CN100539846C - Controlled release formulation of solid chlorine dioxide - Google Patents
Controlled release formulation of solid chlorine dioxide Download PDFInfo
- Publication number
- CN100539846C CN100539846C CNB2005100450061A CN200510045006A CN100539846C CN 100539846 C CN100539846 C CN 100539846C CN B2005100450061 A CNB2005100450061 A CN B2005100450061A CN 200510045006 A CN200510045006 A CN 200510045006A CN 100539846 C CN100539846 C CN 100539846C
- Authority
- CN
- China
- Prior art keywords
- chlorine dioxide
- controlled release
- release formulation
- acidifying
- sustained release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a kind of controlled release formulation of solid chlorine dioxide.This sustained release agent is primary dose with sodium chlorite, and quaternary ammonium salt, quaternary ammonium base, calcium chloride, iron chloride, aluminum sulfate etc. are the acidifying sustained release agent, and talcum powder, calcium carbonate, sodium bicarbonate etc. are stabilizing agent, are mixed with out controlled release formulation of solid chlorine dioxide.The controlled release formulation of solid chlorine dioxide that the present invention produces is that chlorine dioxide content is 3%～28% pulvis and tablet.The product that makes adds and generates chlorine dioxide in the entry as required, also can emit chlorine dioxide in a long time successively.This product can be used for fields such as taste removal, sterilization, sterilization and preserving fruit and vegetable utilizing.Advantage of the present invention is: 1, controlled release formulation of solid chlorine dioxide, produce, transport, store safety; 2, sodium chlorite and acidifying sustained release agent are mixed together, storing, easy to use; 3, as required, this product can be fast or is slowly discharged chlorine dioxide; 4, raw material is easy to get, and technology advanced person is cheap.
Description
(1) technical field
The invention belongs to chemical production technical, specifically a kind of controlled release formulation of solid chlorine dioxide.
(2) background technology
Chlorine dioxide is a kind of good disinfection sanitizer, is widely used in sterilization, sterilization, taste removal, reaches fields such as food, preserving fruit and vegetable utilizing.
At present, many chlorine dioxide products being arranged on the market, mainly is ClO 2 solution and generating means thereof etc.Its shortcoming is that storage life is short, uses inconvenience.As various chlorine dioxide generating devices, the equipment complexity, the use cost height brings inconvenience for production, storage, the transportation use of chlorine dioxide, has limited the extensive use of chlorine dioxide.The production of chlorine dioxide slow-release agent and " stablizing " ClO 2 solution is also arranged on the market, as: be that ClO 2 solution is sprayed on carrier described in the patent CN1175350A (publication number), drying is made preparation, need add water, acidifying during use, promptly emits chlorine dioxide; Be with sour passivation described in the patent 1587029 (publication number) for another example, complex process not only, and need add water and discharge chlorine dioxide, though improvement has been arranged than before, can not control the chlorine dioxide rate of release; Other patents CN1238130A, CN143968A, CN1415533A etc. are the solid chlorine dioxide preparation, aspects such as the transportation of chlorine dioxide, use, safety are improved, but all do not solve the problem that chlorine dioxide quantitatively discharges, hindered the extensive use of chlorine dioxide, also made troubles to the user.
(3) summary of the invention
1, the objective of the invention is a kind of simple, storage, transportation, controlled release formulation of solid chlorine dioxide safe and convenient to use produced.It is by primary dose of sodium chlorite, potassium chlorite or the mixture of the two; The acidifying sustained release agent is by zinc chloride, iron chloride, aluminium chloride, calcium chloride, quaternary ammonium salt R
4Among the NA one or more; Stabilizing agent is by in calcium carbonate, sodium bicarbonate, carbonic hydroammonium, CMC, the diatomite one or more; Be mixed mutually and form.At acidifying sustained release agent quaternary ammonium salt R
4Among the NA, R is C
1～C
18During alkyl, one of them or several hydrogen atom can be substituted, and substituting group can be-CI ,-Br ,-I ,-SO
3H ,-OH ,-COOH ,-OCH
3, phenyl, substituted-phenyl.Can make the controlled release formulation of solid chlorine dioxide that contains chlorine dioxide 3-28% as required.
2, technical scheme of the present invention is achieved in that primary dose of sodium chlorite of chlorine dioxide (potassium) is mixed together with acidifying sustained release agent and stabilizing agent.Under drying regime, the acidifying sustained release agent does not produce the acid with primary dose of sodium chlorite (potassium) reaction, and primary dose does not react no chlorine dioxide generation with the acidifying sustained release agent.When the needs chlorine dioxide produces, moisture is reacted with the acidifying sustained release agent rapidly or lentamente, produce the acid of reacting with primary dose of sodium chlorite (potassium), emit chlorine dioxide rapidly or slowly.Because in the controlled release formulation of solid chlorine dioxide, after the acidifying sustained release agent absorbs moisture, promptly can emit the acidic materials that react with primary dose of sodium chlorite (potassium), generate chlorine dioxide and discharge.So the acidifying sustained release agent obtains moisture fast, controlled release formulation of solid chlorine dioxide can go out chlorine dioxide by rapid release.The acidifying sustained release agent slowly absorbs moisture, controlled release formulation of solid chlorine dioxide is promptly slowly emitted chlorine dioxide, like this, absorption speed by the control sustained release agent, with regard to the release of controlled chlorine dioxide, thus solved need when chlorine dioxide product on the current market uses acidifying, can not sustained release, the Three Difficult Issues of storing, use inconvenience.
The invention has the beneficial effects as follows: 1, easy to use.Sustained release agent is met water can emit chlorine dioxide, does not need acidifying separately; 2, the speed of emitting of chlorine dioxide can be regulated on demand; But 3 long term storage; 4, produce simply, drop into for a short time, cost is low; 5, solid state, storing is convenient.
(4) description of drawings
Figure controlled release formulation of solid chlorine dioxide production procedure schematic diagram
Among the figure: 1 is blender; 2 is charge door; 3 is the pulvis storage tank; 4 are the pulvis packing; 5 is tablet press machine; 6 are the tablet packing; 7 is powder product; 8 is the tablet product.
(5) embodiment
The controlled release formulation of solid chlorine dioxide preparation method:
With 5～45 parts of drying, pulverous sodium chlorites (potassium); 8～60 parts of dry acidifying sustained release agents, dry 20～65 parts of stabilizing agents and other auxiliary material, join in the blender (1) by charge door (2) respectively, at room temperature stirred 50 minutes, go out powder, be temporary in the dry sealing storage tank (3), it is 3%～28% controlled release formulation of solid chlorine dioxide pulvis that the gained powder is chlorine dioxide content.This powder is directly packed (4), is powder product (7), through tablet press machine (5) compressing tablet, packs (6) again, is tablet product (8). and tablet also will be stored in the dry airtight bad border.
Example 1:
10 parts of sodium chlorites, 3 parts in calcium carbonate with drying, 2 parts of sodium bicarbonates, 10 parts of carboxymethyl celluloses, 16 parts of benzyltriethylammoinium chlorides, 10 parts of ferric trichlorides, 8 parts of zinc chloride, 30 parts of aluminum trichloride (anhydrous)s, 11 parts in diatomite, add in the blender respectively, mixed 30 minutes, discharging must contain the controlled release formulation of solid chlorine dioxide pulvis of chlorine dioxide 6%.Above-mentioned pulvis is sub-packed in the sealed plastic bag of 1g/ bag, 2g/ bag, 5g/ bag, 10g/ bag, 1KG/ bag, 5KG/ bag on demand.During use, the pinprick hole is used in packaging bag, and moisture in the pulvis absorbing environmental can slowly discharge out chlorine dioxide.
Packed controlled release formulation of solid chlorine dioxide pulvis is cut off, pulvis is placed vessel, add entry (on a small quantity) and can emit chlorine dioxide fast.
The controlled release formulation of solid chlorine dioxide pulvis is poured in the tablet press machine, and compressing tablet can be made into the tablet of 0.5g/ sheet, 1g/ sheet, 1.5g/ sheet on demand.Tablet is deposited in the plastic sack of sealing.During use, the pinprick hole is used in packaging bag, and the moisture in the tablet absorbing environmental can slowly discharge out chlorine dioxide.
The tablet packaging bag is cut off, tablet is put in the vessel, add entry (on a small quantity) and can discharge out chlorine dioxide.
Example 2:
With 30 parts of the sodium chlorites of drying, 40 parts of benzyltriethylammoinium chlorides, 6 parts in ammonium sulfate, 10 parts of ferric trichlorides, 10 parts of alchlors, 2 parts of sodium bicarbonates, 2 parts in diatomite are poured into respectively in the blender, mix discharging 30 minutes.The controlled release formulation of solid chlorine dioxide pulvis that must contain chlorine dioxide 18%.
The pulvis packing is with example 1.
Tablet manufacturing, packing, storage, using method are with example 1.
Example 3:
With 17 parts of the sodium chlorites of drying, 10 parts in calcium carbonate, 45 parts of OTACs, 15 parts of ferric trichlorides, 5 parts of alchlors, 8 parts in diatomite adds respectively in the blender, mixes discharging 30 minutes.The controlled release formulation of solid chlorine dioxide pulvis that must contain chlorine dioxide 10%.
The production of pulvis, tablet, packing, storage, using method are with example 1.
The slow release of example 4, chlorine dioxide slow-release agent of the present invention
With chlorine dioxide slow-release agent of the present invention, in packaging bag, prick two through holes with the 0.1mm pin, place 25 ℃, the air of relative moisture 70% then, through different time, remaining content of chlorine dioxide such as following table:
As can be seen from the above table, various products all can discharge chlorine dioxide in a long time in the example.
Claims (4)
1, a kind of controlled release formulation of solid chlorine dioxide is characterized in that: formulated by primary dose, acidifying sustained release agent, stabilizing agent; It is characterized in that:
Press mass fraction, this sustained release agent is made up of following component:
Primary dose: 5-45 part
Acidifying sustained release agent: 8-60 part
Stabilizing agent: 20-65 part
Wherein primary dose is sodium chlorite, potassium chlorite or the mixture of the two; The acidifying sustained release agent is zinc chloride, calcium chloride, iron chloride, aluminium chloride, quaternary ammonium salt R
4Among the NA one or more are mixed; Stabilizing agent is that in calcium carbonate, sodium bicarbonate, carbonic hydroammonium, CMC, the diatomite one or more are mixed.
2, controlled release formulation of solid chlorine dioxide according to claim 1 is characterized by: acidifying sustained release agent quaternary ammonium salt R
4Among the NA, R is C
1～C
18Alkyl, A is 1/2SO
4 =, HSO
4 -, 1/2SO
3 =, HSO
3 -, 1/3PO
4 ≡, 1/2HPO
4 =, H
2PO
4 -, CL
-, Br
-, I
-
3, controlled release formulation of solid chlorine dioxide according to claim 1 and 2, its feature: acidifying sustained release agent quaternary ammonium salt R
4Among the NA, R is C
1～C
18During alkyl, one of them or several hydrogen atom can be substituted, and substituting group is-CL ,-Br ,-I ,-SO
3H ,-OH ,-COOH ,-OCH
3, phenyl, substituted-phenyl.
4, controlled release formulation of solid chlorine dioxide according to claim 1 and 2, its feature: be that chlorine dioxide content is 3%～28% in the controlled release formulation of solid chlorine dioxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100450061A CN100539846C (en) | 2005-11-01 | 2005-11-01 | Controlled release formulation of solid chlorine dioxide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100450061A CN100539846C (en) | 2005-11-01 | 2005-11-01 | Controlled release formulation of solid chlorine dioxide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1759679A CN1759679A (en) | 2006-04-19 |
| CN100539846C true CN100539846C (en) | 2009-09-16 |
Family
ID=36706007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100450061A Expired - Fee Related CN100539846C (en) | 2005-11-01 | 2005-11-01 | Controlled release formulation of solid chlorine dioxide |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100539846C (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101631742B (en) * | 2007-03-15 | 2012-05-23 | 大幸药品株式会社 | Composition for stabilizing chlorine dioxide |
| US8992831B2 (en) | 2009-09-25 | 2015-03-31 | E. I. Du Pont De Nemours And Company | Stabilized chlorine dioxide to preserve carbohydrate feedstocks |
| CN101828595A (en) * | 2010-04-27 | 2010-09-15 | 戴永明 | Gas antistaling agent, preparation method and using method thereof |
| CN104012571A (en) * | 2013-08-29 | 2014-09-03 | 四川省龙天源环保设备制造有限公司 | Chlorine dioxide air disinfectant and preparation method thereof |
| CN104606697A (en) * | 2015-02-03 | 2015-05-13 | 吴胜群 | Air sterilizing and purifying plant composite module |
| CN106614558A (en) * | 2016-12-18 | 2017-05-10 | 钦州阜康农副食品有限公司 | Solid chlorine dioxide controlled release formulation and preparation method thereof |
| CN108402075A (en) * | 2018-04-28 | 2018-08-17 | 汉广中药科技（天津）有限公司 | A kind of compound Chinese medicinal material curing agent and preparation method and application of long-acting controllable sustained-release chlorine dioxide |
| CN110679607A (en) * | 2018-07-06 | 2020-01-14 | 广州泰道安医疗科技有限公司 | Stable novel sterilization and disinfection solution and preparation method thereof |
| CN110292050B (en) * | 2019-04-30 | 2021-10-19 | 广州超威生物科技有限公司 | Method for regulating stable release of chlorine dioxide and chlorine dioxide sustained-release gel |
| CN111248221A (en) * | 2020-02-13 | 2020-06-09 | 上海克琴科技有限公司 | Long-acting disinfectant stabilized by synergist |
| CN111528223A (en) * | 2020-03-31 | 2020-08-14 | 德清康邑日化贸易有限公司 | Composite antibacterial material with slow-release chlorine dioxide and preparation method thereof |
| CN111493069A (en) * | 2020-04-21 | 2020-08-07 | 桂方晋 | Solid chlorine dioxide sustained release agent and preparation method thereof |
| CN111567555B (en) * | 2020-06-24 | 2021-09-28 | 珠海佰俐生物科技有限公司 | Slow-release disinfectant, slow-release disinfection bag and preparation method thereof |
| CN112089879A (en) * | 2020-08-31 | 2020-12-18 | 名臣健康用品股份有限公司 | Portable slow-release sterilization bag containing chlorine dioxide |
-
2005
- 2005-11-01 CN CNB2005100450061A patent/CN100539846C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1759679A (en) | 2006-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100539846C (en) | Controlled release formulation of solid chlorine dioxide | |
| CN101228868B (en) | Unitary solid chlorine dioxide effervescent tablet and preparation method thereof | |
| US4689169A (en) | Dry compositions for the production of chlorine dioxide | |
| CN102835421B (en) | Stable product containing chlorine dioxide and preparation method of stable product | |
| CA1234753A (en) | Dry compositions for the production of chlorine dioxide | |
| CN102283246B (en) | Solid chlorine dioxide effervescent tablet and preparation method thereof | |
| US2245495A (en) | Oxygen supplying composition | |
| CN100558238C (en) | A kind of manufacture method of sweet cherry antistaling agent | |
| CN103478247B (en) | Iron-series deoxidizing agent | |
| JP6475303B1 (en) | Method for generating chlorine dioxide gas, kit for generating chlorine dioxide gas, and gel composition | |
| WO2005104703A2 (en) | Solid chlorine dioxide releasing compositions and method for delivery of solid chlorine dioxide release compositions. | |
| CN102847181A (en) | Product capable of delaying generation and releasing of chlorine dioxide and preparation method thereof | |
| CN103621554A (en) | Chlorine dioxide generator and preparation method thereof | |
| EP1154690B1 (en) | Composition for generating chlorine dioxide | |
| CN102144664B (en) | Solid hydrogen peroxide sustained release preparation and preparation method thereof | |
| JPH0199559A (en) | Stabilized chlorine dioxide chemical | |
| CN103300063A (en) | Solid chlorine dioxide release agent | |
| CN106614558A (en) | Solid chlorine dioxide controlled release formulation and preparation method thereof | |
| JPS5930879A (en) | Frothing molded product | |
| US2274252A (en) | Composition | |
| CN109730085A (en) | A kind of disinfecting substance generating agent and preparation method thereof | |
| CN1238130A (en) | Powdered CLO2 disinfectant and preparing process thereof | |
| CN113812419A (en) | Chlorine dioxide effervescent disinfecting tablet | |
| CN107384331B (en) | Spontaneous heating material for non-combustion type cigarette, and method and application thereof | |
| JPS6352604B2 (en) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090916 Termination date: 20171101 |