CN100540046C - The mixture of agkistrodon acutus venom and Chinese herbal medicine extract and application - Google Patents
The mixture of agkistrodon acutus venom and Chinese herbal medicine extract and application Download PDFInfo
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Abstract
The invention discloses the mixture and the application of a kind of agkistrodon acutus venom and Chinese herbal medicine extract, component and parts by weight are: 0.004～0.006 part of agkistrodon acutus venom, 3～6 parts of Chinese herbal medicine extracts; The weight portion of above-mentioned Chinese herbal medicine extract is to be benchmark with herbal raw material before extracting; Said Chinese herbal medicine extract is the feedstock production that adopts following part by weight: 4～6 parts of Scolopendras, 8～12 parts of Gekko Swinhonis, 8～12 parts of Scorpios, 8～12 parts in Radix Notoginseng, 18～22 parts of Ganodermas, 25～35 parts in Radix Glycyrrhizae, 8～17 parts in Rhizoma Zingiberis Recens, 15～25 parts of Herba Lobeliae Chinensis, 4～6 parts of Cordyceps, 3～12 parts of Rhizoma Paridis.The mixture of said step snake venom of the present invention and Chinese herbal medicine extract has significant curative effect for cancer as middle and advanced stage leukemia, the brain cancer, esophageal carcinoma, gastric cancer, pulmonary carcinoma, pouring scar cancer, osteocarcinoma, renal carcinoma etc., can satisfy people's needs, is worthy of popularization.
Description
Technical field
The present invention relates to the mixture and the application of agkistrodon acutus venom and Chinese herbal medicine extract, be specifically related to the application in preparation treatment cancer drug.
Background technology
Cancer, promptly malignant tumor is the important diseases of current harm humans life, existing Therapeutic Method comprises: (1) operative treatment; Need carry out in early days, what have can not perform the operation, and cannot say for sure to effect a radical cure; (2) chemotherapy and radiotherapy: the course of treatment is long, and toxicity is arranged, and has to end, also difficult radical cure; (3) interventional therapy, gamma knife treatment comprise laser and ultrasonic therapeutic: topical application can not be treated the general tumor, though toxicity reduces but still can not eliminate fully, also difficult radical cure; (4) stem cell transplantation: pairing is difficult, and expense is expensive, is limited to the part patient, also dangerous property; (5) Chinese medicine: it is perfect to require study.Employed in the world at present Venine product all be single extract, can't kill cancer cell, have only compatiblely with relevant Chinese medicine, just make the active protease prolonged survival period, reach kill cancer cell.
Therefore, provide a kind of medicine of therapeutic tumor of new safety be people very expectation.
Summary of the invention
The technical issues that need to address of the present invention are mixture and application thereof of open agkistrodon acutus venom and Chinese herbal medicine extract, with quick the deficiencies in the prior art, satisfy people's needs.
Technical conceive of the present invention is such:
Cancerous cell is generally survived between the blood and passages through which vital energy circulates of human body, and it mainly draws the marrow of human body for supporting, and when cancer occurred, the immunity straight line of human body descended, and no longer to offer the five internal organs, six internal organs, also had each cell, passages through which vital energy circulates, the marrow of blood.Human survival mainly just can prolong life with their continuous existence.
In current data, the mankind only know the material that an energy kill cancer cell is arranged in the cobra venom, but use that also can't be correct.After snake venom had left the Serpentis body, the organized enzyme time-to-live can shorten until death in the snake venom.
Agkistrodon acutus venom be blood poison, the material that kill cancer cell also arranged in its snake venom is when it with after relevant Chinese medicine is compatible, the organized enzyme in the snake venom does not have destroyed, on the contrary, its character has played variation.
Plurality of Chinese among the agkistrodon acutus venom organized enzyme can make the immunity of each big organ pipe of human body be improved, the character of the snake venom among the agkistrodon acutus venom organized enzyme can not injure human body with metering, the opposite organized enzyme that it has can directly remove to seek cancerous cell, kill cancer cell after entering the blood of human body.
The component of the mixture of agkistrodon acutus venom of the present invention and Chinese herbal medicine extract and parts by weight are:
0.004～0.006 part of agkistrodon acutus venom
3～6 parts of Chinese herbal medicine extracts.
Preferably:
0.005 part of agkistrodon acutus venom
4 parts of Chinese herbal medicine extracts.
The weight portion of above-mentioned Chinese herbal medicine extract is to be benchmark with herbal raw material before extracting;
Said Chinese herbal medicine extract is the feedstock production that adopts following part by weight:
4～6 parts of Scolopendras, 8～12 parts of Gekko Swinhonis, 8～12 parts of Scorpios, 8～12 parts in Radix Notoginseng, 18～22 parts of Ganodermas, 25～35 parts in Radix Glycyrrhizae, 8～17 parts in Rhizoma Zingiberis Recens, 15～25 parts of Herba Lobeliae Chinensis, 4～6 parts of Cordyceps, 3～12 parts of Rhizoma Paridis;
The preparation method of said Chinese herbal medicine extract is as follows:
Above-mentioned Chinese herbal medicine is pulverized, be soaked in water or volumetric concentration and be 35～95% ethanol water 2～10 hours, water or volumetric concentration are that the weight consumption of 35～95% ethanol water is 300～400 times of Chinese herbal medicine, filter, and collect filtrate;
Proportionally, the filtrate of collecting is mixed with agkistrodon acutus venom, promptly obtain the mixture of said agkistrodon acutus venom and Chinese herbal medicine extract.
The invention still further relates to a kind of compositions, it is characterized in that, contain the said mixture for the treatment of effective dose and pharmaceutically acceptable carrier, said carrier comprises diluent, and as water, sweeting agent such as sucrose etc. are so that different crowds takes.
The mixture of said agkistrodon acutus venom of the present invention and Chinese herbal medicine extract has significant curative effect for cancer as middle and advanced stage leukemia, the brain cancer, esophageal carcinoma, gastric cancer, pulmonary carcinoma, pouring scar cancer, osteocarcinoma, renal carcinoma etc.
Adopt mixture of the present invention, to 100 routine cancer patients (comprising child or adult) treatment, the result is as follows:
| At 2005 on date | 8-12 year | 12-30 year | 30-45 year | 45-80 year |
| June | Effective 93% | Effective 95% | Effective 92% | Effective 93% |
| July | Effective 95% | Effective 94% | Effective 93% | Effective 94% |
| August | Effective 95% | Effective 93% | Effective 93% | Effective 93% |
Wherein:
30 examples are the brain cancer, and 30 examples are gastric cancer, and 40 examples are esophageal carcinoma.
Can be by oral method, above-mentioned mixture is put on the patient who needs treatment, general dosage is 1～3mg/ kg body weight, specifically can be according to patient's the state of an illness, age etc., by doctor's decision, be preferably in the usefulness that is taken at bed time after the dinner.
The toxicity test result is as follows:
| Group | Dosage | Toxic reaction |
| Agkistrodon acutus venom | 0.56mg 0.06mg | The dead immediately white mice survival of white mice |
| Mixture of the present invention | 0.60mg 0.15mg | The survival of mice dying white mice |
By above-mentioned disclosed technical scheme as seen, the mixture of agkistrodon acutus venom of the present invention and Chinese herbal medicine extract all has very significant curative effect to various ages and cancer, can satisfy people's needs, is worthy of popularization.
The specific embodiment
Embodiment 1
Agkistrodon acutus venom 0.005 gram, herbal raw material 4 grams.
In the herbal raw material:
Scolopendra 5 grams, Gekko Swinhonis 10 grams, Scorpio 10 grams, Radix Notoginseng 10 grams, Ganoderma 15 grams, Radix Glycyrrhizae 30 grams, Rhizoma Zingiberis Recens 12 grams, Herba Lobeliae Chinensis 20 grams, Cordyceps 5 grams, Rhizoma Paridis 7 grams;
The preparation method of said Chinese herbal medicine extract is as follows:
Above-mentioned Chinese herbal medicine is pulverized, be soaked in the water, 10 hours, filter, collect filtrate, the weight consumption of water is 300 times of Chinese herbal medicine, proportionally, the filtrate of collecting is mixed with agkistrodon acutus venom, promptly obtains the mixture of said agkistrodon acutus venom and Chinese herbal medicine extract.
Embodiment 2
Agkistrodon acutus venom 0.005 gram, herbal raw material 6 grams.
In the herbal raw material:
Scolopendra 6 grams, Gekko Swinhonis 9 grams, Scorpio 9 grams, Radix Notoginseng 10 grams, Ganoderma 20 grams, Radix Glycyrrhizae 30 grams, Rhizoma Zingiberis Recens 10 grams, Herba Lobeliae Chinensis 20 grams, Cordyceps 5 grams, Rhizoma Paridis 10 grams;
Above-mentioned Chinese herbal medicine is pulverized, be soaked in volumetric concentration and be in 35% the ethanol water, 5 hours, filter, collect filtrate, the weight consumption of water is 400 times of Chinese herbal medicine, proportionally, the filtrate of collecting is mixed with agkistrodon acutus venom, promptly obtain the mixture of said agkistrodon acutus venom and Chinese herbal medicine extract.
Embodiment 3
The product of embodiment 1 or 2 is added sweeting agent sucrose, and part by weight is:
1 part in the mixture of agkistrodon acutus venom and Chinese herbal medicine extract, 0.5 part of sucrose obtains to contain pleasantly sweet oral liquid.
Claims (5)
1. the mixture of agkistrodon acutus venom and Chinese herbal medicine extract is characterized in that component and parts by weight are:
0.004～0.006 part of agkistrodon acutus venom
3～6 parts of Chinese herbal medicine extracts;
The weight portion of above-mentioned Chinese herbal medicine extract is to be benchmark with herbal raw material before extracting;
Said Chinese herbal medicine extract is the feedstock production that adopts following part by weight:
4～6 parts of Scolopendras, 8～12 parts of Gekko Swinhonis, 8～12 parts of Scorpios, 8～12 parts in Radix Notoginseng, 18～22 parts of Ganodermas, 25～35 parts in Radix Glycyrrhizae, 8～17 parts in Rhizoma Zingiberis Recens, 15～25 parts of Herba Lobeliae Chinensis, 4～6 parts of Cordyceps, 3～12 parts of Rhizoma Paridis.
2. the mixture of agkistrodon acutus venom according to claim 1 and Chinese herbal medicine extract is characterized in that: 0.005 part of agkistrodon acutus venom, 4 parts of Chinese herbal medicine extracts.
3. a compositions for the treatment of the brain cancer, esophageal carcinoma or gastric cancer is characterized in that, contains claim 1 or the 2 said mixture and the pharmaceutically acceptable carrier for the treatment of effective dose.
4. claim 1 or the 2 said mixture application in preparation treatment cancer drug, said cancer is the middle and advanced stage brain cancer, esophageal carcinoma or gastric cancer.
5. prepare the method for the mixture of claim 1 or 2 described agkistrodon acutus venom and Chinese herbal medicine extract, it is characterized in that the preparation method of said Chinese herbal medicine extract is as follows:
Above-mentioned Chinese herbal medicine is pulverized, be soaked in water or volumetric concentration and be 35～95% ethanol water 2～10 hours, water or volumetric concentration are that the weight consumption of 35～95% ethanol water is 300～400 times of Chinese herbal medicine, filter, and collect filtrate;
Proportionally, the filtrate of collecting is mixed with agkistrodon acutus venom, promptly obtain the mixture of said agkistrodon acutus venom and Chinese herbal medicine extract.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2006101175206A CN100540046C (en) | 2006-10-25 | 2006-10-25 | The mixture of agkistrodon acutus venom and Chinese herbal medicine extract and application |
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| CNB2006101175206A CN100540046C (en) | 2006-10-25 | 2006-10-25 | The mixture of agkistrodon acutus venom and Chinese herbal medicine extract and application |
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| CN100540046C true CN100540046C (en) | 2009-09-16 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101518607B (en) * | 2008-02-27 | 2011-06-15 | 北京绿源求证科技发展有限责任公司 | Traditional Chinese medicine for treating carcinoma of kidney |
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Non-Patent Citations (2)
| Title |
|---|
| 蛇毒的毒性成分及其应用研究. 贾，艳，胡延春，张乃生.蛇志，第16卷第2期. 2004 |
| 蛇毒的毒性成分及其应用研究. 贾，艳，胡延春，张乃生.蛇志，第16卷第2期. 2004 * |
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