CN100518749C - Medicine for treating oral exulceratio and periodontal turgescene, and preparation method thereof - Google Patents
Medicine for treating oral exulceratio and periodontal turgescene, and preparation method thereof Download PDFInfo
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- CN100518749C CN100518749C CNB2005100327917A CN200510032791A CN100518749C CN 100518749 C CN100518749 C CN 100518749C CN B2005100327917 A CNB2005100327917 A CN B2005100327917A CN 200510032791 A CN200510032791 A CN 200510032791A CN 100518749 C CN100518749 C CN 100518749C
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- abelmoschi manihot
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Abstract
A Chinese medicine in the form of gel for treating oral ulcer and periodontitis is proportionally prepared from sunset abelmoschus flower, bee gelatine and additive. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of oral ulcer and periodontal turgescene and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Oral diseases such as oral ulcer are difficult disease, and sickness rate is more and more higher, and modern medicine lacks effective treatment means at present.It is main clinical manifestation that primary disease forms pain caused with stomatocace, and having in disease damage part in early days feels nervous sends out puckery, scorching hot or mild pain; Occur scorching hot sample during ulcer and have an intense pain, symptom aggravation during feed.Weight person's ulcer number is many, and area is big, and pain is more violent, with sialorrhea, babble, feed difficulty, also diseases such as heating, headache, pharyngalgia, xerostomia, insomnia, constipation can occur.
Toothache is meant and the pain that gingiva causes because of certain reason is one of modal symptom in the oral disease that there are the appearance of this disease in the dental caries in the modern medicine, pulpitis, apicitis, periodontitis and dentin hypersensitiveness etc. more.
Above-mentioned two cards, though sick different, because of consistent, be the disease that excess-fire is a trouble, control method, when being usefulness with heat clearing away, antiinflammatory, pain relieving.
Summary of the invention
The purpose of this invention is to provide a kind of treatment oral ulcer safe, effective, easy to use and the medicine of periodontal turgescene.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
Medicament selection Flos abelmoschi manihot of the present invention be because the Flos abelmoschi manihot analgesic activity less than morphine greater than aspirin.More outstanding is, the mechanism of action in its only road is different from morphine class, aspirin class analgesic, but calcium channel blocker with by stoping human calcium's ion to enter in the neurocyte, reaches analgesic activity.Effects such as remarkable pain relieving, antiinflammatory are arranged.Select for use propolis to be because propolis can suppress and kill bacteria, obvious antiinflammatory, pain relieving, itching-relieving action are arranged, ulcer is had healing effect preferably.
The proportioning of medicine of the present invention is: the propolis that contains the Flos abelmoschi manihot and 1%～99% (weight) of 99%～1% (weight).
The best proportioning of medicine of the present invention is: the propolis that contains the Flos abelmoschi manihot and 5.7% (weight) of 94.3% (weight).
The preparation method of above-mentioned each component being made medicine of the present invention is:
A) get Flos abelmoschi manihot, add 10%～90% ethanol extraction repeatedly, each 0.5～4 hour, merge extractive liquid, reclaimed ethanol, and being concentrated into does not have the alcohol flavor, adds boiling water extraction repeatedly, filters, and filtrate is packed in the macroporous adsorptive resins;
B) with 10%～90% ethanol elution, collect eluent, reclaim ethanol, concentrate;
C) add silica gel, mix thoroughly, drying adds aqueous organic solvent, soaks repeatedly, and merging filtrate reclaims solvent, and drying gets the Flos abelmoschi manihot extract powder;
D) get propolis, be ground into coarse powder, add 10%～90% ethanol extraction repeatedly, each 0.5～4 hour, merging filtrate reclaimed ethanol, concentrated, and drying gets the propolis extract powder;
E) Flos abelmoschi manihot extract powder, propolis extract powder add an amount of adjuvant that can form gel, adopt the preparation method of pharmaceutics to make gel.
Gel is an aqueous gel.
The specific embodiment
Below routine by experiment beneficial effect of further setting forth medicine of the present invention, these experimental examples comprise the pharmacodynamic experiment and the clinical observation on the therapeutic effect experiment of medicine of the present invention.
The clinical observation of [experimental example 1] Drug therapy oral ulcer of the present invention and periodontal turgescene:
Experiment material:
1, is subjected to the reagent thing
Medicine of the present invention.Usage: skin, mucosa delivery.
2, animal and antibacterial
Animal: Kunming mouse (20 ± 2g), the Wistar rat (200 ± 20g), Cavia porcellus (200 ± 20g), be the SPF level, the male and female dual-purpose.Rabbit body weight 2 ± 0.2kg, the male and female dual-purpose.
Pathogenic microorganism: staphylococcus aureus, staphylococcus epidermidis, bacillus pyocyaneus, escherichia coli, Candida albicans are clinical strain.
Experimental technique
Requirement, carried out following observation index:
1. antibacterial action: external inhibitory action to staphylococcus aureus, staphylococcus epidermidis, bacillus pyocyaneus, escherichia coli, Candida albicans.
2. antiinflammatory action: on Carrageenan causes rat paw edema, to Oleum Tiglii induced mice auricle edema, to the swollen influence that forms of rat granuloma.
3. antiulcer action: the influence of bacterial canker, scald property and the acetic acid oral ulcer that the rabbit staphylococcus epidermidis is caused.
4. anti-allergic effects: to the influence of guinea pig skin pruritus due to the histamine.
5. analgesic activity: to the influence of mice thermic pain.
Experimental result
1, antibacterial action
Medicine of the present invention is 1:160 at external minimum inhibitory concentration to staphylococcus aureus (MIC), be 1:80 to the staphylococcic minimum inhibitory concentration of epidermis, to the oidiomycetic minimum inhibitory concentration of white is 1:10, bacillus pyocyaneus and escherichia coli are not had the obvious suppression effect, the results are shown in Table 1～5.
Table 1 medicine of the present invention is to aureus with inhibition
"-" expression asepsis growth, "+" expression have bacteria growing (down together)
Table 2 medicine of the present invention is to the staphylococcic inhibitory action of epidermis
Table 3 medicine of the present invention is to the oidiomycetic inhibitory action of white
Table 4 medicine of the present invention is to the inhibitory action of bacillus pyocyaneus
Table 5 medicine of the present invention is to colibacillary inhibitory action
2, antiinflammatory action
The result shows that medicine of the present invention causes rat paw edema and the swollen hypertrophy of rat granuloma is all had the obvious suppression effect Oleum Tiglii induced mice auricle edema, on Carrageenan.The results are shown in Table 6～8.
Table 6 medicine of the present invention to the inhibitory action of Oleum Tiglii induced mice auricle edema (x ± s, n=12)
Compare with the blank group:
*P＜0.05,
*P＜0.01.
Table 7 medicine on Carrageenan of the present invention cause rat paw edema inhibitory action (x ± s, n=10)
Compare with the blank group:
*P＜0.05,
*P＜0.01
Table 8 medicine of the present invention to the swollen outgrowth influence of rat granuloma (x ± s, n=20)
Compare with the blank group:
*P＜0.05,
*P＜0.01.
3, anti-oral ulcer effect
The result shows that medicine of the present invention can obviously promote the healing of scald property, acetic acid, bacillary oral ulcer, the results are shown in Table 9, table 10, table 11.
Table 9 medicine of the present invention to rabbit scald the property oral ulcer inhibitory action (x ± s, n=10)
Compare with the blank group:
*P＜0.05,
*P＜0.01; With before self medication relatively,
△P＜0.05,
△ △P＜0.01.
Table 10 medicine of the present invention to the inhibitory action of rabbit acetic acid oral ulcer (x ± s, n=10)
Compare with the blank group:
*P＜0.05,
*P＜0.01; With before self medication relatively,
△P＜0.05,
△ △P＜0.01.
Table 11 medicine of the present invention to the inhibitory action of the bacillary oral ulcer of rabbit (x ± s, n=10)
Compare with the blank group:
*P＜0.05,
*P＜0.01; With before self medication relatively,
△P＜0.05,
△ △P＜0.01.
4, itching-relieving action
The result shows, medicine of the present invention has the obvious suppression effect to guinea pig skin pruritus due to the histamine, the results are shown in Table 12.
Table 12 medicine of the present invention to Guinea Pig Histamine cause the inhibitory action of itching (x ± s, n=10)
Compare with the blank group:
*P＜0.05,
*P＜0.01.
5, to thermic influence bitterly
Medicine of the present invention has the obvious suppression effect bitterly to the mice thermic, the results are shown in Table 13.
The influence that table 13 medicine of the present invention reacts bitterly to the mice thermic (x ± s, n=10)
Compare with the blank group:
*P＜0.05,
*P＜0.01.
Experimental result shows, medicine of the present invention has stronger inhibitory action external to staphylococcus aureus, staphylococcus epidermidis, Candida albicans, and Oleum Tiglii induced mice auricle inflammation there is obvious inhibitory action, on Carrageenan causes rat paw edema and the granuloma induced by implantation of cotton pellets hypertrophy also has certain inhibitory action, shows that it has significantly antiinflammatory action.Also promote the healing of chemical, scald property and bacillary oral ulcer significantly.In addition, skin pruritus due to the histamine and thermic pain also there is obvious inhibitory action.
The capsule preparation of [embodiment 1] medicine of the present invention
A) get Flos abelmoschi manihot, add 80% alcohol heating reflux and extract 2 times, each 2 hours, merge extractive liquid, reclaimed ethanol, and being concentrated into does not have the alcohol flavor, adds boiling water extraction 2 times, filtered while hot, and filtrate is packed in the macroporous adsorptive resins;
B) wash with water earlier, abandon water liquid, 15 times of amounts of reuse, 80% ethanol elution is collected eluent, decompression recycling ethanol, and being concentrated into relative density is 1.05;
C) add silica gel, mix thoroughly, drying under reduced pressure is weighed, and adds 10 times of amount ethyl acetate: ethanol: water, its ratio are to make solvent at 82.6: 8.4: 9, soak 3 times, and each 6 hours, merging filtrate reclaimed solvent, and drying under reduced pressure must the Flos abelmoschi manihot extract powder;
D) get propolis, be ground into coarse powder, add 8 times of amount 70% ethanol, 30 ℃ of warm macerating extract 3 times, and each 2 hours, merging filtrate reclaimed ethanol, concentrated, and drying under reduced pressure gets the propolis extract powder;
E) get Flos abelmoschi manihot extract powder, propolis extract powder, add the appropriate amount of auxiliary materials mixing, the snap fit capsule of packing into.
The granule preparation of [embodiment 2] medicine of the present invention
A) get Flos abelmoschi manihot, add 80% alcohol heating reflux and extract 2 times, each 2 hours, merge extractive liquid, reclaimed ethanol, and being concentrated into does not have the alcohol flavor, adds boiling water extraction 2 times, filtered while hot, and filtrate is packed in the macroporous adsorptive resins;
B) wash with water earlier, abandon water liquid, 15 times of amounts of reuse, 80% ethanol elution is collected eluent, decompression recycling ethanol, and being concentrated into relative density is 1.05;
C) add silica gel, mix thoroughly, drying under reduced pressure is weighed, and add 10 times of amount ethyl acetate: ethanol: water, its ratio are that 82.6:8.4:9 makes solvent, soaks 3 times, and each 6 hours, merging filtrate reclaimed solvent, and drying under reduced pressure gets the Flos abelmoschi manihot extract powder;
D) get propolis, be ground into coarse powder, add 8 times of amount 70% ethanol, 30 ℃ of warm macerating extract 3 times, and each 2 hours, merging filtrate reclaimed ethanol, concentrated, and drying under reduced pressure gets the propolis extract powder;
E) get Flos abelmoschi manihot extract powder, propolis extract powder, add the appropriate amount of auxiliary materials mixing, granulate, drying is made granule.
The preparation tablets of [embodiment 3] medicine of the present invention
A) get Flos abelmoschi manihot, add 80% alcohol heating reflux and extract 2 times, each 2 hours, merge extractive liquid, reclaimed ethanol, and being concentrated into does not have the alcohol flavor, adds boiling water extraction 2 times, filtered while hot, and filtrate is packed in the macroporous adsorptive resins;
B) wash with water earlier, abandon water liquid, 15 times of amounts of reuse, 80% ethanol elution is collected eluent, decompression recycling ethanol, and being concentrated into relative density is 1.05;
C) add silica gel, mix thoroughly, drying under reduced pressure is weighed, and add 10 times of amount ethyl acetate: ethanol: water, its ratio are that 82.6:8.4:9 makes solvent, soaks 3 times, and each 6 hours, merging filtrate reclaimed solvent, and drying under reduced pressure gets the Flos abelmoschi manihot extract powder;
D) get propolis, be ground into coarse powder, add 8 times of amount 70% ethanol, 30 ℃ of warm macerating extract 3 times, and each 2 hours, merging filtrate reclaimed ethanol, concentrated, and drying under reduced pressure gets the propolis extract powder;
E) get Flos abelmoschi manihot extract powder, propolis extract powder, add the appropriate amount of auxiliary materials mixing, granulate, drying, compacting is made tablet in flakes.
The above only is the preferred embodiment of patent of the present invention, and all equalizations of being done according to patent claimed range of the present invention change and modify, and all should belong to the covering scope of Patent right requirement of the present invention.
Claims (2)
1. preparation method for the treatment of oral ulcer and periodontal turgescene medicine, it is characterized in that: medicine material contains the Flos abelmoschi manihot of 99%～1% weight and the propolis of 1%～99% weight, and its preparation method comprises the steps:
A) get Flos abelmoschi manihot, add 10%～90% ethanol extraction repeatedly, each 0.5～4 hour, merge extractive liquid, reclaimed ethanol, and being concentrated into does not have the alcohol flavor, adds boiling water extraction repeatedly, filters, and filtrate is packed in the macroporous adsorptive resins;
B) with 10%～90% ethanol elution, collect eluent, reclaim ethanol, concentrate;
C) add silica gel, mix thoroughly, drying adds aqueous organic solvent, soaks repeatedly, and merging filtrate reclaims solvent, and drying gets the Flos abelmoschi manihot extract powder;
D gets propolis, is ground into coarse powder, adds 10～90% ethanol extractions repeatedly, and each 0.5～4 hour, merging filtrate reclaimed ethanol, concentrated, and drying gets the propolis extract powder;
E) Flos abelmoschi manihot extract powder, propolis extract powder add an amount of adjuvant that can form gel, adopt the preparation method of pharmaceutics to make the medicine for the treatment of oral ulcer and periodontal turgescene.
2, according to the preparation method of described treatment oral ulcer of claim 1 and periodontal turgescene medicine, it is characterized in that: medicine material contains the Flos abelmoschi manihot of 94.3% weight and the propolis of 5.7% weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100327917A CN100518749C (en) | 2005-01-19 | 2005-01-19 | Medicine for treating oral exulceratio and periodontal turgescene, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100327917A CN100518749C (en) | 2005-01-19 | 2005-01-19 | Medicine for treating oral exulceratio and periodontal turgescene, and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1679800A CN1679800A (en) | 2005-10-12 |
| CN100518749C true CN100518749C (en) | 2009-07-29 |
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| CNB2005100327917A Expired - Fee Related CN100518749C (en) | 2005-01-19 | 2005-01-19 | Medicine for treating oral exulceratio and periodontal turgescene, and preparation method thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106420506A (en) * | 2016-12-02 | 2017-02-22 | 成都大学 | Sunset abelmoschus root-olive toothpaste and preparation method thereof |
| CN109953930B (en) * | 2017-12-14 | 2022-04-12 | 苏中药业集团股份有限公司 | Chinese herbal medicine toothpaste with dental ulcer repairing effect and preparation method thereof |
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2005
- 2005-01-19 CN CNB2005100327917A patent/CN100518749C/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| 蜂胶治疗口腔疾病的药理作用和临床应用现状,. 刘海鹏，王钦茂.中国临床药理学与治疗学，第7卷第3期. 2002 |
| 蜂胶治疗口腔疾病的药理作用和临床应用现状,. 刘海鹏，王钦茂.中国临床药理学与治疗学，第7卷第3期. 2002 * |
| 黄蜀葵糊剂治疗口腔粘膜溃疡82例. 韩晓兰，司徒曼丽.安徽中医临床杂志，第9卷第6期. 1997 |
| 黄蜀葵糊剂治疗口腔粘膜溃疡82例. 韩晓兰，司徒曼丽.安徽中医临床杂志，第9卷第6期. 1997 * |
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