pad bottom surface is pasted with site, constitutes microneedle array paster installation position; Wherein, the operating frequency of described acoustic vibration generator is 10HZ～100KHZ, and output is less than 60W, and the position that is provided with of described fixed ring piece makes site to the distance of the ring for fixing bottom surface height greater than corresponding microneedle array paster.
In the technique scheme, described acoustic vibration generator can adopt prior art to make up, and need only its operating frequency between 10HZ～100KHZ, and output gets final product less than 60W, and the acoustic vibration generator is closed in the housing; During use, on site, paste the microneedle array paster, for obtaining effect preferably, micropin in the microneedle array paster adopts solid needle, with silicon, material such as metal or high molecular polymer is made, the height of micropin is at 50～250 microns, the needle point diameter is less than 10 microns, equidistant arrangement between the micropin, spacing is the 200-1000 micron, the micropin shape can be conical, how tapered, perhaps the bottom is column type or polygon column type, top is conical, how tapered, the needle point of microneedle array paster is positioned at top, ring for fixing bottom surface, the length that is micropin when acupuncture treatment, is utilized the elasticity of skin less than the distance of fixed ring piece to the ring for fixing bottom surface, ring for fixing is pushed skin, make the needle point contact skin surface of micropin, the small vibrations that produce by the acoustic vibration generator little by little penetrate microneedle array in the skin then, realize the epidermis acupuncture treatment.
In the technique scheme, described fixed ring piece is 1～5 millimeter to the distance of ring for fixing bottom, and the thickness of fixed ring piece is 300～500 microns.
Preferred scheme is that described fixed ring piece to the distance of ring for fixing bottom is 1.5～3 millimeters.In the technique scheme, the diameter of described acoustic vibration generator is 1～5 centimetre, its smooth outer surface, and be provided with the corrosion resistant material layer, decontamination is cleaned easily, is suitable for using repeatedly.
The operating frequency of preferred acoustic vibration generator is 200HZ～20KHZ.
In the technique scheme, fixing by being threaded between described ring for fixing and the acoustic vibration generator, the inner edge of ring for fixing is provided with female thread, and the outer surface of acoustic vibration generator is provided with the external screw thread that is mated, and realizes being threaded.
Another kind of fixedly connected mode is that described ring for fixing top is provided with the projection that bends inwards, corresponding to prominent
The acoustic vibration generator outer surface that plays the place is provided with groove, constitutes engagement connection.
Because the technique scheme utilization, the present invention compared with prior art has following advantage:
1. because the present invention utilizes the vibration frequency of acoustic vibration generator and amplitude to drive microneedle array paster generation vibration, by hundreds of extremely tens thousand of the above small vibrations of per second microneedle array is little by little penetrated in the skin, so can reduce near the sense of discomfort of patient's pain spot;
2. because the height of micropin is certain, thereby can keep using within a certain period of time the time, the degree of depth unanimity that micropin penetrates on various skins of different nature, the difference of avoiding the skin difference to bring.
Description of drawings
Accompanying drawing 1 is the structure cross-sectional schematic of the embodiment of the invention one (the acoustic vibration generator is not cut open);
Accompanying drawing 2 is pasted structural representation behind the microneedle array for Fig. 1;
Accompanying drawing 3 is the upward view of Fig. 2;
Accompanying drawing 4 is for specifically making the plasma concentration curve in the use-case among the embodiment two.
Wherein: 10, acoustic vibration generator; 20, pad; 30, microneedle array paster; 32, site; 40, ring for fixing; 41, fixed ring piece; 42, projection.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is further described:
Embodiment one: referring to accompanying drawing 1 to shown in the accompanying drawing 3, a kind of sound wave inserting needle system of microneedle array paster, comprise ring for fixing 40, acoustic vibration generator 10, the inner edge bottom of described ring for fixing 40 is provided with the fixed ring piece 41 of inside stretching, extension, acoustic vibration generator 10 stretches in the ring for fixing 40, the lower end is through gel pad 20 and fixed ring piece 41 location, and gel pad 20 bottom surfaces are pasted with the site 32 of adhesion, constitute microneedle array paster installation position; Wherein, the operating frequency of described acoustic vibration generator 10 is 10HZ～100KHZ, and output is less than 60W, and diameter is 1～3 centimetre, and its smooth outer surface, outer surface are provided with the corrosion resistant material layer; Described fixed ring piece 41 is 1～5 millimeter to the distance of ring for fixing 40 bottoms, and the thickness of fixed ring piece 41 is 300～500 microns.Described ring for fixing 40 tops are provided with the projection 42 that bends inwards, and are provided with groove corresponding to the acoustic vibration generator outer surface of prominence, constitute engagement connection between the two.
In the present embodiment, said ring for fixing can be a plastic material, also can be that metal such as stainless steel material are made.The gel pad is the pad with certain degree of hardness, and vibrations backs is indeformable, gel pad that can commodity in useization.The use of gel pad is in order particularly to add buffering together between the microneedle array paster of silicon materials at pick off and microneedle array paster, can to prevent that silicon chip is damaged.Microneedle array paster 30 can simultaneously be bonded on the gel paster by double faced adhesive tape.The glue that also can be the single face adhesion directly is attached on the fixed ring piece of ring for fixing.Fixed ring piece to a section of ring for fixing bottom can play the fixedly effect of skin, prevents that whole sensor from causing micropin to fracture because of being subjected to displacement in the vibrations process.The micropin material can be monocrystal silicon, metal or high molecular polymer.Usually, the microneedle array height that be fit to use is at the 50-250 micron, and the needle point diameter is less than 10 microns, equidistant arrangement between the micropin, spacing is the 200-1000 micron, and the micropin shape can be conical, how tapered or the bottom is that column type or polygon column type, top are for conical, how tapered.
Embodiment two: a kind of sound wave inserting needle system of microneedle array paster, comprise ring for fixing, acoustic vibration generator, the inner edge bottom of described ring for fixing is provided with the fixed ring piece of inside stretching, extension, the acoustic vibration generator stretches in the ring for fixing, the lower end is through gel pad and fixed ring piece location, gel pad bottom surface is pasted with site, constitutes microneedle array paster installation position; Wherein, the operating frequency of described acoustic vibration generator is 200HZ～20KHZ, and output is less than 60W, and diameter is 0.5～10 centimetre, and its smooth outer surface, outer surface are provided with the corrosion resistant material layer; Described fixed ring piece is 1～3 millimeter to the distance of ring for fixing bottom, and the thickness of fixed ring piece is 300～500 microns.Fixing between described ring for fixing and the acoustic vibration generator by being threaded.
One of present embodiment specifically makes use-case be:
Acoustic vibration generator vibration frequency is 500Hz, the diameter of the housing 2cm of acoustic vibration generator.Diameter is that 1.9mm, thickness are that the gel pad of 1mm is bonded at the housing bottom surface by double faced adhesive tape.An octahedral tapered solid micro-needle array chip: be of a size of 1cm * 1cm, the micropin height is 160 microns, the thickness 0.4mm of chip egative film is bonded at gel pad central authorities by double faced adhesive tape.Internal diameter is that 2cm, external diameter are that the mode of ring for fixing by spiral of 2.2cm is fixed on the acoustic vibration generator body, and this ring for fixing is a stainless steel material.Apart from the base 2mm place ring-type thin slice that a thickness is arranged is 0.5mm, sheet width is 5mm, is structure as a whole with ring for fixing in ring for fixing.This sound wave inserting needle device is acted on skin 1 minute, remove the patche that the inserting needle device will contain 50 μ g FITC-interferon and be attached to the skin treatment place 24 hours, remove patche.Its plasma concentration curve such as Fig. 4.
Claims (7)
1. the sound wave inserting needle system of a microneedle array paster, it is characterized in that: comprise ring for fixing [40], acoustic vibration generator [10], the inner edge bottom of described ring for fixing is provided with the fixed ring piece [41] of inside stretching, extension, the acoustic vibration generator stretches in the ring for fixing, the lower end is through pad [20] and fixed ring piece [41] location, the pad bottom surface is pasted with site [32], constitutes microneedle array paster installation position; Wherein, the operating frequency of described acoustic vibration generator [10] is 10Hz～100KHz, and output is less than 60W, and the position that is provided with of described fixed ring piece [41] makes site to the distance of the ring for fixing bottom surface height greater than corresponding microneedle array paster.
2. the sound wave inserting needle system of microneedle array paster according to claim 1 is characterized in that: described fixed ring piece is 1～5 millimeter to the distance of ring for fixing bottom, and the thickness of fixed ring piece is 300～500 microns.
3. the sound wave inserting needle system of microneedle array paster according to claim 2 is characterized in that: described fixed ring piece to the distance of ring for fixing bottom is 1.5～3 millimeters.
4. the sound wave inserting needle system of microneedle array paster according to claim 1 is characterized in that: the diameter of described acoustic vibration generator is 0.5～10 centimetre, and its smooth outer surface, outer surface are provided with the corrosion resistant material layer.
5. the sound wave inserting needle system of microneedle array paster according to claim 1 is characterized in that: the operating frequency of described acoustic vibration generator is 200Hz～20KHz.
6. the sound wave inserting needle system of microneedle array paster according to claim 1 is characterized in that: fixing by being threaded between described ring for fixing and the acoustic vibration generator.
7. the sound wave inserting needle system of microneedle array paster according to claim 1 is characterized in that: described ring for fixing top is provided with the projection that bends inwards, and is provided with groove corresponding to the acoustic vibration generator outer surface of prominence, constitutes engagement connection.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100408764A CN100544790C (en) | 2006-07-27 | 2006-07-27 | The sound wave inserting needle system of microneedle array paster |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006100408764A CN100544790C (en) | 2006-07-27 | 2006-07-27 | The sound wave inserting needle system of microneedle array paster |
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| CN1887374A CN1887374A (en) | 2007-01-03 |
| CN100544790C true CN100544790C (en) | 2009-09-30 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011039728A1 (en) * | 2009-10-01 | 2011-04-07 | Sara Gil Almeida | Home use electric machine and system with micro needles for stimulation of collagen and elastin producing cells |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106110490A (en) * | 2016-06-21 | 2016-11-16 | 唐晨 | The method and device that a kind of soft capsule micro-spray formula is microneedle cutaneous |
| KR101898473B1 (en) * | 2016-11-01 | 2018-09-13 | (주)에보소닉 | Microneedle-beauty device using soundwave vibration |
| CN109907763B (en) * | 2017-12-12 | 2021-11-23 | 研能科技股份有限公司 | Blood sugar detection device |
-
2006
- 2006-07-27 CN CNB2006100408764A patent/CN100544790C/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 微针透皮给药系统研究进展. 高云华.中医外治杂志，第14卷第3期. 2005 |
| 微针透皮给药系统研究进展. 高云华.中医外治杂志，第14卷第3期. 2005 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011039728A1 (en) * | 2009-10-01 | 2011-04-07 | Sara Gil Almeida | Home use electric machine and system with micro needles for stimulation of collagen and elastin producing cells |
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| CN1887374A (en) | 2007-01-03 |
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Assignee: Suzhou Natong Biological Nanometer Technology Co., Ltd. Assignor: Nasheng Microelectronics (Suzhou) Co., Ltd. Contract record no.: 2010320000513 Denomination of invention: Sound wave needle inserting system for micro needle array plaster Granted publication date: 20090930 License type: Exclusive License Open date: 20070103 Record date: 20100504 |