CN100516863C - Biological sensor measurement with double inserted slot - Google Patents
Biological sensor measurement with double inserted slot Download PDFInfo
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- CN100516863C CN100516863C CNB2004100961039A CN200410096103A CN100516863C CN 100516863 C CN100516863 C CN 100516863C CN B2004100961039 A CNB2004100961039 A CN B2004100961039A CN 200410096103 A CN200410096103 A CN 200410096103A CN 100516863 C CN100516863 C CN 100516863C
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Abstract
A measuring method of biological transducer with double insertion slots includes inserting code card into double insertion slots first to input parameters in transducer then inserting test block to activate transducer, judging whether it is greater than threshold or not after blood is dropped on reaction zone of test block, outputting voltage as set by node card and having the fetching current value as set by node card as well as carrying out calculation to obtain result according to manner set by node card if it is greater than threshold.
Description
Technical field
The present invention relates to a kind of biological sensor measurement with double inserted slot, particularly a kind ofly can provide the reference voltage of different-effect to test piece (Strip) according to the test piece kind, single power supply for example, many power supplys, the also not switching of frequency of the same race, even the waveform of sawtooth wave can be provided, can decide according to the parameter that code card (main control unit or be online to other assembly of main control unit) gives, to reach the dual slot biology sensor of a tractor serves several purposes effect.
Background technology
Biosensing apparatus is in order to detect contained glucose, cholesterol and protoheme in the blood at present.After the biosensing apparatus inspection test piece inserts, again blood is splashed into the reaction zone of test piece, allow two electrifying electrodes of reaction zone, sensing apparatus promptly carries out Measurement and analysis to input signal, can effectively analyze glucose, cholesterol and protoheme concentration.
Yet, along with science and technology is constantly down progressive, there is numerous biosensing apparatus to be developed, and the factor of measuring is subjected to the influence of specimen preparation always, often allow the design of biosensing apparatus internal hardware not catch up with the test piece step, cause the user need change biosensing apparatus, otherwise be exactly each other between employed test piece all can't intercommunication use, cause a kind of test piece just must a kind of biosensing apparatus of collocation.And, the mistake of the function of no self-correction of some biosensing apparatus itself and detection, thereby appearance measurement often again.
Summary of the invention
Fundamental purpose of the present invention provides a kind of biological sensor measurement with double inserted slot, make biosensing apparatus that the reference voltage of different-effect can be provided according to the test piece kind, more can decide according to the parameter that code card (coded card) (main control unit or be online to other assembly of main control unit) gives, to reach a tractor serves several purposes effect, simultaneously can also avoid to change the design of instrument, maybe need go back to factory and look after and guide again because of the test piece characteristic variations.
Another object of the present invention provides proofreaies and correct and measuring ability, after can inserting by calibrate card, and the function of self-correction and detection sensing apparatus linearity, aging to prevent the sensing apparatus part, cause the measurement mistake.
A further object of the present invention is to make sensing apparatus have whether overdue function of automatic calculating test piece, reminds user's test piece out of date by this, avoids the user to use expired test piece, and causes the measurement mistake.
Another purpose of the present invention is, be that test piece is inserted after, according to the parameter that test piece is imported, can judge to make the why test piece of kind of test piece.
In order to achieve the above object, biological sensor measurement with double inserted slot of the present invention, in the double flute of sensing apparatus, insert earlier code card (main control unit or be online to other assembly of main control unit) to behind the sensing apparatus input parameter, insert test piece again and activate sensing apparatus, wait for that blood splashes into behind the reaction zone of test piece, judge whether greater than threshold values, greater than threshold values the time, this sensing apparatus enters two electrifying electrodes of the test piece of phase one, behind the time output voltage of setting according to code card (main control unit or be online to other assembly of main control unit), the subordinate phase time that sets finishes, sensing apparatus enters the phase III and sets and read current value according to code card (main control unit or be online to other assembly of main control unit), according to code card (main control unit or be online to other assembly of main control unit) establishing method operation result, and on display, show measurement result by the current value of phase III gained.
The present invention is described in detail below in conjunction with accompanying drawing.
Description of drawings
Fig. 1 is a dual slot biology sensor schematic appearance of the present invention;
Fig. 2 is the circuit box synoptic diagram of dual slot biology sensor of the present invention;
Fig. 3 is the control flow synoptic diagram of dual slot biology sensor of the present invention;
Fig. 4 is a reference power source control waveform synoptic diagram of the present invention;
Fig. 5 is the result's of obtaining an of the present invention first method waveform synoptic diagram;
Fig. 6 is the result's of obtaining an of the present invention second method waveform synoptic diagram.
Description of reference numerals: biosensing apparatus 1; Circuit 2; Power supply control 21; Reference voltage 22; Temperature sensor 23; Microprocessor 24; Display 25; Input block 26; Repeatable read/memory write 27; Test piece 3; Reaction zone 31; Two electrodes 32,33; Code card (main control unit or be online to other assembly of main control unit) 4; Phase one 5; Subordinate phase 6; Phase III 7; Area A.
Embodiment
See also dual slot biosensing apparatus outward appearance of the present invention shown in Figure 1 and circuit box and control flow synoptic diagram.As shown in the figure, dual slot biosensing apparatus measuring method of the present invention mainly is to provide two slots 11,12 in biosensing apparatus 1, can about interview and write, even can whether a slot can only be measured a kind of test piece (Strip) 3 in 4 decisions by code card (coded card) (main control unit or be online to other assembly of main control unit), to prevent the error result of human negligence.
Above-mentioned biosensing apparatus 1 can provide the reference voltage of different-effect to test piece (Strip) 3 according to test piece (Strip) 3 kinds, single power supply for example, many power supplys, the also not switching of frequency of the same race, even can provide the waveform of sawtooth wave, can decide according to code card (main control unit or be online to other assembly of main control unit) 4 parameters that give, to reach a tractor serves several purposes effect, can also avoid simultaneously the design that must change instrument because of test piece (Strip) 3 characteristic variations, maybe need go back to factory and look after and guide again.
The above-mentioned circuit block diagram that is disposed at dual slot biosensing apparatus 1 as shown in Figure 2, as seen from the figure, the circuit 2 of sensing apparatus 1 inside comprises power supply control 21, one reference voltage 22, a temperature sensor 23, a microprocessor 24 at least, and the display 25 that is connected with microprocessor 24, input block 26 and repeatable read/memory write 27 constitute, because circuit 2 is a conventional art, seldom do detailed description at this, only to the software program of circuit that the present invention loads on 2 as and the measurement of carrying out dual slot describe.
Dual slot biosensing apparatus 1 in use, after inserting earlier 4 pairs of sensing apparatus 1 input parameters of code card (main control unit or be online to other assembly of main control unit), insert test piece (Strip) 3 again and activate sensing apparatus 1, wait for that blood splashes into behind the reaction zone 31 of test piece (Strip) 3, judge whether greater than threshold values; If judge when being not more than threshold values, be back to waiting status; If when judging greater than threshold values, this sensing apparatus 1 enters two electrodes 32 of phase one test piece (Strip) 3,33 energisings, behind code card (main control unit or be online to other assembly of main control unit) the 4 time output voltages of setting, the subordinate phase time that sets finishes, sensing apparatus 1 enters the phase III and sets according to code card (main control unit or be online to other assembly of main control unit) 4 and read current value, according to code card (main control unit or be online to other assembly of main control unit) 4 establishing method operation results, and on display 25, show measurement result by the current value of phase III gained.
See also Fig. 4, Fig. 5, reference power source control waveform of the present invention shown in Figure 6 and obtain first and second kind method waveform synoptic diagram of result.As shown in the figure, the reference power source control waveform of Fig. 4 was divided into for three stages, and phase one 5 is for waiting for that blood splashes into, and subordinate phase 6 is for waiting for 3 reaction time of test piece, and the phase III is that test piece 3 reacts completely and can grasp the result.
Phase one 5 is two electrodes 32,33 (as shown in Figure 1) energising in the test piece 3, setting voltage.Because of 32,33 at two electrodes for opening circuit, should be lower than the threshold values that sets in the codecard (main control unit or be online to other assembly of main control unit) 4 to sensing apparatus 1 measured current value, after blood splashes into, can make two electrodes 32,33 form path, this moment, sensing apparatus 1 can enter into subordinate phase 6.
Blood splashes into the laggard subordinate phase 6 of going into, because the object difference of measuring has the different reaction time, as measuring the glucose in the blood, its reaction time is 4～20 seconds; Measure the cholesterol in the blood, its reaction time is 90～180 seconds; Measure the protoheme in the blood, its reaction time is 30～120 seconds; These time sets can be before shipment, is set in the codecard (main control unit or be online to other assembly of main control unit) 4 according to test piece 3 kinds.
7 of phase IIIs are to begin to calculate after the time that subordinate phase 6 is measured finishes, and its parameter can be before shipment, are set in the code card (main control unit or be online to other assembly of main control unit) 4 according to test piece 3 kinds.Provide its scope of voltage at 100～500mV by measuring instrument, but its voltage setting can be lower than voltage 50～100mV of phase one 5.Conduction time is different because the target of measuring is different, and as measuring the glucose in the blood, its reaction time is 5～20 seconds; Measure the cholesterol in the blood, its reaction time is 5～30 seconds; Measure the protoheme in the blood, its reaction time is 5～60 seconds; These time sets can be before shipment, is set in the storer (EEPROM) in the codecard (main control unit or be online to other assembly of main control unit) 4 according to the test piece kind.
When the phase III 7 applies voltage, the current value that two electrodes of measurement test piece 3 are 32,33, this is reagent in the test piece 3 and mensuration thing reaction gained.
Therefore, phase III test piece 3 reacts completely and can grasp the result, obtains method as a result as first of Fig. 5, is to utilize integral formula to try to achieve, and through compensation, can calculate the result.Its integral formula is
Area A=∫ di/dt
Be 50,100,150 to get concentration of glucose in the mensuration blood for instance, 200mg/dL, resulting integrated value is 5000,10000,15000,20000.Can obtain by linear regression
Concentration of glucose in the blood (mg/dL)=0.01 * area A
If splashing into the resultant area of blood sample of a unknown concentration is 18000, substitution concentration of glucose (mg/dL)=0.01 * area A, promptly obtaining its concentration of glucose is 180mg/dL.
And second obtained method as a result, is after utilizing the set time to grasp results added, through compensation or conversion, can calculate the result.As shown in Figure 6; To measure in the blood to such an extent that concentration of glucose be 50mg/dL, read some current values in per 0.5 second if use for instance, total reaction time is 5 seconds, thus the current value that obtains be 9 groups (the 0.5th second, the 1.0th second, the 1.5th second, the 2.0th second, the 2.5th second, the 3.0th second, the 3.5th second, the 4.0th second, the 4.5th second, the 5.0th second) itself and be 500, when concentration is 100,150,200mg/dL, resulting and be respectively 1000,1500,2000.Can obtain by linear regression
Concentration of glucose in the blood (mg/dL)=0.1 * area A
If splashing into the resultant area of blood sample of a unknown concentration is 1800, substitution concentration of glucose (mg/dL)=0.1 * area A, promptly obtaining its concentration of glucose is 180mg/dL.
Further, be that the present invention has correction and measuring ability, after can inserting by calibrate card, the function of self-correction and detection sensing apparatus linearity, aging to prevent the sensing apparatus part, cause the measurement mistake.
Further again, be that sensing apparatus of the present invention has whether overdue function of automatic calculating test piece, remind user's test piece out of date by this, avoid the user to use expired test piece, and cause the measurement mistake.
Further, be that test piece is inserted after, according to the parameter that test piece is imported, can judge to make the why test piece of kind of test piece.
Above-mentioned is preferred embodiment of the present invention only, is not to be used for limiting scope of the invention process.Therefore all equalizations of doing according to claim of the present invention change and modify, and all belong to this protection scope of the present invention.
Claims (11)
1, a dual slot bio-sensor measuring method, it is applied to a sensing apparatus, the circuit of this sensing apparatus inside comprises power supply control, a reference voltage, a temperature sensor, a microprocessor, and the display that is connected with microprocessor, input block and repeatable read/memory write, described measuring method may further comprise the steps:
A), earlier insert coded card, described coded card is main control unit or other assembly that is online to main control unit, behind the sensing apparatus input parameter, inserts test piece again and activates sensing apparatus;
B), wait for that blood splashes into behind the reaction zone of test piece, judge whether that greater than threshold values if greater than threshold values, this sensing apparatus enters two electrifying electrodes of phase one test piece, behind the time output voltage of setting according to described coded card, the subordinate phase time that sets finishes;
C), after the subordinate phase time that sets finishes, sensing apparatus enters the phase III, sets according to described coded card and reads current value, according to described coded card establishing method operation result, and shows measurement result by the current value of phase III gained on display.
2, biological sensor measurement with double inserted slot as claimed in claim 1, wherein, this reference voltage is 100～500mV.
3, biological sensor measurement with double inserted slot as claimed in claim 1 wherein, has a reaction zone in this test piece, this reaction zone has two electrodes.
4, biological sensor measurement with double inserted slot as claimed in claim 1, wherein, after blood splashed into, the object difference because of measuring had the different reaction time in subordinate phase, and as measuring the glucose in the blood, its reaction time is 4～20 seconds; Measure the cholesterol in the blood, its reaction time is 90～180 seconds; Measure the protoheme in the blood, its reaction time is 30～120 seconds.
5, biological sensor measurement with double inserted slot as claimed in claim 1, wherein, different because the target of measuring is different in conduction time phase III, as measuring the glucose in the blood, its reaction time is 5～20 seconds; Measure the cholesterol in the blood, its reaction time is 5～30 seconds; Measure the protoheme in the blood, its reaction time is 5～60 seconds.
6, as claim 4 or 5 described biological sensor measurement with double inserted slot, wherein, this reaction time is set, and can be set in the described coded card according to the test piece kind before shipment.
7, biological sensor measurement with double inserted slot as claimed in claim 1, wherein, this phase III test piece react completely can grasp the result first obtain method as a result, be to utilize integral formula to try to achieve, through compensation, can calculate the result, its integral formula is
Area A=∫ di/dt, concentration=0.01 * area A, wherein concentration unit is mg/dL.
8, biological sensor measurement with double inserted slot as claimed in claim 1, wherein, react completely second of can grasp the result of this phase III test piece obtains method as a result, is after utilizing the set time to grasp results added, through compensation or conversion, can calculate the result
Area A=∫ di/dt, concentration=0.1 * area A, wherein concentration unit is mg/dL.
9, biological sensor measurement with double inserted slot as claimed in claim 1, wherein, after this test piece is inserted, the function of self-correction and detection sensing apparatus linearity, aging to prevent the sensing apparatus part, cause the measurement mistake.
10, biological sensor measurement with double inserted slot as claimed in claim 1, wherein, this sensing apparatus has whether overdue function of automatic calculating test piece, reminds user's test piece out of date thus, avoids the user to use expired test piece, and causes the measurement mistake.
11, biological sensor measurement with double inserted slot as claimed in claim 1 wherein, after this test piece is inserted, according to the parameter that test piece is imported, can be judged to make the why test piece of kind of test piece.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100961039A CN100516863C (en) | 2004-11-26 | 2004-11-26 | Biological sensor measurement with double inserted slot |
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| CNB2004100961039A CN100516863C (en) | 2004-11-26 | 2004-11-26 | Biological sensor measurement with double inserted slot |
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| CN1779456A CN1779456A (en) | 2006-05-31 |
| CN100516863C true CN100516863C (en) | 2009-07-22 |
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| US8066866B2 (en) * | 2005-10-17 | 2011-11-29 | Lifescan, Inc. | Methods for measuring physiological fluids |
| CN1866009B (en) * | 2006-06-15 | 2010-07-21 | 热映光电股份有限公司 | Biosensor |
| CN106419891B (en) * | 2010-09-16 | 2020-06-05 | 神经系统检测公司 | Apparatus and method for automated measurement of sural nerve conduction velocity and amplitude |
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