CN100496474C - Oral percarbonateamide oxygen-supply agent and preparation thereof - Google Patents
Oral percarbonateamide oxygen-supply agent and preparation thereof Download PDFInfo
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- CN100496474C CN100496474C CNB2004100653610A CN200410065361A CN100496474C CN 100496474 C CN100496474 C CN 100496474C CN B2004100653610 A CNB2004100653610 A CN B2004100653610A CN 200410065361 A CN200410065361 A CN 200410065361A CN 100496474 C CN100496474 C CN 100496474C
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- Prior art keywords
- percarbamide
- chitosan
- supply agent
- preparation
- oxygen supply
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Abstract
An orally taken percarbonamide as the oxygen donor in the form of tablet, particles or powder for the patients of pneumonectasis, pneumocardial disease, respiration failure, asthma, etc contains the medicinal percarbonamide and deacetyl chitin proportionally.
Description
Technical field:
The present invention relates to oxygen supply agent of a kind of peroral dosage form and preparation method thereof.
Background technology:
At present, percarbamide is used for the human body oxygen supply and has only injection type, and the mode of injection oxygen supply is generally just used during first aid.Inapplicable for health care oxygen supply and general anoxia, the injection system oxygen supply can cause local pain simultaneously.Only the mode of mouth of pipe clothes is very convenient, but the percarbamide chemical compound is owing to be acid, and direct oral meeting causes damage to the part of stomach, thereby is unwell to directly oral.
Thereby up to now, still there is not the percarbonateamide oxygen-supply agent of peroral dosage form.
Summary of the invention:
The present invention is for avoiding above-mentioned existing in prior technology weak point, a kind of oral percarbonateamide oxygen-supply agent is provided, and the preparation method of this oxygen supply agent is provided.
The present invention's technical scheme that is adopted of dealing with problems is:
The characteristics of oral type oxygen supply of the present invention agent are to serve as system oxygen raw material with medicinal percarbamide, are equipped with the peroral dosage form of appropriate amount of auxiliary materials.
The characteristics of oral type oxygen supply of the present invention agent are that also medicinal percarbamide is 50-100g, and adjuvant comprises chitosan (chitin) 1-5g.
The characteristics of oral type oxygen supply method for preparing tablet thereof of the present invention are to have following steps:
The starch slurry of a, the usefulness of getting it filled percarbamide 100g, chitosan (chitin) 1-5g, 6-10% is an amount of;
B, percarbamide grind after drying, cross 80 mesh sieves, make soft material with adding starch slurry behind the chitosan chitin mixing of pulverizing;
C, gained soft material are crossed 18 mesh sieves and are made wet granular, and drying is after 18 mesh sieve granulate, weigh tabletting.
The characteristics of oral type oxygen supply process for producing granula of the present invention are to have following steps:
A, the usefulness of getting it filled percarbamide 100g, chitosan (chitin) 1-5g, dextrin 3-8g;
B, percarbamide drying, dried percarbamide, dextrin and chitosan (chitin) are crossed 100 mesh sieves respectively, by the facing-up method that equal-volume increases progressively percarbamide and adjuvant mix homogeneously are made soft material;
C, gained soft material are crossed 16 mesh sieves and are made the granule after drying, pack with bag.
The characteristics of oral type oxygen supply powder preparation method of the present invention are to have following steps:
A, the usefulness of getting it filled percarbamide 100g, chitosan (chitin) 1-5g, dextrin 3-8g;
B, earlier with chitosan (chitin) and dextrin porphyrize mixing, add percarbamide then, grind altogether also be dispersed into behind the mixing packed.
The characteristics of the preparation method of oral type oxygen supply capsule of the present invention are: get it filled with percarbamide 100g, chitosan (chitin) 1-5g, the porphyrize mixing is crossed 100 mesh sieves altogether, by every ball 0.5g packing.
The characteristics of oral type oxygen supply liquid and preparation method thereof of the present invention are that adding distil water makes its dissolving to 50ml by medicinal percarbamide 5g, chitosan (chitin) 0.1-0.5g, and aqueous solution directly is packaged into bottle, is stored under the room temperature standby.
Compared with the prior art, beneficial effect of the present invention is embodied in:
1, the present invention is the various peroral dosage forms of feedstock production with medicinal percarbamide, provides new way very easily for the anoxia patient obtains oxygen with other biology.
2, the present invention is as oral type oxygen supply preparation, with respect to other the oxygen delivery technique that generally adopts at present special advantages arranged, and it is easy to use, be easy to carry, and can directly decompose in the human body body and is utilized, and the utilization rate of oxygen is very high.
3, the present invention utilizes percarbamide to prepare oral type and can directly be hydrogenated enzyme decomposition release oxygen, and by contrast, other chemical compound must use catalyst to make it to decompose, such as: sodium peroxide need add the MnO2 catalyst decomposes and emit oxygen.
Oxygen supply agent of the present invention can be applicable to various anoxia symptoms, as emphysema, pulmonary heart disease, dyspnea or depletion, the disease of asthma, pneumothorax and various cardio-cerebrovasculars, take oxygen supply agent of the present invention can improve nervous, breathe hard, symptom such as uncomfortable in chest and cyanosis.
The specific embodiment:
Oral type oxygen supply agent in the present embodiment is to serve as system oxygen raw material with medicinal percarbamide, is equipped with appropriate amount of auxiliary materials and makes, and can comprise various peroral dosage forms such as tablet, granule, capsule and liquid preparation.The active o content of medicinal percarbamide is greater than 16.8%, and every gram oxygen-producing amount is no less than 80ml.
Embodiment 1:
The preparation of oral type oxygen supply tablet:
It is an amount of with the starch slurry of percarbamide 100g, chitosan (chitin) 1-5g, 6-10% to get it filled;
Percarbamide ground 80 mesh sieves in 35 ℃ of dryings 24 hours, and added starch slurry behind the chitosan chitin mixing of pulverizing and made soft material;
The gained soft material is crossed 18 mesh sieves and is made wet granular, in 35 ℃ of dryings, after 18 mesh sieve granulate, weigh tabletting.
Every contains percarbamide 0.5g, per hour can obey 4 during use, uses continuously in case of necessity.
Embodiment 2:
The preparation of oral type oxygen supply granule:
Get it filled with percarbamide 100g, chitosan (chitin) 1-5g, dextrin 3-8g;
Percarbamide was in 35 ℃ of dryings 24 hours, and dried percarbamide, dextrin and chitosan chitin cross 100 mesh sieves respectively, by the facing-up method that equal-volume increases progressively percarbamide and adjuvant mix homogeneously are made soft material; In the process of mixing porphyrize, can not overexert and overlong time, cause percarbamide to decompose to avoid temperature to raise, should not play 40 ℃ usually.
The gained soft material is crossed 16 mesh sieves and is made granule drying under 35 ℃, packs with bag.Every bag of 2g, one bag of every clothes, warm boiled water.
Embodiment 3:
The preparation of oral type oxygen supply powder:
Get it filled with percarbamide 100g, chitosan (chitin) 1-5g, dextrin 3-8g;
Earlier, add percarbamide then with chitosan chitin and dextrin porphyrize mixing, grind altogether and mixing after be dispersed into packed.
Every 2g one pouch, one bag of every clothes, warm boiled water.
Embodiment 4:
The preparation of oral type oxygen supply capsule:
Get it filled with percarbamide 100g, chitosan (chitin) 1-5g, the porphyrize mixing is crossed 100 mesh sieves altogether, by every ball 0.5g packing.
Embodiment 5:
The preparation of oral type oxygen supply liquid:
Get it filled with percarbamide 5g, chitosan (chitin) 0.1-0.5g, adding distil water directly is packaged into bottle to 50ml, is stored under the room temperature standby.
In the present embodiment adding of chitosan chitin be for the pH value that keeps preparation in the near neutral scope of 6-7.
Being equipped with the agent of gained oxygen supply according to above each side legal system should preserve in the shady and cool place of room temperature, avoids heap to press, forbid to contact with burning things which may cause a fire disaster.
Using method:
Powder, granule are got a generation at every turn, and tablet is got 4 at every turn, and capsule 0.5g/ grain is got 4 at every turn and poured out medicated powder, respectively at adding warm water 30-50ml in the cup, stir and take after molten.
Except that above-mentioned using method, the various oral formulations among the present invention also can be taken at any time, directly put into mouth eliminating cold for resuscitation water leukorrhagia.
Claims (6)
1, oral percarbonateamide oxygen-supply agent is characterized in that described oxygen supply agent is serves as system oxygen raw material with medicinal percarbamide, is equipped with the peroral dosage form of appropriate amount of auxiliary materials; Described medicinal percarbamide is 50-100g, and adjuvant comprises chitosan 1-5g; The oxygen supply agent of described peroral dosage form is tablet, granule, capsule, powder and liquid preparation.
2, oral percarbonateamide oxygen-supply agent according to claim 1, the active o content that it is characterized in that described medicinal percarbamide are greater than 16.8%, and every gram oxygen-producing amount is no less than 80ml.
3, the preparation method of the described oxygen supply agent of a kind of claim 1, its feature has following steps:
A, to get it filled with percarbamide 100g, chitosan 1-5g, concentration be that 6-10% starch slurry is an amount of;
B, percarbamide grind after drying, cross 80 mesh sieves, make soft material with adding starch slurry behind the chitosan mixing of pulverizing;
C, gained soft material are crossed 18 mesh sieves and are made wet granular, and drying is after 18 mesh sieve granulate, weigh tabletting.
4, the preparation method of the described oxygen supply agent of a kind of claim 1 is characterized in that having following steps:
A, the usefulness of getting it filled percarbamide 100g, chitosan 1-5g, dextrin 3-8g;
B, percarbamide drying, dried percarbamide, dextrin and chitosan are crossed 100 mesh sieves respectively, by the facing-up method that equal-volume increases progressively percarbamide and adjuvant mix homogeneously are made soft material;
C, gained soft material are crossed 16 mesh sieves and are made the granule after drying, pack with bag.
5, the preparation method of the described oxygen supply agent of a kind of claim 1 is characterized in that:
A, the usefulness of getting it filled percarbamide 100g, chitosan 1-5g, dextrin 3-8g;
B, earlier with chitosan and dextrin porphyrize mixing, add percarbamide then, grind altogether and mixing after be dispersed into packed.
6, the preparation method of the described oxygen supply agent of a kind of claim 1 is characterized in that: get it filled with percarbamide 100g, chitosan 1-5g, the porphyrize mixing is crossed 100 mesh sieves altogether, by every ball 0.5g packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100653610A CN100496474C (en) | 2004-11-25 | 2004-11-25 | Oral percarbonateamide oxygen-supply agent and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100653610A CN100496474C (en) | 2004-11-25 | 2004-11-25 | Oral percarbonateamide oxygen-supply agent and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1778291A CN1778291A (en) | 2006-05-31 |
| CN100496474C true CN100496474C (en) | 2009-06-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100653610A Expired - Fee Related CN100496474C (en) | 2004-11-25 | 2004-11-25 | Oral percarbonateamide oxygen-supply agent and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100496474C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105920020B (en) * | 2016-06-23 | 2019-01-08 | 潘海英 | A kind of pharmaceutical composition and its preparation method and application for treating pulmonary disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302441A (en) * | 1979-04-19 | 1981-11-24 | Hans R. Muhlemann | Solid oral preparations of urea hydrogen peroxide without glycerol |
-
2004
- 2004-11-25 CN CNB2004100653610A patent/CN100496474C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4302441A (en) * | 1979-04-19 | 1981-11-24 | Hans R. Muhlemann | Solid oral preparations of urea hydrogen peroxide without glycerol |
Non-Patent Citations (4)
| Title |
|---|
| 一种精细化工新产品-过碳酰胺. 侯钰等.河北化工. 1994 |
| 一种精细化工新产品-过碳酰胺. 侯钰等.河北化工. 1994 * |
| 过碳酰胺开发应用前景广阔. 李乐舜.小氮肥设计技术，第25卷第1期. 2004 |
| 过碳酰胺开发应用前景广阔. 李乐舜.小氮肥设计技术，第25卷第1期. 2004 * |
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| Publication number | Publication date |
|---|---|
| CN1778291A (en) | 2006-05-31 |
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Granted publication date: 20090610 Termination date: 20111125 |