CN100528208C - A medicine for treating alopecia and method for preparing same - Google Patents
A medicine for treating alopecia and method for preparing same Download PDFInfo
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- CN100528208C CN100528208C CNB2006100807158A CN200610080715A CN100528208C CN 100528208 C CN100528208 C CN 100528208C CN B2006100807158 A CNB2006100807158 A CN B2006100807158A CN 200610080715 A CN200610080715 A CN 200610080715A CN 100528208 C CN100528208 C CN 100528208C
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- 201000004384 Alopecia Diseases 0.000 title claims abstract description 27
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- 238000002360 preparation method Methods 0.000 claims abstract description 28
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Abstract
The invention relates to a medicament for treating baldness and process for preparation, which comprises effective constituents and / or pharmaceutically acceptable auxiliary materials, the effective constituents include tuber of multiflower knotweed, ligustrum japonicum, rhizoma dioscoreae, dried rehmannia root, and herba ecliptae. The medicament can be made into various oral administration preparations.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of alopecia, also relate to the preparation method of this medicine, belong to technical field of Chinese medicine.
Technical background
Alopecia is a kind of common skin disease, can be divided into tens kinds of seborrheic alopecia (claiming seborrheic alopecia, male pattern alopecia again), alopecia areata, alopecia totalis etc., and the traditional Chinese medical science is referred to as " alopecia areata ", " alopecia seborrheica ", and common alopecia mostly is seborrheic alopecia (accounting for hair loss patient more than 95%) greatly.Because the adjustment of changes in economic and dietary structure at present, the alopecia crowd is compared with increased sharply in the past.Show according to " contemporary Chinese medical and health statistics " related data in 2004: the alopecia crowd age is obviously tended to become younger, and sickness rate rises with statistics ratio 4.38% year by year, the serious alopecia crowd of China conservative estimation at present has 3,000 ten thousand people approximately, and other is slight, and alopecia person's quantity is then more extensive.More alopecia etiology unknown, modern medicine think and cause that with Nervous and Mental Factors the temporary inhibition of hair growth is relevant, or relevant with dyshormonia, infection, poisoning or other viscera illness, also relevant with inherited genetic factors in addition.Western medical treatment is general rehabilitation therapy, no obvious treatment effect.The traditional Chinese medical science is thought, early whitening of hair, alopecia, alopecia areata are all closely related with Liver and kidney, blood, i.e. blood stored in the liver, hair is the sign of blood condition, the kidney generating marrow and dominating bone, its honor is being sent out, and vim and vigour contain that then kidney qi is strong, and kidney qi bone strengthening marrow is full of, hair is black and glossy, then a little less than the kidney qi, QI and blood can not up honor be supported hair to vim and vigour void, and it is damp and come off to send out then withered and yellow nothings." General Treatise on the Cause and Symptoms of Diseases poliosis disease piece of writing " day: " if vim and vigour are contained, then kidney qi is strong for kidney governing bones marrow, its Hua Zaifa, and then bone marrow is full of, and hair strengthening moistens and deceives; If vim and vigour void, then a little less than the kidney qi, then bone marrow exhaustion a little less than the kidney qi bleaches also so send out "." General Treatise on the Cause and Symptoms of Diseases beard and hair come off a piece of writing " be cloud also: " blood is contained then flourish in beard and hair, so beard and hair U.S.; If vim and vigour are weak, exhaust through deficient pulse, can not Rong Run, so the beard and hair alopecia ", therefore flourishing and withering and deficiency of the liver and kindey, deficient qi and blood interwoveness.So alopecia is treated based on the kidney invigorating, is nourished blood, invigorates blood circulation generally.
Humagsolan tablet is a compound Chinese medicinal preparation, forms by 12 flavor medicines such as Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Radix Rehmanniae, Herba Ecliptae, Poria, order Cortex Moutan, Rhizoma Alismatis, Fructus Mori, Radix Ophiopogonis, Fructus Jujubae, Semen sojae atricolor, and be the medicine commonly used of treatment alopecia.But in disclosed document, the consumption of component is not disclosed.Because the consumption and the prescription curative effect of component are closely related, for this reason, we have found the combination of components of specific consumption through a large amount of clinical trials, have definite curative effect, thereby have finished the present invention.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of alopecia and preparation method thereof, said preparation mainly is made up of 12 flavor medicines such as Radix Polygoni Multiflori, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Radix Rehmanniae, Herba Ecliptae, Poria, Cortex Moutan, Rhizoma Alismatis, Fructus Mori, Radix Ophiopogonis, Fructus Jujubae, Semen sojae atricolor, has nourishing the liver and kidney, benefiting QI and nourishing blood, the effect of growing and blacking hair.Be used for the early whitening of hair due to deficiency of the liver and kindey, the deficiency of qi and blood, come off alopecia areata, alopecia totalis, diseases such as seborrheic alopecia.Clinical practice this product is treated various alopecias and was taken medicine 1 month, and total effective rate is 96.64%.Wherein: alopecia totalis (comprising alopecia universalis) 23 examples, cure 8 examples, produce effects 10 examples, effective 3 examples, invalid 2 examples; Alopecia areata 53 examples are cured 30 examples, produce effects 19 examples, effective 4 examples; Seborrheic alopecia 189 examples are cured 4 examples, produce effects 97 examples, effective 81 examples, invalid 7 examples; Cure congenital hair disease 1 example that fractures.In order to enrich the dosage form kind, better bring into play the curative effect of this medicine, the applicant further studies it, has developed the capsule of this medicine, has not only kept curative effect preferably, and has taken, carries, preserves more convenient.
The present invention is achieved through the following technical solutions:
A kind of medicine for the treatment of alopecia, it is characterized in that, it is mainly to be made up of acceptable auxiliary on active ingredient and/or the pharmaceutics, wherein said active ingredient comprises following raw materials according by weight: Radix Polygoni Multiflori 0.8-1.2 part, Fructus Ligustri Lucidi 0.8-1.2 part, Rhizoma Dioscoreae 0.8-1.2 part, Radix Rehmanniae 0.8-1.2 part, Herba Ecliptae 0.8-1.2 part, Poria 0.8-1.2 part, Cortex Moutan 0.5-0.8 part, Rhizoma Alismatis 0.5-0.8 part, Fructus Mori 1.1-1.5 part, Radix Ophiopogonis 0.8-1.2 part, Fructus Jujubae 0.8-1.2 part, Semen sojae atricolor 0.8-1.2 part.
Preferred prescription is: calculate by weight, described active ingredient comprises following raw materials according: 1 part of Radix Polygoni Multiflori, 1 part of Fructus Ligustri Lucidi, 1 part of Rhizoma Dioscoreae, 1 part of Radix Rehmanniae, 1 part of Herba Ecliptae, 1 part in Poria, 0.65 part of Cortex Moutan, 0.65 part of Rhizoma Alismatis, 1.3 parts of Fructus Mori, 1 part of Radix Ophiopogonis, 1 part of Fructus Jujubae, 1 part in Semen sojae atricolor.
Various oral formulations such as preparation tablet of the present invention, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid.
The preparation method of described medicine is, gets Fructus Jujubae, Semen sojae atricolor decocts with water secondary, and each 3 hours, collecting decoction filtered, and filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, and each 3 hours, collecting decoction filtered, and filtrate and above-mentioned medicinal liquid merge, and being concentrated into relative density is 1.30～1.35 (60 ℃), adds proper auxiliary materials or do not add adjuvant to be prepared into different preparations.
The capsule of described medicine is like this preparation: get Fructus Jujubae, Semen sojae atricolor decocts with water secondary, decocts 3 hours at every turn, adds 6-10 times of water gaging for the first time, adds 4-8 times of water gaging for the second time, collecting decoction filters, and filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, decoct 3 hours at every turn, add 6-10 times of water gaging for the first time, for the second time add 4-8 times of water gaging, collecting decoction filters, filtrate and above-mentioned medicinal liquid merge, and being concentrated into relative density is the thick paste of 1.30～1.35 (60 ℃), drying, be ground into fine powder, add adjuvant, mixing, granulate, drying, encapsulated, promptly.
Described adjuvant includes but not limited to one or more in starch, dextrin, lactose, pregelatinized Starch, calcium sulfate, calcium hydrogen phosphate, magnesium stearate, Pulvis Talci, the micropowder silica gel.
Preferred adjuvant is meant calcium sulfate, magnesium stearate.
At prior art, former preparation determined curative effect is subjected to the welcome of doctor and patient deeply.But former tablet is taken six at every turn, and dose is bigger; For this reason, the inventor develops it, has developed capsule, both kept the advantage of former preparation determined curative effect, and dose reduces significantly; The present invention has carried out a large amount of tests to its supplementary product kind and consumption, the adjuvant of screening and principal agent reasonable mixture ratio, and technology is rationally feasible through lab scale, pilot scale, and is stable and controllable for quality, and suitable the amplification produces, and meets the modern requirement of Chinese medicine preparation.
The inventor has carried out a series of experiments, and is rationally feasible, stable and controllable for quality with proof technology of the present invention, to guarantee the beneficial effect of medicine.
Experimental example 1: amount of water examination
1, the amount of water optimization test of Fructus Jujubae, Semen sojae atricolor
Take by weighing Fructus Jujubae 200g, Semen sojae atricolor 200g for a, totally three parts, according to the amount of water of following table, decoct secondary respectively, each 3 hours, collecting decoction filtered, concentrate, drying, three parts of dry extracts, be evaluation index with the amount of n-butyl alcohol extractum, the result is as follows.
Table amount of water design table
The numbering decocting is amount of water (doubly) decocting amount of water (doubly) second time for the first time
1 6 4
2 8 6
3 10 8
Table amount of water preference data table
Sample number inventory (g) adds water multiple paste volume (g) n-butyl alcohol extractum total amount (g)
1 400.0 6、4 50.2 5.58
2 400.0 8、6 72.4 6.36
3 400.0 10、8 75.4 6.42
Above result shows, amount of water is doubly measured at 6-10 respectively, 4-8 doubly measures basic extracts active ingredients can being come out, but it is more complete that amount of water is respectively 8 times, the 6 times water extraction with 10 times, 8 times, and the extraction effect of the two is suitable, so take all factors into consideration from practical factors such as energy consumptions, determine that amount of water is respectively and add 8 times of water gagings for the first time, add 6 times of water gagings for the second time.
2, the amount of water optimization test of all the other medical materials such as Radix Polygoni Multiflori
Take by weighing Radix Polygoni Multiflori 100g, Fructus Ligustri Lucidi 100g, Rhizoma Dioscoreae 100g, Radix Rehmanniae 100g, Herba Ecliptae 100g, Poria 100g, Cortex Moutan 65g, Rhizoma Alismatis 65g, Fructus Mori 130g, Radix Ophiopogonis 100g for a, totally three parts, the amount of water of according to the form below respectively, decoct secondary, each 3 hours, collecting decoction, filter, concentrate drying, get three parts of dry extracts, with 2,3,5,4 '-tetrahydroxystilbene-2-o-β-D-glucoside total amount is an index, the result is as follows.
The decision design of table amount of water
The numbering decocting is amount of water (doubly) decocting amount of water (doubly) second time for the first time
1 6 4
2 8 6
3 10 8
The table amount of water is investigated the result data table
Numbering inventory (g) adds water multiple extractum and must measure (g) total content (mg)
1 960 6、4 164.3 131.4
2 960 8、6 187.2 155.4
3 960 10、8 189.7 155.7
Above result shows, with 2,3,5,4 '-tetrahydroxystilbene-2-o-β-D-glucoside total amount is an index, amount of water is doubly measured at 6-10 respectively, 4-8 doubly measures basic extracts active ingredients can being come out, but amount of water be respectively 8,6 times with 10,8 times of extracts in total content the highest, and the two is suitable, so take all factors into consideration, determine that twice amount of water is respectively 8 times of amounts and 6 times of amounts of medical material from practical factors such as extraction ratio and energy consumptions.
Experimental example 2 preparations shaping technical studies
1, the selection of adjuvant type:
Diluent commonly used in the Chinese medicinal capsule agent is starch, dextrin, lactose etc., in recent years, calcium sulfate, calcium hydrogen phosphate since its draw moist a little less than, and compressibility is good, is widely used.So respectively above-mentioned adjuvant is carried out preferably.
The proportionally mixing of powder and above-mentioned adjuvant of getting it filled respectively, the % alcohol granulation with 80, drying, room temperature (temperature is 21 ℃, and relative humidity is 60%) was placed 24 hours, investigated the influence of ambient temperature and humidity to it, and the result is as follows:
The table supplementary product kind is investigated test card
Tested number 123456
Medicated powder (g) 60 60 60 60 60 60
Starch (g) 40-----
Dextrin (g)-40----
Lactose (g)--40---
Pregelatinized Starch (g)---40--
Calcium sulfate (g)----40-
Calcium hydrogen phosphate (g)-----40
Made granule
The made granule of the made granule of the made granule of the made granule of made granule
More sticking, granule
More sticking, grain forming is better, and molding is better, and forming is put in forming, puts
Molding is general,
The result
Molding is general, a postpone granule postpone granule after the placement after placing
Place back
Placing the back granule does not have grain substantially and does not have substantially and do not have change substantially and do not have change substantially
Grain feels like jelly portion
The softer variation variationizationization of grain
Divide agglomerating
Above result of the test shows, the independent use of above-mentioned adjuvant can be satisfied the preparation requirement substantially, examine or check with other being used of one or more its any one simultaneously, also can both prepare qualified granule, but because of starch and dextrin have certain moisture, it is bigger influenced by ambient humidity, and prepared grain forming is not fine, and moisture absorption easily; And with lactose, when amylum pregelatinisatum is filler, the grain forming that makes is good, but granule is harder, with calcium sulfate, calcium hydrogen phosphate is filler, owing to itself contain bound water, hygroscopicity is little, character is more stable, also can increase preparation stability, and calcium sulfate is more cheap than the price of lactose, calcium hydrogen phosphate, so preferred list is a filler with calcium sulfate.
2, method of granulating determines
Get 5 parts of dried cream powders,, have certain viscosity, so select the ethanol of 70%-90% concentration to test (23 ℃ of room temperatures because of the medicated powder hygroscopicity is strong; Humidity 50%), its result is as follows.
Table granulating efficiency comparison sheet
Sequence number concentration of alcohol (%) granulating efficiency
1 70 made soft materials are more sticking; The grain forming weak effect
2 75 made soft materials are neither too hard, nor too soft, and the grain forming effect is better
3 80 made soft materials are neither too hard, nor too soft; Grain forming is effective
4 85 made soft materials are neither too hard, nor too soft, and the grain forming effect is better
5 90 made soft materials are harder, and granule is more loose, and molding effect is relatively poor
As seen from the above table, this granule used wetting agent of granulating is 75～85% ethanol.
3, the investigation of lubricant
Lubricant commonly used has magnesium stearate, micropowder silica gel, Pulvis Talci, according to trial test, above-mentioned any adjuvant or any and all the other one or more can both satisfy the preparation requirement when being used, but especially with magnesium stearate for well, so preferred magnesium stearate is a lubricant; Below its consumption is carried out preferably, the result is as follows.
The consumption of table lubricant is preferably shown
The consumption (%) of numbering magnesium stearate is angle of repose as a result
1 0.3 mobility of particles general 37.2
2 0.5 mobility of particles 31.1
3 1.0 mobility of particles 30.8
According to above-mentioned result of the test, the consumption of magnesium stearate can both improve particulate flowability preferably between 0.3-1.0%, but takes all factors into consideration, and the consumption of preferred magnesium stearate is 0.5%.
Experimental example 3: the mensuration of practical physical characteristics
1, the mensuration of mobility of particle
Whether satisfy the encapsulated requirement of production in order to investigate the particulate flowability that makes, so to measuring particulate angle of repose.
Adopt the fixed funnel method, with 3 funnel series connection, lowermost end is apart from horizontal positioned graph paper 1.5cm place, it is an amount of to get dried granule (water content is about 4%～5%), mixing is poured granule in the funnel of going up most carefully till the medicated powder cone tip that bottom funnel forms touches the funnel end opening along hopper walls, measured the diameter of conical base by graph paper, (tg α=H/R), the result is as follows to calculate angle of repose.
Show the granule mensuration of angle of repose
Numbering x angle of repose
1 31.0
2 31.5 31.6
3 32.3
The result shows, capsular fill requirement is satisfied in particulate angle of repose＜40 °.
2, the granule critical relative humidity is measured
In order to investigate ambient humidity to the influence of dried particles, the spy has carried out the mensuration of critical relative humidity.Test method is as follows: it is an amount of to get granule, be ground into fine powder, after being dried to constant weight, get about 1g, the accurate title, decide, and is tiled in the weighing botle bottom that is dried to constant weight, accurately weighing is placed on the constant exsiccator of the formed relative humidity of supersaturated aqueous solution interior (the weighing bottle cap is opened) of the listed different salt of following table, in 25 ℃ of constant incubators, keep weighing after 48 hours, calculate the moisture absorption percentage rate.The result is as follows.
Particulate relative moisture absorption percentage rate (%) under the table different humidity
Saturated salt solution kind relative humidity (%) moisture absorption percentage rate (%)
CH3COOK.1.5H
2O 22.45 2.11
MgCl
2.6H
2O 33.00 3.51
K
2CO
3.2H
2O 42.76 5.28
NaBr.2H
2O 57.70 10.97
NaCl 75.28 22.27
KCl 84.26 31.35
KNO
3 92.48 44.86
More than the hydroscopicity in the table is a vertical coordinate, and relative humidity is the abscissa mapping, and figure sees Figure of description 1.
Accompanying drawing 1 explanation: the hydroscopicity in the above table is a vertical coordinate, and relative humidity is the abscissa mapping, and accompanying drawing 1 shows, envionmental humidity is 64% when following, and particulate hydroscopicity is lower; And greater than 64%, hydroscopicity sharply increases.When packing was described, envionmental humidity should be controlled at below 64%.
Concrete embodiment
Embodiment 1:
Radix Polygoni Multiflori 150g Fructus Ligustri Lucidi 150g Rhizoma Dioscoreae 150g Radix Rehmanniae 150g Herba Ecliptae 150g
Poria 150g Cortex Moutan 97.5g Rhizoma Alismatis 97.5g Fructus Mori 195g 150g Radix Ophiopogonis
Fructus Jujubae 150g Semen sojae atricolor 150g
More than 12 flavors, Fructus Jujubae, Semen sojae atricolor decoct with water secondary, decoct 3 hours at every turn, add for the first time 8 times of water gagings, add 6 times of water gagings for the second time, collecting decoction filters, filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, decoct 3 hours at every turn, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, collecting decoction filters, and filtrate and above-mentioned medicinal liquid merge, being concentrated into relative density is the thick paste of 1.30～1.35 (60 ℃), and drying is ground into fine powder, it is an amount of to add calcium sulfate, and mixing is used 75% alcohol granulation, drying adds magnesium stearate 2.5g, mixing, incapsulate, make 1000, promptly.
Embodiment 2:
Radix Polygoni Multiflori 150g Fructus Ligustri Lucidi 150g Rhizoma Dioscoreae 150g Radix Rehmanniae 150g Herba Ecliptae 150g
Poria 150g Cortex Moutan 97.5g Rhizoma Alismatis 97.5g Fructus Mori 195g 150g Radix Ophiopogonis
Fructus Jujubae 150g Semen sojae atricolor 150g
More than 12 flavors, Fructus Jujubae, Semen sojae atricolor decoct with water secondary, decoct 3 hours at every turn, add for the first time 6 times of water gagings, add 4 times of water gagings for the second time, collecting decoction filters, filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, decoct 3 hours at every turn, add 6 times of water gagings for the first time, add 4 times of water gagings for the second time, collecting decoction filters, and filtrate and above-mentioned medicinal liquid merge, and being concentrated into relative density is the thick paste of 1.30～1.35 (60 ℃), drying is ground into fine powder, and heavily about 250g adds pregelatinized Starch 150g, calcium hydrogen phosphate 100g, mixing is used 70% alcohol granulation, drying adds differential silica gel 5g, mixing, incapsulate, make 1000, promptly.
Embodiment 3:
Radix Polygoni Multiflori 150g Fructus Ligustri Lucidi 150g Rhizoma Dioscoreae 150g Radix Rehmanniae 150g Herba Ecliptae 150g
Poria 150g Cortex Moutan 97.5g Rhizoma Alismatis 97.5g Fructus Mori 195g 150g Radix Ophiopogonis
Fructus Jujubae 150g Semen sojae atricolor 150g
More than 12 flavors, Fructus Jujubae, Semen sojae atricolor decoct with water secondary, decoct 3 hours at every turn, add for the first time 10 times of water gagings, add 8 times of water gagings for the second time, collecting decoction filters, filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, decoct 3 hours at every turn, add 10 times of water gagings for the first time, add 8 times of water gagings for the second time, collecting decoction filters, and filtrate and above-mentioned medicinal liquid merge, and being concentrated into relative density is the thick paste of 1.30～1.35 (60 ℃), drying is ground into fine powder, heavily about 350g, add lactose 150g, mixing is used 70% alcohol granulation, drying adds Pulvis Talci 3g, mixing, incapsulate, make 1000, promptly.
Embodiment 4:
Radix Polygoni Multiflori 150g Fructus Ligustri Lucidi 150g Rhizoma Dioscoreae 150g Radix Rehmanniae 150g Herba Ecliptae 150g
Poria 150g Cortex Moutan 97.5g Rhizoma Alismatis 97.5g Fructus Mori 195g 150g Radix Ophiopogonis
Fructus Jujubae 150g Semen sojae atricolor 150g
More than 12 flavors, Fructus Jujubae, Semen sojae atricolor decoct with water secondary, decoct 3 hours at every turn, add for the first time 8 times of water gagings, add 6 times of water gagings for the second time, collecting decoction filters, filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, decoct 3 hours at every turn, add 6 times of water gagings for the first time, add 6 times of water gagings for the second time, collecting decoction filters, and filtrate and above-mentioned medicinal liquid merge, and being concentrated into relative density is the thick paste of 1.30～1.35 (60 ℃), drying is ground into fine powder, adds starch, and dextrin, calcium hydrogen phosphate are an amount of, mixing is granulated drying, add Pulvis Talci 2g, micropowder silica gel 1g, mixing, encapsulated, make 1000, promptly.
Embodiment 5:
Radix Polygoni Multiflori 150g Fructus Ligustri Lucidi 150g Rhizoma Dioscoreae 150g Radix Rehmanniae 150g Herba Ecliptae 150g
Poria 150g Cortex Moutan 97.5g Rhizoma Alismatis 97.5g Fructus Mori 195g 150g Radix Ophiopogonis
Fructus Jujubae 150g Semen sojae atricolor 150g
More than 12 flavors, Fructus Jujubae, Semen sojae atricolor decoct with water secondary, decoct 3 hours at every turn, add for the first time 8 times of water gagings, add 6 times of water gagings for the second time, collecting decoction filters, filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, decoct 3 hours at every turn, add 6 times of water gagings for the first time, for the second time add 6 times of water gagings, collecting decoction filters, filtrate and above-mentioned medicinal liquid merge, and being concentrated into relative density is the thick paste of 1.30～1.35 (60 ℃), drying, be ground into fine powder, mixing is granulated, dry, encapsulated, make 1000, promptly.
Embodiment 6:
Radix Polygoni Multiflori 150g Fructus Ligustri Lucidi 150g Rhizoma Dioscoreae 150g Radix Rehmanniae 150g Herba Ecliptae 150g
Poria 150g Cortex Moutan 97.5g Rhizoma Alismatis 97.5g Fructus Mori 195g 150g Radix Ophiopogonis
Fructus Jujubae 150g Semen sojae atricolor 150g
More than 12 flavors, Fructus Jujubae, Semen sojae atricolor decoct with water secondary, decoct 3 hours at every turn, add for the first time 8 times of water gagings, add 6 times of water gagings for the second time, collecting decoction filters, filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, the each decoction 3 hours, add for the first time 6 times of water gagings, add for the second time 6 times of water gagings, collecting decoction, filter, filtrate and above-mentioned medicinal liquid merge, being concentrated into relative density is the thick paste of 1.30～1.35 (60 ℃), dry, be ground into fine powder, add adjuvant or do not add adjuvant, be prepared into various oral formulations such as tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation, oral liquid with conventional method.
Claims (8)
1, a kind of medicine for the treatment of alopecia, it is characterized in that it by active ingredient and and pharmaceutics on acceptable auxiliary form, wherein make the raw material medicaments in part by weight of described active ingredient and count: Radix Polygoni Multiflori 0.8-1.2 part, Fructus Ligustri Lucidi 0.8-1.2 part, Rhizoma Dioscoreae 0.8-1.2 part, Radix Rehmanniae 0.8-1.2 part, Herba Ecliptae 0.8-1.2 part, Poria 0.8-1.2 part, Cortex Moutan 0.5-0.8 part, Rhizoma Alismatis 0.5-0.8 part, Fructus Mori 1.1-1.5 part, Radix Ophiopogonis 0.8-1.2 part, Fructus Jujubae 0.8-1.2 part, Semen sojae atricolor 0.8-1.2 part.
2, medicine according to claim 1, it is characterized in that by weight described crude drug is: 1 part of Radix Polygoni Multiflori, 1 part of Fructus Ligustri Lucidi, 1 part of Rhizoma Dioscoreae, 1 part of Radix Rehmanniae, 1 part of Herba Ecliptae, 1 part in Poria, 0.65 part of Cortex Moutan, 0.65 part of Rhizoma Alismatis, 1.3 parts of Fructus Mori, 1 part of Radix Ophiopogonis, 1 part of Fructus Jujubae, 1 part in Semen sojae atricolor.
3, medicine according to claim 1 and 2 is characterized in that, described preparation can be tablet, capsule, granule, pill, powder, the oral liquid in the oral formulations.
4, according to claim 1 or 2 or 3 described medicines, it is characterized in that described preparation can be dispersible tablet, effervescent tablet, oral cavity disintegration tablet, soft capsule, microcapsule, drop pill.
5, the preparation method of medicine according to claim 1 and 2 is characterized in that, gets Fructus Jujubae, Semen sojae atricolor decocts with water secondary, and each 3 hours, collecting decoction filtered, and filtrate device is in addition preserved; All the other Radix Polygoni Multiflori etc. ten flavor decocts with water secondary, and each 3 hours, collecting decoction filtered, and filtrate merges with above-mentioned medicinal liquid, when being concentrated into relative density and being 60 ℃ 1.30～1.35, and adding proper auxiliary materials or do not add adjuvant and be prepared into different preparations.
6, the preparation method of medicine according to claim 5 is characterized in that, capsule is like this preparation: get Fructus Jujubae, Semen sojae atricolor decocts with water secondary, the each decoction 3 hours adds 6-10 times of water gaging for the first time, adds 4-8 times of water gaging for the second time, collecting decoction filters, and filtrate device is in addition preserved; Ten flavors such as all the other Radix Polygoni Multiflori decoct with water secondary, decoct 3 hours at every turn, add 6-10 times of water gaging for the first time, for the second time add 4-8 times of water gaging, collecting decoction filters, filtrate and above-mentioned medicinal liquid merge, 1.30～1.35 thick paste when being concentrated into relative density and being 60 ℃, drying, be ground into fine powder, add adjuvant, mixing, granulate, drying, encapsulated, promptly.
7, the preparation method of medicine according to claim 6 is characterized in that, adjuvant is one or more in starch, dextrin, lactose, pregelatinized Starch, calcium sulfate, calcium hydrogen phosphate, magnesium stearate, Pulvis Talci, the micropowder silica gel.
8, the preparation method of medicine according to claim 7 is characterized in that, adjuvant is meant calcium sulfate, magnesium stearate.
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| CNB2006100807158A CN100528208C (en) | 2006-05-12 | 2006-05-12 | A medicine for treating alopecia and method for preparing same |
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Non-Patent Citations (2)
| Title |
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| 卫生部中药成方制剂第十七册. 卫生部药典委员会，第66页. 1998 |
| 卫生部中药成方制剂第十七册. 卫生部药典委员会，第66页. 1998 * |
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